IL113249A - Permanently ionic derivatives of steroid hormones and their antagonists - Google Patents
Permanently ionic derivatives of steroid hormones and their antagonistsInfo
- Publication number
- IL113249A IL113249A IL11324995A IL11324995A IL113249A IL 113249 A IL113249 A IL 113249A IL 11324995 A IL11324995 A IL 11324995A IL 11324995 A IL11324995 A IL 11324995A IL 113249 A IL113249 A IL 113249A
- Authority
- IL
- Israel
- Prior art keywords
- antagonists
- steroid hormones
- ionic derivatives
- permanently ionic
- permanently
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/223,074 US5650425A (en) | 1994-04-04 | 1994-04-04 | Permanently ionic derivatives of steroid hormones and their antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
IL113249A0 IL113249A0 (en) | 1995-07-31 |
IL113249A true IL113249A (en) | 2003-01-12 |
Family
ID=22834909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11324995A IL113249A (en) | 1994-04-04 | 1995-04-04 | Permanently ionic derivatives of steroid hormones and their antagonists |
Country Status (11)
Country | Link |
---|---|
US (1) | US5650425A (xx) |
EP (1) | EP0754036A4 (xx) |
JP (1) | JPH09511506A (xx) |
KR (1) | KR100370258B1 (xx) |
AU (1) | AU695941B2 (xx) |
BR (1) | BR9507281A (xx) |
CA (1) | CA2186604A1 (xx) |
HU (1) | HUT76061A (xx) |
IL (1) | IL113249A (xx) |
NZ (1) | NZ283648A (xx) |
WO (1) | WO1995026720A1 (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028103A (en) * | 1994-09-16 | 2000-02-22 | Children's Medical Center Corporation | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation |
US5889038A (en) | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
ATE314060T1 (de) * | 1996-03-20 | 2006-01-15 | Harvard College | Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom |
JP2001511182A (ja) * | 1997-02-09 | 2001-08-07 | ファーモス コーポレイション | ステロイドホルモンの永久に荷電された誘導体の増進された抗血管形成誘導活性 |
US6800658B2 (en) | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
US6291449B1 (en) | 1998-09-23 | 2001-09-18 | Children's Medical Center Corporation | Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours |
MXPA00005035A (es) | 1997-11-20 | 2002-10-11 | Harvard College | Compuestos de 11-difenil-dibenzazepina substituidos utiles para el tratamiento o prevencion de enfermedades caracterizadas por proliferacion celular anormal. |
US6992079B2 (en) | 1997-11-20 | 2006-01-31 | President Fellows of Harvard College | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
US20030130316A1 (en) * | 2000-03-20 | 2003-07-10 | Steiner Mitchell S. | Method for chemoprevention of prostate cancer |
US20040092602A1 (en) * | 1998-05-07 | 2004-05-13 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
US20040176470A1 (en) * | 1998-05-07 | 2004-09-09 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
CA2323809C (en) * | 1998-05-07 | 2007-09-18 | The University Of Tennessee Research Corporation | A method for chemoprevention of prostate cancer |
US6413534B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
US6632447B1 (en) | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
US6087378A (en) * | 1998-10-13 | 2000-07-11 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
JP2000119187A (ja) * | 1998-10-15 | 2000-04-25 | Taisho Pharmaceut Co Ltd | 抑うつ気分の予防または改善用組成物 |
TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
US6599921B2 (en) | 2001-02-22 | 2003-07-29 | Nanodesign, Inc. | Non-steroidal estrogen receptor ligands |
BR0211067A (pt) * | 2001-07-09 | 2006-10-31 | Zonagen Inc | métodos e materiais para o tratamento de deficiência de testosterona em homens |
US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
US7090868B2 (en) * | 2002-09-13 | 2006-08-15 | University Of Florida | Materials and methods for drug delivery and uptake |
US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
US20060270641A1 (en) * | 2005-05-31 | 2006-11-30 | Steiner Mitchell S | Method for chemoprevention of prostate cancer |
RU2480207C2 (ru) | 2006-05-22 | 2013-04-27 | Хормос Медикал Лтд. | Способ лечения хронического абактериального простатита селективными модуляторами рецепторов эстрогена или ингибиторами ароматазы |
WO2008099060A2 (en) | 2007-02-14 | 2008-08-21 | Hormos Medical Ltd | Methods for the preparation of fispemifene from ospemifene |
DK2121553T3 (da) | 2007-02-14 | 2012-07-23 | Hormos Medical Ltd | Fremgangsmåde til fremstillingen af terapeutisk værdi-fulde triphenylbutenderivater |
JP6174156B2 (ja) | 2012-10-19 | 2017-08-02 | フェルミオン オサケ ユキチュア | オスペミフェンの製造方法 |
FR3046792B1 (fr) * | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914561A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of triphenylethylene |
US2914564A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of 1, 1, 2-triphenylethane |
US2914562A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of triphenylethanol |
US2971001A (en) * | 1959-10-21 | 1961-02-07 | Wm S Merrell Co | Quaternary salts of triphenylethanols, -ethylenes, and -ethanes |
BE637389A (xx) * | 1962-09-13 | |||
GB2126576B (en) * | 1982-06-25 | 1985-06-19 | Farmos Group Limited | Alkane and alkene derivatives |
EP0168175B1 (en) * | 1984-06-12 | 1987-11-19 | National Research Development Corporation | Preparation of tamoxifen |
US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
EP0287690B1 (de) * | 1987-04-21 | 1992-09-02 | HEUMANN PHARMA GMBH & CO | Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en |
US4990538A (en) * | 1989-08-23 | 1991-02-05 | Harris Adrian L | Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs |
US5219548A (en) * | 1990-10-01 | 1993-06-15 | Board Of Regents, The University Of Texas System | High affinity halogenated-tamoxifen derivatives and uses thereof |
AU664161B2 (en) * | 1990-10-01 | 1995-11-09 | Board Of Regents, The University Of Texas System | High affinity tamoxifen derivatives and uses thereof |
-
1994
- 1994-04-04 US US08/223,074 patent/US5650425A/en not_active Expired - Fee Related
-
1995
- 1995-03-31 JP JP7525829A patent/JPH09511506A/ja not_active Withdrawn
- 1995-03-31 CA CA002186604A patent/CA2186604A1/en not_active Abandoned
- 1995-03-31 BR BR9507281A patent/BR9507281A/pt not_active Application Discontinuation
- 1995-03-31 KR KR1019960705512A patent/KR100370258B1/ko not_active IP Right Cessation
- 1995-03-31 AU AU22017/95A patent/AU695941B2/en not_active Ceased
- 1995-03-31 EP EP95914967A patent/EP0754036A4/en not_active Withdrawn
- 1995-03-31 HU HU9602723A patent/HUT76061A/hu unknown
- 1995-03-31 NZ NZ283648A patent/NZ283648A/en unknown
- 1995-03-31 WO PCT/US1995/003941 patent/WO1995026720A1/en not_active Application Discontinuation
- 1995-04-04 IL IL11324995A patent/IL113249A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0754036A4 (en) | 2003-03-19 |
AU2201795A (en) | 1995-10-23 |
KR970702032A (ko) | 1997-05-13 |
IL113249A0 (en) | 1995-07-31 |
EP0754036A1 (en) | 1997-01-22 |
US5650425A (en) | 1997-07-22 |
HU9602723D0 (en) | 1996-11-28 |
BR9507281A (pt) | 1997-09-23 |
WO1995026720A1 (en) | 1995-10-12 |
JPH09511506A (ja) | 1997-11-18 |
NZ283648A (en) | 1997-12-19 |
KR100370258B1 (ko) | 2003-05-12 |
CA2186604A1 (en) | 1995-10-12 |
AU695941B2 (en) | 1998-08-27 |
HUT76061A (en) | 1997-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
NE | Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967) | ||
MM9K | Patent not in force due to non-payment of renewal fees |