BR9810880A - Medicamentos, compostos derivados de pirazina, processo para preparação dos compostos, e, utilização de um composto - Google Patents

Medicamentos, compostos derivados de pirazina, processo para preparação dos compostos, e, utilização de um composto

Info

Publication number
BR9810880A
BR9810880A BR9810880-8A BR9810880A BR9810880A BR 9810880 A BR9810880 A BR 9810880A BR 9810880 A BR9810880 A BR 9810880A BR 9810880 A BR9810880 A BR 9810880A
Authority
BR
Brazil
Prior art keywords
choh
compounds
hydrogen atom
medicines
represent
Prior art date
Application number
BR9810880-8A
Other languages
English (en)
Inventor
Georges Bashiardes
Jean-Christophe Carry
Michael Evers
Bruno Filoche
Serge Mignani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of BR9810880A publication Critical patent/BR9810880A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"MEDICAMENTOS, COMPOSTOS DERIVADOS DE PIRAZINA, PROCESSO PARA PREPARAçãO DOS COMPOSTOS, E, UTILIZAçãO DE UM COMPOSTO". Medicamentos contendo derivados de pirazina de fórmula: em que, quando R representa um átomo de nitrogênio, R, representa um radical -CO-NR~ 5~R~ 6~, -CO-N(CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~OH)~ 2~, -CO-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~-(CHOH)~ n~-CH~ 2~OH)~ 2~, -CH~ 2~-O-R~ 6'~, -NR~ 5~-CO-R~ 6'~,-CH~ 2~-NR~ 5~R~ 6~, -CH~ 2~-N(CH~ 2~OH)~ 2~, -CH~ 2~-N(CH~ 2~-(CHOH)~ y~-CH~ 2~OH)~ 2~, -CH~ 2~-N(CH(CH~ 2~OH)~ 2~)~ 2~, -CH~ 2~-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~ e um dos substituintes R~ 3~ ou R~ 4~ representa um átomo de hidrogênio e o outro é idêntico a R~ 1~ e R~ 2~ representa um átomo de hidrogênio, quando R representa um radical CH, R~ 1~ e R~ 4~ são idênticos e representam, cada um, um radical -CO-NR~ 5~R~ 6~, -CON(CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~OH)~ 2~, -CO-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~, -CON(CH~ 2~-(CHOH)~ n~-CH~ 2~OH)~ 2~, -CH~ 2~-O-R~ 6~, -NR~ 5~-CO-R~ 6~, -CH~ 2~-NR~ 5~R~ 6~, -CH~ 2~-N(CH~ 2~OH)~ 2~, -CH~ 2~-N(CH~ 2~-(CHOH)~ y~-CH~ 2~OH)2, -CH2-N(CH(CH~ 2~OH)~ 2~)~ 2~, -CH~ 2~-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~ e R~ 2~ e R~ 3~ representam um átomo de hidrogênio, ou então R~ 1~ e R~ 4~ representam um átomo de hidrogênio, ou então R~ 1~ e R~ 3~ são idênticos e representam, cada um, um radical -CO-NR~ 5~R~ 6~, -CON(CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~OH)~ 2~, -CO-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~-(CHOH)~ n~ CH~ 2~OH)~ 2~, -CH~ 2~-O-R~ 6~, -NR~ 5~-CO-R~ 6~, -CH~ 2~-NR~ 5~R~ 6~, -CH~ 2~-N(CH~ 2~OH)~ 2~, -CH~ 2~-N(CH~ 2~-(CHOH)~ y~-CH~ 2~OH)~ 2~, -CH~ 2~-N(CH(CH~ 2~OH)~ 2~)~ 2~,-CH~ 2~-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~ e R~ 4~ representam um átomo de hidrogênio, ou então R~ 2~ e R~ 2~ e R~ 3~ são idênticos e representam, cada um, um radical -CO-NR~ 5~R~ 6~, -CO-N(CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~OH)~ 2~, -CO-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~, -CO-N(CH~ 2~-(CHOH),CH~ 2~OH)~ 2~, -CH~ 2~-O-R~ 6~, -NR~ 5~-CO-R~ 6~, -CH~ 2~-NR~ 5~R~ 6~, -CH~ 2~-N(CH~ 2~OH)~ 2~, -CH~ 2~-N(CH~ 2~-(CHOH)~ y~-CH~ 2~OH)~ 2~, -CH~ 2~N(CH(CH~ 2~OH)~ 2~)~ 2~, -CH~ 2~-N(CH~ 2~-CH(CH~ 2~OH)~ 2~)~ 2~ e R~ 1~ e R~ 4~ representam um átomo de hidrogênio, seus estereoisómeros seus sais os novos derivados de fórmula (1) e sua preparação.
BR9810880-8A 1997-07-17 1998-07-15 Medicamentos, compostos derivados de pirazina, processo para preparação dos compostos, e, utilização de um composto BR9810880A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709058A FR2766187B1 (fr) 1997-07-17 1997-07-17 Derives de pyrazine, leur preparation et les medicaments les contenant
PCT/FR1998/001542 WO1999003844A1 (fr) 1997-07-17 1998-07-15 Derives de pyrazine, leur preparation et les medicaments les contenant

Publications (1)

Publication Number Publication Date
BR9810880A true BR9810880A (pt) 2002-05-21

Family

ID=9509300

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810880-8A BR9810880A (pt) 1997-07-17 1998-07-15 Medicamentos, compostos derivados de pirazina, processo para preparação dos compostos, e, utilização de um composto

Country Status (24)

