ATE407945T1 - Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung - Google Patents
Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendungInfo
- Publication number
- ATE407945T1 ATE407945T1 AT95901912T AT95901912T ATE407945T1 AT E407945 T1 ATE407945 T1 AT E407945T1 AT 95901912 T AT95901912 T AT 95901912T AT 95901912 T AT95901912 T AT 95901912T AT E407945 T1 ATE407945 T1 AT E407945T1
- Authority
- AT
- Austria
- Prior art keywords
- extracellular products
- vaccines
- abundant extracellular
- production
- methods
- Prior art date
Links
- 244000052769 pathogen Species 0.000 abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Multi-Process Working Machines And Systems (AREA)
- Telephone Function (AREA)
- Stringed Musical Instruments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/156,358 US6752993B1 (en) | 1993-11-23 | 1993-11-23 | Abundant extracellular product vaccines and methods for their production and use |
US28966794A | 1994-08-12 | 1994-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407945T1 true ATE407945T1 (de) | 2008-09-15 |
Family
ID=26853097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95901912T ATE407945T1 (de) | 1993-11-23 | 1994-11-18 | Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung |
Country Status (12)
Country | Link |
---|---|
US (1) | US6761894B1 (de) |
EP (1) | EP0771322B9 (de) |
JP (2) | JPH09505588A (de) |
CN (1) | CN1103781C (de) |
AT (1) | ATE407945T1 (de) |
AU (1) | AU1097795A (de) |
BR (1) | BR9408135A (de) |
CA (1) | CA2177249C (de) |
DE (1) | DE69435138D1 (de) |
DK (1) | DK0771322T3 (de) |
ES (1) | ES2313719T3 (de) |
WO (1) | WO1995014713A2 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141244B1 (en) * | 1992-03-02 | 2006-11-28 | Chiron Srl | Helicobacter pylori proteins useful for vaccines and diagnostics |
US6752993B1 (en) | 1993-11-23 | 2004-06-22 | The Regents Of The University Of California | Abundant extracellular product vaccines and methods for their production and use |
WO1995014713A2 (en) | 1993-11-23 | 1995-06-01 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
US7300660B2 (en) | 1993-11-23 | 2007-11-27 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
CA2194237A1 (en) * | 1994-07-01 | 1996-01-18 | Dermot Kelleher | Helicobacter pylori antigenic protein preparation and immunoassays |
WO1996005223A1 (en) * | 1994-08-12 | 1996-02-22 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
BR9608894A (pt) * | 1995-05-23 | 1999-12-07 | Univ California | Produtos extracelulares abundantes e processos para suas producões e usos |
US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6338852B1 (en) | 1995-09-01 | 2002-01-15 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
GB2324093A (en) * | 1996-01-04 | 1998-10-14 | Rican Limited | Helicobacter pylori bacterioferritin |
DK1007688T3 (da) | 1996-07-26 | 2008-08-04 | Pasteur Institut | Desaturase-antigen for mycobacterium tuberculosis |
US6284255B1 (en) * | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
US6013660A (en) * | 1996-10-02 | 2000-01-11 | The Regents Of The University Of California | Externally targeted prophylactic and chemotherapeutic method and agents |
WO1998031388A1 (en) * | 1997-01-21 | 1998-07-23 | Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
US6544522B1 (en) | 1998-12-30 | 2003-04-08 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
US6627198B2 (en) | 1997-03-13 | 2003-09-30 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis antigens and their uses |
US6350456B1 (en) * | 1997-03-13 | 2002-02-26 | Corixa Corporation | Compositions and methods for the prevention and treatment of M. tuberculosis infection |
US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
US5968524A (en) * | 1997-12-23 | 1999-10-19 | Genesis Research & Development Corp. | Methods and compounds for the treatment of immunologically-mediated psoriasis |
US6465633B1 (en) | 1998-12-24 | 2002-10-15 | Corixa Corporation | Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis |
BRPI0518933A2 (pt) | 2004-11-16 | 2008-12-16 | Crucell Holland B V E Aeras Gl | adenovÍrus recombinante defeituoso de replicaÇço, vetor de polinucleotÍdeo recombinante, vacina multivalente da tuberculose, e, uso do antÍgeno tb10.4 de mycobacterium |
CN102850445B (zh) * | 2012-09-24 | 2014-01-08 | 张银辉 | 一组结核分枝杆菌菌体特异性抗原及其纯化方法 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5856073A (en) | 1973-06-28 | 1975-01-30 | Toru Tsumits | Tuberculin active proteins and peptides |
US3888837A (en) | 1973-06-28 | 1975-06-10 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides from the cells of tubercle bacilli |
US4123427A (en) | 1976-07-27 | 1978-10-31 | Daniel Thomas M | Method for the purification of mycobacterial protein antigens and resulting product |
US4460503A (en) | 1983-03-15 | 1984-07-17 | Institut Pasteur | Tuberculine active peptides and a process for preparing same by chemical synthesis |
GB8404280D0 (en) | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
US4777130A (en) | 1984-12-05 | 1988-10-11 | Andra Biologicals | Isolation of mycobacterial a 60 antigen for diagnostic purposes |
US4689397A (en) | 1985-08-12 | 1987-08-25 | Scripps Clinic And Research Foundation | Synthetic polypeptides for detecting mycobacterial infections |
US4906742A (en) | 1986-07-31 | 1990-03-06 | Whitehead Institute For Biomedical Research | Encoding antigens of M. Leprae |
EP0323480A1 (de) | 1986-09-08 | 1989-07-12 | Applied Biotechnology, Inc. | Genetisch veränderte impfstoffe gegen mykobakterien |
US5268170A (en) | 1986-09-09 | 1993-12-07 | Yeda Research And Development Co., Ltd. | Methods of treatment and diagnosis of autoimmune diseases, especially arthritic conditions |
WO1988005823A2 (en) | 1987-02-02 | 1988-08-11 | Whitehead Institute For Biomedical Research | Mycobacterium tuberculosis genes encoding protein antigens |
US4976958A (en) | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
US4952395A (en) | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
EP0347425B1 (de) | 1987-03-02 | 1995-12-27 | Whitehead Institute For Biomedical Research | Rekombinant-mykobakterielle impfstoffe |
US5225324A (en) | 1987-04-24 | 1993-07-06 | Bioscience International, Inc. | Diagnostics for mycobacteria in public health, medical, and veterinary practice |
NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
WO1989005825A1 (en) | 1987-12-22 | 1989-06-29 | Immunex Corporation | EXPRESSION OF RECOMBINANT 18/16.6 AND 15.2 kD PROTEIN ANTIGENS OF MYCOBACTERIUM LEPRAE |
WO1989012455A1 (en) | 1988-06-15 | 1989-12-28 | Whitehead Institute For Biomedical Research | Stress proteins and uses therefor |
US5108745B1 (en) | 1988-08-16 | 1998-06-30 | Univ California | Tuberculosis and legionellosis vaccines and methods for their production |
WO1990002564A1 (en) | 1988-09-12 | 1990-03-22 | Codon | Vaccine diagnostic employing proteins homologous to heat shock proteins of trypanosoma cruzi |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
CA2063414A1 (en) | 1989-06-19 | 1990-12-20 | Richard A. Young | Vector-mediated genomic insertion and expression of dna in bcg |
JP2756368B2 (ja) * | 1989-09-19 | 1998-05-25 | エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム | 組換えポリペプチド及びペプチド、それをコードする核酸並びに結核の診断におけるこれらのポリペプチド及びペプチドの使用 |
EP0419355B1 (de) * | 1989-09-19 | 2000-02-09 | N.V. Innogenetics S.A. | Rekombinante Polypeptide und Peptide, dafür kodierende Nukleinsäuren und ihre Verwendung in der Tuberkulose-Diagnose |
SE9001105D0 (sv) | 1990-03-27 | 1990-03-27 | Astra Ab | New methods foer diagnosis of tuberculosis |
AU6807390A (en) | 1989-12-22 | 1991-06-27 | Astra Aktiebolag | New methods of diagnosis of tuberculosis |
CA2045842A1 (en) | 1990-07-16 | 1992-01-17 | William R. Jacobs | Dna capable of site-specific integration into mycobacteria |
GB9015888D0 (en) | 1990-07-19 | 1990-09-05 | Smithkline Biolog | Vectors |
US5171839A (en) | 1990-08-23 | 1992-12-15 | Patarroyo Manuel E | Nucleotide and amino acid sequences of protein mtp40 of m. tuberculosis and synthetic peptides derived therefrom |
US5169940A (en) | 1990-08-23 | 1992-12-08 | Patarroyo Manuel E | Nucleotide sequences of protein MTP40 of M. tuberculosis |
US5254459A (en) | 1990-08-23 | 1993-10-19 | Patarroyo Manuel E | Nucleotide and amino acid sequences of protein MTP40 of M. tuberculosis and synthetic peptides derived therefrom |
AU660422B2 (en) | 1990-09-06 | 1995-06-29 | Immulogic Pharmaceutical Corporation | Pathogen-specific CTL therapy |
EP0499003A1 (de) * | 1991-02-14 | 1992-08-19 | N.V. Innogenetics S.A. | Polypeptide und Peptide, insbesondere rekombinante Polypeptide und Peptide, dafür kodierende Nukleinsäuren und Verwendung dieser Polypeptide und Peptide in der Tuberkulosediagnose |
IL101359A0 (en) | 1991-03-25 | 1992-11-15 | Innogenetics Nv | Polypeptides and peptides,particularly recombinant,nucleic acids coding for the same and use of these polypeptides and peptides in the diagnosis and prevention of paratuberculosis |
GB9111291D0 (en) | 1991-05-24 | 1991-07-17 | Medical Res Council | Diagnostic peptides |
EP0587775A4 (de) | 1991-06-06 | 1994-11-02 | Medimmune Inc | Induktion der ctl-antwort durch in mycobakterien exprimierte fremde antigene. |
FR2677365B1 (fr) | 1991-06-07 | 1995-08-04 | Pasteur Institut | Proteines de mycobacterium et applications. |
AU2189392A (en) | 1991-06-13 | 1993-01-12 | Albert Einstein College Of Medicine Of Yeshiva University | Insertional mutations in mycobacteria |
WO1993007897A1 (en) | 1991-10-21 | 1993-04-29 | Medimmune, Inc. | Bacterial expression vectors containing dna encoding secretion signals of lipoproteins |
FR2682967B1 (fr) | 1991-10-25 | 1994-01-14 | Pasteur Institut | Nouveau promoteur de m. paratuberculosis. son utilisation pour le clonage et l'expression de sequences nucleotidiques. |
GB9200949D0 (en) | 1992-01-17 | 1992-03-11 | Medical Res Council | Diagnostic peptides |
WO1993014789A1 (en) | 1992-01-22 | 1993-08-05 | New England Medical Center Hospitals, Inc. | Pathogen-specific ctl therapy |
FR2687410A1 (fr) | 1992-02-14 | 1993-08-20 | Pasteur Institut | Beta-lactamase recombinante, utilisable en tant que molecule porteuse pour la preparation de compositions immunogenes. |
FR2688785B1 (fr) | 1992-03-19 | 1995-07-07 | Pasteur Institut | Sequence peptidique apte a induire une reaction d'hypersensibilite de type retarde en presence de bacteries vivantes du complexe mycobacterium tuberculosis, et ses applications. |
MX9304388A (es) | 1992-07-22 | 1994-03-31 | Proteus Molecular Design | Polopeptido sintetico y proceso para su fabricacion. |
DK79893D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
DK79793D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | Diagnostic test |
WO1995014713A2 (en) | 1993-11-23 | 1995-06-01 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
-
1994
- 1994-11-18 WO PCT/US1994/013145 patent/WO1995014713A2/en active Application Filing
- 1994-11-18 DE DE69435138T patent/DE69435138D1/de not_active Expired - Lifetime
- 1994-11-18 AU AU10977/95A patent/AU1097795A/en not_active Abandoned
- 1994-11-18 EP EP95901912A patent/EP0771322B9/de not_active Expired - Lifetime
- 1994-11-18 CA CA2177249A patent/CA2177249C/en not_active Expired - Lifetime
- 1994-11-18 JP JP7515114A patent/JPH09505588A/ja not_active Ceased
- 1994-11-18 ES ES95901912T patent/ES2313719T3/es not_active Expired - Lifetime
- 1994-11-18 DK DK95901912T patent/DK0771322T3/da active
- 1994-11-18 BR BR9408135A patent/BR9408135A/pt not_active Application Discontinuation
- 1994-11-18 AT AT95901912T patent/ATE407945T1/de not_active IP Right Cessation
- 1994-11-18 CN CN94194859A patent/CN1103781C/zh not_active Expired - Fee Related
-
1995
- 1995-05-23 US US08/447,398 patent/US6761894B1/en not_active Expired - Lifetime
-
2004
- 2004-11-04 JP JP2004321293A patent/JP4537178B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2177249C (en) | 2010-10-19 |
EP0771322A1 (de) | 1997-05-07 |
CN1142231A (zh) | 1997-02-05 |
CN1103781C (zh) | 2003-03-26 |
EP0771322B1 (de) | 2008-09-10 |
EP0771322B9 (de) | 2009-08-12 |
BR9408135A (pt) | 1997-08-05 |
ES2313719T3 (es) | 2009-03-01 |
CA2177249A1 (en) | 1995-06-01 |
WO1995014713A2 (en) | 1995-06-01 |
WO1995014713A3 (en) | 1995-12-28 |
DK0771322T3 (da) | 2008-11-24 |
US6761894B1 (en) | 2004-07-13 |
DE69435138D1 (de) | 2008-10-23 |
AU1097795A (en) | 1995-06-13 |
JP2005104983A (ja) | 2005-04-21 |
JPH09505588A (ja) | 1997-06-03 |
JP4537178B2 (ja) | 2010-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |