HUP0004602A2 - Pirazin -és piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Pirazin -és piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0004602A2 HUP0004602A2 HU0004602A HUP0004602A HUP0004602A2 HU P0004602 A2 HUP0004602 A2 HU P0004602A2 HU 0004602 A HU0004602 A HU 0004602A HU P0004602 A HUP0004602 A HU P0004602A HU P0004602 A2 HUP0004602 A2 HU P0004602A2
- Authority
- HU
- Hungary
- Prior art keywords
- ch2oh
- group
- nr5r6
- choh
- nch2
- Prior art date
Links
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az általános képletű pirazinszármazékok - ahol Rnitrogénatom, R1 -CO-NR5R6, -CO-N CH (CH2OH)2 2, -CO-N (CH2OH)2, -CO-NCH2-CH (CH2OH)2 2, -CO-N[CH2- (CHOH)n-CH2OH]2, -CH2-O-R6, -NR5-CO-R6,-CH2-NR5R6, -CH2-N (CH2OH)2, -CH2-NCH2- (CHOH)Y-CH2OH2, -CH2-NCH(CH2OH)2 2 vagy -CH2-N[CH2-CH(CH2OH)2]2 képletű csoport, és R3 vagyR4 egyike hidrogénatom, a másik pedig azonos R1-gyel, és R2hidrogénatom; vagy pedig R metincsoport, R1 és R4 azonosan -CO-NR5R6,-CO-N[CH(CH2OH)2]2, -CO-N(CH2OH)2, -CO-NCH2-CH(CH2OH)2 2, -CO-NCH2-(CHOH)n-CH2OH2, -CH2-O-R6, -NR5-CO-R6, -CH2-NR5R6, -CH2-N(CH2OH)2, -CH2-N CH2-(CHOH)Y-CH2OH2, -CH2-NCH(CH2OH)2 2 vagy -CH2-N[CH2-CH(CH2OH)2]2 képletű csoport, és R2 és R3 hidrogénatom; vagy pedig R1és R3 azonosan -CO-NR5R6, -CO-N[CH(CH2OH)2]2, -CO-N(CH2OH)2, -CO-N[CH2-CH(CH2OH)2]2, -CO-N[CH2-(CHOH)n-CH2OH]2, -CH2-O-R6, -NR5-CO-R6,-CH2-NR5R6, -CH2-N (CH2OH)2, -CH2-N CH2-(CHOH)y-CH2OH2, -CH2-NCH(CH2OH)2 2 vagy -CH2-N CH2CH(CH2OH)2 2 képletű csoport, és R2 és R4hidrogénatom; vagy pedig R2 és R3 azonosan -CO-NR5R6, -CO-N[CH(CH2OH)2]2, -CO-N (CH2OH)2, -CO-N[CH2-CH(CH2OH)2]2, -CO-N[CH2-(CHOH)n-CH2OH]2, -CH2-O-R6, -NR5-CO-R6, -CH2-NR5R6, -CH2-N(CH2OH)2, -CH2-NCH2-(CHOH)Y-CH2OH2, -CH2-NCH(CH2OH)2 2 vagy -CH2-NCH2-CH(CH2OH)2 2 képletűcsoport, és Rl és R4 hidrogénatom -és sztereoizomereik és sóik -kivéve azokat, amelyek képletében R metincsoport, R2 és R3 azonosan -NR5-CO-R6 általános képletű csoport, amelyben R5 hidrogénatom, R6 -alk(1C)-O-alk(1C) csoport, és R1 és R4 hidrogénatom; vagy pedig Rmetincsoport, R1 és R4 vagy R1 és R3 vagy R2 és R3 azonosan -CH2NR5R6általános képletű csoport, amelyben R5 hidrogénatom vagy alkilcsoport,R6 -alk-O-alk általános képletű csoport, és a többi R1, R2, R3, R4hidrogénatom -és ezeket tartalmazó gyógyszerkészítmények éselőállításuk képezik, melyek vércukorszint csökkentő hatássalrendelkeznek. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9709058A FR2766187B1 (fr) | 1997-07-17 | 1997-07-17 | Derives de pyrazine, leur preparation et les medicaments les contenant |
| PCT/FR1998/001542 WO1999003844A1 (fr) | 1997-07-17 | 1998-07-15 | Derives de pyrazine, leur preparation et les medicaments les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004602A2 true HUP0004602A2 (hu) | 2001-11-28 |
| HUP0004602A3 HUP0004602A3 (en) | 2001-12-28 |
Family
ID=9509300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004602A HUP0004602A3 (en) | 1997-07-17 | 1998-07-15 | Pyrazine and pyridine derivatives, preparation and medicines containing them |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6399613B1 (hu) |
| EP (1) | EP1001944B1 (hu) |
| JP (1) | JP4443036B2 (hu) |
| KR (1) | KR20010021901A (hu) |
| CN (1) | CN1264371A (hu) |
| AT (1) | ATE251144T1 (hu) |
| AU (1) | AU747127B2 (hu) |
| BR (1) | BR9810880A (hu) |
| CA (1) | CA2296727C (hu) |
| DE (1) | DE69818679T2 (hu) |
| DK (1) | DK1001944T3 (hu) |
| ES (1) | ES2205536T3 (hu) |
| FR (1) | FR2766187B1 (hu) |
| HU (1) | HUP0004602A3 (hu) |
| IL (1) | IL134040A0 (hu) |
| MX (1) | MXPA00000280A (hu) |
| NO (1) | NO20000198D0 (hu) |
| NZ (1) | NZ501906A (hu) |
| PL (1) | PL338148A1 (hu) |
| PT (1) | PT1001944E (hu) |
| RU (1) | RU2194703C2 (hu) |
| SK (1) | SK482000A3 (hu) |
| WO (1) | WO1999003844A1 (hu) |
| ZA (1) | ZA986337B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905771D0 (en) * | 1999-03-12 | 1999-05-05 | Isis Innovation | Compounds |
| US7598278B2 (en) * | 2002-04-11 | 2009-10-06 | L'oreal | Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss |
| EP2007768A2 (en) * | 2006-04-20 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
| EP1904499A1 (en) * | 2006-06-26 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Process for the preparation of zopiclone |
| WO2008094690A2 (en) * | 2007-01-31 | 2008-08-07 | Teva Pharmaceutical Industries Ltd. | Methods for preparing eszopiclone |
| CN101891679B (zh) * | 2009-05-19 | 2014-04-16 | 上海华明高技术（集团）有限公司 | 吡啶二甲酸与二氨基吡啶质子转移化合物的制备方法 |
| FR3030248B1 (fr) | 2014-12-22 | 2018-03-23 | L'oreal | Association derive d'acide pyridine-dicarboxylique/agent anti-oxydant particulier |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220650A (en) * | 1978-10-18 | 1980-09-02 | Pfizer Inc. | Organic diamine therapeutic compositions and methods |
| DE3703959A1 (de) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| JPH01117863A (ja) * | 1987-10-30 | 1989-05-10 | Toyobo Co Ltd | 新規なアミド化合物 |
| DE4020570A1 (de) * | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
-
1997
- 1997-07-17 FR FR9709058A patent/FR2766187B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-15 WO PCT/FR1998/001542 patent/WO1999003844A1/fr not_active Application Discontinuation
- 1998-07-15 AT AT98939676T patent/ATE251144T1/de not_active IP Right Cessation
- 1998-07-15 KR KR1020007000465A patent/KR20010021901A/ko not_active Application Discontinuation
- 1998-07-15 DK DK98939676T patent/DK1001944T3/da active
- 1998-07-15 PL PL98338148A patent/PL338148A1/xx unknown
- 1998-07-15 CN CN98807199A patent/CN1264371A/zh active Pending
- 1998-07-15 PT PT98939676T patent/PT1001944E/pt unknown
- 1998-07-15 IL IL13404098A patent/IL134040A0/xx unknown
- 1998-07-15 NZ NZ501906A patent/NZ501906A/en unknown
- 1998-07-15 EP EP98939676A patent/EP1001944B1/fr not_active Expired - Lifetime
- 1998-07-15 ES ES98939676T patent/ES2205536T3/es not_active Expired - Lifetime
- 1998-07-15 AU AU88102/98A patent/AU747127B2/en not_active Ceased
- 1998-07-15 HU HU0004602A patent/HUP0004602A3/hu unknown
- 1998-07-15 SK SK48-2000A patent/SK482000A3/sk unknown
- 1998-07-15 RU RU2000103449/04A patent/RU2194703C2/ru not_active IP Right Cessation
- 1998-07-15 CA CA002296727A patent/CA2296727C/fr not_active Expired - Fee Related
- 1998-07-15 JP JP2000503069A patent/JP4443036B2/ja not_active Expired - Fee Related
- 1998-07-15 BR BR9810880-8A patent/BR9810880A/pt not_active IP Right Cessation
- 1998-07-15 DE DE69818679T patent/DE69818679T2/de not_active Expired - Lifetime
- 1998-07-15 MX MXPA00000280A patent/MXPA00000280A/es unknown
- 1998-07-16 ZA ZA986337A patent/ZA986337B/xx unknown
-
2000
- 2000-01-14 NO NO20000198A patent/NO20000198D0/no not_active Application Discontinuation
- 2000-01-14 US US09/483,984 patent/US6399613B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818679D1 (de) | 2003-11-06 |
| ZA986337B (en) | 1999-01-27 |
| CA2296727A1 (fr) | 1999-01-28 |
| MXPA00000280A (es) | 2002-04-17 |
| HUP0004602A3 (en) | 2001-12-28 |
| NO20000198L (no) | 2000-01-14 |
| KR20010021901A (ko) | 2001-03-15 |
| JP4443036B2 (ja) | 2010-03-31 |
| PL338148A1 (en) | 2000-09-25 |
| DK1001944T3 (da) | 2004-02-09 |
| WO1999003844A1 (fr) | 1999-01-28 |
| FR2766187A1 (fr) | 1999-01-22 |
| CA2296727C (fr) | 2009-06-09 |
| NZ501906A (en) | 2002-04-26 |
| JP2001510188A (ja) | 2001-07-31 |
| DE69818679T2 (de) | 2004-07-29 |
| CN1264371A (zh) | 2000-08-23 |
| AU747127B2 (en) | 2002-05-09 |
| SK482000A3 (en) | 2000-06-12 |
| ES2205536T3 (es) | 2004-05-01 |
| US6399613B1 (en) | 2002-06-04 |
| ATE251144T1 (de) | 2003-10-15 |
| EP1001944B1 (fr) | 2003-10-01 |
| NO20000198D0 (no) | 2000-01-14 |
| FR2766187B1 (fr) | 2000-06-02 |
| PT1001944E (pt) | 2004-02-27 |
| IL134040A0 (en) | 2001-04-30 |
| BR9810880A (pt) | 2002-05-21 |
| EP1001944A1 (fr) | 2000-05-24 |
| RU2194703C2 (ru) | 2002-12-20 |
| AU8810298A (en) | 1999-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU49295A (sh) | 6-člani sa azotom heteroaril-oksazolidinoni, njihova upotreba i preparati, koji ih sadrže | |
| DE69715888T2 (de) | Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel | |
| GEP20002210B (en) | Acridine Derivatives | |
| CA2093798A1 (en) | Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof | |
| HUT49890A (en) | Process for production of pt /iv/ complexes and medical compositions containing them | |
| HUP0004602A2 (hu) | Pirazin -és piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| PT722319E (pt) | Derivados de antraciclinona e a sua utilizacao no tratamento da amiloidose | |
| MY114282A (en) | Anthracycline derivatives | |
| HUP9701660A2 (hu) | 10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények | |
| MY132057A (en) | Quinoxalinones, a process for their preparation and their use | |
| UA21900A (uk) | Похідhі глутатіоhу або їх фармацевтичhо прийhятhі солі, які проявляють протизапальhу, протиалергійhу та гепатотропhу активhість, і спосіб їх одержаhhя | |
| DE69029781D1 (de) | Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung | |
| HUT58065A (en) | Process for producing new 4'-epi-4'-aminoanthracyclines and pharmaceutical composiktions comprising same | |
| NO174963C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 8-fluorantracyklinglucosider | |
| HU9502769D0 (en) | Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them | |
| AU1459192A (en) | Aminoacyl derivatives of gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them | |
| DE69215511T2 (de) | Gem-diphosphonsäure-nitrosocarbamoylderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zubereitungen | |
| MY103030A (en) | Diacyl derivatives of 4-(triakylbenzyl) -piperazinyl compounds | |
| ATE124945T1 (de) | 2,13-disubstituierte ergoline, deren herstellung und verwendung in arzneimitteln. | |
| ES2064086T3 (es) | Derivados de hidrazina. | |
| HUT48625A (en) | Process for producing new glycolamide esters and pharmaceutical compositions comprising same as active ingredient |