BRPI0210771B8 - construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna - Google Patents

construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna

Info

Publication number
BRPI0210771B8
BRPI0210771B8 BRPI0210771A BR0210771A BRPI0210771B8 BR PI0210771 B8 BRPI0210771 B8 BR PI0210771B8 BR PI0210771 A BRPI0210771 A BR PI0210771A BR 0210771 A BR0210771 A BR 0210771A BR PI0210771 B8 BRPI0210771 B8 BR PI0210771B8
Authority
BR
Brazil
Prior art keywords
sequence
dna
nucleic acid
star
regulatory sequences
Prior art date
Application number
BRPI0210771A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0210771A (pt
BRPI0210771B1 (pt
Inventor
Pieter Otte Arie
Leo Kruckeberg Arthur
Original Assignee
Chromagenics Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202581A external-priority patent/EP1273666A1/en
Application filed by Chromagenics Bv filed Critical Chromagenics Bv
Publication of BR0210771A publication Critical patent/BR0210771A/pt
Publication of BRPI0210771B1 publication Critical patent/BRPI0210771B1/pt
Publication of BRPI0210771B8 publication Critical patent/BRPI0210771B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4705Regulators; Modulating activity stimulating, promoting or activating activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0210771A 2001-07-04 2002-06-14 construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna BRPI0210771B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01202581A EP1273666A1 (en) 2001-07-04 2001-07-04 Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
US30319901P 2001-07-05 2001-07-05
PCT/NL2002/000390 WO2003004704A2 (en) 2001-07-04 2002-06-14 Method of selecting dna sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
US10/190,312 US7192741B2 (en) 2001-07-04 2002-07-05 DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

Publications (3)

Publication Number Publication Date
BR0210771A BR0210771A (pt) 2004-07-13
BRPI0210771B1 BRPI0210771B1 (pt) 2015-12-22
BRPI0210771B8 true BRPI0210771B8 (pt) 2021-05-25

Family

ID=47915807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0210771A BRPI0210771B8 (pt) 2001-07-04 2002-06-14 construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna

Country Status (21)

Country Link
US (9) US7192741B2 (enExample)
EP (8) EP1842919B1 (enExample)
JP (3) JP4500044B2 (enExample)
KR (2) KR100942117B1 (enExample)
CN (1) CN1266282C (enExample)
AT (8) ATE466944T1 (enExample)
AU (3) AU2002314629B2 (enExample)
BR (1) BRPI0210771B8 (enExample)
CA (2) CA2812799C (enExample)
CY (1) CY1107678T1 (enExample)
DE (8) DE60215502T2 (enExample)
DK (8) DK1808488T3 (enExample)
ES (8) ES2344073T3 (enExample)
IL (4) IL159674A0 (enExample)
MX (1) MXPA03011801A (enExample)
NO (1) NO338477B1 (enExample)
NZ (1) NZ530218A (enExample)
PT (1) PT1600510E (enExample)
SG (1) SG143066A1 (enExample)
WO (1) WO2003004704A2 (enExample)
ZA (1) ZA200309599B (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2812799C (en) 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
EP1513936A2 (en) 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
WO2003106684A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
SI1523496T1 (sl) 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
EP1573058B1 (en) 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
EP2395017A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1670925B1 (en) 2003-10-02 2013-05-01 Crucell Holland B.V. Packaging cells for recombinant adenovirus
WO2005059149A2 (en) * 2003-12-12 2005-06-30 Chromagenics B.V. Improved protein production
EP1737971B1 (en) 2004-01-20 2017-08-16 Merus N.V. Mixtures of binding proteins
US7825232B2 (en) * 2004-07-08 2010-11-02 Chromagenics B.V. Sequence for improving expression of nucleic acid
DK1786908T3 (da) * 2004-08-18 2010-06-07 Bayer Cropscience Ag Planter med forøget plastidisk aktivitet af stivelsesphosphorylerende R3-enzym
KR101271884B1 (ko) 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
CN101090968B (zh) * 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US20060195935A1 (en) * 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
KR100984602B1 (ko) * 2004-11-18 2010-09-30 고쿠리츠다이가쿠호진 히로시마다이가쿠 유전자 증폭에 의해 형성된 반복서열로부터, 발현이 억제된단백질을 발현시키는 방법, 키트, 및 형질전환체
WO2007107578A1 (en) 2006-03-20 2007-09-27 Chromagenics B.V. Expression augmenting dna fragments, use thereof, and methods for finding thereof
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
EP2109674A2 (en) * 2007-01-08 2009-10-21 Millipore Corporation High expression cell line that eliminates gene amplification
DK2443239T3 (en) 2009-06-15 2016-02-15 Cellagenics B V New stringent selection markers
US8566596B2 (en) 2010-08-24 2013-10-22 Cisco Technology, Inc. Pre-association mechanism to provide detailed description of wireless services
EP2611915B1 (en) 2010-09-01 2015-04-15 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
ES2743399T3 (es) 2012-04-20 2020-02-19 Merus Nv Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
CN104736174B (zh) 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
US10358492B2 (en) 2012-09-27 2019-07-23 Merus N.V. Bispecific IgG antibodies as T cell engagers
US10417380B1 (en) 2013-12-31 2019-09-17 Mckesson Corporation Systems and methods for determining and communicating a prescription benefit coverage denial to a prescriber
US10489552B2 (en) 2014-02-14 2019-11-26 Mckesson Corporation Systems and methods for determining and communicating patient incentive information to a prescriber
SG11201607109QA (en) 2014-02-28 2016-09-29 Merus Nv Antibodies that bind egfr and erbb3
SI3110849T1 (sl) 2014-02-28 2021-01-29 Merus N.V. Protitelo, ki veže ERBB-2 in ERBB-3
US10157262B1 (en) 2015-03-10 2018-12-18 Mckesson Corporation Systems and methods for determining patient financial responsibility for multiple prescription products
EP3345928B1 (en) 2015-07-10 2020-06-24 Merus N.V. Human cd3 binding antibody
BR112018008068A2 (en) 2015-10-23 2018-11-13 Merus N.V. binding molecules that inhibit cancer growth
US11514137B1 (en) 2016-03-30 2022-11-29 Mckesson Corporation Alternative therapy identification system
US10999224B1 (en) 2017-02-01 2021-05-04 Mckesson Corporation Method and apparatus for parsing an electronic message and constructing multiple differently prioritized messages therefrom
CA3058343A1 (en) 2017-03-31 2018-10-04 Merus N.V. Erbb-2 and erbb-3 binding bispecific antibodies for use in the treatment of cells that have an nrg1 fusion gene
US12195551B2 (en) 2017-05-17 2025-01-14 Merus N.V. Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
HUE071182T2 (hu) 2017-08-09 2025-08-28 Merus Nv EGFR és CMET kötõ antitestek
US10862832B1 (en) 2018-07-24 2020-12-08 Mckesson Corporation Computing system and method for automatically reversing an action indicated by an electronic message
US11043437B2 (en) 2019-01-07 2021-06-22 Applied Materials, Inc. Transparent substrate with light blocking edge exclusion zone
US11562437B1 (en) 2019-06-26 2023-01-24 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
US12469040B1 (en) 2019-06-26 2025-11-11 Mckesson Corporation Method, apparatus, and computer program product for providing real-time pricing information
US11636548B1 (en) 2019-06-26 2023-04-25 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
EP3772518A1 (en) 2019-08-07 2021-02-10 Merus N.V. Modified human variable domains
US20230104317A1 (en) * 2020-01-31 2023-04-06 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods to Identify Genetic Silencers and Applications Thereof
US11610240B1 (en) 2020-02-17 2023-03-21 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US12229834B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US12229833B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for reformatting an electronic prescription transaction
EP4153315A1 (en) 2020-05-21 2023-03-29 Merus N.V. Methods and means for the production of ig-like molecules
US11587657B2 (en) 2020-09-04 2023-02-21 Mckesson Corporation Method, apparatus, and computer program product for performing an alternative evaluation procedure in response to an electronic message
US12367954B1 (en) 2021-01-08 2025-07-22 Mckesson Corporation Method, apparatus, and computer program product for estimating a target quantitative measure based upon historical electronic messages
CN113539357B (zh) * 2021-06-10 2024-04-30 阿里巴巴达摩院(杭州)科技有限公司 基因检测方法、模型训练方法、装置、设备及系统
US12197972B1 (en) 2022-03-28 2025-01-14 Mckesson Corporation Method, apparatus, and computer program product for generating alternative evaluation messages

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US719271A (en) * 1902-01-13 1903-01-27 Solomon P Smith Furnace.
US5610053A (en) 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5972605A (en) 1994-07-07 1999-10-26 Geron Corporation Assays for regulators of mammalian telomerase expression
EP0818536A4 (en) * 1995-03-24 2000-09-06 Shionogi & Co DNA MOLECULE DRAWN ON THE SUPPRESSION OF THE GENE EXPRESSION AND CORRESPONDING PROTEIN
DE19539493A1 (de) * 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US6037525A (en) * 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
WO2000005393A2 (en) 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
US6872524B1 (en) 1998-08-14 2005-03-29 Chromagenics B.V. Method of detecting an expression-enhancing sequence
US6800457B2 (en) 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6521419B1 (en) 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
WO2000023606A1 (en) 1998-10-22 2000-04-27 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
NZ529329A (en) * 1999-08-25 2005-06-24 Immunex Corp Compositions and methods for improved cell culture
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
AU2001238178A1 (en) 2000-02-11 2001-08-20 Millennium Pharmaceuticals, Inc. Seven-transmembrane proteins/g-protein coupled receptors
KR100996016B1 (ko) 2000-09-20 2010-11-22 밀리포어 코포레이션 폴리뉴클레오티드
EP1273666A1 (en) 2001-07-04 2003-01-08 Chromagenics B.V. Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
CA2812799C (en) 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
WO2003106684A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
EP1573058B1 (en) 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors

Also Published As

Publication number Publication date
KR20090037960A (ko) 2009-04-16
DK1829972T3 (da) 2010-09-13
US20070031936A1 (en) 2007-02-08
ATE467682T1 (de) 2010-05-15
ATE358183T1 (de) 2007-04-15
HK1068652A1 (en) 2005-04-29
DE60236332D1 (de) 2010-06-17
AU2011202193A1 (en) 2011-06-02
US7951586B2 (en) 2011-05-31
US7655441B2 (en) 2010-02-02
DK1845162T3 (da) 2010-08-16
CA2450020A1 (en) 2003-01-16
EP1808488B1 (en) 2010-07-14
EP1404872B1 (en) 2006-10-18
EP1829971A1 (en) 2007-09-05
BR0210771A (pt) 2004-07-13
US7662591B2 (en) 2010-02-16
US20070037256A1 (en) 2007-02-15
AU2011202193B2 (en) 2011-09-29
ATE474053T1 (de) 2010-07-15
ATE343004T1 (de) 2006-11-15
US7749733B2 (en) 2010-07-06
IL193374A (en) 2010-12-30
KR100942117B1 (ko) 2010-02-12
CA2812799A1 (en) 2003-01-16
ATE466942T1 (de) 2010-05-15
US20070031935A1 (en) 2007-02-08
ES2344074T3 (es) 2010-08-17
DK1404872T3 (da) 2007-02-19
NZ530218A (en) 2005-09-30
PT1600510E (pt) 2007-06-25
NO20040011L (no) 2004-03-03
JP2010131024A (ja) 2010-06-17
BRPI0210771B1 (pt) 2015-12-22
EP1808488A3 (en) 2007-11-14
DE60236334D1 (de) 2010-06-17
CY1107678T1 (el) 2013-04-18
JP5014444B2 (ja) 2012-08-29
DE60236379D1 (de) 2010-06-24
ZA200309599B (en) 2006-05-31
US20070026499A1 (en) 2007-02-01
DE60215502D1 (de) 2006-11-30
JP2010131025A (ja) 2010-06-17
US20070031933A1 (en) 2007-02-08
DE60236331D1 (de) 2010-06-17
MXPA03011801A (es) 2005-03-07
EP1806407A2 (en) 2007-07-11
DK1842919T3 (da) 2010-08-16
EP1808488A2 (en) 2007-07-18
SG143066A1 (en) 2008-06-27
EP1842919A1 (en) 2007-10-10
WO2003004704A2 (en) 2003-01-16
CA2812799C (en) 2016-01-26
US7736868B2 (en) 2010-06-15
KR20090037485A (ko) 2009-04-15
EP1829972A2 (en) 2007-09-05
EP1845162A1 (en) 2007-10-17
ES2344072T3 (es) 2010-08-17
EP1829971B1 (en) 2010-05-05
IL159674A (en) 2009-02-11
WO2003004704A3 (en) 2003-10-16
US20030199468A1 (en) 2003-10-23
NO338477B1 (no) 2016-08-22
US20070128717A1 (en) 2007-06-07
EP1806407B1 (en) 2010-05-05
CA2450020C (en) 2013-08-13
DK1829971T3 (da) 2010-08-16
ES2344070T3 (es) 2010-08-17
ATE466941T1 (de) 2010-05-15
US7192741B2 (en) 2007-03-20
ES2285630T3 (es) 2007-11-16
DE60237048D1 (de) 2010-08-26
DK1806407T3 (da) 2010-08-16
DK1600510T3 (da) 2007-06-25
AU2007234619B2 (en) 2011-06-02
CN1524128A (zh) 2004-08-25
EP1842919B1 (en) 2010-05-05
ES2348174T3 (es) 2010-11-30
US7736869B2 (en) 2010-06-15
EP1600510A2 (en) 2005-11-30
JP5014443B2 (ja) 2012-08-29
EP1600510B1 (en) 2007-03-28
EP1829971A3 (en) 2008-06-04
DE60215502T2 (de) 2007-08-30
US20070031934A1 (en) 2007-02-08
EP1600510A3 (en) 2006-02-22
IL159674A0 (en) 2004-06-20
CN1266282C (zh) 2006-07-26
ES2344071T3 (es) 2010-08-17
DE60219221D1 (de) 2007-05-10
US20070026498A1 (en) 2007-02-01
EP1829972A3 (en) 2007-10-24
ES2274045T3 (es) 2007-05-16
EP1806407A3 (en) 2008-06-04
AU2002314629B2 (en) 2007-08-30
EP1845162B1 (en) 2010-05-05
US7659094B2 (en) 2010-02-09
DE60236333D1 (de) 2010-06-17
ATE466944T1 (de) 2010-05-15
JP2004533262A (ja) 2004-11-04
ES2344073T3 (es) 2010-08-17
JP4500044B2 (ja) 2010-07-14
EP1829972B1 (en) 2010-05-12
KR100942116B1 (ko) 2010-02-12
ATE466943T1 (de) 2010-05-15
US7736870B2 (en) 2010-06-15
IL193373A (en) 2010-12-30
EP1404872A2 (en) 2004-04-07
DE60219221T2 (de) 2008-01-03
AU2007234619A1 (en) 2007-12-13
DK1808488T3 (da) 2010-10-18

Similar Documents

Publication Publication Date Title
BRPI0210771B8 (pt) construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna
Le et al. Guardians of the genome: BRCA2 and its partners
NO974964L (no) Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse
Bos et al. BapE DNA endonuclease induces an apoptotic-like response to DNA damage in Caulobacter
DE69316368D1 (de) Verfahren und diagnostische kits zur bestimmung der toxizität einer verbindung unter verwendung von an bakterielle stresspromotoren fusionierten reportergenen
BRPI0615657A2 (pt) seqüência de nucleotìdeos que codificam proteìnas inseticidas
Waterhouse et al. Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies
BR112017025929A2 (pt) genes pesticidas e métodos de uso
Borok et al. Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila
US12460201B2 (en) Methods of multiplexing CRISPR
ATE338828T1 (de) Amplifikation von einfachen sequenz wiederholungen
BR112018012893A2 (pt) genes pesticidas e métodos de uso
O’Toole et al. Prediction error neurons in mouse cortex are molecularly targetable cell types
Negrón-Piñeiro et al. Cis-regulatory interfaces reveal the molecular mechanisms underlying the notochord gene regulatory network of Ciona
Sureka et al. Identification of evolutionarily conserved nuclear matrix proteins and their prokaryotic origins
Balakireva et al. The lifespan of D. melanogaster depends on the function of the Gagr gene, a domesticated gag gene of Drosophila LTR retrotransposons
Drum et al. Genomics analysis of hexanoic acid exposure in Drosophila species
WO2013186359A1 (de) Analyseverfahren auf basis eines arrays
JP2019502120A (ja) スクリーニングの方法
Kumagai et al. Development of a bicistronic expression system in the branchiopod crustacean Daphnia magna
Palermo et al. Expression profiling Smackdown: human transcriptome Array HTA 2.0 vs. RNA-Seq
BR112017027821A2 (pt) genes pesticidas e métodos de uso
DE60036645D1 (de) Methoden zur identifizierung evolutionär signifikanter änderungen in polynukleotid- und polypeptidsequenzen in domestizierten pflanzen und tieren
Guéroult-Bellone et al. Spacer sequences separating transcription factor binding motifs set enhancer quality and strength
DE50312502D1 (de) Screeningverfahren zum identifizieren protektiver substanzen für die behandlung neurodegenerativer und/oder ischämischer erkrankungen

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2015, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B15V Prolongation of time limit allowed
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2726 DE 04/04/2023 POR TER SIDO INDEVIDA.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 14/06/2022