BRPI0413492A - polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição - Google Patents
polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composiçãoInfo
- Publication number
- BRPI0413492A BRPI0413492A BRPI0413492-3A BRPI0413492A BRPI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A
- Authority
- BR
- Brazil
- Prior art keywords
- gdh
- polypeptide
- nucleic acid
- polynucleotide
- acid sequence
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 239000013604 expression vector Substances 0.000 title abstract 3
- 150000007523 nucleic acids Chemical group 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 abstract 8
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003319 supportive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49430003P | 2003-08-11 | 2003-08-11 | |
US54565704P | 2004-02-18 | 2004-02-18 | |
PCT/US2004/026194 WO2005045016A2 (en) | 2003-08-11 | 2004-08-11 | Improved glucose dehydrogenase polypeptides and related polynucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413492A true BRPI0413492A (pt) | 2006-10-17 |
Family
ID=34576547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413492-3A BRPI0413492A (pt) | 2003-08-11 | 2004-08-11 | polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição |
Country Status (11)
Families Citing this family (53)
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BR0305767A (pt) | 2002-08-09 | 2005-05-24 | Codexis Inc | Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico |
CA2511656A1 (en) | 2002-12-24 | 2004-07-15 | Ikeda Food Research Co., Ltd. | Coenzyme-binding glucose dehydrogenase |
GB0330016D0 (en) * | 2003-12-24 | 2004-01-28 | Danisco | Method |
MXPA06001719A (es) | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
WO2005018579A2 (en) | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
BRPI0417533B1 (pt) * | 2003-12-24 | 2016-03-01 | Danisco | enzima variante glicolipídio aciltransferase, uso e método para sua produção, método para o preparo de um produto alimentício e produto assado de farinha, processo de refinamento enzimático |
DE102004059376A1 (de) * | 2004-12-09 | 2006-06-22 | Consortium für elektrochemische Industrie GmbH | GDH-Mutante mit verbesserter chemischer Stabilität |
CN101160397A (zh) | 2005-03-25 | 2008-04-09 | 池田食研株式会社 | 辅酶结合型葡萄糖脱氢酶及编码该酶的多核苷酸 |
DE102005036880A1 (de) * | 2005-08-02 | 2007-02-08 | Julich Chiral Solutions Gmbh | Stereoselektive Synthese von chiralen Diolen |
US7879585B2 (en) | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
CN101535476B (zh) * | 2006-11-14 | 2012-10-24 | 东洋纺织株式会社 | 修饰型黄素腺嘌呤二核苷酸依赖性葡萄糖脱氢酶 |
JP2009034062A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼ |
JP2009034063A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼの安定性向上方法 |
US7977078B2 (en) | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
EP2093284A1 (de) | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8288131B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
EP2329014B1 (en) | 2008-08-29 | 2014-10-22 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
CA2750474C (en) | 2009-02-19 | 2017-07-25 | F. Hoffmann-La Roche Ag | Fast reaction kinetics of enzymes having low activity in dry chemistry layers |
EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
DK2446025T3 (en) | 2009-06-22 | 2018-10-22 | Codexis Inc | : KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROAD TO ALFA CHLORAL ALCOHOLS |
SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
EP2292751A1 (de) | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
US8883434B2 (en) * | 2009-12-05 | 2014-11-11 | Amano Enzyme Inc. | Mutant enzyme and application thereof |
EP2510089B1 (en) | 2009-12-08 | 2015-10-21 | Codexis, Inc. | Synthesis of prazole compounds |
WO2011073258A1 (de) | 2009-12-16 | 2011-06-23 | F. Hoffmann-La Roche Ag | Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt |
EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
JP5949757B2 (ja) * | 2011-03-30 | 2016-07-13 | ニプロ株式会社 | 改変型グルコースデヒドロゲナーゼ |
HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
SG11201402401TA (en) | 2011-11-18 | 2014-06-27 | Codexis Inc | Biocatalysts for the preparation of hydroxy substituted carbamates |
EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
US9193957B2 (en) | 2012-05-11 | 2015-11-24 | Codexis, Inc. | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds |
EP2770064A1 (de) | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
US10150959B2 (en) | 2013-03-15 | 2018-12-11 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
CN105358687B (zh) | 2013-04-17 | 2018-10-09 | 科学与工业研究委员会 | 在有效生产对映体富集的醇中用于酮的对映体选择性还原的设计师细胞及其应用 |
WO2014180939A1 (en) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilization of enzymes by nicotinic acid |
WO2015073555A1 (en) | 2013-11-13 | 2015-05-21 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
WO2015078899A1 (en) | 2013-11-27 | 2015-06-04 | Roche Diagnostics Gmbh | Composition comprising up-converting phosphors for detecting an analyte |
EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
CN106164054B (zh) | 2014-04-14 | 2019-05-07 | 豪夫迈·罗氏有限公司 | 吩嗪介导剂 |
EP3183246B1 (en) | 2014-08-22 | 2020-09-23 | Roche Diagnostics GmbH | Redoxindicators |
WO2016085916A1 (en) | 2014-11-25 | 2016-06-02 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
US10696953B2 (en) | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
PL3523639T3 (pl) | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
MX2020006222A (es) | 2017-12-13 | 2020-08-31 | Codexis Inc | Polipeptidos de carboxiesterasa para acoplamiento de amidas. |
EP3587393B1 (en) | 2018-06-21 | 2024-01-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Enzymatic process for the preparation of droxidopa |
JP6480629B1 (ja) * | 2018-08-07 | 2019-03-13 | キッコーマン株式会社 | グルコースデヒドロゲナーゼの組換え製造方法 |
WO2020123563A1 (en) * | 2018-12-10 | 2020-06-18 | The Regents Of The University Of California | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof |
EP3963058A4 (en) * | 2019-05-01 | 2024-01-03 | Codexis, Inc. | MODIFIED GLUCOSE DEHYDROGENASES AND PROCESSES FOR THE REDUCTIVE AMINATION OF KETONE AND AMINO COMPOUNDS |
WO2024150146A1 (en) | 2023-01-12 | 2024-07-18 | Novartis Ag | Engineered ketoreductase polypeptides |
Family Cites Families (19)
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DE3019450A1 (de) * | 1980-05-21 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus |
US4542098A (en) * | 1983-05-06 | 1985-09-17 | Institut Francais Du Petrole | Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine |
US4877733A (en) * | 1986-05-02 | 1989-10-31 | Toyo Jozo Kabushiki Kaisha | Glucose dehydrogenase and its production |
DE3711881A1 (de) * | 1987-04-08 | 1988-10-27 | Merck Patent Gmbh | Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium |
DE3808531C1 (enrdf_load_stackoverflow) * | 1988-03-15 | 1989-07-13 | Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De | |
JPH0286779A (ja) * | 1988-09-22 | 1990-03-27 | Amano Pharmaceut Co Ltd | 改良型組換えdna、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法 |
JP2850515B2 (ja) * | 1990-09-25 | 1999-01-27 | 東洋紡績株式会社 | グルコースデヒドロゲナーゼおよびその製造法 |
GB9512837D0 (en) * | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
CA2305618C (en) * | 1997-12-19 | 2004-08-17 | Warner-Lambert Company | Process for the synthesis of 1,3-diols |
ES2207202T3 (es) * | 1998-04-30 | 2004-05-16 | Kaneka Corporation | Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico. |
DE69917204T2 (de) * | 1998-08-05 | 2005-06-23 | Kaneka Corp. | Verfahren zur herstellung optisch aktiver 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure-derivate |
SK11742001A3 (sk) * | 1999-02-19 | 2002-03-05 | Merck Patent Gmbh | Glukózové dehydrogenázové fúzne proteíny a ich použitie v expresných systémoch |
EP1194582A1 (de) * | 1999-07-09 | 2002-04-10 | Forschungszentrum Jülich Gmbh | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
EP1152054B1 (en) * | 1999-12-03 | 2005-03-23 | Kaneka Corporation | Novel carbonyl reductase, gene thereof and method of using the same |
US6884607B2 (en) * | 2000-12-07 | 2005-04-26 | Sumitomo Chemical Company, Limited | Process for producing optically active 4-halo-3-hydroxybutanoate |
JP4039037B2 (ja) * | 2001-06-11 | 2008-01-30 | 住友化学株式会社 | 還元酵素遺伝子及びその利用 |
BR0305767A (pt) | 2002-08-09 | 2005-05-24 | Codexis Inc | Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico |
WO2005018579A2 (en) * | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
MXPA06001719A (es) | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
-
2004
- 2004-08-11 MX MXPA06001719A patent/MXPA06001719A/es unknown
- 2004-08-11 WO PCT/US2004/026194 patent/WO2005045016A2/en active Application Filing
- 2004-08-11 CA CA002535147A patent/CA2535147A1/en not_active Abandoned
- 2004-08-11 US US10/915,927 patent/US7816111B2/en active Active
- 2004-08-11 KR KR1020067002919A patent/KR20060064620A/ko not_active Ceased
- 2004-08-11 BR BRPI0413492-3A patent/BRPI0413492A/pt not_active IP Right Cessation
- 2004-08-11 EP EP04816807.4A patent/EP1660648B1/en not_active Expired - Lifetime
- 2004-08-11 AU AU2004288134A patent/AU2004288134B2/en not_active Expired
- 2004-08-11 JP JP2006523377A patent/JP2007502114A/ja active Pending
-
2006
- 2006-01-19 IL IL173260A patent/IL173260A0/en unknown
- 2006-02-02 NO NO20060543A patent/NO20060543L/no not_active Application Discontinuation
-
2010
- 2010-05-28 US US12/790,784 patent/US7939309B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2004288134A1 (en) | 2005-05-19 |
WO2005045016A3 (en) | 2005-11-10 |
EP1660648A2 (en) | 2006-05-31 |
KR20060064620A (ko) | 2006-06-13 |
US20050095619A1 (en) | 2005-05-05 |
US7816111B2 (en) | 2010-10-19 |
MXPA06001719A (es) | 2006-05-19 |
EP1660648B1 (en) | 2013-10-09 |
CA2535147A1 (en) | 2005-05-19 |
IL173260A0 (en) | 2006-06-11 |
AU2004288134B2 (en) | 2009-12-17 |
JP2007502114A (ja) | 2007-02-08 |
NO20060543L (no) | 2006-03-13 |
US7939309B2 (en) | 2011-05-10 |
WO2005045016A2 (en) | 2005-05-19 |
US20100304459A1 (en) | 2010-12-02 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |