BR9915841A - Processo de moagem para a produção de substâncias medicinais finamente moìdas - Google Patents
Processo de moagem para a produção de substâncias medicinais finamente moìdasInfo
- Publication number
- BR9915841A BR9915841A BR9915841-8A BR9915841A BR9915841A BR 9915841 A BR9915841 A BR 9915841A BR 9915841 A BR9915841 A BR 9915841A BR 9915841 A BR9915841 A BR 9915841A
- Authority
- BR
- Brazil
- Prior art keywords
- grinding
- production
- medicinal substances
- grinding process
- finely ground
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/18—Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
- B02C19/186—Use of cold or heat for disintegrating
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Disintegrating Or Milling (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Crushing And Grinding (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO DE MOAGEM PARA A PRODUçãO DE SUBSTâNCIAS MEDICINAIS FINAMENTE MOìDAS"<D>. A presente invenção refere-se a um método de moagem de materiais para formar um pó fino com um tamanho de partícula média abaixo de 10 micrómetros que é adequado para inalação e que substancialmente não tem conteúdo amorfo gerado durante a moagem. O método é particularmente adequado para moagem de materiais que são macios. O método compreende moer o material em um moinho de energia fluida em temperatura reduzida usando hélio, ou hélio misturado com um outro gás, como o fluido de moagem. Temperaturas de -30°C ou menor são usadas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9826286.8A GB9826286D0 (en) | 1998-12-01 | 1998-12-01 | Process |
| PCT/GB1999/004047 WO2000032313A1 (en) | 1998-12-01 | 1999-12-01 | Milling process for the production of finely milled medicinal substances |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9915841A true BR9915841A (pt) | 2001-09-04 |
| BRPI9915841B1 BRPI9915841B1 (pt) | 2016-11-22 |
| BRPI9915841B8 BRPI9915841B8 (pt) | 2021-05-25 |
Family
ID=10843362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9915841A BRPI9915841B8 (pt) | 1998-12-01 | 1999-12-01 | processo de moagem para a produção de substâncias medicinais finamente moídas |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7041318B2 (pt) |
| EP (2) | EP1338273B1 (pt) |
| JP (1) | JP4592955B2 (pt) |
| KR (1) | KR100658010B1 (pt) |
| CN (1) | CN1096886C (pt) |
| AT (1) | ATE234684T1 (pt) |
| AU (1) | AU758212B2 (pt) |
| BR (1) | BRPI9915841B8 (pt) |
| CA (1) | CA2352779A1 (pt) |
| CZ (2) | CZ307438B6 (pt) |
| DE (1) | DE69906147T2 (pt) |
| DK (2) | DK1338273T3 (pt) |
| ES (2) | ES2634255T3 (pt) |
| GB (1) | GB9826286D0 (pt) |
| HK (1) | HK1037563A1 (pt) |
| HU (1) | HU226221B1 (pt) |
| IL (1) | IL143345A (pt) |
| MX (1) | MXPA01005471A (pt) |
| NO (1) | NO324231B1 (pt) |
| NZ (1) | NZ512091A (pt) |
| PL (1) | PL193799B1 (pt) |
| PT (1) | PT1146964E (pt) |
| RU (1) | RU2234375C2 (pt) |
| SI (1) | SI1146964T1 (pt) |
| WO (1) | WO2000032313A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| JO3510B1 (ar) | 2011-03-04 | 2020-07-05 | Heptares Therapeutics Ltd | استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب |
| DE102011102614A1 (de) * | 2011-05-27 | 2012-11-29 | Roland Nied | Verfahren zum Betrieb einer Strahlmühle sowie Strahlmühle |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| UA115958C2 (uk) | 2014-09-09 | 2018-01-10 | Вектура Лімітед | Препарат, що містить глікопіролат, спосіб та пристрій |
| RU2623608C1 (ru) * | 2016-02-09 | 2017-06-28 | Владимир Никитович Анциферов | Способ размола порошка из пластичного материала |
| CN109097582B (zh) * | 2018-08-17 | 2020-07-03 | 安阳工学院 | 一种机械工程粉状废弃物处理系统 |
| US20210386665A1 (en) * | 2018-10-02 | 2021-12-16 | Meijo University Educational Foundation | Inhalation powder medicine, evaluation method thereof, and use thereof |
| CN113751171A (zh) * | 2021-09-14 | 2021-12-07 | 威海德尚医中医药科技有限公司 | 一种中药超微细粉制剂的制备方法 |
| CN115737610B (zh) * | 2021-12-13 | 2024-02-27 | 苏州欧米尼医药有限公司 | 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897010A (en) * | 1971-07-02 | 1975-07-29 | Linde Ag | Method of and apparatus for the milling of granular materials |
| DE2133019A1 (de) * | 1971-07-02 | 1973-01-18 | Linde Ag | Verfahren und vorrichtung zum kaltstrahlmahlen |
| GB1481304A (en) * | 1974-09-05 | 1977-07-27 | Boc International Ltd | Powder forming |
| GB8432063D0 (en) * | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
| US4767612A (en) * | 1987-01-23 | 1988-08-30 | Rorer Pharmaceutical Corporation | Triamcinolone acetonide for the treatment of allergic rhinitis |
| FR2628415A1 (fr) * | 1988-03-09 | 1989-09-15 | Rhone Poulenc Chimie | Procede de fabrication de materiaux supraconducteurs et produits ainsi obtenus |
| DE407028T1 (de) | 1989-05-31 | 1994-03-17 | Fisons Plc | Medikament und Inhalationsvorrichtung dafür. |
| SE9302777D0 (sv) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| SE9101090D0 (sv) | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| US5747002A (en) * | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
| SE9501384D0 (sv) * | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
| US5682658A (en) | 1996-03-04 | 1997-11-04 | Utica Enterprises, Inc. | Rotary index table assembly |
| DE69704110T2 (de) * | 1996-03-08 | 2001-07-19 | E.I. Du Pont De Nemours And Company, Wilmington | Verbesserte fluidenergie-mühle |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
-
1998
- 1998-12-01 GB GBGB9826286.8A patent/GB9826286D0/en not_active Ceased
-
1999
- 1999-12-01 HU HU0201662A patent/HU226221B1/hu unknown
- 1999-12-01 PL PL99348613A patent/PL193799B1/pl unknown
- 1999-12-01 CA CA002352779A patent/CA2352779A1/en not_active Abandoned
- 1999-12-01 PT PT99972947T patent/PT1146964E/pt unknown
- 1999-12-01 AU AU14012/00A patent/AU758212B2/en not_active Expired
- 1999-12-01 DE DE69906147T patent/DE69906147T2/de not_active Expired - Lifetime
- 1999-12-01 SI SI9930289T patent/SI1146964T1/xx unknown
- 1999-12-01 NZ NZ512091A patent/NZ512091A/xx not_active IP Right Cessation
- 1999-12-01 EP EP02079497.0A patent/EP1338273B1/en not_active Expired - Lifetime
- 1999-12-01 AT AT99972947T patent/ATE234684T1/de active
- 1999-12-01 JP JP2000584994A patent/JP4592955B2/ja not_active Expired - Lifetime
- 1999-12-01 CN CN99813829A patent/CN1096886C/zh not_active Expired - Lifetime
- 1999-12-01 DK DK02079497.0T patent/DK1338273T3/en active
- 1999-12-01 BR BRPI9915841A patent/BRPI9915841B8/pt not_active IP Right Cessation
- 1999-12-01 CZ CZ2006-171A patent/CZ307438B6/cs not_active IP Right Cessation
- 1999-12-01 KR KR1020017006781A patent/KR100658010B1/ko active IP Right Grant
- 1999-12-01 DK DK99972947T patent/DK1146964T3/da active
- 1999-12-01 IL IL14334599A patent/IL143345A/xx not_active IP Right Cessation
- 1999-12-01 WO PCT/GB1999/004047 patent/WO2000032313A1/en active IP Right Grant
- 1999-12-01 RU RU2001117833/03A patent/RU2234375C2/ru active
- 1999-12-01 ES ES02079497.0T patent/ES2634255T3/es not_active Expired - Lifetime
- 1999-12-01 EP EP99972947A patent/EP1146964B1/en not_active Expired - Lifetime
- 1999-12-01 MX MXPA01005471A patent/MXPA01005471A/es active IP Right Grant
- 1999-12-01 ES ES99972947T patent/ES2195668T3/es not_active Expired - Lifetime
- 1999-12-01 CZ CZ20011874A patent/CZ296782B6/cs not_active IP Right Cessation
-
2001
- 2001-05-30 NO NO20012653A patent/NO324231B1/no not_active IP Right Cessation
- 2001-06-01 US US09/871,876 patent/US7041318B2/en not_active Expired - Lifetime
- 2001-11-05 HK HK01107711A patent/HK1037563A1/xx not_active IP Right Cessation
-
2005
- 2005-09-07 US US11/221,186 patent/US20060002864A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO DISPOSTO NOS ARTIGOS 8O E 13 DA LPI |
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/11/2016, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 19A ANUIDADE. |
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| B21H | Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2494 DE 23/10/2018 POR TER SIDO INDEVIDA. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/12/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 01/12/2019 |