BR9913516A - Processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada, e, substrato modificado em superfìcie - Google Patents
Processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada, e, substrato modificado em superfìcieInfo
- Publication number
- BR9913516A BR9913516A BR9913516-7A BR9913516A BR9913516A BR 9913516 A BR9913516 A BR 9913516A BR 9913516 A BR9913516 A BR 9913516A BR 9913516 A BR9913516 A BR 9913516A
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- modified substrate
- improved non
- thrombogenic activity
- surface modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSO PARA A PRODUçãO DE UMA MODIFICAçãO EM SUPERFìCIE QUE TEM UMA ATIVIDADE NãO TROMBOGêNICA MELHORADA, E, SUBSTRATO MODIFICADO EM SUPERFìCIE". A presente invenção refere-se a um processo para a preparação de modificações de superfície que têm uma atividade antitrombogênica melhorada, sendo que o melhoramento é conseguido por tratamento de heparina a temperaturas elevadas ou a pH elevado ou em contato com catalisadores nucleofílicos tais como aminas, álcoois, tióis ou grupos amino imobilizado, hidroxila ou tiol antes de ligação da dita heparina à superfície a ser modificada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO984143A NO984143L (no) | 1998-09-09 | 1998-09-09 | Ny prosess for å fremstille overflatemodifiserende stoffer |
PCT/NO1999/000277 WO2000013718A1 (en) | 1998-09-09 | 1999-09-08 | New process for preparing surface modification substances |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9913516A true BR9913516A (pt) | 2001-06-05 |
BR9913516B1 BR9913516B1 (pt) | 2010-09-21 |
Family
ID=19902393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9913516-7A BR9913516B1 (pt) | 1998-09-09 | 1999-09-08 | processo para a produção de uma modificação em superfìcie que tem uma atividade não trombogênica melhorada. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6461665B1 (pt) |
EP (1) | EP1112097B1 (pt) |
JP (1) | JP4152075B2 (pt) |
KR (1) | KR100669132B1 (pt) |
AT (1) | ATE243538T1 (pt) |
AU (1) | AU757913B2 (pt) |
BR (1) | BR9913516B1 (pt) |
CA (1) | CA2342991C (pt) |
DE (1) | DE69909104T2 (pt) |
DK (1) | DK1112097T3 (pt) |
ES (1) | ES2203177T3 (pt) |
NO (1) | NO984143L (pt) |
PT (1) | PT1112097E (pt) |
WO (1) | WO2000013718A1 (pt) |
Families Citing this family (96)
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SE515295C2 (sv) * | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
WO2003094788A2 (en) * | 2002-05-10 | 2003-11-20 | Salviac Limited | An embolic protection system |
US6926965B2 (en) * | 2002-09-11 | 2005-08-09 | Novartis Ag | LbL-coated medical device and method for making the same |
US8071569B2 (en) * | 2002-09-20 | 2011-12-06 | Mousa Shaker A | Oxidized heparin fractions and their use in inhibiting angiogenesis |
US20050281857A1 (en) * | 2004-05-25 | 2005-12-22 | Heyer Toni M | Methods and reagents for preparing biomolecule-containing coatings |
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DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
MX2008007716A (es) | 2005-12-13 | 2008-09-26 | Exthera Ab | Metodo para eliminar extra corporalmente de la sangre un microbio patogeno, una celula inflamatoria o una proteina inflamatoria. |
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US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
US8496953B2 (en) * | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
US8986713B2 (en) * | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
US8733557B2 (en) | 2006-09-15 | 2014-05-27 | Toray Industries, Inc. | Substrate and method for production thereof |
US20080200421A1 (en) | 2007-02-21 | 2008-08-21 | Zhao Jonathon Z | Coating for a medical device having an anti-thrombotic conjugate |
US20090281059A1 (en) * | 2007-02-21 | 2009-11-12 | Robert Falotico | Coating for a medical device having an anti-thrombotic conjugate |
US9693841B2 (en) | 2007-04-02 | 2017-07-04 | Ension, Inc. | Surface treated staples, sutures and dental floss and methods of manufacturing the same |
US8114465B2 (en) * | 2007-04-02 | 2012-02-14 | Ension, Inc. | Process for preparing a substrate coated with a biomolecule |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8383156B2 (en) | 2007-04-30 | 2013-02-26 | Cordis Corporation | Coating for a medical device having an anti-thrombotic conjugate |
WO2008155683A1 (en) | 2007-06-18 | 2008-12-24 | Firmenich Sa | Malodor counteracting compositions and method for their use |
AU2008265838A1 (en) * | 2007-06-18 | 2008-12-24 | Exthera Medical Llc | Device and method for restoration of the condition of blood |
US20090018646A1 (en) * | 2007-07-10 | 2009-01-15 | Zhao Jonathon Z | Coating Employing an Anti-Thrombotic Conjugate |
US20090192079A1 (en) * | 2007-10-09 | 2009-07-30 | Genzyme Corporation | Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
GB0816783D0 (en) * | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
US7819914B2 (en) * | 2008-12-16 | 2010-10-26 | Cordis Corporation | Adhesion promoting primer for coated surfaces |
US20100161039A1 (en) * | 2008-12-23 | 2010-06-24 | Vipul Dave | Adhesion promoting temporary mask for coated surfaces |
AU2010200316A1 (en) * | 2009-01-30 | 2010-08-19 | Cordis Corporation | Reservoir Eluting Stent |
AU2010215936B2 (en) | 2009-02-21 | 2015-03-05 | Covidien Lp | Medical devices having activated surfaces |
EP2398525B1 (en) * | 2009-02-21 | 2012-12-05 | Sofradim Production | Medical device with degradation-retarding coating |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
US8658707B2 (en) | 2009-03-24 | 2014-02-25 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products |
US8591932B2 (en) * | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
KR101876794B1 (ko) | 2009-12-01 | 2018-07-10 | 엑스테라 메디컬 코퍼레이션 | 표면 고정화된 다당류를 이용하여 혈액으로부터 사이토카인을 제거하는 방법 |
TWI476020B (zh) | 2009-12-24 | 2015-03-11 | Toray Industries | 具有抗血液凝固作用之親水性高分子化合物、包含其之醫療器材或醫療材料之表面處理劑、以及經其處理之醫療器材或醫療材料 |
GB201004101D0 (en) | 2010-03-12 | 2010-04-28 | Carmeda Ab | Immobilised biological entities |
BR112012029896A2 (pt) | 2010-05-25 | 2017-06-20 | Jenavalve Tech Inc | válcula cardíaca protética para endoprótese e endoprótese |
US10166128B2 (en) | 2011-01-14 | 2019-01-01 | W. L. Gore & Associates. Inc. | Lattice |
US9839540B2 (en) | 2011-01-14 | 2017-12-12 | W. L. Gore & Associates, Inc. | Stent |
WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
US20120310210A1 (en) | 2011-03-04 | 2012-12-06 | Campbell Carey V | Eluting medical devices |
US9415193B2 (en) | 2011-03-04 | 2016-08-16 | W. L. Gore & Associates, Inc. | Eluting medical devices |
RU2625756C2 (ru) | 2011-03-11 | 2017-07-18 | В.Л. Гор Энд Ассошиейтс, Инк. | Усовершенствованные иммобилизованные биологические объекты |
TW201309354A (zh) | 2011-06-23 | 2013-03-01 | Toray Industries | 醫療材料 |
TW201311774A (zh) | 2011-06-23 | 2013-03-16 | Toray Industries | 具有抗血液凝固作用的疏水性高分子化合物 |
US9775933B2 (en) | 2012-03-02 | 2017-10-03 | W. L. Gore & Associates, Inc. | Biocompatible surfaces and devices incorporating such surfaces |
DK2861273T3 (da) | 2012-06-13 | 2017-11-27 | Exthera Medical Corp | Anvendelse af heparin og kulhydrater til behandling af cancer. |
US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
US9931193B2 (en) | 2012-11-13 | 2018-04-03 | W. L. Gore & Associates, Inc. | Elastic stent graft |
US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
JP6648009B2 (ja) | 2013-06-24 | 2020-02-14 | エクステラ・メディカル・コーポレーション | マンノース被覆基材を含有する血液濾過システム |
US9867694B2 (en) | 2013-08-30 | 2018-01-16 | Jenavalve Technology Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
MX2016005959A (es) | 2013-11-08 | 2016-10-14 | Exthera Medical Corp | Métodos para diagnosticar enfermedades infecciosas usando medio de adsorción. |
JP6435863B2 (ja) | 2013-11-28 | 2018-12-12 | 東レ株式会社 | 抗血栓性材料 |
KR20160058902A (ko) | 2013-11-28 | 2016-05-25 | 도레이 카부시키가이샤 | 항혈전성 재료 |
US10842918B2 (en) | 2013-12-05 | 2020-11-24 | W.L. Gore & Associates, Inc. | Length extensible implantable device and methods for making such devices |
KR101835449B1 (ko) | 2014-02-12 | 2018-03-08 | 도레이 카부시키가이샤 | 인공혈관 |
US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
CN106255520B (zh) | 2014-04-24 | 2022-08-12 | 艾克塞拉医疗公司 | 使用高流速从血液除去细菌的方法 |
US9827094B2 (en) | 2014-09-15 | 2017-11-28 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with retention elements |
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US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
JP7248430B2 (ja) | 2016-04-21 | 2023-03-29 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 直径を調節可能な内部人工器官ならびに関連したシステムおよび方法 |
CN109475419B (zh) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法 |
EP3845573B1 (en) | 2016-09-30 | 2023-08-09 | Toray Industries, Inc. | Copolymer and medical material containing the same |
KR20190058493A (ko) | 2016-10-07 | 2019-05-29 | 도레이 카부시키가이샤 | 통형상 직물 |
EP3318294A1 (en) | 2016-11-08 | 2018-05-09 | Defymed | Kit for in situ delivery of a compound of interest |
CN110392557A (zh) | 2017-01-27 | 2019-10-29 | 耶拿阀门科技股份有限公司 | 心脏瓣膜模拟 |
CA3058121A1 (en) | 2017-03-31 | 2018-10-04 | Toray Industries, Inc. | Cylindrical structure |
CN111182856B (zh) | 2017-09-12 | 2022-04-29 | W.L.戈尔及同仁股份有限公司 | 用于假体瓣膜的瓣叶框架附连件 |
CA3178271A1 (en) | 2017-09-27 | 2019-04-04 | W.L. Gore & Associates, Inc. | Prosthetic valve with expandable frame and associated systems and methods |
CN115024861A (zh) | 2017-09-27 | 2022-09-09 | W.L.戈尔及同仁股份有限公司 | 具有机械联接的瓣叶的假体瓣膜 |
CN111447890B (zh) | 2017-10-13 | 2023-01-31 | W.L.戈尔及同仁股份有限公司 | 叠套式假体瓣膜及递送系统 |
CA3205219A1 (en) | 2017-10-31 | 2019-05-09 | Edwards Lifesciences Corporation | Medical valve and leaflet promoting tissue ingrowth |
WO2019150937A1 (ja) | 2018-01-30 | 2019-08-08 | 東レ株式会社 | 平織物、その製造方法およびステントグラフト |
US20190275213A1 (en) | 2018-03-09 | 2019-09-12 | Carmeda Ab | Immobilising biological entities |
WO2019170858A1 (en) | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to processes for immobilising biological entities |
AU2019306239B2 (en) | 2018-07-18 | 2022-08-25 | W. L. Gore & Associates, Inc. | Implantable medical device deployment system |
WO2020070258A1 (en) | 2018-10-03 | 2020-04-09 | Carmeda Ab | Immobilised biological entities |
US20200179663A1 (en) | 2018-12-11 | 2020-06-11 | W. L. Gore & Associates, Inc. | Medical devices for shunts, occluders, fenestrations and related systems and methods |
EP3897369B1 (en) | 2018-12-21 | 2024-03-27 | W. L. Gore & Associates, Inc. | Implantable cardiac sensors |
CN113330151A (zh) | 2019-01-30 | 2021-08-31 | 东丽株式会社 | 心血管留置装置用的医疗基材 |
US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
EP3969014A4 (en) | 2019-05-16 | 2023-01-25 | ExThera Medical Corporation | METHOD OF MODULATING ENDOTHELIAL GLYCOCALYX STRUCTURE |
WO2021097412A1 (en) | 2019-11-15 | 2021-05-20 | W. L. Gore & Associates, Inc. | Left atrial appendage device and methods |
CA3168927A1 (en) | 2020-02-04 | 2022-08-11 | W. L. Gore & Associates, Inc. | Inflow / outflow cannula |
EP3892259A1 (en) | 2020-04-09 | 2021-10-13 | Defymed | Membranes for medical devices |
CA3179703A1 (en) | 2020-04-09 | 2021-10-14 | Defymed | Membranes for medical devices |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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SE8200751L (sv) * | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
US4600652A (en) | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
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IT1260136B (it) | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 |
US5679659A (en) * | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
US6174326B1 (en) * | 1996-09-25 | 2001-01-16 | Terumo Kabushiki Kaisha | Radiopaque, antithrombogenic stent and method for its production |
-
1998
- 1998-09-09 NO NO984143A patent/NO984143L/no not_active Application Discontinuation
-
1999
- 1999-09-08 ES ES99944936T patent/ES2203177T3/es not_active Expired - Lifetime
- 1999-09-08 BR BRPI9913516-7A patent/BR9913516B1/pt not_active IP Right Cessation
- 1999-09-08 AU AU57652/99A patent/AU757913B2/en not_active Expired
- 1999-09-08 DK DK99944936T patent/DK1112097T3/da active
- 1999-09-08 CA CA002342991A patent/CA2342991C/en not_active Expired - Lifetime
- 1999-09-08 KR KR1020017002986A patent/KR100669132B1/ko not_active IP Right Cessation
- 1999-09-08 PT PT99944936T patent/PT1112097E/pt unknown
- 1999-09-08 AT AT99944936T patent/ATE243538T1/de active
- 1999-09-08 WO PCT/NO1999/000277 patent/WO2000013718A1/en active IP Right Grant
- 1999-09-08 US US09/763,873 patent/US6461665B1/en not_active Expired - Lifetime
- 1999-09-08 DE DE69909104T patent/DE69909104T2/de not_active Expired - Lifetime
- 1999-09-08 EP EP99944936A patent/EP1112097B1/en not_active Expired - Lifetime
- 1999-09-08 JP JP2000568523A patent/JP4152075B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100669132B1 (ko) | 2007-01-17 |
EP1112097A1 (en) | 2001-07-04 |
CA2342991A1 (en) | 2000-03-16 |
AU5765299A (en) | 2000-03-27 |
KR20010088799A (ko) | 2001-09-28 |
AU757913B2 (en) | 2003-03-13 |
JP2003507082A (ja) | 2003-02-25 |
DE69909104D1 (de) | 2003-07-31 |
NO984143D0 (no) | 1998-09-09 |
EP1112097B1 (en) | 2003-06-25 |
BR9913516B1 (pt) | 2010-09-21 |
CA2342991C (en) | 2009-01-27 |
NO984143L (no) | 2000-03-10 |
WO2000013718A1 (en) | 2000-03-16 |
DK1112097T3 (da) | 2003-10-20 |
ATE243538T1 (de) | 2003-07-15 |
PT1112097E (pt) | 2003-11-28 |
US6461665B1 (en) | 2002-10-08 |
DE69909104T2 (de) | 2004-04-08 |
ES2203177T3 (es) | 2004-04-01 |
JP4152075B2 (ja) | 2008-09-17 |
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