CN1312723A - 诊断结核病的化合物和方法 - Google Patents

诊断结核病的化合物和方法 Download PDF

Info

Publication number
CN1312723A
CN1312723A CN99809541A CN99809541A CN1312723A CN 1312723 A CN1312723 A CN 1312723A CN 99809541 A CN99809541 A CN 99809541A CN 99809541 A CN99809541 A CN 99809541A CN 1312723 A CN1312723 A CN 1312723A
Authority
CN
China
Prior art keywords
seq
ala
pro
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99809541A
Other languages
English (en)
Chinese (zh)
Inventor
S·G·里德
Y·A·W·斯凯基
D·C·狄龙
A·坎波斯－内托
R·霍顿
T·S·韦德维克
D·R·特德齐克
M·J·洛德斯
R·C·亨德里克森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of CN1312723A publication Critical patent/CN1312723A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
CN99809541A 1998-02-18 1999-02-17 诊断结核病的化合物和方法 Pending CN1312723A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2475398A 1998-02-18 1998-02-18
US09/024,753 1998-02-18
US09/072,596 1998-05-05
US09/072,596 US6458366B1 (en) 1995-09-01 1998-05-05 Compounds and methods for diagnosis of tuberculosis

Publications (1)

Publication Number Publication Date
CN1312723A true CN1312723A (zh) 2001-09-12

Family

ID=26698832

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99809541A Pending CN1312723A (zh) 1998-02-18 1999-02-17 诊断结核病的化合物和方法

Country Status (8)

Country Link
US (4) US6458366B1 (enExample)
EP (1) EP1091749A1 (enExample)
JP (1) JP2002530050A (enExample)
CN (1) CN1312723A (enExample)
AU (1) AU2681999A (enExample)
BR (1) BR9908083A (enExample)
CA (1) CA2322617A1 (enExample)
WO (1) WO1999042118A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101925819A (zh) * 2007-12-28 2010-12-22 株式会社比尔生命 结核分歧杆菌复合群的免疫检出方法
CN103814139A (zh) * 2011-04-01 2014-05-21 澳康姆生物实验室公司 用于检测无细胞的病原体特异性核酸的方法和试剂盒
CN106011296A (zh) * 2016-08-01 2016-10-12 武汉大学 一种结核分枝杆菌Rv1768基因微滴数字PCR绝对定量检测试剂盒
CN113004362A (zh) * 2021-02-26 2021-06-22 南方科技大学 一种订书钉核酸、dna纳米机器人及其制备方法和应用
CN113388623A (zh) * 2020-03-11 2021-09-14 北京蛋白质组研究中心 结核分枝杆菌H37Rv新基因Rv2203c及其编码蛋白和应用
CN114034860A (zh) * 2021-11-01 2022-02-11 宁夏大学 一种结核分枝杆菌mtb39a蛋白抗体间接elisa检测方法及其试剂盒
CN114989312A (zh) * 2022-06-27 2022-09-02 安徽理工大学 一种结合分枝杆菌融合蛋白dr2及其应用

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
DE69941545D1 (de) 1998-11-04 2009-11-26 Isis Innovation Tuberkulose diagnose test
US6196917B1 (en) * 1998-11-20 2001-03-06 Philips Electronics North America Corp. Goal directed user interface
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
PT1517913E (pt) * 1999-10-07 2007-05-31 Corixa Corp Sequência codificante de mycobacterium turberculosis para expressão de proteínas heterólogas.
US7009042B1 (en) 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
CA2386841A1 (en) 1999-10-07 2001-04-12 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
WO2001062893A2 (en) 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
AU6867801A (en) * 2000-06-20 2002-01-02 Corixa Corp Fusion proteins of mycobacterium tuberculosis
WO2003070187A2 (en) * 2002-02-15 2003-08-28 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
RU2277540C2 (ru) * 2003-07-29 2006-06-10 Зао "Велес Фарма" Способ диагностики туберкулезной инфекции, рекомбинантная плазмидная днк, кодирующая синтез гибридного белка cfp10-esat6 из mycobacterium tuberculosis, способ его получения, гибридный белок cfp10-esat6 и его применение
US8475735B2 (en) * 2004-11-01 2013-07-02 Uma Mahesh Babu Disposable immunodiagnostic test system
KR101255870B1 (ko) * 2004-11-16 2013-04-17 아에라스 글로벌 티비 백신 파운데이션 재조합 바이러스 벡터를 포함하는 다가 백신
WO2006060484A2 (en) * 2004-12-01 2006-06-08 Gene Therapy Systems, Inc. Tuberculosis nucleic acids, polypeptides and immunogenic compositions
WO2007005627A2 (en) 2005-07-01 2007-01-11 Forsyth Dental Infirmary For Children Tuberculosis antigen detection assays and vaccines
US20070081944A1 (en) * 2005-09-30 2007-04-12 Reed Steven G Iontophoresis apparatus and method for the diagnosis of tuberculosis
CN101438165A (zh) * 2006-03-13 2009-05-20 奥洁克公司 结核分枝杆菌的体内诱导基因
WO2007136781A2 (en) * 2006-05-18 2007-11-29 Ericson Daniel G Rapid detection of mycobacterium tuberculosis and antimicrobial drug resistance
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
ES2657392T3 (es) 2006-09-26 2018-03-05 Infectious Disease Research Institute Composición de vacuna que contiene un adyuvante sintético
EP2087128A4 (en) 2006-11-01 2009-11-04 Immport Therapeutics Inc COMPOSITIONS AND METHODS FOR IMMUNOMINANT ANTIGENES
CN103224932A (zh) * 2008-05-28 2013-07-31 和光纯药工业株式会社 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针检测胞内分枝杆菌的方法
NO2315597T3 (enExample) 2008-07-25 2018-01-20
EP2315834B1 (en) 2008-07-25 2018-06-13 GlaxoSmithKline Biologicals S.A. The tuberculosis rv2386c protein, compositions and uses thereof
US20100159485A1 (en) * 2008-12-19 2010-06-24 Centre For Dna Fingerprinting And Diagnostics Detection of mycobacterium tuberculosis
WO2010089098A1 (de) 2009-02-05 2010-08-12 Deklatec Gmbh Verfahren und mittel für die tuberkulose diagnostik
PT2437753T (pt) 2009-06-05 2016-11-23 Infectious Disease Res Inst Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos
US8932600B2 (en) 2010-01-27 2015-01-13 Glaxosmithkline Biologicals S.A. Modified tuberculosis antigens
EP3632463A1 (en) 2011-04-08 2020-04-08 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
EP2573107A1 (en) * 2011-09-21 2013-03-27 Norwegian Institute of Public Health A recombinant fusion protein
RS58868B1 (sr) 2012-02-07 2019-08-30 Infectious Disease Res Inst Poboljšane adjuvansne formulacije koje sadrže agoniste tlr4 i postupci upotrebe istih
SMT201800368T1 (it) 2012-05-16 2018-09-13 Immune Design Corp Vaccini per l'infezione da virus-2 herpes simplex
EP3711768A1 (en) 2013-04-18 2020-09-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
US10597734B2 (en) 2013-12-03 2020-03-24 European Molecular Biology Laboratory Genetic markers for diagnosis of tuberculosis caused by Mycobacterium tuberculosis
IL310015B1 (en) 2013-12-31 2025-10-01 Access To Advanced Health Inst Single vial formulation
WO2017210364A1 (en) 2016-06-01 2017-12-07 Infectious Disease Research Institute Nanoalum particles containing a sizing agent
EP3516394B1 (en) * 2016-09-22 2023-06-21 Pace Diagnostics, Inc Mycobacterium tuberculosis proteins in diagnostic assays and devices for tuberculosis detection and diagnosis
BR112021023726A2 (pt) 2019-05-25 2022-02-15 Infectious Disease Res Inst Composição e método para secagem por pulverização de uma emulsão de vacina adjuvante

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5856073A (en) 1973-06-28 1975-01-30 Toru Tsumits Tuberculin active proteins and peptides
FR2244539A1 (en) 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4876089A (en) 1984-09-06 1989-10-24 Chiron Corporation Feline leukemia virus protein vaccines
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4689397A (en) * 1985-08-12 1987-08-25 Scripps Clinic And Research Foundation Synthetic polypeptides for detecting mycobacterial infections
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
AU1548388A (en) 1987-02-02 1988-08-24 Whitehead Institute For Biomedical Research Mycobacterium tuberculosis genes and encoding protein antigens
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US4976958A (en) * 1987-02-26 1990-12-11 Scripps Clinic And Research Foundation Mycobacterial recombinants and peptides
US4952395A (en) * 1987-02-26 1990-08-28 Scripps Clinic And Research Foundation Mycobacterial recombinants and peptides
US5504005A (en) 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine
US5583112A (en) 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5108745B1 (en) 1988-08-16 1998-06-30 Univ California Tuberculosis and legionellosis vaccines and methods for their production
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
JPH0775324B2 (ja) 1989-08-18 1995-08-09 日本電気株式会社 携帯無線機
AU631460B2 (en) 1989-09-19 1992-11-26 N.V. Innogenetics S.A. Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis
EP0419355B1 (en) 1989-09-19 2000-02-09 N.V. Innogenetics S.A. Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
SE9001105D0 (sv) 1990-03-27 1990-03-27 Astra Ab New methods foer diagnosis of tuberculosis
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
WO1992004049A1 (en) 1990-09-06 1992-03-19 Rijksuniversiteit Te Utrecht Inhibitor of lymphocyte response and immune-related disease
ATE154759T1 (de) 1990-11-08 1997-07-15 Univ London Mycobacterium als adjuvans für antigene
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
EP0499003A1 (en) 1991-02-14 1992-08-19 N.V. Innogenetics S.A. Polypeptides and peptides, particularly recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnosis of tuberculosis
RU2024021C1 (ru) 1991-05-05 1994-11-30 Научно-исследовательский институт хирургии Восточно-Сибирского филиала СО РАМН Способ диагностики туберкулеза
DE4116249A1 (de) 1991-05-17 1992-11-19 Biotechnolog Forschung Gmbh Hybrid-plasmid fuer m.-tuberculosis-antigen, e. coli als wirt und antigen
FR2677365B1 (fr) 1991-06-07 1995-08-04 Pasteur Institut Proteines de mycobacterium et applications.
US5240856A (en) 1991-10-23 1993-08-31 Cellpro Incorporated Apparatus for cell separation
US6037135A (en) 1992-08-07 2000-03-14 Epimmune Inc. Methods for making HLA binding peptides and their uses
ATE155681T1 (de) 1992-05-18 1997-08-15 Minnesota Mining & Mfg Einrichtung zur transmucosalen wirkstoffabgabe
US5330754A (en) 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
NL9202197A (nl) * 1992-12-17 1994-07-18 Kreatech Biotech Bv Werkwijze en inrichting voor het identificeren van een voor een mycobacteriële infectie verantwoordelijk mycobacterium species.
DE69418699T2 (de) 1993-01-11 1999-09-30 Dana-Farber Cancer Institute, Boston Induktion der antworten zytotoxischer t-lymphozyten
US5616500A (en) 1993-04-30 1997-04-01 The United States Of America As Represented By The Department Of Health & Human Services Trichohyalin and transglutaminase-3 and methods of using same
DK79893D0 (da) 1993-07-02 1993-07-02 Statens Seruminstitut New vaccine
DK79793D0 (da) 1993-07-02 1993-07-02 Statens Seruminstitut Diagnostic test
US5955077A (en) 1993-07-02 1999-09-21 Statens Seruminstitut Tuberculosis vaccine
US5639653A (en) 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
WO1995014713A2 (en) 1993-11-23 1995-06-01 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
GB9409985D0 (en) 1994-05-18 1994-07-06 Medical Res Council Vaccine against mycobacterial infections
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
DE4446509A1 (de) 1994-12-24 1996-06-27 Sel Alcatel Ag Verfahren zur Herstellung von Leiterbahnen auf einem Vertiefungen aufweisenden Substrat
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5714593A (en) 1995-02-01 1998-02-03 Institut Pasteur DNA from mycobacterium tuberculosis which codes for a 45/47 kilodalton protein
US5580579A (en) 1995-02-15 1996-12-03 Nano Systems L.L.C. Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
AU706367B2 (en) 1995-03-13 1999-06-17 Astra Aktiebolag New DNA molecules
PT1203817E (pt) 1995-09-01 2006-08-31 Corixa Corp Compostos e metodos para imunoterapia e le diagnostic de tuberculose
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6338852B1 (en) 1995-09-01 2002-01-15 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
DE69636075D1 (de) 1995-09-01 2006-06-01 Corixa Corp Verbindungen und verfahren zur diagnose von tuberkulose
US6290969B1 (en) 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
KR19990087802A (ko) 1996-03-15 1999-12-27 길리스 스티브 전립선암의 면역치료 및 면역진단을 위한 화합물 및 방법
US6284255B1 (en) 1996-08-29 2001-09-04 Genesis Research & Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US5985287A (en) 1996-08-29 1999-11-16 Genesis Research And Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
US6544522B1 (en) 1998-12-30 2003-04-08 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6350456B1 (en) 1997-03-13 2002-02-26 Corixa Corporation Compositions and methods for the prevention and treatment of M. tuberculosis infection
US6627198B2 (en) 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6355257B1 (en) 1997-05-08 2002-03-12 Corixa Corporation Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6555653B2 (en) 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
CZ302870B6 (cs) 1998-04-07 2011-12-28 Corixa Corporation Polynukleotid, polypeptid, farmaceutický prostredek, vakcínový prostredek a jejich použití k lécbe a prevenci infekce tuberkulózou
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US8143386B2 (en) 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
CA2386841A1 (en) 1999-10-07 2001-04-12 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
WO2001062893A2 (en) 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
AU6867801A (en) 2000-06-20 2002-01-02 Corixa Corp Fusion proteins of mycobacterium tuberculosis
WO2003070187A2 (en) 2002-02-15 2003-08-28 Corixa Corporation Fusion proteins of mycobacterium tuberculosis

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101925819A (zh) * 2007-12-28 2010-12-22 株式会社比尔生命 结核分歧杆菌复合群的免疫检出方法
CN101925819B (zh) * 2007-12-28 2013-06-12 株式会社比尔生命 结核分歧杆菌复合群的免疫检出方法
CN103123353B (zh) * 2007-12-28 2014-11-12 株式会社比尔生命 结核分歧杆菌复合群的免疫检出方法
CN103814139A (zh) * 2011-04-01 2014-05-21 澳康姆生物实验室公司 用于检测无细胞的病原体特异性核酸的方法和试剂盒
CN103814139B (zh) * 2011-04-01 2018-11-13 澳康姆生物实验室公司 用于检测无细胞的病原体特异性核酸的方法和试剂盒
CN106011296A (zh) * 2016-08-01 2016-10-12 武汉大学 一种结核分枝杆菌Rv1768基因微滴数字PCR绝对定量检测试剂盒
CN113388623A (zh) * 2020-03-11 2021-09-14 北京蛋白质组研究中心 结核分枝杆菌H37Rv新基因Rv2203c及其编码蛋白和应用
CN113004362A (zh) * 2021-02-26 2021-06-22 南方科技大学 一种订书钉核酸、dna纳米机器人及其制备方法和应用
CN113004362B (zh) * 2021-02-26 2023-08-15 南方科技大学 一种订书钉核酸、dna纳米机器人及其制备方法和应用
CN114034860A (zh) * 2021-11-01 2022-02-11 宁夏大学 一种结核分枝杆菌mtb39a蛋白抗体间接elisa检测方法及其试剂盒
CN114989312A (zh) * 2022-06-27 2022-09-02 安徽理工大学 一种结合分枝杆菌融合蛋白dr2及其应用
CN114989312B (zh) * 2022-06-27 2023-07-21 安徽理工大学 一种结核分枝杆菌融合蛋白dr2及其应用

Also Published As

Publication number Publication date
US6458366B1 (en) 2002-10-01
US20070141087A1 (en) 2007-06-21
WO1999042118A2 (en) 1999-08-26
CA2322617A1 (en) 1999-08-26
JP2002530050A (ja) 2002-09-17
US6949246B2 (en) 2005-09-27
US7122196B2 (en) 2006-10-17
AU2681999A (en) 1999-09-06
WO1999042118A8 (en) 1999-10-21
BR9908083A (pt) 2007-07-17
US20030135026A1 (en) 2003-07-17
EP1091749A1 (en) 2001-04-18
US7906277B2 (en) 2011-03-15
US20050181419A1 (en) 2005-08-18

Similar Documents

Publication Publication Date Title
CN1312723A (zh) 诊断结核病的化合物和方法
CN1117149C (zh) 用于免疫治疗和诊断结核病的化合物和方法
CN1154730C (zh) 用于结核病诊断的化合物和方法
US6592877B1 (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
CZ126599A3 (cs) Polypeptid pro imunoterapii a diagnosu tuberkulosy
WO1998016646A9 (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
CZ126699A3 (cs) Polypeptid obsahující antigenní část rozpustného antigenu M. tuberculosis nebo variantu uvedeného antigenu, molekula DNA kódující tento polypeptid, expresivní vektor, hostitelská buňka, způsoby diagnostiky infekce M. tuberculosis a diagnostické kity
US6350456B1 (en) Compositions and methods for the prevention and treatment of M. tuberculosis infection
SA99200488B1 (ar) تركيبات وطرق لاج والوقاية من الاصابة بعدوي بكتيريا العصيات الفطرية للدرنM.tuberculosis
US6338852B1 (en) Compounds and methods for diagnosis of tuberculosis
CN1235555A (zh) 治疗和诊断分枝杆菌感染的化合物和方法
CN1307639A (zh) 杀虫毒素和编码这些毒素的核苷酸序列
CN1241212A (zh) 免疫治疗和诊断结核病的化合物和方法
CN1242047A (zh) 诊断结核病的化合物和方法
HK1040366A (en) Compounds and methods for diagnosis of tuberculosis
CN1210401C (zh) 源自粘膜炎莫拉氏菌的化合物
MXPA99003393A (en) Compounds and methods for diagnosis of tuberculosis
HK1072061A (en) Compounds and methods for diagnosis of tuberculosis
MXPA99003392A (en) Compounds and methods for immunotherapy and diagnosis of tuberculosis
CN1311820A (zh) 得自粘膜炎莫拉氏菌的basb027蛋白和basb027基因、抗原、抗体及应用
HK1023511A (en) Compounds and methods for treatment and diagnosis of mycobacterial infections
CN1443773A (zh) 钩端螺旋体致病相关蛋白及其编码序列
CN1420930A (zh) 新颖的化合物
HK1036479A (en) Compositions derived from mycobacterium vaccae and methods for their use
HK1034719A (en) Novel surface protein of neisseria meningitidis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1040366

Country of ref document: HK