BRPI0313363A8 - dehidrofenilahistinas e seus análogos, e sua síntese - Google Patents
dehidrofenilahistinas e seus análogos, e sua síntese Download PDFInfo
- Publication number
- BRPI0313363A8 BRPI0313363A8 BRPI0313363A BRPI0313363A BRPI0313363A8 BR PI0313363 A8 BRPI0313363 A8 BR PI0313363A8 BR PI0313363 A BRPI0313363 A BR PI0313363A BR PI0313363 A BRPI0313363 A BR PI0313363A BR PI0313363 A8 BRPI0313363 A8 BR PI0313363A8
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- aldehyde
- compounds
- methods
- imidazolecarboxaldehyde
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 150000001299 aldehydes Chemical class 0.000 abstract 4
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- TYHOSUCCUICRLM-UHFFFAOYSA-N 1,3-oxazole-2-carbaldehyde Chemical compound O=CC1=NC=CO1 TYHOSUCCUICRLM-UHFFFAOYSA-N 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40107402P | 2002-08-02 | 2002-08-02 | |
| US41112802P | 2002-09-16 | 2002-09-16 | |
| US45006303P | 2003-02-24 | 2003-02-24 | |
| PCT/US2003/024232 WO2004054498A2 (en) | 2002-08-02 | 2003-08-01 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0313363A8 true BRPI0313363A8 (pt) | 2019-01-02 |
Family
ID=32600863
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0313363A BRPI0313363A8 (pt) | 2002-08-02 | 2003-08-01 | dehidrofenilahistinas e seus análogos, e sua síntese |
| BR0313363-0A BR0313363A (pt) | 2002-08-02 | 2003-08-01 | Deidrofenilahistinas e seus análogos, e sua sìntese |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0313363-0A BR0313363A (pt) | 2002-08-02 | 2003-08-01 | Deidrofenilahistinas e seus análogos, e sua sìntese |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7064201B2 (enExample) |
| EP (1) | EP1529044B1 (enExample) |
| JP (1) | JP4616649B2 (enExample) |
| KR (2) | KR101049100B1 (enExample) |
| CN (1) | CN100540548C (enExample) |
| AT (1) | ATE374767T1 (enExample) |
| AU (1) | AU2003302721B2 (enExample) |
| BR (2) | BRPI0313363A8 (enExample) |
| CA (1) | CA2494049C (enExample) |
| CO (1) | CO5721010A2 (enExample) |
| DE (1) | DE60316688T2 (enExample) |
| DK (1) | DK1529044T5 (enExample) |
| ES (1) | ES2295695T3 (enExample) |
| IL (2) | IL166628A0 (enExample) |
| MX (1) | MXPA05001217A (enExample) |
| NZ (1) | NZ538433A (enExample) |
| PT (1) | PT1529044E (enExample) |
| WO (1) | WO2004054498A2 (enExample) |
| ZA (1) | ZA200501616B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026322B2 (en) * | 1998-11-12 | 2006-04-11 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
| BR0017067A (pt) * | 2000-01-18 | 2002-10-22 | Nereus Pharmaceuticals Inc | Inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto |
| CN100553636C (zh) | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| ES2295695T3 (es) * | 2002-08-02 | 2008-04-16 | Nereus Pharmaceuticals, Inc. | Deshidrofenilahistinas y sus analogos y la sintesis de deshidrofenilahistinas y sus analogos. |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| JP4674317B2 (ja) | 2002-10-02 | 2011-04-20 | ディエムアイ アクイジション コーポレイション | 疾病の判定および監視 |
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| PT1830847E (pt) * | 2004-12-06 | 2015-02-05 | Pitney Pharmaceuticals Pty Ltd | Tratamento para o cancro |
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| KR100932093B1 (ko) | 2006-09-27 | 2009-12-16 | 주식회사종근당 | 미세소관 형성 저해제로서 유용한 벤조페논 유도체 |
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| CN106279039B (zh) | 2015-06-02 | 2019-01-11 | 青岛海洋生物医药研究院股份有限公司 | 氘代脱氢苯基阿夕斯丁类化合物及其制备方法和在制备抗肿瘤的药物中的应用 |
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| CN107778297B (zh) * | 2016-08-12 | 2021-11-19 | 深圳华大海洋科技有限公司 | 氘代脱氢苯基阿夕斯丁类化合物的多晶型及其制备方法和应用 |
| US10851086B2 (en) | 2016-08-12 | 2020-12-01 | Marine Biomedical Research Institute Of Qingdao Co., Ltd. | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof |
| CN107011322B (zh) * | 2016-08-12 | 2020-02-18 | 青岛海洋生物医药研究院股份有限公司 | 一种脱氢苯基阿夕斯丁类化合物的制备纯化方法 |
| CN106565685B (zh) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
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| CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
| KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
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| CN111018840B (zh) * | 2017-10-25 | 2022-09-09 | 西南大学 | 3-咪唑取代的靛红唑醇类化合物及其制备方法和医药应用 |
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| CN111840291B (zh) * | 2020-07-14 | 2021-12-21 | 深圳海王医药科技研究院有限公司 | 一种在肿瘤治疗中具有增效作用的化合物的应用 |
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| WO2023232113A1 (zh) * | 2022-06-02 | 2023-12-07 | 上海旭成医药科技有限公司 | 哌嗪酮类化合物及其制备方法和用途 |
| CN117285516A (zh) * | 2022-06-16 | 2023-12-26 | 大连万众益生大健康有限公司 | 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用 |
| CN117860672A (zh) | 2022-10-11 | 2024-04-12 | 大连万春布林医药有限公司 | 一种普那布林胶束组合物及其制备方法 |
| CN121127241A (zh) | 2023-03-10 | 2025-12-12 | 万春药业公司 | 肿瘤联合治疗及使用方法 |
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-
2003
- 2003-08-01 ES ES03811651T patent/ES2295695T3/es not_active Expired - Lifetime
- 2003-08-01 WO PCT/US2003/024232 patent/WO2004054498A2/en not_active Ceased
- 2003-08-01 CN CNB038234645A patent/CN100540548C/zh not_active Expired - Lifetime
- 2003-08-01 AU AU2003302721A patent/AU2003302721B2/en not_active Expired
- 2003-08-01 NZ NZ538433A patent/NZ538433A/en not_active IP Right Cessation
- 2003-08-01 KR KR1020057001947A patent/KR101049100B1/ko not_active Expired - Lifetime
- 2003-08-01 DE DE60316688T patent/DE60316688T2/de not_active Expired - Lifetime
- 2003-08-01 EP EP03811651A patent/EP1529044B1/en not_active Expired - Lifetime
- 2003-08-01 DK DK03811651T patent/DK1529044T5/da active
- 2003-08-01 US US10/632,531 patent/US7064201B2/en not_active Expired - Lifetime
- 2003-08-01 AT AT03811651T patent/ATE374767T1/de active
- 2003-08-01 BR BRPI0313363A patent/BRPI0313363A8/pt unknown
- 2003-08-01 IL IL16662803A patent/IL166628A0/xx unknown
- 2003-08-01 BR BR0313363-0A patent/BR0313363A/pt not_active Application Discontinuation
- 2003-08-01 PT PT03811651T patent/PT1529044E/pt unknown
- 2003-08-01 MX MXPA05001217A patent/MXPA05001217A/es active IP Right Grant
- 2003-08-01 CA CA2494049A patent/CA2494049C/en not_active Expired - Lifetime
- 2003-08-01 KR KR1020117006692A patent/KR101184374B1/ko not_active Expired - Lifetime
- 2003-08-01 JP JP2004560278A patent/JP4616649B2/ja not_active Expired - Lifetime
-
2005
- 2005-02-01 IL IL166628A patent/IL166628A/en active IP Right Grant
- 2005-02-24 ZA ZA2005/01616A patent/ZA200501616B/en unknown
- 2005-02-28 CO CO05018564A patent/CO5721010A2/es active IP Right Grant
-
2006
- 2006-06-07 US US11/448,283 patent/US20060223822A1/en not_active Abandoned
- 2006-06-07 US US11/448,948 patent/US7674903B2/en active Active
- 2006-06-07 US US11/448,924 patent/US7956058B2/en active Active
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