DE69435138D1 - Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung - Google Patents
Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendungInfo
- Publication number
- DE69435138D1 DE69435138D1 DE69435138T DE69435138T DE69435138D1 DE 69435138 D1 DE69435138 D1 DE 69435138D1 DE 69435138 T DE69435138 T DE 69435138T DE 69435138 T DE69435138 T DE 69435138T DE 69435138 D1 DE69435138 D1 DE 69435138D1
- Authority
- DE
- Germany
- Prior art keywords
- extracellular products
- vaccines
- majorly abundant
- methods
- stimulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 244000052769 pathogen Species 0.000 abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Telephone Function (AREA)
- Stringed Musical Instruments (AREA)
- Multi-Process Working Machines And Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/156,358 US6752993B1 (en) | 1993-11-23 | 1993-11-23 | Abundant extracellular product vaccines and methods for their production and use |
US28966794A | 1994-08-12 | 1994-08-12 | |
PCT/US1994/013145 WO1995014713A2 (en) | 1993-11-23 | 1994-11-18 | Abundant extracellular products and methods for their production and use |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69435138D1 true DE69435138D1 (de) | 2008-10-23 |
Family
ID=26853097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435138T Expired - Lifetime DE69435138D1 (de) | 1993-11-23 | 1994-11-18 | Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung |
Country Status (12)
Country | Link |
---|---|
US (1) | US6761894B1 (de) |
EP (1) | EP0771322B9 (de) |
JP (2) | JPH09505588A (de) |
CN (1) | CN1103781C (de) |
AT (1) | ATE407945T1 (de) |
AU (1) | AU1097795A (de) |
BR (1) | BR9408135A (de) |
CA (1) | CA2177249C (de) |
DE (1) | DE69435138D1 (de) |
DK (1) | DK0771322T3 (de) |
ES (1) | ES2313719T3 (de) |
WO (1) | WO1995014713A2 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141244B1 (en) * | 1992-03-02 | 2006-11-28 | Chiron Srl | Helicobacter pylori proteins useful for vaccines and diagnostics |
US6752993B1 (en) | 1993-11-23 | 2004-06-22 | The Regents Of The University Of California | Abundant extracellular product vaccines and methods for their production and use |
AU1097795A (en) | 1993-11-23 | 1995-06-13 | Regents Of The University Of California, The | Abundant extracellular products and methods for their production and use |
US7300660B2 (en) | 1993-11-23 | 2007-11-27 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
JPH10502366A (ja) * | 1994-07-01 | 1998-03-03 | リカン・リミテッド | ヘリコバクター・ピロリ抗原タンパク質調製品およびイムノアッセイ |
WO1996005223A1 (en) * | 1994-08-12 | 1996-02-22 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
JPH11506320A (ja) * | 1995-05-23 | 1999-06-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 豊富な細胞外産物、ならびにそれらを産生および使用するための方法 |
US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6338852B1 (en) | 1995-09-01 | 2002-01-15 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
AU1463097A (en) * | 1996-01-04 | 1997-08-01 | Rican Limited | Helicobacter pylori bacterioferritin |
US6010855A (en) | 1996-07-26 | 2000-01-04 | Institut Pasteur | Desaturase antigen of mycobacterium tuberculosis |
US6284255B1 (en) * | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
US6013660A (en) * | 1996-10-02 | 2000-01-11 | The Regents Of The University Of California | Externally targeted prophylactic and chemotherapeutic method and agents |
JP2001512435A (ja) * | 1997-01-21 | 2001-08-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 豊富な細胞外産物ならびにそれらの産生および使用方法 |
US6627198B2 (en) | 1997-03-13 | 2003-09-30 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis antigens and their uses |
US6350456B1 (en) * | 1997-03-13 | 2002-02-26 | Corixa Corporation | Compositions and methods for the prevention and treatment of M. tuberculosis infection |
US6544522B1 (en) | 1998-12-30 | 2003-04-08 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
US5968524A (en) * | 1997-12-23 | 1999-10-19 | Genesis Research & Development Corp. | Methods and compounds for the treatment of immunologically-mediated psoriasis |
US6465633B1 (en) | 1998-12-24 | 2002-10-15 | Corixa Corporation | Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis |
MX2007005256A (es) | 2004-11-16 | 2008-03-11 | Crucell Holland Bv | Vacunas multivalentes que comprenden vectores virales recombinantes. |
CN102850445B (zh) * | 2012-09-24 | 2014-01-08 | 张银辉 | 一组结核分枝杆菌菌体特异性抗原及其纯化方法 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888837A (en) | 1973-06-28 | 1975-06-10 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides from the cells of tubercle bacilli |
AU5856073A (en) | 1973-06-28 | 1975-01-30 | Toru Tsumits | Tuberculin active proteins and peptides |
US4123427A (en) | 1976-07-27 | 1978-10-31 | Daniel Thomas M | Method for the purification of mycobacterial protein antigens and resulting product |
US4460503A (en) | 1983-03-15 | 1984-07-17 | Institut Pasteur | Tuberculine active peptides and a process for preparing same by chemical synthesis |
GB8404280D0 (en) | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
US4777130A (en) | 1984-12-05 | 1988-10-11 | Andra Biologicals | Isolation of mycobacterial a 60 antigen for diagnostic purposes |
US4689397A (en) | 1985-08-12 | 1987-08-25 | Scripps Clinic And Research Foundation | Synthetic polypeptides for detecting mycobacterial infections |
US4906742A (en) | 1986-07-31 | 1990-03-06 | Whitehead Institute For Biomedical Research | Encoding antigens of M. Leprae |
EP0323480A1 (de) | 1986-09-08 | 1989-07-12 | Applied Biotechnology, Inc. | Genetisch veränderte impfstoffe gegen mykobakterien |
US5268170A (en) | 1986-09-09 | 1993-12-07 | Yeda Research And Development Co., Ltd. | Methods of treatment and diagnosis of autoimmune diseases, especially arthritic conditions |
AU1548388A (en) | 1987-02-02 | 1988-08-24 | Whitehead Institute For Biomedical Research | Mycobacterium tuberculosis genes and encoding protein antigens |
US4976958A (en) | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
US4952395A (en) | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
EP0681026A1 (de) | 1987-03-02 | 1995-11-08 | Whitehead Institute For Biomedical Research | Rekombinant-mykobakterielle Impfstoffe |
US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
US5225324A (en) | 1987-04-24 | 1993-07-06 | Bioscience International, Inc. | Diagnostics for mycobacteria in public health, medical, and veterinary practice |
WO1989005825A1 (en) | 1987-12-22 | 1989-06-29 | Immunex Corporation | EXPRESSION OF RECOMBINANT 18/16.6 AND 15.2 kD PROTEIN ANTIGENS OF MYCOBACTERIUM LEPRAE |
NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
WO1989012455A1 (en) | 1988-06-15 | 1989-12-28 | Whitehead Institute For Biomedical Research | Stress proteins and uses therefor |
US5108745B1 (en) | 1988-08-16 | 1998-06-30 | Univ California | Tuberculosis and legionellosis vaccines and methods for their production |
WO1990002564A1 (en) | 1988-09-12 | 1990-03-22 | Codon | Vaccine diagnostic employing proteins homologous to heat shock proteins of trypanosoma cruzi |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
AU5848090A (en) | 1989-06-19 | 1991-01-08 | Whitehead Institute For Biomedical Research | Vector-mediated genomic insertion and expression of dna in bcg |
DD295869A5 (de) * | 1989-09-19 | 1991-11-14 | �K�K@������������@�K�Kk�� | Rekombinante polypeptide und peptide, diese codierende nucleinsaeuren und verwendung dieser polypeptide und peptide in der diagnose von tuberkulose |
EP0419355B1 (de) * | 1989-09-19 | 2000-02-09 | N.V. Innogenetics S.A. | Rekombinante Polypeptide und Peptide, dafür kodierende Nukleinsäuren und ihre Verwendung in der Tuberkulose-Diagnose |
GB2239246A (en) | 1989-12-22 | 1991-06-26 | Astra Ab | Protein antigen from Mycobacterium tuberculosis |
SE9001105D0 (sv) | 1990-03-27 | 1990-03-27 | Astra Ab | New methods foer diagnosis of tuberculosis |
CA2045842A1 (en) | 1990-07-16 | 1992-01-17 | William R. Jacobs | Dna capable of site-specific integration into mycobacteria |
GB9015888D0 (en) | 1990-07-19 | 1990-09-05 | Smithkline Biolog | Vectors |
US5254459A (en) | 1990-08-23 | 1993-10-19 | Patarroyo Manuel E | Nucleotide and amino acid sequences of protein MTP40 of M. tuberculosis and synthetic peptides derived therefrom |
US5169940A (en) | 1990-08-23 | 1992-12-08 | Patarroyo Manuel E | Nucleotide sequences of protein MTP40 of M. tuberculosis |
US5171839A (en) | 1990-08-23 | 1992-12-15 | Patarroyo Manuel E | Nucleotide and amino acid sequences of protein mtp40 of m. tuberculosis and synthetic peptides derived therefrom |
EP0547166A1 (de) | 1990-09-06 | 1993-06-23 | Immulogic Pharmaceutical Corporation | Pathogenspezifische therapie durch zytotoxische t-lymphozyten |
EP0499003A1 (de) * | 1991-02-14 | 1992-08-19 | N.V. Innogenetics S.A. | Polypeptide und Peptide, insbesondere rekombinante Polypeptide und Peptide, dafür kodierende Nukleinsäuren und Verwendung dieser Polypeptide und Peptide in der Tuberkulosediagnose |
CA2106962C (en) | 1991-03-25 | 2003-10-21 | Carlo Cocito | Polypeptides from mycobacterium paratuberculosis |
GB9111291D0 (en) | 1991-05-24 | 1991-07-17 | Medical Res Council | Diagnostic peptides |
EP0587775A4 (de) | 1991-06-06 | 1994-11-02 | Medimmune Inc | Induktion der ctl-antwort durch in mycobakterien exprimierte fremde antigene. |
FR2677365B1 (fr) | 1991-06-07 | 1995-08-04 | Pasteur Institut | Proteines de mycobacterium et applications. |
JPH06511145A (ja) | 1991-06-13 | 1994-12-15 | アルバート アインシュタイン カレッジ オブ メディシン、ア ディビジョン オブ イェシーバ ユニバーシティ | ミコバクテリア内での挿入突然変異 |
AU681572B2 (en) | 1991-10-21 | 1997-09-04 | Med Immune, Inc. | Bacterial expression vectors containing DNA encoding secretion signals of lipoproteins |
FR2682967B1 (fr) | 1991-10-25 | 1994-01-14 | Pasteur Institut | Nouveau promoteur de m. paratuberculosis. son utilisation pour le clonage et l'expression de sequences nucleotidiques. |
GB9200949D0 (en) | 1992-01-17 | 1992-03-11 | Medical Res Council | Diagnostic peptides |
WO1993014789A1 (en) | 1992-01-22 | 1993-08-05 | New England Medical Center Hospitals, Inc. | Pathogen-specific ctl therapy |
FR2687410A1 (fr) | 1992-02-14 | 1993-08-20 | Pasteur Institut | Beta-lactamase recombinante, utilisable en tant que molecule porteuse pour la preparation de compositions immunogenes. |
FR2688785B1 (fr) | 1992-03-19 | 1995-07-07 | Pasteur Institut | Sequence peptidique apte a induire une reaction d'hypersensibilite de type retarde en presence de bacteries vivantes du complexe mycobacterium tuberculosis, et ses applications. |
WO1994002508A2 (en) | 1992-07-22 | 1994-02-03 | Proteus Molecular Design Limited | Polypeptide antigens of mycobacterium bovis |
DK79893D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
DK79793D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | Diagnostic test |
AU1097795A (en) | 1993-11-23 | 1995-06-13 | Regents Of The University Of California, The | Abundant extracellular products and methods for their production and use |
-
1994
- 1994-11-18 AU AU10977/95A patent/AU1097795A/en not_active Abandoned
- 1994-11-18 BR BR9408135A patent/BR9408135A/pt not_active Application Discontinuation
- 1994-11-18 CN CN94194859A patent/CN1103781C/zh not_active Expired - Fee Related
- 1994-11-18 DK DK95901912T patent/DK0771322T3/da active
- 1994-11-18 ES ES95901912T patent/ES2313719T3/es not_active Expired - Lifetime
- 1994-11-18 CA CA2177249A patent/CA2177249C/en not_active Expired - Lifetime
- 1994-11-18 EP EP95901912A patent/EP0771322B9/de not_active Expired - Lifetime
- 1994-11-18 JP JP7515114A patent/JPH09505588A/ja not_active Ceased
- 1994-11-18 AT AT95901912T patent/ATE407945T1/de not_active IP Right Cessation
- 1994-11-18 DE DE69435138T patent/DE69435138D1/de not_active Expired - Lifetime
- 1994-11-18 WO PCT/US1994/013145 patent/WO1995014713A2/en active Application Filing
-
1995
- 1995-05-23 US US08/447,398 patent/US6761894B1/en not_active Expired - Lifetime
-
2004
- 2004-11-04 JP JP2004321293A patent/JP4537178B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1097795A (en) | 1995-06-13 |
WO1995014713A2 (en) | 1995-06-01 |
CN1142231A (zh) | 1997-02-05 |
JP2005104983A (ja) | 2005-04-21 |
US6761894B1 (en) | 2004-07-13 |
CN1103781C (zh) | 2003-03-26 |
WO1995014713A3 (en) | 1995-12-28 |
EP0771322B9 (de) | 2009-08-12 |
EP0771322A1 (de) | 1997-05-07 |
EP0771322B1 (de) | 2008-09-10 |
CA2177249C (en) | 2010-10-19 |
DK0771322T3 (da) | 2008-11-24 |
JPH09505588A (ja) | 1997-06-03 |
ES2313719T3 (es) | 2009-03-01 |
BR9408135A (pt) | 1997-08-05 |
ATE407945T1 (de) | 2008-09-15 |
JP4537178B2 (ja) | 2010-09-01 |
CA2177249A1 (en) | 1995-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |