BR9912968A - Imidazo[1,2a]azinas substituìdas como inibidores de cox-2 seletivos - Google Patents
Imidazo[1,2a]azinas substituìdas como inibidores de cox-2 seletivosInfo
- Publication number
- BR9912968A BR9912968A BR9912968-0A BR9912968A BR9912968A BR 9912968 A BR9912968 A BR 9912968A BR 9912968 A BR9912968 A BR 9912968A BR 9912968 A BR9912968 A BR 9912968A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- substituted
- azines
- imidazo
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
<B>"IMIDAZO[1,2A]AZINAS SUBSTITUìDAS COMO INIBIDORES DE COX-2 SELETIVOS"<D> A invenção se refere a novos compostos da fórmula (I), na qual A e B são selecionados do grupo que consiste em N e CH, com a condição de que, quando A é N, B é N; R¹ é selecionado do grupo que consiste em CH~ 3~ e NH~ 2~; R² e R³ são selecionados do grupo que consiste em H, CH~ 3~, Br, Cl, COCH~ 3~ e OCH~ 3~; e R^ 4^, R^ 5^ e R^ 6^ são selecionados do grupo que consiste em H, F, Cl, Br, (C1-C3)-alquila, trifluoro metila, (C1-C3)alcóxi e trifluoro metóxi). Os compostos da fórmula (I) são preparados através da reação de uma aminoazina substituía por uma 2-bromo-2-(4-R¹-sulfonifenil)-1-fenil etanona substituída em um solvente polar. Esses novos compostos inibem a COX-2 com alta seletividade em relação a COX-1. Eles são úteis para o tratamento de inflamação e/ou de doenças mediadas por ciclooxigenase, que têm a vantagem adicional de um potencial reduzido para efeitos ulcerogênicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009801652A ES2140354B1 (es) | 1998-08-03 | 1998-08-03 | Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2. |
| PCT/ES1999/000235 WO2000008024A1 (es) | 1998-08-03 | 1999-07-23 | IMIDAZO[1,2a]AZINAS SUSTITUIDAS COMO INHIBIDORES SELECTIVOS DE LA COX-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9912968A true BR9912968A (pt) | 2001-05-08 |
Family
ID=8304755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9912968-0A BR9912968A (pt) | 1998-08-03 | 1999-07-23 | Imidazo[1,2a]azinas substituìdas como inibidores de cox-2 seletivos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6670365B1 (pt) |
| EP (1) | EP1104762B1 (pt) |
| JP (1) | JP2002522438A (pt) |
| KR (1) | KR20010079602A (pt) |
| CN (1) | CN1131865C (pt) |
| AP (1) | AP2001002082A0 (pt) |
| AT (1) | ATE224391T1 (pt) |
| AU (1) | AU749770B2 (pt) |
| BG (1) | BG105299A (pt) |
| BR (1) | BR9912968A (pt) |
| CA (1) | CA2339187A1 (pt) |
| CZ (1) | CZ291783B6 (pt) |
| DE (1) | DE69903046T2 (pt) |
| DK (1) | DK1104762T3 (pt) |
| EA (1) | EA003399B1 (pt) |
| ES (2) | ES2140354B1 (pt) |
| HK (1) | HK1037629A1 (pt) |
| HU (1) | HUP0103004A3 (pt) |
| ID (1) | ID28539A (pt) |
| IL (1) | IL141242A0 (pt) |
| MX (1) | MXPA01001332A (pt) |
| NO (1) | NO20010568L (pt) |
| NZ (1) | NZ510196A (pt) |
| OA (1) | OA11592A (pt) |
| PL (1) | PL345804A1 (pt) |
| PT (1) | PT1104762E (pt) |
| SK (1) | SK1662001A3 (pt) |
| TR (1) | TR200100359T2 (pt) |
| WO (1) | WO2000008024A1 (pt) |
| YU (1) | YU7401A (pt) |
| ZA (1) | ZA200101632B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8241622B2 (en) * | 2001-07-13 | 2012-08-14 | University Of Iowa Research Foundation | Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences |
| US20030100594A1 (en) * | 2001-08-10 | 2003-05-29 | Pharmacia Corporation | Carbonic anhydrase inhibitor |
| DE10247271A1 (de) * | 2002-10-10 | 2004-08-26 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yle |
| DE10256881A1 (de) * | 2002-12-05 | 2004-06-24 | Beiersdorf Ag | Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten |
| PT1534305E (pt) | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
| ATE380816T1 (de) * | 2003-07-30 | 2007-12-15 | S A L V A T Lab Sa | Substituierte imidazopyrimidine zur prävention und behandlung von krebs |
| WO2007034278A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Fused imidazole derivatives as c3a receptor antagonists |
| WO2007079141A2 (en) * | 2005-12-30 | 2007-07-12 | University Of Iowa Research Foundation | Method of identifying compounds useful to treat neuronal degenerative diseases |
| WO2007096764A2 (en) * | 2006-02-27 | 2007-08-30 | Glenmark Pharmaceuticals S.A. | Bicyclic heteroaryl derivatives as cannabinoid receptor modulators |
| EP2220083B1 (en) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US20100130522A1 (en) * | 2008-10-01 | 2010-05-27 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| GB201321732D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| CA3198936A1 (en) | 2016-03-07 | 2017-09-14 | University Of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
| IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785133A (en) * | 1954-03-26 | 1957-03-12 | Gen Aniline & Film Corp | Compositions for a method of whitening fine fabrics |
| US3455924A (en) * | 1967-02-08 | 1969-07-15 | Upjohn Co | Dianisylimidazoles |
| CA2098177A1 (en) * | 1990-12-13 | 1992-06-13 | Jerry L. Adams | Csaids |
| MX9301458A (es) * | 1992-03-17 | 1994-01-31 | Nippon Shinyaku Co Ltd | Derivados de imidazopiridina y composicion farmaceutica que los comprende. |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| HUP9801602A3 (en) * | 1995-04-04 | 1999-01-28 | Glaxo Group Ltd | Imidazo[1,2-a]pyridine derivatives, process for their production, pharmaceutical compositions and use thereof |
| UA57002C2 (uk) * | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
-
1998
- 1998-08-03 ES ES009801652A patent/ES2140354B1/es not_active Expired - Lifetime
-
1999
- 1999-07-23 ES ES99931266T patent/ES2182546T3/es not_active Expired - Lifetime
- 1999-07-23 AP APAP/P/2001/002082A patent/AP2001002082A0/en unknown
- 1999-07-23 EP EP99931266A patent/EP1104762B1/en not_active Expired - Lifetime
- 1999-07-23 WO PCT/ES1999/000235 patent/WO2000008024A1/es not_active Application Discontinuation
- 1999-07-23 CA CA002339187A patent/CA2339187A1/en not_active Abandoned
- 1999-07-23 OA OA1200100033A patent/OA11592A/en unknown
- 1999-07-23 ID IDW20010517A patent/ID28539A/id unknown
- 1999-07-23 DK DK99931266T patent/DK1104762T3/da active
- 1999-07-23 BR BR9912968-0A patent/BR9912968A/pt not_active IP Right Cessation
- 1999-07-23 PT PT99931266T patent/PT1104762E/pt unknown
- 1999-07-23 YU YU7401A patent/YU7401A/sh unknown
- 1999-07-23 PL PL99345804A patent/PL345804A1/xx not_active IP Right Cessation
- 1999-07-23 TR TR2001/00359T patent/TR200100359T2/xx unknown
- 1999-07-23 NZ NZ510196A patent/NZ510196A/xx unknown
- 1999-07-23 HU HU0103004A patent/HUP0103004A3/hu unknown
- 1999-07-23 SK SK166-2001A patent/SK1662001A3/sk unknown
- 1999-07-23 DE DE69903046T patent/DE69903046T2/de not_active Expired - Fee Related
- 1999-07-23 JP JP2000563657A patent/JP2002522438A/ja active Pending
- 1999-07-23 AU AU47824/99A patent/AU749770B2/en not_active Ceased
- 1999-07-23 EA EA200100212A patent/EA003399B1/ru not_active IP Right Cessation
- 1999-07-23 AT AT99931266T patent/ATE224391T1/de not_active IP Right Cessation
- 1999-07-23 MX MXPA01001332A patent/MXPA01001332A/es unknown
- 1999-07-23 US US09/762,146 patent/US6670365B1/en not_active Expired - Fee Related
- 1999-07-23 IL IL14124299A patent/IL141242A0/xx unknown
- 1999-07-23 CN CN998116750A patent/CN1131865C/zh not_active Expired - Fee Related
- 1999-07-23 KR KR1020017001453A patent/KR20010079602A/ko not_active Application Discontinuation
- 1999-07-23 CZ CZ2001433A patent/CZ291783B6/cs not_active IP Right Cessation
-
2001
- 2001-02-02 NO NO20010568A patent/NO20010568L/no not_active Application Discontinuation
- 2001-02-27 ZA ZA200101632A patent/ZA200101632B/en unknown
- 2001-02-28 BG BG105299A patent/BG105299A/xx unknown
- 2001-12-04 HK HK01108500A patent/HK1037629A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1954 DE 17/06/2008. |