SG148180A1 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents

Improved halohydrin dehalogenases and related polynucleotides

Info

Publication number
SG148180A1
SG148180A1 SG200808477-4A SG2008084774A SG148180A1 SG 148180 A1 SG148180 A1 SG 148180A1 SG 2008084774 A SG2008084774 A SG 2008084774A SG 148180 A1 SG148180 A1 SG 148180A1
Authority
SG
Singapore
Prior art keywords
related polynucleotides
polynucleotides
improved halohydrin
polypeptides
halohydrin dehalogenases
Prior art date
Application number
SG200808477-4A
Other languages
English (en)
Inventor
S Christopher Davis
Richard John Fox
Vesna Gavrilovic
Gjalt W Huisman
Lisa Marie Newman
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG148180A1 publication Critical patent/SG148180A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG200808477-4A 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides SG148180A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18

Publications (1)

Publication Number Publication Date
SG148180A1 true SG148180A1 (en) 2008-12-31

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200808477-4A SG148180A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Country Status (12)

Country Link
US (3) US7824898B2 (enExample)
EP (1) EP1654356A1 (enExample)
JP (1) JP2007502123A (enExample)
KR (1) KR20060064617A (enExample)
AU (1) AU2004265693A1 (enExample)
BR (1) BRPI0413501A (enExample)
CA (1) CA2535255A1 (enExample)
IL (1) IL173261A0 (enExample)
MX (1) MXPA06001725A (enExample)
NO (1) NO20060405L (enExample)
SG (1) SG148180A1 (enExample)
WO (1) WO2005017141A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
JP2007502123A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改善されたハロヒドリンデハロゲナーゼおよび関連するポリヌクレオチド
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
BRPI0413498A (pt) 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
ATE556141T1 (de) 2005-12-21 2012-05-15 Basf Se Verfahren zur herstellung eines optisch angereicherten tertiären alkohols
DE602007001794D1 (de) 2006-03-03 2009-09-10 Basf Se Verfahren zur herstellung optisch aktiver 5-substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase
KR20090083900A (ko) 2006-10-02 2009-08-04 코덱시스, 인코포레이티드 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법
EP2518152A3 (en) 2007-03-07 2013-03-06 Mitsubishi Rayon Co., Ltd. Improved halohydrin epoxidase
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
CN102066561B (zh) 2008-06-13 2013-09-25 科德克希思公司 合成多核苷酸变体的方法
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
EP2379713A4 (en) * 2008-12-18 2013-07-10 Codexis Inc RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES
WO2010099501A2 (en) 2009-02-26 2010-09-02 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
DK3409765T3 (da) 2009-06-22 2021-09-27 Codexis Inc Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
DK2478137T3 (da) 2009-09-18 2017-11-27 Codexis Inc Reduceret kodonmutagenese
US8895271B2 (en) 2009-12-08 2014-11-25 Codexis, Inc. Synthesis of prazole compounds
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
WO2013074650A1 (en) 2011-11-18 2013-05-23 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
CN107904216B (zh) 2012-05-11 2021-06-29 科德克希思公司 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
DK3068793T3 (da) 2013-11-13 2021-03-22 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
EP3093337A3 (en) 2015-05-13 2017-03-15 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
EP3178922B1 (en) 2015-12-07 2019-05-22 Samsung Electronics Co., Ltd. Bacterial cytochrome p450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
WO2020093142A1 (en) * 2018-11-07 2020-05-14 The Royal Institution For The Advancement Of Learning/Mcgill University Testosterone-inducing peptide compounds and associated combinations
WO2024150146A1 (en) 2023-01-12 2024-07-18 Novartis Ag Engineered ketoreductase polypeptides
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2840722B2 (ja) * 1989-07-20 1998-12-24 日東化学工業株式会社 ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法
US5210031A (en) * 1989-07-20 1993-05-11 Nitto Chemical Industry Co., Ltd. Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
JP3073037B2 (ja) 1991-03-04 2000-08-07 三菱レイヨン株式会社 ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物
JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US5908953A (en) * 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
JP3728045B2 (ja) 1997-01-31 2005-12-21 三菱レイヨン株式会社 ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質
EP0879890A1 (en) 1997-05-21 1998-11-25 Rijksuniversiteit te Groningen Enantioselective epoxide hydrolases and genes encoding these
DK1054860T3 (da) * 1997-12-19 2007-07-02 Pfizer Ireland Pharmaceuticals Proces for syntesen af 1,3-dioler
US6344569B1 (en) * 1998-04-30 2002-02-05 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
ATE375989T1 (de) * 1998-08-05 2007-11-15 Kaneka Corp Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
WO2001004336A1 (de) * 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
HUP0105331A3 (en) * 1999-12-03 2005-10-28 Kaneka Corp Novel carbonyl reductase, gene thereof and method of using the same
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
JP2007502123A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改善されたハロヒドリンデハロゲナーゼおよび関連するポリヌクレオチド
BRPI0413498A (pt) 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
NO20060405L (no) 2006-03-10
MXPA06001725A (es) 2006-04-27
US20100167345A1 (en) 2010-07-01
BRPI0413501A (pt) 2006-10-10
US20050153417A1 (en) 2005-07-14
AU2004265693A1 (en) 2005-02-24
US7824898B2 (en) 2010-11-02
CA2535255A1 (en) 2005-02-24
KR20060064617A (ko) 2006-06-13
JP2007502123A (ja) 2007-02-08
IL173261A0 (en) 2006-06-11
US8101395B2 (en) 2012-01-24
WO2005017141A1 (en) 2005-02-24
US8535910B2 (en) 2013-09-17
US20120208259A1 (en) 2012-08-16
EP1654356A1 (en) 2006-05-10

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