SG148180A1 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents
Improved halohydrin dehalogenases and related polynucleotidesInfo
- Publication number
- SG148180A1 SG148180A1 SG200808477-4A SG2008084774A SG148180A1 SG 148180 A1 SG148180 A1 SG 148180A1 SG 2008084774 A SG2008084774 A SG 2008084774A SG 148180 A1 SG148180 A1 SG 148180A1
- Authority
- SG
- Singapore
- Prior art keywords
- related polynucleotides
- polynucleotides
- improved halohydrin
- polypeptides
- halohydrin dehalogenases
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 108010013164 halohydrin dehalogenase Proteins 0.000 title 1
- 150000003944 halohydrins Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49438203P | 2003-08-11 | 2003-08-11 | |
| US54603304P | 2004-02-18 | 2004-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG148180A1 true SG148180A1 (en) | 2008-12-31 |
Family
ID=34197997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200808477-4A SG148180A1 (en) | 2003-08-11 | 2004-08-11 | Improved halohydrin dehalogenases and related polynucleotides |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7824898B2 (enExample) |
| EP (1) | EP1654356A1 (enExample) |
| JP (1) | JP2007502123A (enExample) |
| KR (1) | KR20060064617A (enExample) |
| AU (1) | AU2004265693A1 (enExample) |
| BR (1) | BRPI0413501A (enExample) |
| CA (1) | CA2535255A1 (enExample) |
| IL (1) | IL173261A0 (enExample) |
| MX (1) | MXPA06001725A (enExample) |
| NO (1) | NO20060405L (enExample) |
| SG (1) | SG148180A1 (enExample) |
| WO (1) | WO2005017141A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132267B2 (en) * | 2002-08-09 | 2006-11-07 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| EP1537222B1 (en) * | 2002-08-09 | 2011-03-09 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| EP1654356A1 (en) | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved halohydrin dehalogenases and related polynucleotides |
| US8198069B2 (en) | 2005-12-21 | 2012-06-12 | Basf Se | Method of producing an optically enriched tertiary alcohol from an epoxide using halohydrin dehalogenase |
| US7993904B2 (en) | 2006-03-03 | 2011-08-09 | Basf Se | Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase |
| EP2066788B1 (en) * | 2006-10-02 | 2014-07-23 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| US8637272B2 (en) | 2007-03-07 | 2014-01-28 | Mitsubishi Rayon Co., Ltd. | Halohydrin epoxidase |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| HUE041367T2 (hu) | 2008-06-13 | 2019-05-28 | Codexis Inc | Eljárás polinukleotid-változatok szintézisére |
| HUE026181T2 (en) | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| WO2010027710A2 (en) * | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| WO2010080635A2 (en) * | 2008-12-18 | 2010-07-15 | Codexis, Inc. | Recombinant halohydrin dehalogenase polypeptides |
| US8293507B2 (en) | 2009-02-26 | 2012-10-23 | Codexis, Inc. | Transaminase biocatalysts |
| WO2011005527A2 (en) | 2009-06-22 | 2011-01-13 | Codexis, Inc. | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| EP2446026B1 (en) | 2009-06-22 | 2017-08-09 | Codexis, Inc. | Transaminase reactions |
| US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| DK2478137T3 (da) | 2009-09-18 | 2017-11-27 | Codexis Inc | Reduceret kodonmutagenese |
| WO2011071982A2 (en) | 2009-12-08 | 2011-06-16 | Codexis, Inc. | Synthesis of prazole compounds |
| WO2011140219A1 (en) | 2010-05-04 | 2011-11-10 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| WO2012024104A2 (en) | 2010-08-16 | 2012-02-23 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| CN104053771B (zh) | 2011-11-18 | 2016-11-09 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| DK2847214T3 (en) | 2012-05-11 | 2018-03-12 | Codexis Inc | CONSTRUCTED IMINE REDUCTIONS AND PROCEDURES FOR THE REDUCED AMINING OF KETON AND AMINE COMPOUNDS |
| CN104372038A (zh) * | 2013-08-12 | 2015-02-25 | 南京朗恩生物科技有限公司 | 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
| DK3068793T3 (da) | 2013-11-13 | 2021-03-22 | Codexis Inc | Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser |
| SG11201703258PA (en) | 2014-11-25 | 2017-05-30 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| EP3256577B1 (en) | 2015-02-10 | 2020-08-26 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN104745557B (zh) * | 2015-03-05 | 2017-09-22 | 浙江工业大学 | 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用 |
| US10344286B2 (en) | 2015-05-13 | 2019-07-09 | Samsung Electronics Co., Ltd. | Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same |
| US10358632B2 (en) | 2015-12-07 | 2019-07-23 | Samsung Electronics Co., Ltd. | Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same |
| EP3587393B1 (en) | 2018-06-21 | 2024-01-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Enzymatic process for the preparation of droxidopa |
| CN109295044A (zh) * | 2018-10-26 | 2019-02-01 | 浙江大学 | 一种卤醇脱卤酶突变体及其应用 |
| WO2020093142A1 (en) * | 2018-11-07 | 2020-05-14 | The Royal Institution For The Advancement Of Learning/Mcgill University | Testosterone-inducing peptide compounds and associated combinations |
| EP4649143A1 (en) | 2023-01-12 | 2025-11-19 | Novartis AG | Engineered ketoreductase polypeptides |
| CN119530210B (zh) * | 2024-11-12 | 2025-10-03 | 南京师范大学 | 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2840722B2 (ja) * | 1989-07-20 | 1998-12-24 | 日東化学工業株式会社 | ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法 |
| US5210031A (en) * | 1989-07-20 | 1993-05-11 | Nitto Chemical Industry Co., Ltd. | Process for the production of R(-)-4-halo-3-hydroxybutyronitrile |
| JP3073037B2 (ja) | 1991-03-04 | 2000-08-07 | 三菱レイヨン株式会社 | ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物 |
| JP3171931B2 (ja) * | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法 |
| GB9512837D0 (en) * | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| US5908953A (en) * | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
| JP3728045B2 (ja) | 1997-01-31 | 2005-12-21 | 三菱レイヨン株式会社 | ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質 |
| EP0879890A1 (en) | 1997-05-21 | 1998-11-25 | Rijksuniversiteit te Groningen | Enantioselective epoxide hydrolases and genes encoding these |
| WO1999032434A1 (en) * | 1997-12-19 | 1999-07-01 | Warner-Lambert Export Limited | Process for the synthesis of 1,3-diols |
| DE69910562T2 (de) * | 1998-04-30 | 2004-06-17 | Kaneka Corp. | Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure |
| CA2305564C (en) * | 1998-08-05 | 2008-06-17 | Kaneka Corporation | Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives |
| WO2001004336A1 (de) * | 1999-07-09 | 2001-01-18 | Forschungszentrum Jülich GmbH | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
| JP4510351B2 (ja) * | 1999-12-03 | 2010-07-21 | 株式会社カネカ | 新規カルボニル還元酵素、その遺伝子、およびその利用法 |
| EP1158054A1 (en) | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Enzymatic conversion of epoxides |
| EP1537222B1 (en) * | 2002-08-09 | 2011-03-09 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| US7132267B2 (en) * | 2002-08-09 | 2006-11-07 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| EP1654356A1 (en) | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved halohydrin dehalogenases and related polynucleotides |
| US7588928B2 (en) | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
-
2004
- 2004-08-11 EP EP04781364A patent/EP1654356A1/en not_active Withdrawn
- 2004-08-11 SG SG200808477-4A patent/SG148180A1/en unknown
- 2004-08-11 MX MXPA06001725A patent/MXPA06001725A/es unknown
- 2004-08-11 CA CA002535255A patent/CA2535255A1/en not_active Abandoned
- 2004-08-11 AU AU2004265693A patent/AU2004265693A1/en not_active Abandoned
- 2004-08-11 JP JP2006523447A patent/JP2007502123A/ja active Pending
- 2004-08-11 KR KR1020067002876A patent/KR20060064617A/ko not_active Ceased
- 2004-08-11 BR BRPI0413501-6A patent/BRPI0413501A/pt not_active IP Right Cessation
- 2004-08-11 US US10/917,179 patent/US7824898B2/en active Active
- 2004-08-11 WO PCT/US2004/026654 patent/WO2005017141A1/en not_active Ceased
-
2006
- 2006-01-19 IL IL173261A patent/IL173261A0/en unknown
- 2006-01-25 NO NO20060405A patent/NO20060405L/no not_active Application Discontinuation
-
2009
- 2009-10-05 US US12/573,824 patent/US8101395B2/en not_active Expired - Lifetime
-
2012
- 2012-01-12 US US13/349,514 patent/US8535910B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO20060405L (no) | 2006-03-10 |
| US7824898B2 (en) | 2010-11-02 |
| US8101395B2 (en) | 2012-01-24 |
| AU2004265693A1 (en) | 2005-02-24 |
| KR20060064617A (ko) | 2006-06-13 |
| MXPA06001725A (es) | 2006-04-27 |
| JP2007502123A (ja) | 2007-02-08 |
| WO2005017141A1 (en) | 2005-02-24 |
| EP1654356A1 (en) | 2006-05-10 |
| US20100167345A1 (en) | 2010-07-01 |
| US20120208259A1 (en) | 2012-08-16 |
| IL173261A0 (en) | 2006-06-11 |
| US8535910B2 (en) | 2013-09-17 |
| US20050153417A1 (en) | 2005-07-14 |
| BRPI0413501A (pt) | 2006-10-10 |
| CA2535255A1 (en) | 2005-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG148180A1 (en) | Improved halohydrin dehalogenases and related polynucleotides | |
| WO2006073839A3 (en) | Acid fungal proteases | |
| CY1122672T1 (el) | Βελτιωμενα nanobodiestm εναντι του παραγοντα νεκρωσης ογκων αλφα | |
| ATE512980T1 (de) | Polypeptide mit beta-glucosidase-aktivität sowie diese codierende polynukleotide | |
| MX2009012846A (es) | Polipeptidos que tienen actividad celulosica mejorada y polinucleotidos que los codifican. | |
| WO2005056759A3 (en) | Methods of generating variant proteins with increased host string content and compositions thereof | |
| WO2006039541A3 (en) | Polypeptides having lipase activity and polynucleotides encoding same | |
| WO2005121331A3 (en) | Truncated galnact2 polypeptides and nucleic acids | |
| WO2009105141A3 (en) | Polypeptides having endoglucanase activity and polynucleotides encoding same | |
| AU2001242299A1 (en) | Fungal transcriptional activator useful in methods for producing polypeptides | |
| WO2006047469A3 (en) | Polypeptides having lipase activity and polynucleotides encoding same | |
| WO2006091470A3 (en) | Improved halohydrin dehalogenases and related polynucleotides | |
| WO2006053021A3 (en) | Methods for engineering polypeptide variants via somatic hypermutation and polypeptides made thereby | |
| DK1157100T3 (da) | Oxaloacetathydrolase-defekte svampeværtsceller | |
| WO2005024006A8 (en) | Coagulation factor VII polypeptides | |
| WO2006005032A3 (en) | Polypeptides having alpha-glucosidase activity and polynucleotides encoding same | |
| WO2006003009A3 (en) | New esterases from rumen | |
| WO2005014790A3 (en) | Polypeptides having oxaloecetate hydrolase activity and polynucleotides encoding same |