BR9911626A - B - dicetonas substituìdas e seu uso - Google Patents
B - dicetonas substituìdas e seu usoInfo
- Publication number
- BR9911626A BR9911626A BR9911626-0A BR9911626A BR9911626A BR 9911626 A BR9911626 A BR 9911626A BR 9911626 A BR9911626 A BR 9911626A BR 9911626 A BR9911626 A BR 9911626A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- relates
- diseases
- halogen
- prevention
- Prior art date
Links
- 125000005594 diketone group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 2
- 208000006673 asthma Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Materials For Medical Uses (AREA)
- Tents Or Canopies (AREA)
- Paper (AREA)
- Electrophonic Musical Instruments (AREA)
- Stringed Musical Instruments (AREA)
- Detergent Compositions (AREA)
Abstract
<B>ß-DICETONAS SUBSTITUìDAS E SEU USO<D> A invenção refere-se aos compostos da fórmula (I) em que um de X~ 1~ e X~ 2~ é MeSO~ 2~ e o outro é hidrogênio ou halogênio e X~ 3~ é hidrogênio ou halogênio. Verificou-se que estes compostos são úteis na prevenção e tratamento de doenças respiratórias, especialmente asma, ARDS (Síndrome da Angústia Respiratória Aguda), COPD (doenças pulmonares obstrutivas crónicas), rinite alérgica e condições inflamatórias correlatas. Mais especificamente, a invenção refere-se ao uso do referido composto na prevenção e tratamento de asma em pacientes resistentes a esteróide. A invenção também se refere a formulações farmacêuticas utilizadas no tratamento das referidas doenças.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI981521A FI981521A0 (fi) | 1998-07-01 | 1998-07-01 | Substituoidut beta-diketonit ja niiden käyttö |
| PCT/FI1999/000575 WO2000001667A1 (en) | 1998-07-01 | 1999-06-30 | SUBSTITUTED β-DIKETONES AND THEIR USE |
| US09/346,397 US6201027B1 (en) | 1998-07-01 | 1999-07-01 | Substituted β diketones and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9911626A true BR9911626A (pt) | 2001-03-20 |
Family
ID=26160612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9911626-0A BR9911626A (pt) | 1998-07-01 | 1999-06-30 | B - dicetonas substituìdas e seu uso |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6201027B1 (pt) |
| EP (1) | EP1091933B1 (pt) |
| JP (1) | JP2002519407A (pt) |
| CN (1) | CN1258526C (pt) |
| AT (1) | ATE255088T1 (pt) |
| AU (1) | AU745338B2 (pt) |
| BG (1) | BG64529B1 (pt) |
| BR (1) | BR9911626A (pt) |
| CA (1) | CA2336300A1 (pt) |
| CZ (1) | CZ296378B6 (pt) |
| DE (1) | DE69913145T2 (pt) |
| DK (1) | DK1091933T3 (pt) |
| EA (1) | EA002693B1 (pt) |
| EE (1) | EE200000789A (pt) |
| ES (1) | ES2212590T3 (pt) |
| FI (1) | FI981521A0 (pt) |
| HK (1) | HK1036054A1 (pt) |
| HR (1) | HRP20000911B1 (pt) |
| HU (1) | HUP0103006A3 (pt) |
| IL (1) | IL139963A0 (pt) |
| IS (1) | IS2037B (pt) |
| NO (1) | NO20006665L (pt) |
| PL (1) | PL195216B1 (pt) |
| PT (1) | PT1091933E (pt) |
| SI (1) | SI1091933T1 (pt) |
| SK (1) | SK284934B6 (pt) |
| TR (1) | TR200003773T2 (pt) |
| WO (1) | WO2000001667A1 (pt) |
| ZA (1) | ZA200006961B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2519601A (en) * | 1999-12-30 | 2001-07-16 | Orion Corporation | A process for preparing 3-((3-chloro-4-(methylsulfonyl)-phenyl)methylene)-2,4- pentanedione |
| FI20011386A0 (fi) * | 2001-06-28 | 2001-06-28 | Orion Corp | Inhalaatiopartikkeleja |
| FI20020126A0 (fi) * | 2002-01-23 | 2002-01-23 | Orion Corp | Koostumuksia pulmonaaliseen antoon |
| SI3255043T1 (sl) * | 2011-07-12 | 2021-04-30 | Astrazeneca Ab | N-(6-((2R,3S)-3,4-dihidroksibutan-2-iloksi)-2-(4-fluorobenziltio) pirimidin-4-il)-3-metilazetidin-1-sulfonamid, kot modulator kemokinskega receptorja |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6230767A (ja) | 1985-08-01 | 1987-02-09 | Taisho Pharmaceut Co Ltd | イミダゾ−ル誘導体 |
| US4741769A (en) | 1986-06-09 | 1988-05-03 | Stauffer Chemical Company | Certain 1-phenyl-3-alkyl-1,3-propanediones |
| YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| MTP1031B (en) | 1987-12-24 | 1990-10-04 | Orion Yhtymae Oy | New use of cathecol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters |
| IL91382A (en) | 1988-09-01 | 1995-06-29 | Orion Yhtymae Oy | Dicitons are converted into alkanyl or ethylmethylene, through their preparation and pharmaceutical preparations containing them |
| US5185370A (en) * | 1988-09-01 | 1993-02-09 | Orion-Yhtyma Oy | Substituted β-diketones and their use |
| GB9002337D0 (en) * | 1990-02-02 | 1990-04-04 | Orion Yhtymae Oy | Compounds useful in treating inflammatory bowel disease |
| US5804532A (en) * | 1991-01-25 | 1998-09-08 | Rhone-Poulenc Agriculture Limited | Herbicidal 2-cyano-1,3-diones |
-
1998
- 1998-07-01 FI FI981521A patent/FI981521A0/fi unknown
-
1999
- 1999-06-30 PL PL99344856A patent/PL195216B1/pl not_active IP Right Cessation
- 1999-06-30 CZ CZ20004774A patent/CZ296378B6/cs not_active IP Right Cessation
- 1999-06-30 EE EEP200000789A patent/EE200000789A/xx unknown
- 1999-06-30 TR TR2000/03773T patent/TR200003773T2/xx unknown
- 1999-06-30 JP JP2000558072A patent/JP2002519407A/ja active Pending
- 1999-06-30 BR BR9911626-0A patent/BR9911626A/pt not_active Application Discontinuation
- 1999-06-30 IL IL13996399A patent/IL139963A0/xx not_active IP Right Cessation
- 1999-06-30 EP EP99934722A patent/EP1091933B1/en not_active Expired - Lifetime
- 1999-06-30 SI SI9930503T patent/SI1091933T1/xx unknown
- 1999-06-30 PT PT99934722T patent/PT1091933E/pt unknown
- 1999-06-30 AT AT99934722T patent/ATE255088T1/de not_active IP Right Cessation
- 1999-06-30 EA EA200100094A patent/EA002693B1/ru unknown
- 1999-06-30 WO PCT/FI1999/000575 patent/WO2000001667A1/en active IP Right Grant
- 1999-06-30 CA CA002336300A patent/CA2336300A1/en not_active Abandoned
- 1999-06-30 ES ES99934722T patent/ES2212590T3/es not_active Expired - Lifetime
- 1999-06-30 AU AU50392/99A patent/AU745338B2/en not_active Ceased
- 1999-06-30 SK SK1985-2000A patent/SK284934B6/sk unknown
- 1999-06-30 DK DK99934722T patent/DK1091933T3/da active
- 1999-06-30 DE DE69913145T patent/DE69913145T2/de not_active Expired - Fee Related
- 1999-06-30 HU HU0103006A patent/HUP0103006A3/hu unknown
- 1999-06-30 CN CNB998080535A patent/CN1258526C/zh not_active Expired - Fee Related
- 1999-07-01 US US09/346,397 patent/US6201027B1/en not_active Expired - Fee Related
-
2000
- 2000-11-27 ZA ZA200006961A patent/ZA200006961B/en unknown
- 2000-12-21 BG BG105080A patent/BG64529B1/bg unknown
- 2000-12-27 IS IS5793A patent/IS2037B/is unknown
- 2000-12-27 NO NO20006665A patent/NO20006665L/no not_active Application Discontinuation
- 2000-12-29 HR HR20000911A patent/HRP20000911B1/xx not_active IP Right Cessation
-
2001
- 2001-10-05 HK HK01106992A patent/HK1036054A1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM O ARTIGO 8O DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |