BR9908083A - polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção de m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpo monoclonal, e, proteìna de fusão - Google Patents
polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção de m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpo monoclonal, e, proteìna de fusãoInfo
- Publication number
- BR9908083A BR9908083A BRPI9908083-4A BR9908083A BR9908083A BR 9908083 A BR9908083 A BR 9908083A BR 9908083 A BR9908083 A BR 9908083A BR 9908083 A BR9908083 A BR 9908083A
- Authority
- BR
- Brazil
- Prior art keywords
- tuberculosis
- polypeptide
- host cell
- expression vector
- dna molecule
- Prior art date
Links
- 201000008827 tuberculosis Diseases 0.000 title abstract 3
- 108020004414 DNA Proteins 0.000 title abstract 2
- 102000053602 DNA Human genes 0.000 title abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000003259 recombinant expression Methods 0.000 title abstract 2
- 239000012472 biological sample Substances 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2475398A | 1998-02-18 | 1998-02-18 | |
| US09/072,596 US6458366B1 (en) | 1995-09-01 | 1998-05-05 | Compounds and methods for diagnosis of tuberculosis |
| PCT/US1999/003265 WO1999042118A2 (en) | 1998-02-18 | 1999-02-17 | Compounds and methods for diagnosis of tuberculosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908083A true BR9908083A (pt) | 2007-07-17 |
Family
ID=26698832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9908083-4A BR9908083A (pt) | 1998-02-18 | 1999-02-17 | polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção de m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpo monoclonal, e, proteìna de fusão |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6458366B1 (enExample) |
| EP (1) | EP1091749A1 (enExample) |
| JP (1) | JP2002530050A (enExample) |
| CN (1) | CN1312723A (enExample) |
| AU (1) | AU2681999A (enExample) |
| BR (1) | BR9908083A (enExample) |
| CA (1) | CA2322617A1 (enExample) |
| WO (1) | WO1999042118A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6290969B1 (en) * | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6592877B1 (en) * | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| CA2348475A1 (en) * | 1998-11-04 | 2000-05-11 | Isis Innovation Limited | Tuberculosis diagnostic test |
| US6196917B1 (en) * | 1998-11-20 | 2001-03-06 | Philips Electronics North America Corp. | Goal directed user interface |
| US8143386B2 (en) * | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| US7009042B1 (en) | 1999-10-07 | 2006-03-07 | Corixa Corporation | Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins |
| JP2003510370A (ja) | 1999-10-07 | 2003-03-18 | コリクサ コーポレイション | Mycobacteriumtuberculosisの融合タンパク質 |
| ATE354663T1 (de) * | 1999-10-07 | 2007-03-15 | Corixa Corp | Eine mycobacterium tuberculosis kodierende sequenz zur expression von heterologen proteinen |
| US6316205B1 (en) | 2000-01-28 | 2001-11-13 | Genelabs Diagnostics Pte Ltd. | Assay devices and methods of analyte detection |
| AU2001241738A1 (en) | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
| EP1542732B1 (en) | 2000-06-20 | 2009-09-16 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| WO2003070187A2 (en) * | 2002-02-15 | 2003-08-28 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| RU2277540C2 (ru) * | 2003-07-29 | 2006-06-10 | Зао "Велес Фарма" | Способ диагностики туберкулезной инфекции, рекомбинантная плазмидная днк, кодирующая синтез гибридного белка cfp10-esat6 из mycobacterium tuberculosis, способ его получения, гибридный белок cfp10-esat6 и его применение |
| US8475735B2 (en) * | 2004-11-01 | 2013-07-02 | Uma Mahesh Babu | Disposable immunodiagnostic test system |
| JP4838259B2 (ja) * | 2004-11-16 | 2011-12-14 | クルセル ホランド ベー ヴェー | 組み換えウイルスベクターを含む多価ワクチン |
| US7608277B2 (en) * | 2004-12-01 | 2009-10-27 | Gene Therapy Systems, Inc. | Tuberculosis nucleic acids, polypeptides and immunogenic compositions |
| WO2007005627A2 (en) | 2005-07-01 | 2007-01-11 | Forsyth Dental Infirmary For Children | Tuberculosis antigen detection assays and vaccines |
| US20070081944A1 (en) * | 2005-09-30 | 2007-04-12 | Reed Steven G | Iontophoresis apparatus and method for the diagnosis of tuberculosis |
| AU2007226658B2 (en) * | 2006-03-13 | 2011-10-27 | Oragenics, Inc. | In vivo induced genes of Mycobacterium tuberculosis |
| WO2007136781A2 (en) * | 2006-05-18 | 2007-11-29 | Ericson Daniel G | Rapid detection of mycobacterium tuberculosis and antimicrobial drug resistance |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| WO2008153541A1 (en) | 2006-09-26 | 2008-12-18 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| WO2008140478A2 (en) * | 2006-11-01 | 2008-11-20 | Immport Therapeutics, Inc. | Compositions and methods for immunodominant antigens |
| RU2473095C2 (ru) * | 2007-12-28 | 2013-01-20 | БиЭл КО., ЛТД | Анализ иммунодетекции комплекса mycobacterium tuberculosis |
| CN102046788B (zh) * | 2008-05-28 | 2013-07-10 | 和光纯药工业株式会社 | 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针检测胞内分枝杆菌的方法 |
| SI2315834T1 (sl) | 2008-07-25 | 2018-09-28 | Glaxosmithkline Biologicals S.A. | Tuberkulozni Rv2386c protein, sestavki in njegove uporabe |
| NO2315597T3 (enExample) | 2008-07-25 | 2018-01-20 | ||
| US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
| WO2010089098A1 (de) | 2009-02-05 | 2010-08-12 | Deklatec Gmbh | Verfahren und mittel für die tuberkulose diagnostik |
| EP3124491B1 (en) | 2009-06-05 | 2019-10-30 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions as well as pharmaceutical compositions containing them |
| WO2011092253A1 (en) | 2010-01-27 | 2011-08-04 | Glaxosmithkline Biologicals S.A. | Modified tuberculosis antigens |
| JP6430826B2 (ja) * | 2011-04-01 | 2018-11-28 | オッカム・バイオラブズ・インコーポレイテッドOccam Biolabs, Inc. | 無細胞病原体特異的核酸を検出する方法およびキット |
| AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| EP2573107A1 (en) * | 2011-09-21 | 2013-03-27 | Norwegian Institute of Public Health | A recombinant fusion protein |
| EP3563834A1 (en) | 2012-02-07 | 2019-11-06 | Infectious Disease Research Institute | Improved adjuvant formulations comprising tlr4 agonists and methods of using the same |
| EA034351B1 (ru) | 2012-05-16 | 2020-01-30 | Иммьюн Дизайн Корп. | Трехкомпонентная вакцина против впг-2 и способы ее применения |
| CN105209047B (zh) | 2013-04-18 | 2020-08-18 | 免疫设计股份有限公司 | 用于癌症治疗的gla单一疗法 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| WO2015083056A2 (en) | 2013-12-03 | 2015-06-11 | Kusuma School Of Biological Sciences | Genetic markers for diagnosis of tuberculosis caused by mycobacterium tuberculosis |
| IL310015B1 (en) | 2013-12-31 | 2025-10-01 | Access To Advanced Health Inst | Single vial formulation |
| AU2017273650B2 (en) | 2016-06-01 | 2022-08-18 | Access To Advanced Health Institute | Nanoalum particles containing a sizing agent |
| CN106011296B (zh) * | 2016-08-01 | 2019-10-25 | 武汉大学 | 一种结核分枝杆菌Rv1768基因微滴数字PCR绝对定量检测试剂盒 |
| CN110073215B (zh) * | 2016-09-22 | 2024-04-30 | 佩斯诊断公司 | 结核分枝杆菌蛋白诊断测定和结核病检测和诊断装置 |
| MX2021014363A (es) | 2019-05-25 | 2022-02-21 | Infectious Disease Res Inst | Composicion y metodo para secar por pulverizacion una emulsion de vacuna adyuvante. |
| CN113388623A (zh) * | 2020-03-11 | 2021-09-14 | 北京蛋白质组研究中心 | 结核分枝杆菌H37Rv新基因Rv2203c及其编码蛋白和应用 |
| CN113004362B (zh) * | 2021-02-26 | 2023-08-15 | 南方科技大学 | 一种订书钉核酸、dna纳米机器人及其制备方法和应用 |
| CN114034860A (zh) * | 2021-11-01 | 2022-02-11 | 宁夏大学 | 一种结核分枝杆菌mtb39a蛋白抗体间接elisa检测方法及其试剂盒 |
| CN114989312B (zh) * | 2022-06-27 | 2023-07-21 | 安徽理工大学 | 一种结核分枝杆菌融合蛋白dr2及其应用 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5856073A (en) | 1973-06-28 | 1975-01-30 | Toru Tsumits | Tuberculin active proteins and peptides |
| FR2244539A1 (en) | 1973-07-13 | 1975-04-18 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides prepn - from tubercle bacillus |
| FR2265402A1 (en) | 1974-03-29 | 1975-10-24 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides prepn - from tubercle bacillus |
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4876089A (en) | 1984-09-06 | 1989-10-24 | Chiron Corporation | Feline leukemia virus protein vaccines |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4689397A (en) * | 1985-08-12 | 1987-08-25 | Scripps Clinic And Research Foundation | Synthetic polypeptides for detecting mycobacterial infections |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
| EP0345299A1 (en) | 1987-02-02 | 1989-12-13 | Whitehead Institute For Biomedical Research | Mycobacterium tuberculosis genes encoding protein antigens |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| US4976958A (en) * | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US4952395A (en) * | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| US5583112A (en) | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5108745B1 (en) | 1988-08-16 | 1998-06-30 | Univ California | Tuberculosis and legionellosis vaccines and methods for their production |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| JPH0775324B2 (ja) | 1989-08-18 | 1995-08-09 | 日本電気株式会社 | 携帯無線機 |
| CA2042016C (en) | 1989-09-19 | 2004-04-06 | Jean Content | Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis |
| EP0419355B1 (en) | 1989-09-19 | 2000-02-09 | N.V. Innogenetics S.A. | Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| SE9001105D0 (sv) | 1990-03-27 | 1990-03-27 | Astra Ab | New methods foer diagnosis of tuberculosis |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| EP0503055A1 (en) | 1990-09-06 | 1992-09-16 | Rijksuniversiteit Utrecht | Inhibitor of lymphocyte response and immune-related disease |
| DE69126668T2 (de) | 1990-11-08 | 1997-10-23 | University College London, London | Mycobacterium als adjuvans für antigene |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| EP0499003A1 (en) | 1991-02-14 | 1992-08-19 | N.V. Innogenetics S.A. | Polypeptides and peptides, particularly recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnosis of tuberculosis |
| RU2024021C1 (ru) | 1991-05-05 | 1994-11-30 | Научно-исследовательский институт хирургии Восточно-Сибирского филиала СО РАМН | Способ диагностики туберкулеза |
| DE4116249A1 (de) | 1991-05-17 | 1992-11-19 | Biotechnolog Forschung Gmbh | Hybrid-plasmid fuer m.-tuberculosis-antigen, e. coli als wirt und antigen |
| FR2677365B1 (fr) | 1991-06-07 | 1995-08-04 | Pasteur Institut | Proteines de mycobacterium et applications. |
| US5240856A (en) | 1991-10-23 | 1993-08-31 | Cellpro Incorporated | Apparatus for cell separation |
| US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| WO1993023011A1 (en) | 1992-05-18 | 1993-11-25 | Minnesota Mining And Manufacturing Company | Transmucosal drug delivery device |
| US5330754A (en) * | 1992-06-29 | 1994-07-19 | Archana Kapoor | Membrane-associated immunogens of mycobacteria |
| NL9202197A (nl) * | 1992-12-17 | 1994-07-18 | Kreatech Biotech Bv | Werkwijze en inrichting voor het identificeren van een voor een mycobacteriële infectie verantwoordelijk mycobacterium species. |
| DK0678034T3 (da) | 1993-01-11 | 1999-11-08 | Dana Farber Cancer Inst Inc | Induktion af cytotoksiske T-lymfocytreaktioner |
| US5616500A (en) | 1993-04-30 | 1997-04-01 | The United States Of America As Represented By The Department Of Health & Human Services | Trichohyalin and transglutaminase-3 and methods of using same |
| DK79893D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
| DK79793D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | Diagnostic test |
| US5955077A (en) | 1993-07-02 | 1999-09-21 | Statens Seruminstitut | Tuberculosis vaccine |
| US5639653A (en) | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| DE69435138D1 (de) | 1993-11-23 | 2008-10-23 | Univ California | Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung |
| GB9409985D0 (en) | 1994-05-18 | 1994-07-06 | Medical Res Council | Vaccine against mycobacterial infections |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| DE4446509A1 (de) | 1994-12-24 | 1996-06-27 | Sel Alcatel Ag | Verfahren zur Herstellung von Leiterbahnen auf einem Vertiefungen aufweisenden Substrat |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5714593A (en) * | 1995-02-01 | 1998-02-03 | Institut Pasteur | DNA from mycobacterium tuberculosis which codes for a 45/47 kilodalton protein |
| US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| IE960132A1 (en) | 1995-03-13 | 1996-09-18 | Astra Ab | New DNA molecules |
| US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6338852B1 (en) | 1995-09-01 | 2002-01-15 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| PT2154248E (pt) | 1995-09-01 | 2012-01-16 | Corixa Corp | Compostos e métodos para diagnóstico de tuberculose |
| BR9610262B1 (pt) | 1995-09-01 | 2013-11-26 | Compostos e métodos para a imunoterapia e diagnose de tuberculose. | |
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| CO4600637A1 (es) | 1996-03-15 | 1998-05-08 | Corixa Corp | Compuestos para inmunoterapia e inmunodiagnosis del cancer de prostata |
| US6284255B1 (en) | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
| US5985287A (en) | 1996-08-29 | 1999-11-16 | Genesis Research And Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US6350456B1 (en) | 1997-03-13 | 2002-02-26 | Corixa Corporation | Compositions and methods for the prevention and treatment of M. tuberculosis infection |
| US6544522B1 (en) | 1998-12-30 | 2003-04-08 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| US6627198B2 (en) | 1997-03-13 | 2003-09-30 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis antigens and their uses |
| US6355257B1 (en) | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6555653B2 (en) | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
| US6613881B1 (en) | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
| KR100692227B1 (ko) | 1998-04-07 | 2007-03-09 | 코릭사 코포레이션 | 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도 |
| US6465633B1 (en) | 1998-12-24 | 2002-10-15 | Corixa Corporation | Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis |
| US8143386B2 (en) | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| JP2003510370A (ja) | 1999-10-07 | 2003-03-18 | コリクサ コーポレイション | Mycobacteriumtuberculosisの融合タンパク質 |
| AU2001241738A1 (en) | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
| EP1542732B1 (en) | 2000-06-20 | 2009-09-16 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| WO2003070187A2 (en) | 2002-02-15 | 2003-08-28 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
-
1998
- 1998-05-05 US US09/072,596 patent/US6458366B1/en not_active Expired - Fee Related
-
1999
- 1999-02-17 CA CA002322617A patent/CA2322617A1/en not_active Abandoned
- 1999-02-17 WO PCT/US1999/003265 patent/WO1999042118A2/en not_active Ceased
- 1999-02-17 JP JP2000532132A patent/JP2002530050A/ja not_active Withdrawn
- 1999-02-17 BR BRPI9908083-4A patent/BR9908083A/pt not_active IP Right Cessation
- 1999-02-17 EP EP99907065A patent/EP1091749A1/en not_active Withdrawn
- 1999-02-17 AU AU26819/99A patent/AU2681999A/en not_active Abandoned
- 1999-02-17 CN CN99809541A patent/CN1312723A/zh active Pending
-
2002
- 2002-07-10 US US10/193,002 patent/US6949246B2/en not_active Expired - Fee Related
-
2005
- 2005-03-15 US US11/082,005 patent/US7122196B2/en not_active Expired - Fee Related
-
2006
- 2006-08-16 US US11/505,569 patent/US7906277B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030135026A1 (en) | 2003-07-17 |
| US20070141087A1 (en) | 2007-06-21 |
| WO1999042118A2 (en) | 1999-08-26 |
| US7906277B2 (en) | 2011-03-15 |
| US6949246B2 (en) | 2005-09-27 |
| AU2681999A (en) | 1999-09-06 |
| JP2002530050A (ja) | 2002-09-17 |
| US6458366B1 (en) | 2002-10-01 |
| CA2322617A1 (en) | 1999-08-26 |
| EP1091749A1 (en) | 2001-04-18 |
| CN1312723A (zh) | 2001-09-12 |
| US20050181419A1 (en) | 2005-08-18 |
| US7122196B2 (en) | 2006-10-17 |
| WO1999042118A8 (en) | 1999-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9908083A (pt) | polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção de m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpo monoclonal, e, proteìna de fusão | |
| BR9809443A (pt) | Polipeptìdeo compreendendo uma porção antigênica de um antìgeno de m. tuberculosis, molécula de dna, vetor recombinante de expressão, célula hospedeira, processo para detecção de infecção de m. tuberculosis em uma amostra biológica, kit de diganóstico, anticorpo monoclonal, anticorpo policlonal, e, proteìna de fusão. | |
| BR9712298A (pt) | Polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção por m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpos monoclonal, e, policlonal, e, proteìna de fusão | |
| Nilsson et al. | Protein assembly by orthogonal chemical ligation methods | |
| CO4870792A1 (es) | Compuestos y conjunto de medios de diagnostico para detectar y vigilar la progresion de cancer de prostata | |
| BR9710968A (pt) | Antìgenos de célula b humana; reagentes correlatos | |
| SE9500023D0 (sv) | Method of detecting cancer | |
| BR9712518A (pt) | Polipeptìdeo, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processo para detectar tuberculose em um paciente, e, kit diagnóstico | |
| BRPI0508722A (pt) | proteìna recombinante, polinucleotìdeo, vetor de expressão e célula hospedeira recombinantes, composição imunogênica, uso de proteìna recombinante, composição de vacina, composição de droga, kit diagnóstico de, ou um kit para imunomonitorar, uma infecção com hpv, método para o diagnóstico in vitro ou para a imunomonitoração de uma infecção com hpv, uso de uma proteìna recombinante, e, processo para a triagem de epìtopos de células t crìticos desconhecidos ou sub-dominantes em um polipeptìdio | |
| BR0112119A (pt) | Polipeptìdeo isolado, molécula de ácido nucléico isolado, vetor, célula hospedeira recombinante, método de produzir a proteìna zcyto21, anticorpo ou fragmento de anticorpo, método de detectar a presença da expressão do gene zcyto21 em uma amostra biológica | |
| NO975435D0 (no) | Modifiserte/chimeriske proteiner samt anvendelser derav | |
| FI972390A0 (fi) | Sytokiini nimeltä Lerk-7 | |
| EA200001023A1 (ru) | Специфическое в отношении fapa-(протеин альфа активации фибробласта) антитело с повышенной продуктивностью | |
| GEP20012421B (en) | Method for Typing Hepatitis C Virus and Reagents for Use Therein | |
| WO2008012362A3 (en) | New protein isoforms and uses thereof | |
| AU1629192A (en) | Methods and compositions for enzyme complementation assays using the omega region of beta-galactosidase | |
| NO900474D0 (no) | Bukspyttkjertel-islet-celleantigener tilveiebragt ved molekylaer kloning. | |
| ES2173471T3 (es) | Analisis para homocisteina y homocisteina desulfurasa a partir de tricomonas viginalis de protozoos. | |
| DE69716305D1 (de) | Peptidereagenz zum nachweis von humanem cytomegalovirus (cmv) | |
| BRPI9611455B1 (pt) | Método para detectar infecção por t. cruzi em uma amostra biológica; vetor de expressão recombinante; célula hospedeira; kit de diagnóstico; composição farmacêutica; vacina para estimular a produção de anticorpos; e combinação de polipeptídeos. | |
| ATE389881T1 (de) | Detektion von kleinen molekülen mit piezo- elektrischem sensor | |
| BR0016458A (pt) | Reagentes, métodos e kits para detectar proteìnas de bacillus thuringiensis | |
| Zanders et al. | Separation and characterization of a protein antigen from cells of Streptococcus mutans | |
| BRPI0406265B8 (pt) | método para análise por eletroforese capilar, método para pesquisa e tipagem de proteínas monoclonais, método de preparação de anticorpos modificados sobrecarregados negativamente e kit para detecção e tipagem de proteínas monoclonais | |
| BR9910725A (pt) | Indução de proteìnas e peptìdeos antibióticos por proteìnas lait/s cd14 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |