NO20060405L - Forbedrede halohydrindehalogenaser og relaterte polynukleotider - Google Patents

Forbedrede halohydrindehalogenaser og relaterte polynukleotider

Info

Publication number
NO20060405L
NO20060405L NO20060405A NO20060405A NO20060405L NO 20060405 L NO20060405 L NO 20060405L NO 20060405 A NO20060405 A NO 20060405A NO 20060405 A NO20060405 A NO 20060405A NO 20060405 L NO20060405 L NO 20060405L
Authority
NO
Norway
Prior art keywords
halohydrin
halogenases
enhanced
related polynucleotides
polypeptides
Prior art date
Application number
NO20060405A
Other languages
English (en)
Norwegian (no)
Inventor
Christopher S Davis
Gjalr W Huisman
Lisa Marie Newman
Richard John Fox
Vesna Gavrilovic
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of NO20060405L publication Critical patent/NO20060405L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20060405A 2003-08-11 2006-01-25 Forbedrede halohydrindehalogenaser og relaterte polynukleotider NO20060405L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18
PCT/US2004/026654 WO2005017141A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Publications (1)

Publication Number Publication Date
NO20060405L true NO20060405L (no) 2006-03-10

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060405A NO20060405L (no) 2003-08-11 2006-01-25 Forbedrede halohydrindehalogenaser og relaterte polynukleotider

Country Status (12)

Country Link
US (3) US7824898B2 (enExample)
EP (1) EP1654356A1 (enExample)
JP (1) JP2007502123A (enExample)
KR (1) KR20060064617A (enExample)
AU (1) AU2004265693A1 (enExample)
BR (1) BRPI0413501A (enExample)
CA (1) CA2535255A1 (enExample)
IL (1) IL173261A0 (enExample)
MX (1) MXPA06001725A (enExample)
NO (1) NO20060405L (enExample)
SG (1) SG148180A1 (enExample)
WO (1) WO2005017141A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
EP1654356A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
MXPA06001718A (es) 2003-08-11 2006-05-19 Codexis Inc Procedimiento enzimatico para la produccion de derivados de acido 3-hidroxibutirico 4-sustituido y esteres de acido carboxilico sustituido con ciano e hidroxi vecinales.
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1966385B1 (en) 2005-12-21 2012-05-02 Basf Se A process for the production of an optically enriched tertiary alcohol
WO2007099107A1 (en) 2006-03-03 2007-09-07 Basf Se Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
KR20090083900A (ko) 2006-10-02 2009-08-04 코덱시스, 인코포레이티드 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법
EP2130922A4 (en) * 2007-03-07 2010-03-31 Mitsubishi Rayon Co IMPROVED HALOHYDRIN EPOXIDASE
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
DK2285958T3 (en) 2008-06-13 2016-03-29 Codexis Inc Method for synthesizing polynucleotides
ES2560459T3 (es) 2008-08-27 2016-02-19 Codexis, Inc. Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
SG172231A1 (en) 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
US8293507B2 (en) 2009-02-26 2012-10-23 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
HUE055413T2 (hu) 2009-06-22 2021-11-29 Codexis Inc Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
EP3301208B1 (en) 2009-09-18 2020-11-04 Codexis, Inc. Reduced codon mutagenesis
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
HUE046089T2 (hu) 2011-11-18 2020-01-28 Codexis Inc Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
US9193957B2 (en) 2012-05-11 2015-11-24 Codexis, Inc. Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
HUE053379T2 (hu) 2013-11-13 2021-06-28 Codexis Inc Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
US10344286B2 (en) 2015-05-13 2019-07-09 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
US10358632B2 (en) 2015-12-07 2019-07-23 Samsung Electronics Co., Ltd. Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
BR112021008642A2 (pt) * 2018-11-07 2021-08-10 The Royal Institution For The Advancement Of Learning/ Mcgill University compostos peptídicos indutores de testosterona e combinações associadas
CN120981566A (zh) 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210031A (en) 1989-07-20 1993-05-11 Nitto Chemical Industry Co., Ltd. Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
JP2840722B2 (ja) 1989-07-20 1998-12-24 日東化学工業株式会社 ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法
JP3073037B2 (ja) 1991-03-04 2000-08-07 三菱レイヨン株式会社 ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物
JP3171931B2 (ja) 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US5908953A (en) 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
JP3728045B2 (ja) 1997-01-31 2005-12-21 三菱レイヨン株式会社 ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質
EP0879890A1 (en) 1997-05-21 1998-11-25 Rijksuniversiteit te Groningen Enantioselective epoxide hydrolases and genes encoding these
US6433213B1 (en) 1997-12-19 2002-08-13 Warner-Lambert Company Process for the synthesis of 1,3-diols
DE69910562T2 (de) 1998-04-30 2004-06-17 Kaneka Corp. Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
ES2294236T3 (es) 1998-08-05 2008-04-01 Kaneka Corporation Procedimiento para la preparacion de esteres sustituidos con 3,5-dihidroxi como intermedios para producir derivados de acido 2-(6-hiximetil)-1,3-dioxan-4-il) acetico opticamente activos.
JP2003504070A (ja) 1999-07-09 2003-02-04 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトカルボン酸及びそのエステルの還元のための方法
WO2001040450A1 (en) 1999-12-03 2001-06-07 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
JP4578240B2 (ja) 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
MXPA06001718A (es) 2003-08-11 2006-05-19 Codexis Inc Procedimiento enzimatico para la produccion de derivados de acido 3-hidroxibutirico 4-sustituido y esteres de acido carboxilico sustituido con ciano e hidroxi vecinales.
EP1654356A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
US20120208259A1 (en) 2012-08-16
IL173261A0 (en) 2006-06-11
EP1654356A1 (en) 2006-05-10
WO2005017141A1 (en) 2005-02-24
CA2535255A1 (en) 2005-02-24
US7824898B2 (en) 2010-11-02
SG148180A1 (en) 2008-12-31
JP2007502123A (ja) 2007-02-08
MXPA06001725A (es) 2006-04-27
US20100167345A1 (en) 2010-07-01
US20050153417A1 (en) 2005-07-14
KR20060064617A (ko) 2006-06-13
US8535910B2 (en) 2013-09-17
BRPI0413501A (pt) 2006-10-10
AU2004265693A1 (en) 2005-02-24
US8101395B2 (en) 2012-01-24

Similar Documents

Publication Publication Date Title
NO20060405L (no) Forbedrede halohydrindehalogenaser og relaterte polynukleotider
Elsayed et al. Chaxapeptin, a lasso peptide from extremotolerant Streptomyces leeuwenhoekii strain C58 from the hyperarid Atacama Desert
Griffiths et al. Site‐Selective Installation of Nϵ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation
WO2005065339A3 (en) Cell cycle genes and related methods of using
DK2079706T3 (da) Fremgangsmåde til fremstilling af medetomidin og saltene deraf
DK1641910T3 (da) Glucanaser, nucleinsyrer, som koder for disse, og fremgangsmåder til at fremstille og benytte disse
WO2005077091A3 (en) Nicotinamide riboside kinase compositions and methods for using the same
MX2008013073A (es) Metodos y aparatos para codificar y decodificar señales de audio basadas en objeto.
NO20052524L (no) Aminerte isofiavonoidderivater og anvendelse derav
WO2010073140A3 (en) Portable and stationary oxygen concentrator system
NO20071116L (no) Radikaler og bruk av de som paramagnetisk middel i en DNP-prosess
Szantai-Kis et al. Thieme Chemistry Journals Awardees–Where Are They Now? Improved Fmoc Deprotection Methods for the Synthesis of Thioamide-Containing Peptides and Proteins
NO20031141L (no) Nye forbindelser
Barrio et al. Asymmetric Synthesis of Fluorinated Isoindolinones through Palladium‐Catalyzed Carbonylative Amination of Enantioenriched Benzylic Carbamates
WO2004092348A3 (en) Method for production of oncolytic adenoviruses
NO20025151L (no) Nye forbindelser
WO2006116322A3 (en) Nicotinamide riboside kinase compositions and methods for using the same
NO20072966L (no) Polypeptider som har antimikrobeaktivitet og polynukleotider som koder for disse
WO2004111836A3 (en) Apparatus and method that accommodate multiple instruction sets and multiple decode modes
NO20045025L (no) Nye forbindelser
Shepherd et al. Synthesis of Unsymmetrical Tweezer Receptor Libraries and Identification of Receptors for Lys‐D‐Ala‐D‐Ala in Aqueous Solution
NO20073652L (no) Enantiomerer av 3-heteroaryl-8H-8-azabisyklo(3.2.1)okt-2-en og deres anvendelse som monoaminnevrotransmitter-gjenopptaksinhibitorer
WO2007034487A8 (en) Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
AU2003278286A1 (en) Method for producing acrylic acid from propane, in the presence of molecular oxygen
EP1448940A4 (en) DEVICE FOR FAST, HIGH VOLUME PRODUCTION OF SOLID CO2 PELLS

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application