BRPI0409954A - espécies leveduras geneticamente modificados e processos de fermentação utilizando levedura geneticamente modificada - Google Patents

espécies leveduras geneticamente modificados e processos de fermentação utilizando levedura geneticamente modificada

Info

Publication number
BRPI0409954A
BRPI0409954A BRPI0409954-0A BRPI0409954A BRPI0409954A BR PI0409954 A BRPI0409954 A BR PI0409954A BR PI0409954 A BRPI0409954 A BR PI0409954A BR PI0409954 A BRPI0409954 A BR PI0409954A
Authority
BR
Brazil
Prior art keywords
genetically modified
modified yeast
fermentation processes
species
gene
Prior art date
Application number
BRPI0409954-0A
Other languages
English (en)
Inventor
Vineet Rajgarhia
Kari Koivuranta
Merja Penttilo
Marja Ilmen
Pirkko Suominen
Aristos Aristidou
Chris Miller
Stacey Olson
Laura Ruohonen
Original Assignee
Cargill Dow Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Dow Llc filed Critical Cargill Dow Llc
Publication of BRPI0409954A publication Critical patent/BRPI0409954A/pt
Publication of BRPI0409954B1 publication Critical patent/BRPI0409954B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/14—Multiple stages of fermentation; Multiple types of microorganisms or re-use of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01017—Xylulokinase (2.7.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02003—Phosphoglycerate kinase (2.7.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01037—Xylan 1,4-beta-xylosidase (3.2.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01001—Pyruvate decarboxylase (4.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03002—UDP-glucose 4-epimerase (5.1.3.2), i.e. UDP-galactose 4-epimerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01005—Xylose isomerase (5.3.1.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"ESPéCIES LEVEDURAS GENETICAMENTE MODIFICADAS E PROCESSOS DE FERMENTAçãO UTILIZANDO LEVEDURA GENETICAMENTE MODIFICADA". Células leveduras são transformadas com um gene xilose isomerase exógeno. Modificações genéticas adicionais acentuam a capacidade das células transformadas para fermentar xilose a etanol ou outros produtos de fermentação desejados. Essas modificações incluem a deleção de gene(s) aldose redutase não-específicos ou específicos, a deleção de gene(s) xilitol desidrogenase e/ou a superexpressão de xiluloquinase.
BRPI0409954A 2003-05-02 2004-05-03 espécies leveduras geneticamente modificados e processos de fermentação utilizando levedura geneticamente modificada BRPI0409954B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46772703P 2003-05-02 2003-05-02
PCT/US2004/013592 WO2004099381A2 (en) 2003-05-02 2004-05-03 Genetically modified yeast species and fermentation processes using genetically modified yeast

Publications (2)

Publication Number Publication Date
BRPI0409954A true BRPI0409954A (pt) 2006-04-25
BRPI0409954B1 BRPI0409954B1 (pt) 2016-07-12

Family

ID=33435110

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409954A BRPI0409954B1 (pt) 2003-05-02 2004-05-03 espécies leveduras geneticamente modificados e processos de fermentação utilizando levedura geneticamente modificada

Country Status (12)

Country Link
US (5) US7943366B2 (pt)
EP (4) EP2338895B1 (pt)
JP (1) JP4711955B2 (pt)
CN (2) CN1922198B (pt)
AU (1) AU2004236724B2 (pt)
BR (1) BRPI0409954B1 (pt)
CA (1) CA2524387C (pt)
DK (4) DK2338895T3 (pt)
ES (4) ES2543385T3 (pt)
PL (4) PL1626979T3 (pt)
WO (1) WO2004099381A2 (pt)
ZA (1) ZA200509697B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016065453A1 (pt) * 2014-10-30 2016-05-06 Biocelere Agroindustrial Ltda. Cassete de expressão para a transformação de célula eucariótica, processo para a transformação de célula eucariótica, micro-organismo geneticamente modificado, processo de produção de biocombustíveis e/ou bioquímicos e biocombustível e/ou bioquímico assim produzidos

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
DE60325457D1 (de) 2002-01-23 2009-02-05 Royal Nedalco B V Fermentation von pentosezuckern
CA2573483C (en) * 2004-07-16 2014-10-28 Technische Universiteit Delft Metabolic engineering of xylose-fermenting eukaryotic cells
US20150328347A1 (en) 2005-03-24 2015-11-19 Xyleco, Inc. Fibrous materials and composites
US7708214B2 (en) 2005-08-24 2010-05-04 Xyleco, Inc. Fibrous materials and composites
BRPI0610951A2 (pt) * 2005-06-02 2010-08-03 Cargill Inc levedura geneticamente modificada da espécie issatchenkia orientalis e espécies estreitamente relacionadas e processos de fermentação utilizando as mesmas
EP1929009A2 (en) 2005-09-22 2008-06-11 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
WO2007117282A2 (en) 2005-11-23 2007-10-18 Natureworks Llc Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene
EP2586313B1 (en) 2006-03-13 2017-02-22 Cargill, Incorporated Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol
US20080090283A1 (en) * 2006-10-13 2008-04-17 Rowan Universtity Ethanol resistant and furfural resistant strains of E. coli FBR5 for production of ethanol from cellulosic biomass
CN101463328B (zh) * 2007-12-19 2011-06-29 中国科学院微生物研究所 一株利用木糖发酵产乙醇的代谢工程酵母菌
US8455239B2 (en) * 2007-12-23 2013-06-04 Gevo, Inc. Yeast organism producing isobutanol at a high yield
US8101808B2 (en) 2007-12-27 2012-01-24 Gevo, Inc. Recovery of higher alcohols from dilute aqueous solutions
US8440449B2 (en) * 2008-09-30 2013-05-14 The United States Of America, As Represented By The Secretary Of Agriculture Transformed Saccharomyces cerevisiae engineered for xylose utilization
CA3092340A1 (en) * 2008-11-21 2010-05-27 Universiteit Stellenbosch Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose
GB0822937D0 (en) 2008-12-16 2009-01-21 Terranol As Microorganism
US9334488B2 (en) 2008-12-24 2016-05-10 Dsm Ip Assets B.V. Xylose isomerase genes and their use in fermentation of pentose sugars
US20100311137A1 (en) 2009-06-08 2010-12-09 Ut-Battelle, Llc Microorganisms Having Enhanced Tolerance To Inhibitors and Stress
WO2010151525A1 (en) * 2009-06-22 2010-12-29 Gevo, Inc. Yeast organisms for the production of isobutanol
US20120184007A1 (en) 2009-07-09 2012-07-19 Stephen Picataggio Engineered microorganisms with enhanced fermentation activity
CA2785276C (en) 2009-12-22 2019-04-23 Kabushiki Kaisha Toyota Chuo Kenkyusho Xylose isomerase and use thereof
JP5804378B2 (ja) * 2010-02-09 2015-11-04 国立大学法人山口大学 クルイベロマイセス・マルシアヌス由来の高発現プロモーター
JP2013524797A (ja) * 2010-04-21 2013-06-20 ディーエスエム アイピー アセッツ ビー．ブイ． アラビノースを転化できる細胞を製造する方法
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
WO2011153516A2 (en) 2010-06-03 2011-12-08 Mascoma Corporation Yeast expressing saccharolytic enzymes for consolidated bioprocessing using starch and cellulose
US8859248B2 (en) * 2010-11-11 2014-10-14 Toyota Jidosha Kabushiki Kaisha Method for producing ethanol using recombinant yeast strain
PL2663645T3 (pl) 2010-11-18 2015-05-29 Dsm Ip Assets Bv Szczepy drożdży zmodyfikowane do wytwarzania etanolu z glicerolu
WO2012071470A2 (en) 2010-11-22 2012-05-31 Cargill, Incorporated Compositions and methods for increased ethanol titer from biomass
US9605285B2 (en) 2011-01-25 2017-03-28 Cargill, Incorporated Compositions and methods for succinate production
CN102174549B (zh) 2011-02-22 2012-10-10 山东大学 一种编码木糖异构酶的核酸分子及其编码的木糖异构酶
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
CA2832587A1 (en) 2011-04-11 2012-10-18 Cargill, Incorporated Compositions and methods for increased ethanol production from biomass
EP2546336A1 (en) 2011-07-11 2013-01-16 DSM IP Assets B.V. Yeast strains that consume uronic acids and produce fermentation products such as ethanol
CN102304541A (zh) * 2011-08-17 2012-01-04 中国药科大学 一种含组成型启动子pPGK和G418抗性基因的酿酒酵母表达载体及其构建方法
EP3321368A3 (en) 2011-11-30 2018-05-23 DSM IP Assets B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
MY173716A (en) 2012-01-13 2020-02-18 Toray Industries Method for producing chemical substance
EP2803731A4 (en) 2012-01-13 2015-08-26 Toray Industries PROCESS FOR THE PRODUCTION OF CHEMICAL SUBSTANCE
AU2013211605B2 (en) 2012-01-23 2017-04-06 Dsm Ip Assets B.V. Diterpene production
CN102719481B (zh) * 2012-06-14 2014-11-05 中国科学院微生物研究所 一种将多个基因同时导入微生物基因组的方法
WO2014003439A1 (ko) * 2012-06-26 2014-01-03 한국생명공학연구원 에탄올 생산 경로가 봉쇄된 클루이베로마이세스 막시아누스 균주 및 이의 용도
US9850507B2 (en) 2012-07-25 2017-12-26 Cargill, Incorporated Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme
WO2014033018A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
WO2014033019A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
US9745560B2 (en) 2012-08-29 2017-08-29 Lallemand Hungary Liquidity Management Llc Expression of enzymes in yeast for lignocellulose derived oligomer CBP
US8748152B1 (en) 2012-09-14 2014-06-10 The United States Of America, As Represented By The Secretary Of Agriculture Prevotella ruminicola xylose isomerase and co-expression with xylulokinase in yeast for xylose fermentation
US20140178954A1 (en) 2012-12-20 2014-06-26 E I Du Pont De Nemours And Company Expression of xylose isomerase activity in yeast
US8669076B1 (en) 2013-03-11 2014-03-11 E I Du Pont De Nemours And Company Cow rumen xylose isomerases active in yeast cells
US9187743B2 (en) 2013-03-11 2015-11-17 E I Du Pont De Nemours And Company Bacterial xylose isomerases active in yeast cells
JP6027559B2 (ja) 2013-03-28 2016-11-16 株式会社豊田中央研究所 キシロースイソメラーゼ活性を有するタンパク質及びその利用
TW201437367A (zh) 2013-03-29 2014-10-01 Far Eastern New Century Corp 可利用五碳糖及六碳糖生產乳酸之酵母菌
FI20135333L (fi) * 2013-04-05 2014-10-06 Teknologian Tutkimuskeskus Vtt Oy Hapon / happojen ja alkoholin tuotto sokereista käyttämällä hiivaa
DK3004366T3 (da) 2013-05-31 2019-05-20 Dsm Ip Assets Bv Mikroorganismer til diterpenproduktion
BR112016000745B1 (pt) 2013-07-15 2021-01-05 Dsm Ip Assets B.V. processo para a preparação de rebaudiosídeo m
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
CN104419716B (zh) * 2013-08-27 2017-12-29 天津大学 一种标准化、高精度、通用的功能模块构建方法
AR097480A1 (es) 2013-08-29 2016-03-16 Dsm Ip Assets Bv Células de levadura convertidoras de glicerol y ácido acético con una conversión de ácido acético mejorada
CN103421698B (zh) * 2013-09-05 2015-04-22 中国科学技术大学 木糖醇高温高产工程菌株的构建及应用
WO2015160257A1 (en) 2014-04-18 2015-10-22 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
TWI551688B (zh) * 2015-02-04 2016-10-01 遠東新世紀股份有限公司 發酵纖維素水解液來生成乙醇的方法
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
WO2016151046A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
US11344051B2 (en) 2015-04-03 2022-05-31 Dsm Ip Assets B.V. Steviol glycosides
CA2980649A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase
WO2017009294A1 (en) 2015-07-10 2017-01-19 Dsm Ip Assets B.V. Steviol glycoside composition
BR112018000690A2 (pt) 2015-07-13 2018-09-18 MARA Renewables Corporation micro-organismo recombinante, e, métodos para preparar um micro-organismo de metabolização de xilose e para produzir óleo.
BR112018002284A2 (pt) 2015-08-05 2018-12-11 Cargill Inc método de fermentação para produzir um bioproduto, levedura crabtree negativa geneticamente engenheirada e método para reduzir a produção de glicerol por uma levedura engenheirada
CA2993744A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
EP4043558A3 (en) 2015-10-05 2022-11-16 DSM IP Assets B.V. Kaurenoic acid hydroxylases
EP3380624A1 (en) 2015-11-24 2018-10-03 Cargill, Incorporated Genetically modified yeasts and fermentation processes using genetically modified yeasts
JP6858191B2 (ja) * 2015-12-17 2021-04-14 エボニック デグサ チャイナ カンパニー リミテッド 酵母細胞の相同的組み換えノックアウトのための遺伝子カセット
WO2017176875A1 (en) 2016-04-08 2017-10-12 E I Du Pont De Nemours And Company Arabinose isomerases for yeast
KR101827822B1 (ko) 2016-06-07 2018-03-23 강원대학교 산학협력단 자일리톨 생산능이 향상된 클루이베로마이세스 마르시아누스 36907-fmel1 (kctc18459p) 및 이를 이용한 자일리톨의 생산방법
WO2018029272A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
CA3033243A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
AU2017350309A1 (en) 2016-10-27 2019-05-02 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
EP3551751A1 (en) 2016-12-08 2019-10-16 DSM IP Assets B.V. Kaurenoic acid hydroxylases
CA3047840A1 (en) 2016-12-21 2018-06-28 Creatus Biosciences Inc. Method and organism expressing metschnikowia xylose transporters for increased xylose uptake
WO2018114995A1 (en) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Fermentation process for producing steviol glycosides
EP4155400A1 (en) 2017-06-27 2023-03-29 DSM IP Assets B.V. Udp-glycosyltransferases
EP3668306A4 (en) 2017-08-17 2021-06-09 Cargill, Incorporated GENETICALLY MODIFIED HAPLOIDISSATCHENKIA ORIENTALIS
KR20200135469A (ko) 2018-03-27 2020-12-02 바스프 에스이 자일로스 대사 효모
US11608364B2 (en) 2018-04-30 2023-03-21 Dsm Ip Assets B.V. Steviol glycoside transport
EP4165063A1 (en) 2020-06-15 2023-04-19 Melio Peptide Systems Inc. Microorganisms and methods for reducing bacterial contamination
CA3198626A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
US4771001A (en) 1986-03-27 1988-09-13 Neurex Corp. Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification
US5866382A (en) * 1990-04-06 1999-02-02 Xyrofin Oy Xylose utilization by recombinant yeasts
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
US5132456A (en) 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
FI913197A0 (fi) * 1991-07-01 1991-07-01 Xyrofin Oy Nya jaeststammar med reducerad foermaoga att metabolisera xylitol, foerfarande foer bildande av dessa och deras anvaendning vid framstaellning av xylitol.
US5420304A (en) 1992-03-19 1995-05-30 Biopak Technology, Ltd. Method to produce cyclic esters
AT398982B (de) 1993-02-18 1995-02-27 Vogelbusch Gmbh Verfahren zur abtrennung und reinigung von milchsäure
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
US5789210A (en) 1993-11-08 1998-08-04 Purdue Research Foundation Recombinant yeasts for effective fermentation of glucose and xylose
FR2712147B1 (fr) 1993-11-08 1996-02-02 Agronomique Inst Nat Rech Produit alimentaire, obtention et application à la fabrication de jus de fruits ou de vin.
IL109003A (en) 1994-03-16 1999-09-22 Yissum Res Dev Co Process and extractant composition for extracting water-soluble carboxylic and mineral acids
IN191596B (pt) 1996-05-06 2003-12-06 Purdue Research Foundation
US6717014B1 (en) * 1996-06-28 2004-04-06 Fmc Corporation Processes for preparing haloamines and tertiary aminoalkylorganometallic compounds
IT1294728B1 (it) * 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
EP1071786B1 (en) * 1998-04-20 2005-11-30 Forskarpatent i Syd AB Genetically engineered yeast and mutants thereof for the efficient fermentation of lignocellulose hydrolysates
SE9901298D0 (sv) * 1999-04-09 1999-04-09 Forskarpatent I Syd Ab Xylose isomerase with improved kinetic properties
PL352434A1 (en) 1999-05-21 2003-08-25 Cargill Dow Llc Methods and materials for the synthesis of organic products
US6762339B1 (en) 1999-05-21 2004-07-13 3M Innovative Properties Company Hydrophilic polypropylene fibers having antimicrobial activity
EP1301618A1 (en) * 2000-07-13 2003-04-16 Danisco Sweeteners Oy Method for the production of xylitol
WO2002042471A2 (en) 2000-11-22 2002-05-30 Cargill Dow Polymers Llc Methods and materials for the synthesis of organic products
CA2474152A1 (en) 2001-11-23 2003-06-19 Cargill Dow Llc Methods and materials for the production of organic products in cells of candida species
DE60325457D1 (de) 2002-01-23 2009-02-05 Royal Nedalco B V Fermentation von pentosezuckern
AU2003251381B2 (en) 2002-05-30 2008-04-03 Natureworks Llc Fermentation process using specific oxygen uptake rates as a process control
SE0302421D0 (sv) * 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Construction of new xylose utilizing Saccharomyces cerevisiae strain
BRPI0610951A2 (pt) * 2005-06-02 2010-08-03 Cargill Inc levedura geneticamente modificada da espécie issatchenkia orientalis e espécies estreitamente relacionadas e processos de fermentação utilizando as mesmas
WO2007117282A2 (en) * 2005-11-23 2007-10-18 Natureworks Llc Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene
JP5219074B2 (ja) * 2008-01-24 2013-06-26 独立行政法人産業技術総合研究所 キシロース発酵能が優れた六炭糖・五炭糖同時発酵酵母およびそれを用いたエタノールの高効率生産方法
EP2464736A4 (en) * 2009-08-12 2013-07-31 Gevo Inc PATIENT LOCALIZATION OF CYTOSOLIC ISOBUTANOL FOR THE MANUFACTURE OF ISOBUTANOL

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016065453A1 (pt) * 2014-10-30 2016-05-06 Biocelere Agroindustrial Ltda. Cassete de expressão para a transformação de célula eucariótica, processo para a transformação de célula eucariótica, micro-organismo geneticamente modificado, processo de produção de biocombustíveis e/ou bioquímicos e biocombustível e/ou bioquímico assim produzidos

Also Published As

Publication number Publication date
ES2543385T3 (es) 2015-08-18
PL2338895T3 (pl) 2013-11-29
PL2345662T3 (pl) 2016-11-30
US20110287505A1 (en) 2011-11-24
EP1626979A2 (en) 2006-02-22
EP2345662A1 (en) 2011-07-20
EP1626979A4 (en) 2006-11-15
CN102703336A (zh) 2012-10-03
EP2301949A1 (en) 2011-03-30
US20140080192A1 (en) 2014-03-20
JP2006525029A (ja) 2006-11-09
CN1922198B (zh) 2012-07-11
PL2301949T3 (pl) 2015-10-30
ZA200509697B (en) 2007-03-28
US20060234364A1 (en) 2006-10-19
US20160340697A1 (en) 2016-11-24
US9410158B2 (en) 2016-08-09
JP4711955B2 (ja) 2011-06-29
DK2338895T3 (da) 2013-09-08
CA2524387A1 (en) 2004-11-18
EP2338895B1 (en) 2013-08-14
US20110287506A1 (en) 2011-11-24
EP2301949B1 (en) 2015-06-24
US7943366B2 (en) 2011-05-17
CN1922198A (zh) 2007-02-28
DK1626979T3 (da) 2012-07-09
ES2586618T3 (es) 2016-10-17
BRPI0409954B1 (pt) 2016-07-12
CA2524387C (en) 2012-12-04
AU2004236724B2 (en) 2008-07-10
EP1626979B1 (en) 2012-06-06
US8623633B2 (en) 2014-01-07
PL1626979T3 (pl) 2012-09-28
US8440451B2 (en) 2013-05-14
US9758799B2 (en) 2017-09-12
DK2301949T3 (en) 2015-07-20
AU2004236724A1 (en) 2004-11-18
EP2338895A1 (en) 2011-06-29
WO2004099381A2 (en) 2004-11-18
EP2345662B1 (en) 2016-06-22
ES2426966T3 (es) 2013-10-28
ES2385561T3 (es) 2012-07-26
DK2345662T3 (en) 2016-08-15
WO2004099381A3 (en) 2005-05-06

Similar Documents

Publication Publication Date Title
BRPI0409954A (pt) espécies leveduras geneticamente modificados e processos de fermentação utilizando levedura geneticamente modificada
ATE290589T1 (de) Rekombinante hefe zur effizienten fermentation von glucose und xylose
Hoang Nguyen Tran et al. Improved simultaneous co-fermentation of glucose and xylose by Saccharomyces cerevisiae for efficient lignocellulosic biorefinery
WO2008133638A3 (en) Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
Otterstedt et al. Switching the mode of metabolism in the yeast Saccharomyces cerevisiae
DK1727890T3 (da) Muteret xylosereduktase ved xylosefermentering i S. cerevisiae
ATE418616T2 (de) Fermentation von pentosezuckern
BR0115558A (pt) ácido nucleico isolado, construção de expressão recombinante, célula de levedura transformada com a construção de expressão recombinante, e, método para produzir ácido lático
WO2004067760A3 (en) Xylose-fermenting recombinant yeast strains
BRPI0513437A (pt) célula hospedeira eucariótica com a capacidade para isomerizar diretamente xilose em xilulose, e, processos para produzir etanol e um produto de fermentação
WO2005069840A3 (en) Processes for producing a fermentation product
Liu et al. Pathway-based signature transcriptional profiles as tolerance phenotypes for the adapted industrial yeast Saccharomyces cerevisiae resistant to furfural and HMF
ATE370223T1 (de) Rekombinante hefe zur fermentation von lignocellulose aus rohmaterial
Sharma et al. Fermentation of enzymatically saccharified sunflower stalks for ethanol production and its scale up
SE0400815D0 (sv) Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis
WO2009076343A3 (en) Alcoholic xylose fermentation at high temperatures by the thermotolerant yeast hansenula polymorpha
NO923880D0 (no) Rekombinante gjaertyper inneholdende dna-sekvenser som koder for xylosereduktase- og xylitoldehydrogenaseenzymer
Liu et al. Engineering Clostridium beijerinckii with the Cbei_4693 gene knockout for enhanced ferulic acid tolerance
Huang et al. Furfural-tolerant Zymomonas mobilis derived from error-prone PCR-based whole genome shuffling and their tolerant mechanism
WO1999054477A3 (en) Genetically engineered yeast and mutants thereof for the efficient fermentation of lignocellulose hydrolysates
ATE338109T1 (de) Aspergillus niger beta-glukosidase gen, protein, sowie verwendungen derselben
SE0200855D0 (sv) SACCHAROMYCES cerevisiae MUTANT
Ho et al. Recombinant yeasts for effective fermentation of glucose and xylose
WO2006097945A3 (en) A method for achieving high-level expression of recombinant human interleukin-2 upon destabilization of the rna secondary structure
WANG et al. Redox-sensitive genetic parts improve the tolerance of yeast to lignocellulosic hydrolysate inhibitors

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07H 21/04 , C12N 9/90 , C12N 9/12 , C12N 1/21

Ipc: C12N 1/19 (2006.01), C12N 9/90 (2006.01), C07H 21/

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2016, OBSERVADAS AS CONDICOES LEGAIS.