BR9507281A - Composição farmacêutica que possui uma atividade bio-afetante selecionada do grupo constituido por atividade antiinflamatória e atividade anti-tumores composição farmacêutica que possui atividade anti-tumores composto permanentemente iônico método para o tratamento de condições inflamatórias método para o tratamento de deficiências hormonais método para o tratamento de tumores método para o tratamento de câncer dos seios ovários e próstata método para impedir ou retardar o crescimento de câncer células malignas ou neoplasmas método para reduzir ou impedir a metástase de células cancerosas - Google Patents

Composição farmacêutica que possui uma atividade bio-afetante selecionada do grupo constituido por atividade antiinflamatória e atividade anti-tumores composição farmacêutica que possui atividade anti-tumores composto permanentemente iônico método para o tratamento de condições inflamatórias método para o tratamento de deficiências hormonais método para o tratamento de tumores método para o tratamento de câncer dos seios ovários e próstata método para impedir ou retardar o crescimento de câncer células malignas ou neoplasmas método para reduzir ou impedir a metástase de células cancerosas

Info

Publication number
BR9507281A
BR9507281A BR9507281A BR9507281A BR9507281A BR 9507281 A BR9507281 A BR 9507281A BR 9507281 A BR9507281 A BR 9507281A BR 9507281 A BR9507281 A BR 9507281A BR 9507281 A BR9507281 A BR 9507281A
Authority
BR
Brazil
Prior art keywords
treatment
activity
pharmaceutical composition
cancer
prevent
Prior art date
Application number
BR9507281A
Other languages
English (en)
Inventor
Anat Biegon
Marcus Brewster
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp filed Critical Pharmos Corp
Publication of BR9507281A publication Critical patent/BR9507281A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
BR9507281A 1994-04-04 1995-03-31 Composição farmacêutica que possui uma atividade bio-afetante selecionada do grupo constituido por atividade antiinflamatória e atividade anti-tumores composição farmacêutica que possui atividade anti-tumores composto permanentemente iônico método para o tratamento de condições inflamatórias método para o tratamento de deficiências hormonais método para o tratamento de tumores método para o tratamento de câncer dos seios ovários e próstata método para impedir ou retardar o crescimento de câncer células malignas ou neoplasmas método para reduzir ou impedir a metástase de células cancerosas BR9507281A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/223,074 US5650425A (en) 1994-04-04 1994-04-04 Permanently ionic derivatives of steroid hormones and their antagonists
PCT/US1995/003941 WO1995026720A1 (en) 1994-04-04 1995-03-31 Permanently ionic derivatives of steroid hormones and their antagonists

Publications (1)

Publication Number Publication Date
BR9507281A true BR9507281A (pt) 1997-09-23

Family

ID=22834909

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507281A BR9507281A (pt) 1994-04-04 1995-03-31 Composição farmacêutica que possui uma atividade bio-afetante selecionada do grupo constituido por atividade antiinflamatória e atividade anti-tumores composição farmacêutica que possui atividade anti-tumores composto permanentemente iônico método para o tratamento de condições inflamatórias método para o tratamento de deficiências hormonais método para o tratamento de tumores método para o tratamento de câncer dos seios ovários e próstata método para impedir ou retardar o crescimento de câncer células malignas ou neoplasmas método para reduzir ou impedir a metástase de células cancerosas

Country Status (11)

Country Link
US (1) US5650425A (pt)
EP (1) EP0754036A4 (pt)
JP (1) JPH09511506A (pt)
KR (1) KR100370258B1 (pt)
AU (1) AU695941B2 (pt)
BR (1) BR9507281A (pt)
CA (1) CA2186604A1 (pt)
HU (1) HUT76061A (pt)
IL (1) IL113249A (pt)
NZ (1) NZ283648A (pt)
WO (1) WO1995026720A1 (pt)

Families Citing this family (29)

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US6028103A (en) * 1994-09-16 2000-02-22 Children's Medical Center Corporation Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation
BR9708230A (pt) 1996-03-20 2000-01-04 Harvard College Compostos de triaril metano, composição farmacêutica, e métodos de inibição do transporte de potássio ativado por cálcio de uma célula, para reduzir a desidrataçào de eritrócito falciforme e/ou retaradar a ocorrência de afoiçamento ou deformação de eritrócitos, e tratamento ou prevenção de doença, de inibição da proliferação celular em mamìferos, e de tratamento ou prevenção de uma desordem.
US5889038A (en) 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
CA2280181A1 (en) * 1997-02-09 1998-08-13 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
US6800658B2 (en) 1997-11-20 2004-10-05 Children's Medical Center Corporation Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
US6992079B2 (en) 1997-11-20 2006-01-31 President Fellows of Harvard College Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
DE69838002T2 (de) 1997-11-20 2008-03-06 President And Fellows Of Harvard College, Cambridge Substituierte 11-phenyl-dibenzazepin-verbindungen, die nützlich sind zur behandlung oder vorbeugung von durch abnormale zellproliferation gekennzeichneten krankheiten
US6291449B1 (en) 1998-09-23 2001-09-18 Children's Medical Center Corporation Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
US20040092602A1 (en) * 1998-05-07 2004-05-13 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
EP2277514A1 (en) * 1998-05-07 2011-01-26 The University Of Tennessee Research Corporation A method for chemoprevention of prostate cancer
US20030130316A1 (en) * 2000-03-20 2003-07-10 Steiner Mitchell S. Method for chemoprevention of prostate cancer
US6413534B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US20040186185A1 (en) * 1998-05-07 2004-09-23 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US6632447B1 (en) 1998-05-07 2003-10-14 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US6413533B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US6258826B1 (en) * 1998-10-13 2001-07-10 Eli Lilly And Company Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome
JP2000119187A (ja) * 1998-10-15 2000-04-25 Taisho Pharmaceut Co Ltd 抑うつ気分の予防または改善用組成物
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6599921B2 (en) 2001-02-22 2003-07-29 Nanodesign, Inc. Non-steroidal estrogen receptor ligands
AU2002318225B2 (en) * 2001-07-09 2007-12-13 Repros Therapeutics Inc. Methods and materials for the treatment of testosterone deficiency in men
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US7090868B2 (en) * 2002-09-13 2006-08-15 University Of Florida Materials and methods for drug delivery and uptake
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
KR101505884B1 (ko) 2006-05-22 2015-03-25 호르모스 메디칼 리미티드 만성 비세균성 전립선염 치료용 선택적 에스트로겐 수용체 조절제 또는 아로마타아제 저해제
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
SI2121553T1 (sl) 2007-02-14 2012-11-30 Hormos Medical Ltd Postopek za pripravo terapevtsko uporabnih trifenilbutenskih derivatov
US9321712B2 (en) 2012-10-19 2016-04-26 Fermion Oy Process for the preparation of ospemifene
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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US2914561A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethylene
US2914564A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of 1, 1, 2-triphenylethane
US2914562A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethanol
US2971001A (en) * 1959-10-21 1961-02-07 Wm S Merrell Co Quaternary salts of triphenylethanols, -ethylenes, and -ethanes
BE637389A (pt) * 1962-09-13
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB2160202B (en) * 1984-06-12 1987-12-02 Nat Res Dev Preparation of tamoxifen
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
EP0287690B1 (de) * 1987-04-21 1992-09-02 HEUMANN PHARMA GMBH & CO Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en
US4990538A (en) * 1989-08-23 1991-02-05 Harris Adrian L Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
US5219548A (en) * 1990-10-01 1993-06-15 Board Of Regents, The University Of Texas System High affinity halogenated-tamoxifen derivatives and uses thereof
JPH06504522A (ja) * 1990-10-01 1994-05-26 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 高親和性タモキシフェン誘導体とその使用

Also Published As

Publication number Publication date
WO1995026720A1 (en) 1995-10-12
KR970702032A (ko) 1997-05-13
IL113249A (en) 2003-01-12
US5650425A (en) 1997-07-22
AU2201795A (en) 1995-10-23
EP0754036A1 (en) 1997-01-22
KR100370258B1 (ko) 2003-05-12
CA2186604A1 (en) 1995-10-12
EP0754036A4 (en) 2003-03-19
HU9602723D0 (en) 1996-11-28
HUT76061A (en) 1997-06-30
AU695941B2 (en) 1998-08-27
JPH09511506A (ja) 1997-11-18
IL113249A0 (en) 1995-07-31
NZ283648A (en) 1997-12-19

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B25G Requested change of headquarter approved

Owner name: PHARMOS CORPORATION (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 055904/RJ DE 09/10/2002.