BR9713492A - ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação - Google Patents

ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação

Info

Publication number
BR9713492A
BR9713492A BR9713492-9A BR9713492A BR9713492A BR 9713492 A BR9713492 A BR 9713492A BR 9713492 A BR9713492 A BR 9713492A BR 9713492 A BR9713492 A BR 9713492A
Authority
BR
Brazil
Prior art keywords
fatty acid
glycolic acid
salts
glycolic
incorporated
Prior art date
Application number
BR9713492-9A
Other languages
English (en)
Inventor
Srinivasan Venkateshwaran
David Fikstad
Sonal R Patel
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Publication of BR9713492A publication Critical patent/BR9713492A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

Patente de Invenção: <B>"ESTERES DE áCIDO GRAXO DE áCIDO GLICóLICO E SEUS SAIS COMO REALçADORES DE PERMEAçãO"<D>. Um sistema de liberação transdérmica de medicamento, que acentua a liberação do medicamento, compreende uma composição contendo, como um reforçador, um ou mais C~ 5~ a C~ 21~ ésteres de ácido graxo de ácido glicórico e seus sais. Estas composições são compostas de uma quantidade segura de um permeante farmacêutico ativo contido em num veículo de intensificação da penetração, compreendendo de 0,25 a 50% em peso do acentuador de éster de ácido graxos em um veículo portador adequado. Estes reforçadores de éster de ácido glicórico de ácidos graxos podem ser usados em vários veículos portadores para acentuar a liberação transdérmica dos permeantes ativos, ou na forma livre ou usado em um dispositivo oclusivo, particularmente em um emplastro transdérmico na forma de matriz ou de reservatório. Quando usado na forma de emplastro de matriz, os reforçadores de éster de ácido glicórico de ácidos graxos e os permeantes são incorporados em um adesivo biocompatível. quando usado em um emplastro tipo reservatório, o permeante e os reforçadores de éster de ácido glicórico de ácidos graxos são incorporados em um fluido portador de viscosidade controlada, tal como um gel ou um unguento, preferivelmente contendo um alcanol inferior e água. Na forma livre o reforçador e o permeante podem ser incorporados em um unguento, loção, creme ou formulação similar.
BR9713492-9A 1996-10-30 1997-10-29 ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação BR9713492A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74107196A 1996-10-30 1996-10-30
PCT/US1997/019600 WO1998018416A1 (en) 1996-10-30 1997-10-29 Fatty acid esters of glycolic acid and its salts as permeation enhancers

Publications (1)

Publication Number Publication Date
BR9713492A true BR9713492A (pt) 2000-02-29

Family

ID=24979259

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9712474-5A BR9712474A (pt) 1996-10-30 1997-10-29 •steres de ácido graxo de sais de ácido láctico como melhoradores de permeação
BR9713492-9A BR9713492A (pt) 1996-10-30 1997-10-29 ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9712474-5A BR9712474A (pt) 1996-10-30 1997-10-29 •steres de ácido graxo de sais de ácido láctico como melhoradores de permeação

Country Status (10)

Country Link
US (2) US5912009A (pt)
EP (2) EP0942697A1 (pt)
JP (2) JP2001503062A (pt)
KR (2) KR20000035800A (pt)
CN (2) CN1231593A (pt)
AU (2) AU717183B2 (pt)
BR (2) BR9712474A (pt)
CA (2) CA2263300A1 (pt)
WO (2) WO1998018416A1 (pt)
ZA (2) ZA979771B (pt)

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Also Published As

Publication number Publication date
AU5157098A (en) 1998-05-22
AU717183B2 (en) 2000-03-16
ZA979765B (en) 1998-05-22
US5912009A (en) 1999-06-15
CN1231592A (zh) 1999-10-13
KR20000035800A (ko) 2000-06-26
AU5240998A (en) 1998-05-22
ZA979771B (en) 1998-05-22
JP2001503062A (ja) 2001-03-06
BR9712474A (pt) 1999-10-26
AU718811B2 (en) 2000-04-20
EP0971662A1 (en) 2000-01-19
CA2263300A1 (en) 1998-05-07
JP2001503749A (ja) 2001-03-21
US5952000A (en) 1999-09-14
CA2263334A1 (en) 1998-05-07
KR20000035801A (ko) 2000-06-26
EP0942697A1 (en) 1999-09-22
WO1998018416A1 (en) 1998-05-07
WO1998018417A1 (en) 1998-05-07
CN1231593A (zh) 1999-10-13

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