BRPI0412282A - imunidade especìfica e não-especìfica induzida de dsrna em crustáceos e outros invertebrados, e veìculos de bioliberação para uso nestes - Google Patents
imunidade especìfica e não-especìfica induzida de dsrna em crustáceos e outros invertebrados, e veìculos de bioliberação para uso nestesInfo
- Publication number
- BRPI0412282A BRPI0412282A BRPI0412282-8A BRPI0412282A BRPI0412282A BR PI0412282 A BRPI0412282 A BR PI0412282A BR PI0412282 A BRPI0412282 A BR PI0412282A BR PI0412282 A BRPI0412282 A BR PI0412282A
- Authority
- BR
- Brazil
- Prior art keywords
- dsrna
- specific
- invertebrates
- crustacean
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Farming Of Fish And Shellfish (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
"IMUNIDADE ESPECìFICA E INESPECìFICA INDUZIDA POR dsRNA EM CRUSTáCEOS E OUTROS INVERTEBRADOS E VEìCULOS DE BIOLIBERAçãO PARA USO NESTES". São fornecidos métodos para a indução de respostas imunes sistêmicas, inespecíficas, e/ou com especificidade de seqüência em invertebrados, por exemplo, invertebrados marinhos, tais como moluscos, poríferos, ctenóforos, equinodermos, vermes marinhos, cnidários e, preferivelmente, crustáceos, pela administração de pelo menos um dsRNA, que confere imunidade contra um patógeno ou que modula a expressão gênica que afeta o crescimento, reprodução e saúde geral ou 'robustez'. Também são fornecidos métodos de identificação de genes de invertebrados, por exemplo, genes de crustáceos, cuja expressão esteja envolvida na indução de respostas imunes inespecíficas (sistêmicas) contra patógenos. Também são revelados sistemas de liberação e métodos preferidos para a administração de forma estável de pelo menos um dsRNA a um crustáceo, através do qual o dsRNA é administrado por meio de injeção, imersão, em uma ração ou meio nutriente ou contido em um microorganismo, por exemplo, levedura ou microalga, que expresse o referido dsRNA e seja passível de ingestão pelo referido crustáceo, por exemplo, um camarão.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48453103P | 2003-07-02 | 2003-07-02 | |
US49860303P | 2003-08-29 | 2003-08-29 | |
US50571403P | 2003-09-25 | 2003-09-25 | |
US56429504P | 2004-04-22 | 2004-04-22 | |
PCT/US2004/021271 WO2005005613A2 (en) | 2003-07-02 | 2004-07-02 | Dsrna induced specific and non-specific immunity in crustaceans and other invertebrates and biodelivery vehicles for use therein |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412282A true BRPI0412282A (pt) | 2006-09-19 |
Family
ID=34069336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412282-8A BRPI0412282A (pt) | 2003-07-02 | 2004-07-02 | imunidade especìfica e não-especìfica induzida de dsrna em crustáceos e outros invertebrados, e veìculos de bioliberação para uso nestes |
Country Status (4)
Country | Link |
---|---|
US (1) | US8633028B2 (pt) |
JP (2) | JP5183064B2 (pt) |
BR (1) | BRPI0412282A (pt) |
WO (1) | WO2005005613A2 (pt) |
Families Citing this family (41)
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WO2006047495A2 (en) | 2004-10-21 | 2006-05-04 | Venganza Inc | Methods and materials for conferring resistance to pests and pathogens of plants |
CN100485036C (zh) * | 2005-09-19 | 2009-05-06 | 中国科学院海洋研究所 | 一种中国明对虾抗菌蛋白基因及重组表达和应用 |
FR2908136A1 (fr) * | 2006-11-07 | 2008-05-09 | Ifremer | Utilisation de peptides antimicrobiens comme marqueurs de resistance aux infections bacteriennes chez les crevettes peneides |
US8097712B2 (en) * | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
FR2926367B1 (fr) * | 2008-01-10 | 2013-01-04 | Novaleads | Procede fluorimetrique pour evaluer l'influence d'une condition sur un echantillon biologique et ses applications. |
CN101981046B (zh) * | 2008-02-04 | 2015-01-07 | 内盖夫研究与发展部本-古里安大学 | 对虾中的胰岛素样基因和其用途 |
US8440878B2 (en) | 2008-02-04 | 2013-05-14 | Ben-Gurion University Of The Negev Research And Development Authority | Insulin-like gene in prawns and uses thereof |
CN101617638B (zh) * | 2008-07-04 | 2011-08-31 | 中国科学院海洋研究所 | 一种三疣梭子蟹抗病品系的构建方法 |
CA2760883A1 (en) | 2009-05-05 | 2010-11-11 | Beeologics Inc. | Prevention and treatment of nosema disease in bees |
US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
EP2629599A4 (en) * | 2010-10-22 | 2014-04-02 | Donald Danforth Plant Sci Ct | FIGHTING PATHOGENS AND PARASITES |
EP2632486A1 (en) | 2010-10-27 | 2013-09-04 | Harrisvaccines Inc | Method of rapidly producing vaccines for animals |
US10004797B2 (en) | 2010-10-27 | 2018-06-26 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
US8822427B2 (en) | 2010-10-27 | 2014-09-02 | Harrisvaccines | Methods and compositions to protect aquatic invertebrates from disease |
CN102816815A (zh) * | 2012-03-30 | 2012-12-12 | 浙江海洋学院 | 重组抗菌肽rCrustinI的酵母发酵生产方法 |
US9133461B2 (en) | 2012-04-10 | 2015-09-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the ALAS1 gene |
US9127274B2 (en) * | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
CN102787073B (zh) * | 2012-07-13 | 2014-05-14 | 苏州大学 | 一种构建转基因家蚕微孢子虫的方法 |
US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
EP3608412A3 (en) | 2013-07-19 | 2020-04-08 | Monsanto Technology LLC | Compositions and methods for controlling leptinotarsa |
KR102307389B1 (ko) | 2013-10-04 | 2021-09-30 | 알닐람 파마슈티칼스 인코포레이티드 | Alas1 유전자의 발현을 억제하기 위한 조성물 및 방법 |
WO2015153339A2 (en) | 2014-04-01 | 2015-10-08 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
UA125244C2 (uk) | 2014-07-29 | 2022-02-09 | Монсанто Текнолоджі Елелсі | Спосіб умертвіння або припинення росту комахи |
PL3256589T3 (pl) | 2015-01-22 | 2022-02-21 | Monsanto Technology Llc | Kompozycje i sposoby kontrolowania leptinotarsa |
WO2017009838A1 (en) | 2015-07-14 | 2017-01-19 | Transalgae Israel Ltd. | Transgenic microalgae and use thereof as a feed for delivery of interfering rna molecules |
US11091759B2 (en) | 2015-12-07 | 2021-08-17 | Genzyme Corporation | Methods and compositions for treating a Serpinc1-associated disorder |
US10844382B2 (en) | 2016-04-11 | 2020-11-24 | Microsynbiotix, Ltd. | DNA constructs for manufacturing bio-therapuetic polypeptides for use in animal vaccines and therapeutics |
CN109689106B (zh) * | 2016-04-26 | 2023-01-24 | 微而广治疗有限公司 | 治疗虾类病毒感染的组合物和方法 |
TWI605816B (zh) * | 2016-11-02 | 2017-11-21 | 國立屏東科技大學 | 針對酪氨酸羥化酶之雙股rna的用途 |
PE20200483A1 (es) * | 2017-03-31 | 2020-03-03 | Pebble Labs Usa Inc | Sistema novedoso para el biocontrol de patogenos en sistemas de acuicultura y otros sistemas animales |
US11446339B2 (en) | 2017-03-31 | 2022-09-20 | Pebble Labs Inc. | System for the biocontrol of white spot syndrome virus (WSSV) in aquaculture |
CN106973864A (zh) * | 2017-04-25 | 2017-07-25 | 遵义医学院 | 一种适用于白背飞虱注射法rna干扰实验的饲养装置及其使用方法 |
CN106942162A (zh) * | 2017-04-25 | 2017-07-14 | 遵义医学院 | 一种适用于白背飞虱饲喂法rna干扰实验的装置及其使用方法 |
CN111433349A (zh) * | 2017-08-07 | 2020-07-17 | 卵石实验室公司 | 用于急性肝胰腺坏死病的控制的系统和方法 |
CN109479899A (zh) * | 2018-09-30 | 2019-03-19 | 中国农业科学院植物保护研究所 | 鞘翅目金龟类昆虫rna干扰的方法 |
CN109652420B (zh) * | 2019-01-22 | 2022-06-14 | 汕头大学 | 一种高效抵抗WSSV的siRNA分子wsv147在制备抗WSSV制剂的应用 |
CN111304146B (zh) * | 2020-03-11 | 2022-06-17 | 浙江省淡水水产研究所 | 一种促中华绒螯蟹造血组织发育免疫增强剂的筛选模型构建方法 |
CN113502337B (zh) * | 2021-07-13 | 2022-03-22 | 华中农业大学 | 一种提高克氏原螯虾抗病能力的snp分子标记及应用 |
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WO2024033948A1 (en) * | 2022-08-11 | 2024-02-15 | Karyotica Biologicals Private Limited | Chimeric dna targeted to white spot syndrome |
CN115589972B (zh) * | 2022-09-07 | 2023-10-20 | 南京市水产科学研究所 | 一种基于池塘改造的螺蛳河蟹接力生态养殖方法 |
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US20080194504A1 (en) | 2004-02-06 | 2008-08-14 | Advanced Bionutrition Corporation | Rna-Mediated Interference to Control Disease in Terrestrial and Aquaculture Animals |
WO2007089732A2 (en) | 2006-01-27 | 2007-08-09 | Carnegie Institution Of Washington | Improvement of levels and/or sustainability of dna-based gene expression |
JP2008063302A (ja) * | 2006-09-11 | 2008-03-21 | Fisheries Research Agency | クルマエビ属ホワイトスポット病用経口ワクチン |
JP2008169131A (ja) * | 2007-01-10 | 2008-07-24 | Univ Of Miyazaki | 甲殻類急性ウイルス血症に対するdnaワクチン |
EP2188297B1 (en) * | 2007-08-01 | 2012-02-01 | Council of Scientific & Industrial Research | Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent |
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2004
- 2004-07-02 US US10/883,009 patent/US8633028B2/en not_active Expired - Fee Related
- 2004-07-02 JP JP2006518782A patent/JP5183064B2/ja not_active Expired - Fee Related
- 2004-07-02 BR BRPI0412282-8A patent/BRPI0412282A/pt not_active Application Discontinuation
- 2004-07-02 WO PCT/US2004/021271 patent/WO2005005613A2/en active Application Filing
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2011
- 2011-08-19 JP JP2011179435A patent/JP2012036187A/ja active Pending
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