BR9712548A - Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal. - Google Patents
Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal.Info
- Publication number
- BR9712548A BR9712548A BR9712548-2A BR9712548A BR9712548A BR 9712548 A BR9712548 A BR 9712548A BR 9712548 A BR9712548 A BR 9712548A BR 9712548 A BR9712548 A BR 9712548A
- Authority
- BR
- Brazil
- Prior art keywords
- fetal
- erythrocyte
- identifying
- kit
- erythroblastic cell
- Prior art date
Links
- 230000001605 fetal effect Effects 0.000 title abstract 8
- 210000004027 cell Anatomy 0.000 title abstract 5
- 210000003924 normoblast Anatomy 0.000 title abstract 4
- 150000007523 nucleic acids Chemical group 0.000 title abstract 4
- 210000004369 blood Anatomy 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002449 erythroblastic effect Effects 0.000 title 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 210000003743 erythrocyte Anatomy 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 108091005461 Nucleic proteins Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"PROCESSO PARA IDENTIFICAR UMA CéLULA ERITRóCITA OU ERITROBLáSTCA FETAL EM UMA AMOSTRA SANGUìNEA, KIT PARA IDENTIFICAçãO DE UMA CéLULA ERITRóCITA OU ERITROBLáSTICA NUCLEADA FETAL, E, KIT PARA SELEçãO OU ISOLAMENTO DE UMA SEQUêNCIA DE áCIDO NUCLéICO DENTRO DE UMA CéLULA ERITRóCITA NUCLEADA FETAL". é descrito um processo in vitro de identificação ou de isolamento de células fetais de uma amostra sanguínea. Eritrócitos ou eritroblastos nucleados fetais são identificados pelo uso de um anticorpo ou de um fragmento de anticorpo específico para hemoglobina embriónica ou uma cadeia de hemoglobina embriónica. Tendo sido identicadas as células fetais, elas podem ser tratadas para tornar disponíveis as proteínas ou os ácidos nucléicos fetais para a identificação ou a amplificação. Detecção da ocorrência ou da existência de proteínas ou ácidos nucléicos fetais selecionados permite um diagnóstico qualitativo ou quantitativo ou uma avaliação pré-natal, incluindo a determinação do sexo do feto, a determinação de anormalidades cromossómicas, de único gene ou de proteína, e a determinação da presenção ou da ausência de específicos genes, sequências de ácidos nucleícos ou de proteínas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/734,556 US5731156A (en) | 1996-10-21 | 1996-10-21 | Use of anti-embryonic hemoglobin antibodies to identify fetal cells |
PCT/US1997/019447 WO1998018005A1 (en) | 1996-10-21 | 1997-10-20 | Use of anti-embryonic hemoglobin antibodies to identify fetal cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712548A true BR9712548A (pt) | 1999-12-21 |
Family
ID=24952172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712548-2A BR9712548A (pt) | 1996-10-21 | 1997-10-20 | Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5731156A (pt) |
EP (1) | EP1007965B1 (pt) |
JP (1) | JP4091123B2 (pt) |
KR (1) | KR100523381B1 (pt) |
CN (1) | CN1234117A (pt) |
AT (1) | ATE290210T1 (pt) |
AU (1) | AU735380B2 (pt) |
BR (1) | BR9712548A (pt) |
CA (1) | CA2269327A1 (pt) |
DE (1) | DE69732662T2 (pt) |
HK (1) | HK1031255A1 (pt) |
IL (1) | IL129382A (pt) |
RU (1) | RU2178703C2 (pt) |
WO (1) | WO1998018005A1 (pt) |
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JP2002514762A (ja) * | 1998-05-09 | 2002-05-21 | アイコニシス,インコーポレーテッド | コンピュータによって制御された、胎児細胞を含む希少細胞に基づく診断のための方法および装置 |
FR2781055B1 (fr) * | 1998-07-09 | 2000-10-13 | Immunotech Sa | Reactif et methode pour la permeabilisation et l'identification des erythrocytes |
AU4745200A (en) * | 1999-05-25 | 2000-12-12 | Britta Christensen | Isolation and culturing of fetal cells |
US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
DE10035433C2 (de) * | 2000-07-20 | 2002-07-18 | Tuma Wolfgang | Schonende Hochanreicherung von fetalen Zellen aus pripherem Blut und Verwendung derselben |
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US20070059719A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Business methods for prenatal Diagnosis |
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CN104977284B (zh) * | 2015-07-03 | 2018-05-29 | 石莹 | 一种胎儿有核红细胞的捕获及鉴定方法 |
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CN109115584A (zh) * | 2018-09-10 | 2019-01-01 | 首都医科大学附属北京妇产医院 | 一种检测红细胞中血红蛋白f的检测试剂及其应用 |
JP7559043B2 (ja) | 2019-07-15 | 2024-10-01 | エー. メナリニ バイオマーカーズ シンガポール プライベート リミテッド | 胎児細胞を単離、検出及び解析する組成物及び方法 |
CN111948404B (zh) * | 2020-08-03 | 2023-04-07 | 融智生物科技(青岛)有限公司 | 用于筛查地中海贫血的特征蛋白标记组合物、质谱模型及其应用 |
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---|---|---|---|---|
EP0500727B1 (en) * | 1989-11-13 | 1998-01-21 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal dna |
WO1994002646A1 (en) * | 1992-07-17 | 1994-02-03 | Aprogenex Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
US5457024A (en) * | 1993-01-22 | 1995-10-10 | Aprogenex, Inc. | Isolation of fetal erythrocytes |
AU7474394A (en) * | 1993-07-19 | 1995-02-20 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
US5580724A (en) * | 1994-03-25 | 1996-12-03 | Board Of Regents, The University Of Texas System | Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis |
-
1996
- 1996-10-21 US US08/734,556 patent/US5731156A/en not_active Expired - Lifetime
-
1997
- 1997-10-20 IL IL12938297A patent/IL129382A/en not_active IP Right Cessation
- 1997-10-20 CN CN97199005A patent/CN1234117A/zh active Pending
- 1997-10-20 DE DE69732662T patent/DE69732662T2/de not_active Expired - Fee Related
- 1997-10-20 AT AT97911938T patent/ATE290210T1/de not_active IP Right Cessation
- 1997-10-20 EP EP97911938A patent/EP1007965B1/en not_active Expired - Lifetime
- 1997-10-20 CA CA002269327A patent/CA2269327A1/en not_active Abandoned
- 1997-10-20 AU AU49200/97A patent/AU735380B2/en not_active Ceased
- 1997-10-20 WO PCT/US1997/019447 patent/WO1998018005A1/en active IP Right Grant
- 1997-10-20 JP JP51969498A patent/JP4091123B2/ja not_active Expired - Fee Related
- 1997-10-20 KR KR10-1999-7003439A patent/KR100523381B1/ko not_active IP Right Cessation
- 1997-10-20 RU RU99110373/14A patent/RU2178703C2/ru not_active IP Right Cessation
- 1997-10-20 BR BR9712548-2A patent/BR9712548A/pt not_active Application Discontinuation
-
2000
- 2000-12-14 HK HK00108086A patent/HK1031255A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100523381B1 (ko) | 2005-10-24 |
ATE290210T1 (de) | 2005-03-15 |
EP1007965A4 (en) | 2000-06-14 |
HK1031255A1 (en) | 2001-06-08 |
CA2269327A1 (en) | 1998-04-30 |
IL129382A0 (en) | 2000-02-17 |
DE69732662T2 (de) | 2005-12-29 |
EP1007965A1 (en) | 2000-06-14 |
AU4920097A (en) | 1998-05-15 |
US5731156A (en) | 1998-03-24 |
KR20000052662A (ko) | 2000-08-25 |
AU735380B2 (en) | 2001-07-05 |
JP4091123B2 (ja) | 2008-05-28 |
DE69732662D1 (de) | 2005-04-07 |
JP2001502805A (ja) | 2001-02-27 |
IL129382A (en) | 2002-09-12 |
WO1998018005A1 (en) | 1998-04-30 |
EP1007965B1 (en) | 2005-03-02 |
CN1234117A (zh) | 1999-11-03 |
RU2178703C2 (ru) | 2002-01-27 |
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