BRPI0413501A - polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh - Google Patents

polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh

Info

Publication number
BRPI0413501A
BRPI0413501A BRPI0413501-6A BRPI0413501A BRPI0413501A BR PI0413501 A BRPI0413501 A BR PI0413501A BR PI0413501 A BRPI0413501 A BR PI0413501A BR PI0413501 A BRPI0413501 A BR PI0413501A
Authority
BR
Brazil
Prior art keywords
polypeptide
isolated
preparing
expression vector
host cell
Prior art date
Application number
BRPI0413501-6A
Other languages
English (en)
Portuguese (pt)
Inventor
S Christopher Davis
Richard John Fox
Vesna Gavrilovic
Gjalt W Huisman
Lisa Marie Newman
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of BRPI0413501A publication Critical patent/BRPI0413501A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0413501-6A 2003-08-11 2004-08-11 polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh BRPI0413501A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18
PCT/US2004/026654 WO2005017141A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Publications (1)

Publication Number Publication Date
BRPI0413501A true BRPI0413501A (pt) 2006-10-10

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413501-6A BRPI0413501A (pt) 2003-08-11 2004-08-11 polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh

Country Status (12)

Country Link
US (3) US7824898B2 (enExample)
EP (1) EP1654356A1 (enExample)
JP (1) JP2007502123A (enExample)
KR (1) KR20060064617A (enExample)
AU (1) AU2004265693A1 (enExample)
BR (1) BRPI0413501A (enExample)
CA (1) CA2535255A1 (enExample)
IL (1) IL173261A0 (enExample)
MX (1) MXPA06001725A (enExample)
NO (1) NO20060405L (enExample)
SG (1) SG148180A1 (enExample)
WO (1) WO2005017141A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4578240B2 (ja) 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
KR20060064617A (ko) 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드
EP1660669A4 (en) * 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
ATE556141T1 (de) 2005-12-21 2012-05-15 Basf Se Verfahren zur herstellung eines optisch angereicherten tertiären alkohols
US7993904B2 (en) 2006-03-03 2011-08-09 Basf Se Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
EP2130922A4 (en) * 2007-03-07 2010-03-31 Mitsubishi Rayon Co IMPROVED HALOHYDRIN EPOXIDASE
EP2195443B1 (en) 2007-08-24 2015-01-07 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
EP2285958B1 (en) 2008-06-13 2016-03-09 Codexis, Inc. Method of synthesizing polynucleotide variants
WO2010027710A2 (en) 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
ES2560459T3 (es) 2008-08-27 2016-02-19 Codexis, Inc. Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina
US8187856B2 (en) * 2008-12-18 2012-05-29 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
SG173815A1 (en) 2009-02-26 2011-09-29 Codexis Inc Transaminase biocatalysts
DK2446025T3 (en) 2009-06-22 2018-10-22 Codexis Inc : KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROAD TO ALFA CHLORAL ALCOHOLS
ES2644992T3 (es) 2009-06-22 2017-12-01 Codexis, Inc. Reacciones de transaminasa
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
EP2478137B1 (en) 2009-09-18 2017-09-13 Codexis, Inc. Reduced codon mutagenesis
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
EP2697662B1 (en) 2011-04-13 2018-06-06 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
EP2780448B1 (en) 2011-11-18 2019-09-11 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
SG11201407297VA (en) 2012-05-11 2014-12-30 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
EP3068793B1 (en) 2013-11-13 2021-02-17 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG10202012428PA (en) 2014-11-25 2021-01-28 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
US10344286B2 (en) 2015-05-13 2019-07-09 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
US10358632B2 (en) 2015-12-07 2019-07-23 Samsung Electronics Co., Ltd. Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
JP2022509042A (ja) * 2018-11-07 2022-01-20 ザ ロイヤル インスティテューション フォー ザ アドバンスメント オブ ラーニング／マクギル ユニバーシティ テストステロン誘導ペプチド化合物及び関連する組合せ
JP2026504068A (ja) 2023-01-12 2026-02-03 ノバルティス アーゲー 改変ケトレダクターゼポリペプチド
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210031A (en) 1989-07-20 1993-05-11 Nitto Chemical Industry Co., Ltd. Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
JP2840722B2 (ja) 1989-07-20 1998-12-24 日東化学工業株式会社 ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法
JP3073037B2 (ja) 1991-03-04 2000-08-07 三菱レイヨン株式会社 ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物
JP3171931B2 (ja) 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US5908953A (en) 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
JP3728045B2 (ja) 1997-01-31 2005-12-21 三菱レイヨン株式会社 ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質
EP0879890A1 (en) 1997-05-21 1998-11-25 Rijksuniversiteit te Groningen Enantioselective epoxide hydrolases and genes encoding these
EP1054860B1 (en) 1997-12-19 2007-04-25 Pfizer Ireland Pharmaceuticals Process for the synthesis of 1,3-diols
ES2207202T3 (es) 1998-04-30 2004-05-16 Kaneka Corporation Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico.
CN1162422C (zh) 1998-08-05 2004-08-18 钟渊化学工业株式会社 制备光学活性的2－[6－(羟甲基)－1,3－二噁烷－4－基]乙酸衍生物的方法
EP1194582A1 (de) 1999-07-09 2002-04-10 Forschungszentrum Jülich Gmbh Verfahren zur reduktion von keto-carbonsäuren und deren estern
SI20642A (sl) 1999-12-03 2002-02-28 Kaneka Corporation Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
JP4578240B2 (ja) 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660669A4 (en) 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
KR20060064617A (ko) 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드

Also Published As

Publication number Publication date
EP1654356A1 (en) 2006-05-10
MXPA06001725A (es) 2006-04-27
IL173261A0 (en) 2006-06-11
US20120208259A1 (en) 2012-08-16
WO2005017141A1 (en) 2005-02-24
NO20060405L (no) 2006-03-10
US8535910B2 (en) 2013-09-17
KR20060064617A (ko) 2006-06-13
SG148180A1 (en) 2008-12-31
CA2535255A1 (en) 2005-02-24
US20050153417A1 (en) 2005-07-14
JP2007502123A (ja) 2007-02-08
US7824898B2 (en) 2010-11-02
US20100167345A1 (en) 2010-07-01
US8101395B2 (en) 2012-01-24
AU2004265693A1 (en) 2005-02-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.