DE69828042D1 - Verfahren und zusammensetzung zur behandlung von krebs - Google Patents
Verfahren und zusammensetzung zur behandlung von krebsInfo
- Publication number
- DE69828042D1 DE69828042D1 DE1998628042 DE69828042T DE69828042D1 DE 69828042 D1 DE69828042 D1 DE 69828042D1 DE 1998628042 DE1998628042 DE 1998628042 DE 69828042 T DE69828042 T DE 69828042T DE 69828042 D1 DE69828042 D1 DE 69828042D1
- Authority
- DE
- Germany
- Prior art keywords
- composition
- cancer
- treatment
- preventing
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/857,413 US5962527A (en) | 1995-03-21 | 1997-05-16 | Method and composition for treating cancers |
US857413 | 1997-05-16 | ||
PCT/US1998/009703 WO1998051294A2 (en) | 1997-05-16 | 1998-05-14 | Method and composition for treating cancers |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69828042D1 true DE69828042D1 (de) | 2005-01-13 |
DE69828042T2 DE69828042T2 (de) | 2006-04-13 |
Family
ID=25325942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69828042T Expired - Fee Related DE69828042T2 (de) | 1997-05-16 | 1998-05-14 | Verfahren und zusammensetzung zur behandlung von krebs |
Country Status (6)
Country | Link |
---|---|
US (1) | US5962527A (de) |
EP (2) | EP0981342B1 (de) |
AT (1) | ATE284210T1 (de) |
CA (1) | CA2289684A1 (de) |
DE (1) | DE69828042T2 (de) |
WO (1) | WO1998051294A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869535A (en) * | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
EP1473301A3 (de) * | 1997-06-04 | 2005-01-26 | Cornell Research Foundation, Inc. | Betulinol-Derivate |
US6228850B1 (en) * | 1997-09-30 | 2001-05-08 | Dabur Research Foundation | Antiangiogenic activity of betulinic acid and its derivatives |
US6670345B1 (en) * | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
US6369109B1 (en) * | 1998-10-28 | 2002-04-09 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor |
WO2000046235A1 (en) * | 1998-11-18 | 2000-08-10 | Dabur Research Foundation | Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors |
DE69917684T2 (de) * | 1999-09-09 | 2005-07-21 | Dabur Research Foundation, Sahibabad | Betulinsäure-derivate mit antiangiogener wirkung, verfahren zur herstellung solcher derivate und deren verwendung für die behandlung tumorassoziierter angiogenese |
GB0012528D0 (en) | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
WO2001090046A1 (en) * | 2000-05-23 | 2001-11-29 | Univerzita Palackeho V Olomouci | Triterpenoid derivatives |
CN1450900A (zh) * | 2000-07-31 | 2003-10-22 | 日清奥利友株式会社 | 抗肿瘤剂 |
NZ524087A (en) * | 2000-08-18 | 2004-08-27 | Univ Illinois | Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV |
US6428823B1 (en) | 2001-03-28 | 2002-08-06 | Council Of Scientific & Industrial Research | Biologically active aqueous fraction of an extract obtained from a mangrove plant Salvadora persica L |
US20030003171A1 (en) | 2001-03-28 | 2003-01-02 | Usha Goswami | Biologically active chloroform fraction of an extract obtained from a mangroone plant Salvadora persica L |
AU2002307217A1 (en) | 2001-03-28 | 2002-10-15 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
AU2002367429A1 (en) * | 2001-12-28 | 2003-07-24 | The Nisshin Oillio, Ltd. | Apoptosis inductor |
US20060147420A1 (en) * | 2004-03-10 | 2006-07-06 | Juan Fueyo | Oncolytic adenovirus armed with therapeutic genes |
ATE420099T1 (de) * | 2003-02-11 | 2009-01-15 | Novelix Pharmaceuticals Inc | Medikament zur wachstumsinhibierung von tumoren |
KR100659771B1 (ko) | 2003-04-04 | 2006-12-20 | 학교법인 현동학원 | 한국산 겨우살이 유기추출물로부터 항암 화합물 베루틴과베투린 산의 정제 및 이 추출물의 제조방법 |
US7026305B2 (en) * | 2003-04-14 | 2006-04-11 | Meharry Medical College | Anti-HIV agents with dual sites of action |
KR100559489B1 (ko) * | 2003-08-05 | 2006-03-10 | 한국생명공학연구원 | 대추 추출물 및 그로부터 분리된 화합물을 유효성분으로함유하는 항암제 및 암전이 억제제 |
US8618082B2 (en) * | 2004-03-02 | 2013-12-31 | Wisconsin Alumni Research Foundation | Lupeol anti-tumor agent and uses thereof |
US20080227762A1 (en) * | 2004-03-02 | 2008-09-18 | Wisconsin Alumni Research Foundation | Lupeol anti-tumor agent and uses thereof |
US7282521B2 (en) * | 2004-05-24 | 2007-10-16 | University Of North Carolina At Chapel Hill | Anti-retroviral moronic acid derivatives |
US20060252733A1 (en) * | 2005-04-07 | 2006-11-09 | Novelix Pharmaceuticals, Inc. | Betulin, betulin derivatives, betulinic acid and betulinic acid derivatives as novel therapeutics in the treatment of disease of lipid and/or glucose metabolism |
US20070191490A1 (en) * | 2006-02-02 | 2007-08-16 | Sebti Said M | Withacnistin compounds for treatment of cancer |
WO2012106190A1 (en) | 2011-01-31 | 2012-08-09 | Bristol-Myers Squibb Company | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
US20110077297A1 (en) * | 2008-05-30 | 2011-03-31 | Novelix Pharmaceuticals, Inc. | Compositions and methods for treatment of inflammation and hyperkeratotic lesions |
US20100104669A1 (en) * | 2008-10-28 | 2010-04-29 | Scheffler Armin | Method for preparing an aqueous solution containing triterpenic acid, aqueous solution containing triterpenic acid, and use thereof |
ES2612452T3 (es) | 2010-06-04 | 2017-05-17 | VIIV Healthcare UK (No.5) Limited | Derivados de ácido betulínico C-3 modificados como inhibidores de la maduración del VIH |
US8802661B2 (en) | 2010-06-04 | 2014-08-12 | Bristol-Myers Squibb Company | C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors |
PT2670764E (pt) | 2011-01-31 | 2015-11-20 | Bristol Myers Squibb Co | C-28 aminas de derivados de ácido betulínico c-3 modificado como inibidores de maturação de vih |
ES2611727T3 (es) | 2011-09-21 | 2017-05-10 | VIIV Healthcare UK (No.5) Limited | Derivados de ácido betulínico novedosos con actividad antivírica |
US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
CN104910239B (zh) * | 2014-03-14 | 2018-12-07 | 中国科学院上海药物研究所 | 五环三萜类化合物及其制备方法、药物组合物和用途 |
CN104910238B (zh) * | 2014-03-14 | 2017-08-11 | 中国科学院上海药物研究所 | 一类五环三萜类化合物及其在制备治疗阿尔兹海默病的药物中的用途 |
US9808011B2 (en) | 2014-12-15 | 2017-11-07 | Biovectra Inc. | Pentacyclic triterpene compounds and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
US5643884A (en) * | 1993-08-09 | 1997-07-01 | Glycomed Incorporated | Lupane triterpenoid derivatives |
US5658947A (en) * | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
US5869535A (en) * | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
US5679828A (en) * | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
DE19532006A1 (de) * | 1995-08-31 | 1997-03-06 | Thomas Samland | Medizinisches bzw. kosmetisches Präparat zur Vermeidung bzw. Abbau von Hautkrebs |
JPH0987156A (ja) * | 1995-09-19 | 1997-03-31 | Pola Chem Ind Inc | 光老化防止剤及び皮膚化粧料 |
US6670345B1 (en) * | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
DE69832363D1 (de) * | 1998-03-18 | 2005-12-22 | Dabur Pharma Ltd | Betulinsauer Derivate zur Hemmung von Krebswachstum |
-
1997
- 1997-05-16 US US08/857,413 patent/US5962527A/en not_active Expired - Lifetime
-
1998
- 1998-05-14 WO PCT/US1998/009703 patent/WO1998051294A2/en active IP Right Grant
- 1998-05-14 DE DE69828042T patent/DE69828042T2/de not_active Expired - Fee Related
- 1998-05-14 EP EP98924758A patent/EP0981342B1/de not_active Expired - Lifetime
- 1998-05-14 EP EP04024256A patent/EP1495754A3/de not_active Withdrawn
- 1998-05-14 AT AT98924758T patent/ATE284210T1/de not_active IP Right Cessation
- 1998-05-14 CA CA002289684A patent/CA2289684A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69828042T2 (de) | 2006-04-13 |
CA2289684A1 (en) | 1998-11-19 |
US5962527A (en) | 1999-10-05 |
EP0981342B1 (de) | 2004-12-08 |
WO1998051294A3 (en) | 1999-04-01 |
EP1495754A2 (de) | 2005-01-12 |
ATE284210T1 (de) | 2004-12-15 |
EP0981342A2 (de) | 2000-03-01 |
EP1495754A3 (de) | 2009-07-29 |
WO1998051294A2 (en) | 1998-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |