BR9913516A - Processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada, e, substrato modificado em superfìcie - Google Patents
Processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada, e, substrato modificado em superfìcieInfo
- Publication number
- BR9913516A BR9913516A BR9913516-7A BR9913516A BR9913516A BR 9913516 A BR9913516 A BR 9913516A BR 9913516 A BR9913516 A BR 9913516A BR 9913516 A BR9913516 A BR 9913516A
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- modified substrate
- improved non
- thrombogenic activity
- surface modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSO PARA A PRODUçãO DE UMA MODIFICAçãO EM SUPERFìCIE QUE TEM UMA ATIVIDADE NãO TROMBOGêNICA MELHORADA, E, SUBSTRATO MODIFICADO EM SUPERFìCIE". A presente invenção refere-se a um processo para a preparação de modificações de superfície que têm uma atividade antitrombogênica melhorada, sendo que o melhoramento é conseguido por tratamento de heparina a temperaturas elevadas ou a pH elevado ou em contato com catalisadores nucleofílicos tais como aminas, álcoois, tióis ou grupos amino imobilizado, hidroxila ou tiol antes de ligação da dita heparina à superfície a ser modificada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO984143A NO984143L (no) | 1998-09-09 | 1998-09-09 | Ny prosess for å fremstille overflatemodifiserende stoffer |
PCT/NO1999/000277 WO2000013718A1 (en) | 1998-09-09 | 1999-09-08 | New process for preparing surface modification substances |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9913516A true BR9913516A (pt) | 2001-06-05 |
BR9913516B1 BR9913516B1 (pt) | 2010-09-21 |
Family
ID=19902393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9913516-7A BR9913516B1 (pt) | 1998-09-09 | 1999-09-08 | processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6461665B1 (pt) |
EP (1) | EP1112097B1 (pt) |
JP (1) | JP4152075B2 (pt) |
KR (1) | KR100669132B1 (pt) |
AT (1) | ATE243538T1 (pt) |
AU (1) | AU757913B2 (pt) |
BR (1) | BR9913516B1 (pt) |
CA (1) | CA2342991C (pt) |
DE (1) | DE69909104T2 (pt) |
DK (1) | DK1112097T3 (pt) |
ES (1) | ES2203177T3 (pt) |
NO (1) | NO984143L (pt) |
PT (1) | PT1112097E (pt) |
WO (1) | WO2000013718A1 (pt) |
Families Citing this family (92)
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US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
SE515295C2 (sv) * | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
DE60324787D1 (de) * | 2002-05-10 | 2009-01-02 | Salviac Ltd | System zum filtern von emboli |
US6926965B2 (en) * | 2002-09-11 | 2005-08-09 | Novartis Ag | LbL-coated medical device and method for making the same |
US8071569B2 (en) * | 2002-09-20 | 2011-12-06 | Mousa Shaker A | Oxidized heparin fractions and their use in inhibiting angiogenesis |
WO2005115490A2 (en) * | 2004-05-25 | 2005-12-08 | Surmodics, Inc. | Natural biodegradable polysaccharide coatings for meical articles |
US20060159650A1 (en) * | 2005-01-14 | 2006-07-20 | Bacterin, Inc. | Composition and method for covalently coupling an antithrombotic substance and a hydrophilic polymer |
DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
WO2007069983A1 (en) | 2005-12-13 | 2007-06-21 | Exthera Ab | Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood |
US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
US8986713B2 (en) * | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
US8496953B2 (en) * | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
US8021677B2 (en) | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
CN101516413B (zh) | 2006-09-15 | 2013-11-13 | 东丽株式会社 | 基材及其制造方法 |
US20090281059A1 (en) | 2007-02-21 | 2009-11-12 | Robert Falotico | Coating for a medical device having an anti-thrombotic conjugate |
US20080200421A1 (en) | 2007-02-21 | 2008-08-21 | Zhao Jonathon Z | Coating for a medical device having an anti-thrombotic conjugate |
US9693841B2 (en) | 2007-04-02 | 2017-07-04 | Ension, Inc. | Surface treated staples, sutures and dental floss and methods of manufacturing the same |
WO2008122034A1 (en) * | 2007-04-02 | 2008-10-09 | Ension, Inc. | Process for preparing a substrate coated with a biomolecule |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8383156B2 (en) | 2007-04-30 | 2013-02-26 | Cordis Corporation | Coating for a medical device having an anti-thrombotic conjugate |
WO2008157570A2 (en) * | 2007-06-18 | 2008-12-24 | Exthera Ab | Device and method for restoration of the condition of blood |
WO2008155683A1 (en) | 2007-06-18 | 2008-12-24 | Firmenich Sa | Malodor counteracting compositions and method for their use |
US20090018646A1 (en) | 2007-07-10 | 2009-01-15 | Zhao Jonathon Z | Coating Employing an Anti-Thrombotic Conjugate |
US20090192079A1 (en) * | 2007-10-09 | 2009-07-30 | Genzyme Corporation | Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
GB0816783D0 (en) * | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
US7819914B2 (en) | 2008-12-16 | 2010-10-26 | Cordis Corporation | Adhesion promoting primer for coated surfaces |
US20100161039A1 (en) * | 2008-12-23 | 2010-06-24 | Vipul Dave | Adhesion promoting temporary mask for coated surfaces |
AU2010200316A1 (en) * | 2009-01-30 | 2010-08-19 | Cordis Corporation | Reservoir Eluting Stent |
WO2010096654A1 (en) | 2009-02-21 | 2010-08-26 | Tyco Healthcare Group Lp | Medical devices having activated surfaces |
US8829071B2 (en) * | 2009-02-21 | 2014-09-09 | Sofradim Production | Medical device with degradation-retarding coating |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
US8658707B2 (en) | 2009-03-24 | 2014-02-25 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products |
US8591932B2 (en) | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
US8758286B2 (en) | 2009-12-01 | 2014-06-24 | Exthera Medical Corporation | Method for removing cytokines from blood with surface immobilized polysaccharides |
RU2539566C2 (ru) | 2009-12-24 | 2015-01-20 | Торэй Индастриз, Инк. | Гидрофильное полимерное соединение, имеющее антикоагулянтный эффект |
GB201004101D0 (en) | 2010-03-12 | 2010-04-28 | Carmeda Ab | Immobilised biological entities |
WO2011147849A1 (en) | 2010-05-25 | 2011-12-01 | Jenavalve Technology Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US10166128B2 (en) | 2011-01-14 | 2019-01-01 | W. L. Gore & Associates. Inc. | Lattice |
US9839540B2 (en) | 2011-01-14 | 2017-12-12 | W. L. Gore & Associates, Inc. | Stent |
WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
US20120310210A1 (en) | 2011-03-04 | 2012-12-06 | Campbell Carey V | Eluting medical devices |
US9415193B2 (en) | 2011-03-04 | 2016-08-16 | W. L. Gore & Associates, Inc. | Eluting medical devices |
BR112013023241B1 (pt) | 2011-03-11 | 2019-07-02 | W. L. Gore & Associates, Inc. | Molécula de polímero catiônico hiper ramificado e dispositivo |
TW201311774A (zh) | 2011-06-23 | 2013-03-16 | Toray Industries | 具有抗血液凝固作用的疏水性高分子化合物 |
TW201309354A (zh) | 2011-06-23 | 2013-03-01 | Toray Industries | 醫療材料 |
US9775933B2 (en) | 2012-03-02 | 2017-10-03 | W. L. Gore & Associates, Inc. | Biocompatible surfaces and devices incorporating such surfaces |
ES2647577T3 (es) | 2012-06-13 | 2017-12-22 | Exthera Medical Corporation | Uso de heparina y carbohidratos para tratar el cáncer |
US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
US9931193B2 (en) | 2012-11-13 | 2018-04-03 | W. L. Gore & Associates, Inc. | Elastic stent graft |
US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
CN110772677A (zh) | 2013-06-24 | 2020-02-11 | 艾克塞拉医疗公司 | 含有涂覆甘露糖的基质的血液过滤系统 |
JP6563394B2 (ja) | 2013-08-30 | 2019-08-21 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法 |
WO2015069942A1 (en) | 2013-11-08 | 2015-05-14 | Exthera Medical Corporation | Methods for diagnosing infectious diseases using adsorption media |
US20170157303A1 (en) | 2013-11-28 | 2017-06-08 | Toray Industries, Inc. | Anti-thrombotic material |
JP6435863B2 (ja) | 2013-11-28 | 2018-12-12 | 東レ株式会社 | 抗血栓性材料 |
US10842918B2 (en) | 2013-12-05 | 2020-11-24 | W.L. Gore & Associates, Inc. | Length extensible implantable device and methods for making such devices |
CA2935808C (en) | 2014-02-12 | 2018-08-21 | Toray Industries, Inc. | Artificial blood vessel |
US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
JP2017513636A (ja) | 2014-04-24 | 2017-06-01 | エクスセラ メディカル コーポレイション | 高流量を用いて血液から細菌を除去するための方法 |
US9827094B2 (en) | 2014-09-15 | 2017-11-28 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with retention elements |
JP7100454B2 (ja) | 2014-09-22 | 2022-07-13 | エクスセラ メディカル コーポレイション | 装着型血液潅流デバイス |
WO2016177562A1 (en) | 2015-05-01 | 2016-11-10 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
EP3095509A1 (en) | 2015-05-18 | 2016-11-23 | Defymed | Membranes functionalized with heparin for bioartificial organs |
US10561766B2 (en) | 2015-09-15 | 2020-02-18 | W. L. Gore & Associates, Inc. | Drug composition and coating |
WO2017151797A1 (en) | 2016-03-02 | 2017-09-08 | Exthera Medical Corporation | Method for treating drug intoxication |
US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
JP7248430B2 (ja) | 2016-04-21 | 2023-03-29 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 直径を調節可能な内部人工器官ならびに関連したシステムおよび方法 |
EP4183371A1 (en) | 2016-05-13 | 2023-05-24 | JenaValve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
ES2864502T3 (es) | 2016-09-30 | 2021-10-13 | Toray Industries | Copolímero y material médico que lo contiene |
EP3533914B1 (en) | 2016-10-07 | 2023-03-15 | Toray Industries, Inc. | Tubular fabric |
EP3318294A1 (en) | 2016-11-08 | 2018-05-09 | Defymed | Kit for in situ delivery of a compound of interest |
WO2018138658A1 (en) | 2017-01-27 | 2018-08-02 | Jenavalve Technology, Inc. | Heart valve mimicry |
JP7157930B2 (ja) | 2017-03-31 | 2022-10-21 | 東レ株式会社 | 筒状構造体 |
CA3178271A1 (en) | 2017-09-27 | 2019-04-04 | W.L. Gore & Associates, Inc. | Prosthetic valve with expandable frame and associated systems and methods |
WO2019067220A1 (en) | 2017-09-27 | 2019-04-04 | W. L. Gore & Associates, Inc. | PROSTHETIC VALVES WITH MECHANICALLY COUPLED VALVULAR BLADES |
JP7052032B2 (ja) | 2017-10-31 | 2022-04-11 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 組織内方成長を促進する医療用弁及び弁膜 |
CN111655917B (zh) | 2018-01-30 | 2022-09-06 | 东丽株式会社 | 平纹织物、其制造方法及支架移植体 |
WO2019170858A1 (en) | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to processes for immobilising biological entities |
WO2019170859A2 (en) | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to immobilising biological entities |
JP2022504294A (ja) | 2018-10-03 | 2022-01-13 | カルメダ エービー | 固定化された生物学的実体 |
US20200179663A1 (en) | 2018-12-11 | 2020-06-11 | W. L. Gore & Associates, Inc. | Medical devices for shunts, occluders, fenestrations and related systems and methods |
US20200196876A1 (en) | 2018-12-21 | 2020-06-25 | W. L. Gore & Associates, Inc. | Implantable cardiac sensors |
WO2020158847A1 (ja) | 2019-01-30 | 2020-08-06 | 東レ株式会社 | 心血管留置デバイス用の医療基材 |
US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
US20220401105A1 (en) | 2019-11-15 | 2022-12-22 | W. L. Gore & Associates, Inc. | Left atrial appendage device and methods |
JP2023515766A (ja) | 2020-02-04 | 2023-04-14 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 流入/流出カニューレ |
EP3892259A1 (en) | 2020-04-09 | 2021-10-13 | Defymed | Membranes for medical devices |
CA3179703A1 (en) | 2020-04-09 | 2021-10-14 | Defymed | Membranes for medical devices |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
US4600652A (en) | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
IT1260136B (it) | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 |
US5679659A (en) * | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
US6174326B1 (en) * | 1996-09-25 | 2001-01-16 | Terumo Kabushiki Kaisha | Radiopaque, antithrombogenic stent and method for its production |
-
1998
- 1998-09-09 NO NO984143A patent/NO984143L/no not_active Application Discontinuation
-
1999
- 1999-09-08 CA CA002342991A patent/CA2342991C/en not_active Expired - Lifetime
- 1999-09-08 WO PCT/NO1999/000277 patent/WO2000013718A1/en active IP Right Grant
- 1999-09-08 PT PT99944936T patent/PT1112097E/pt unknown
- 1999-09-08 KR KR1020017002986A patent/KR100669132B1/ko not_active IP Right Cessation
- 1999-09-08 ES ES99944936T patent/ES2203177T3/es not_active Expired - Lifetime
- 1999-09-08 DE DE69909104T patent/DE69909104T2/de not_active Expired - Lifetime
- 1999-09-08 BR BRPI9913516-7A patent/BR9913516B1/pt not_active IP Right Cessation
- 1999-09-08 DK DK99944936T patent/DK1112097T3/da active
- 1999-09-08 AT AT99944936T patent/ATE243538T1/de active
- 1999-09-08 US US09/763,873 patent/US6461665B1/en not_active Expired - Lifetime
- 1999-09-08 AU AU57652/99A patent/AU757913B2/en not_active Expired
- 1999-09-08 EP EP99944936A patent/EP1112097B1/en not_active Expired - Lifetime
- 1999-09-08 JP JP2000568523A patent/JP4152075B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK1112097T3 (da) | 2003-10-20 |
US6461665B1 (en) | 2002-10-08 |
AU5765299A (en) | 2000-03-27 |
NO984143D0 (no) | 1998-09-09 |
BR9913516B1 (pt) | 2010-09-21 |
ATE243538T1 (de) | 2003-07-15 |
JP2003507082A (ja) | 2003-02-25 |
KR100669132B1 (ko) | 2007-01-17 |
PT1112097E (pt) | 2003-11-28 |
CA2342991A1 (en) | 2000-03-16 |
NO984143L (no) | 2000-03-10 |
AU757913B2 (en) | 2003-03-13 |
CA2342991C (en) | 2009-01-27 |
DE69909104D1 (de) | 2003-07-31 |
DE69909104T2 (de) | 2004-04-08 |
KR20010088799A (ko) | 2001-09-28 |
JP4152075B2 (ja) | 2008-09-17 |
WO2000013718A1 (en) | 2000-03-16 |
EP1112097B1 (en) | 2003-06-25 |
ES2203177T3 (es) | 2004-04-01 |
EP1112097A1 (en) | 2001-07-04 |
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