Country Link
US (1) US6399613B1 (pt)
EP (1) EP1001944B1 (pt)
JP (1) JP4443036B2 (pt)
KR (1) KR20010021901A (pt)
CN (1) CN1264371A (pt)
AT (1) ATE251144T1 (pt)
AU (1) AU747127B2 (pt)
BR (1) BR9810880A (pt)
CA (1) CA2296727C (pt)
DE (1) DE69818679T2 (pt)
DK (1) DK1001944T3 (pt)
ES (1) ES2205536T3 (pt)
FR (1) FR2766187B1 (pt)
HU (1) HUP0004602A3 (pt)
IL (1) IL134040A0 (pt)
MX (1) MXPA00000280A (pt)
NO (1) NO20000198D0 (pt)
NZ (1) NZ501906A (pt)
PL (1) PL338148A1 (pt)
PT (1) PT1001944E (pt)
RU (1) RU2194703C2 (pt)
SK (1) SK482000A3 (pt)
WO (1) WO1999003844A1 (pt)
ZA (1) ZA986337B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905771D0 (en) * 1999-03-12 1999-05-05 Isis Innovation Compounds
US7598278B2 (en) * 2002-04-11 2009-10-06 L'oreal Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss
US20070270590A1 (en) * 2006-04-20 2007-11-22 Marioara Mendelovici Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
US20080015197A1 (en) * 2006-06-26 2008-01-17 Alex Mainfeld Process for the preparatrion of zopiclone
US20080287447A1 (en) * 2007-01-31 2008-11-20 Nina Finkelstein Methods for preparing eszopiclone
CN101891679B (zh) * 2009-05-19 2014-04-16 上海华明高技术（集团）有限公司 吡啶二甲酸与二氨基吡啶质子转移化合物的制备方法
FR3030248B1 (fr) 2014-12-22 2018-03-23 L'oreal Association derive d'acide pyridine-dicarboxylique/agent anti-oxydant particulier

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220650A (en) * 1978-10-18 1980-09-02 Pfizer Inc. Organic diamine therapeutic compositions and methods
DE3703959A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
JPH01117863A (ja) * 1987-10-30 1989-05-10 Toyobo Co Ltd 新規なアミド化合物
DE4020570A1 (de) * 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung

Also Published As

Publication number Publication date
FR2766187A1 (fr) 1999-01-22
HUP0004602A2 (hu) 2001-11-28
MXPA00000280A (es) 2002-04-17
IL134040A0 (en) 2001-04-30
DE69818679T2 (de) 2004-07-29
PT1001944E (pt) 2004-02-27
ATE251144T1 (de) 2003-10-15
NO20000198L (no) 2000-01-14
CA2296727C (fr) 2009-06-09
HUP0004602A3 (en) 2001-12-28
DK1001944T3 (da) 2004-02-09
KR20010021901A (ko) 2001-03-15
RU2194703C2 (ru) 2002-12-20
CN1264371A (zh) 2000-08-23
JP2001510188A (ja) 2001-07-31
NZ501906A (en) 2002-04-26
JP4443036B2 (ja) 2010-03-31
FR2766187B1 (fr) 2000-06-02
ES2205536T3 (es) 2004-05-01
US6399613B1 (en) 2002-06-04
AU8810298A (en) 1999-02-10
NO20000198D0 (no) 2000-01-14
EP1001944B1 (fr) 2003-10-01
PL338148A1 (en) 2000-09-25
CA2296727A1 (fr) 1999-01-28
EP1001944A1 (fr) 2000-05-24
ZA986337B (en) 1999-01-27
AU747127B2 (en) 2002-05-09
SK482000A3 (en) 2000-06-12
WO1999003844A1 (fr) 1999-01-28
DE69818679D1 (de) 2003-11-06

Similar Documents

Publication Publication Date Title
BR9913592A (pt) Compostos, processo de preparação dos compostos, e, composições farmacêuticas
BR9813390A (pt) Composto, processo para a preparação do mesmo, e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, processo para efetuar a imunossupressão
MY100300A (en) Antimycotic nail varnish
MX171822B (es) Proceso quimico
BR9811521A (pt) Composição para tratar ou impedir a glomerulopatia
BR9914451A (pt) Composto de oxazol, processo para sua preparação, composição farmacêutica compreendendo dito composto, uso da composição e métodos de tratamento
BR0016395A (pt) Derivados de adamantano
BR9916282A (pt) Composto, uso de um um composto e método de tratamento
ES8103088A1 (es) Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas)
CO4940499A1 (es) Derivados de isoquinolinio sustituidos
DE69507293T2 (de) Benzamid-derivate als vasopressin-antagonisten
BR9810880A (pt) Medicamentos, compostos derivados de pirazina, processo para preparação dos compostos, e, utilização de um composto
BR9916318A (pt) Compostos bicìclicos
AU2868689A (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
FI841738A (fi) Imidazol-etanolestrar.
BR9813217A (pt) Tetraciclos, processo para a produção dos mesmos e preparações farmacêuticas contendo estes compostos
AU4471497A (en) Novel diamide compounds and drugs containing the same
DE3879258D1 (de) Praeparat gegen ulcus.
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
NO855241L (no) Fremgangsmaate til fremstilling av karbapenemforbindelser.
AU5132185A (en) Tetrazole derivatives
IT1237529B (it) Composti spiro-indolino-ossazine con caratteristiche fotocromatiche e fotosensibilizzatrici e procedimento per la loro preparazione
NO173278C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive 5-androsten-17-on-derivater
ES2012695A6 (es) Un procedimiento para la preparacion de 4-(6'-metoxi -2'- naftil)-but-3-en -2-ona.
ATE78032T1 (de) 2-pyridylessigsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007.