IL173261A0 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents

Improved halohydrin dehalogenases and related polynucleotides

Info

Publication number
IL173261A0
IL173261A0 IL173261A IL17326106A IL173261A0 IL 173261 A0 IL173261 A0 IL 173261A0 IL 173261 A IL173261 A IL 173261A IL 17326106 A IL17326106 A IL 17326106A IL 173261 A0 IL173261 A0 IL 173261A0
Authority
IL
Israel
Prior art keywords
related polynucleotides
improved halohydrin
halohydrin dehalogenases
dehalogenases
improved
Prior art date
Application number
IL173261A
Other languages
English (en)
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IL173261A0 publication Critical patent/IL173261A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL173261A 2003-08-11 2006-01-19 Improved halohydrin dehalogenases and related polynucleotides IL173261A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18
PCT/US2004/026654 WO2005017141A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Publications (1)

Publication Number Publication Date
IL173261A0 true IL173261A0 (en) 2006-06-11

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
IL173261A IL173261A0 (en) 2003-08-11 2006-01-19 Improved halohydrin dehalogenases and related polynucleotides

Country Status (12)

Country Link
US (3) US7824898B2 (enExample)
EP (1) EP1654356A1 (enExample)
JP (1) JP2007502123A (enExample)
KR (1) KR20060064617A (enExample)
AU (1) AU2004265693A1 (enExample)
BR (1) BRPI0413501A (enExample)
CA (1) CA2535255A1 (enExample)
IL (1) IL173261A0 (enExample)
MX (1) MXPA06001725A (enExample)
NO (1) NO20060405L (enExample)
SG (1) SG148180A1 (enExample)
WO (1) WO2005017141A1 (enExample)

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US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
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KR20090083900A (ko) 2006-10-02 2009-08-04 코덱시스, 인코포레이티드 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법
EP2130922A4 (en) * 2007-03-07 2010-03-31 Mitsubishi Rayon Co IMPROVED HALOHYDRIN EPOXIDASE
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
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US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
SG172231A1 (en) 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
US8293507B2 (en) 2009-02-26 2012-10-23 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
HUE055413T2 (hu) 2009-06-22 2021-11-29 Codexis Inc Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
EP3301208B1 (en) 2009-09-18 2020-11-04 Codexis, Inc. Reduced codon mutagenesis
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
HUE046089T2 (hu) 2011-11-18 2020-01-28 Codexis Inc Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
US9193957B2 (en) 2012-05-11 2015-11-24 Codexis, Inc. Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
HUE053379T2 (hu) 2013-11-13 2021-06-28 Codexis Inc Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
US10344286B2 (en) 2015-05-13 2019-07-09 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
US10358632B2 (en) 2015-12-07 2019-07-23 Samsung Electronics Co., Ltd. Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
BR112021008642A2 (pt) * 2018-11-07 2021-08-10 The Royal Institution For The Advancement Of Learning/ Mcgill University compostos peptídicos indutores de testosterona e combinações associadas
CN120981566A (zh) 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

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JP2003504070A (ja) 1999-07-09 2003-02-04 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトカルボン酸及びそのエステルの還元のための方法
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US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
MXPA06001718A (es) 2003-08-11 2006-05-19 Codexis Inc Procedimiento enzimatico para la produccion de derivados de acido 3-hidroxibutirico 4-sustituido y esteres de acido carboxilico sustituido con ciano e hidroxi vecinales.
EP1654356A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
US20120208259A1 (en) 2012-08-16
EP1654356A1 (en) 2006-05-10
WO2005017141A1 (en) 2005-02-24
CA2535255A1 (en) 2005-02-24
US7824898B2 (en) 2010-11-02
SG148180A1 (en) 2008-12-31
JP2007502123A (ja) 2007-02-08
MXPA06001725A (es) 2006-04-27
US20100167345A1 (en) 2010-07-01
US20050153417A1 (en) 2005-07-14
KR20060064617A (ko) 2006-06-13
NO20060405L (no) 2006-03-10
US8535910B2 (en) 2013-09-17
BRPI0413501A (pt) 2006-10-10
AU2004265693A1 (en) 2005-02-24
US8101395B2 (en) 2012-01-24

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