BR9105718A - Conjugados de hidroxiapatita-antigeno e metodos para a geracao de uma resposta poli-ig imune - Google Patents

Conjugados de hidroxiapatita-antigeno e metodos para a geracao de uma resposta poli-ig imune

Info

Publication number
BR9105718A
BR9105718A BR919105718A BR9105718A BR9105718A BR 9105718 A BR9105718 A BR 9105718A BR 919105718 A BR919105718 A BR 919105718A BR 9105718 A BR9105718 A BR 9105718A BR 9105718 A BR9105718 A BR 9105718A
Authority
BR
Brazil
Prior art keywords
hydroxyapatite
immune
poly
generation
response
Prior art date
Application number
BR919105718A
Other languages
English (en)
Inventor
Jean-Pierre Kraehenbuhl
Helen M Amerongen
Marian R Neutra
Original Assignee
Harvard College
Suisse Rech Experiment
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Suisse Rech Experiment filed Critical Harvard College
Publication of BR9105718A publication Critical patent/BR9105718A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
BR919105718A 1990-04-16 1991-04-16 Conjugados de hidroxiapatita-antigeno e metodos para a geracao de uma resposta poli-ig imune BR9105718A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/510,154 US5443832A (en) 1990-04-16 1990-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
PCT/US1991/002599 WO1991016072A1 (en) 1990-04-16 1991-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-ig immune response

Publications (1)

Publication Number Publication Date
BR9105718A true BR9105718A (pt) 1992-07-21

Family

ID=24029591

Family Applications (1)

Application Number Title Priority Date Filing Date
BR919105718A BR9105718A (pt) 1990-04-16 1991-04-16 Conjugados de hidroxiapatita-antigeno e metodos para a geracao de uma resposta poli-ig imune

Country Status (16)

Country Link
US (2) US5443832A (pt)
EP (1) EP0477339B1 (pt)
JP (1) JPH04507106A (pt)
KR (1) KR100188836B1 (pt)
AT (1) ATE144428T1 (pt)
AU (1) AU643011B2 (pt)
BG (1) BG60371B1 (pt)
BR (1) BR9105718A (pt)
CA (1) CA2060318A1 (pt)
DE (1) DE69122828T2 (pt)
HU (1) HU216103B (pt)
OA (1) OA09525A (pt)
RO (1) RO109817B1 (pt)
RU (1) RU2126270C1 (pt)
WO (1) WO1991016072A1 (pt)
ZA (1) ZA912838B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6440425B1 (en) 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US6290970B1 (en) 1995-10-11 2001-09-18 Aventis Pasteur Limited Transferrin receptor protein of Moraxella
AU733712B2 (en) * 1996-06-21 2001-05-24 Synsorb Biotech Inc. Use of oligosaccharides for neutralising E. coli toxins
JPH107575A (ja) * 1996-06-21 1998-01-13 Synsorb Biotec Inc 細菌性赤痢の処置
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
CA2361377C (en) * 1999-02-05 2009-02-03 Alk-Abello A/S Novel mucosal delivery system
US20020051794A1 (en) * 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
AU2006204620B2 (en) * 2000-09-14 2008-05-29 Px Biosolutions Pty Ltd Composition comprising immunogenic nanoparticles
AUPR011700A0 (en) * 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
AU2002248289A1 (en) * 2000-10-20 2002-09-04 Etex Corporation Chemotherapeutic composition using calcium phosphate paste
AU2004229502C1 (en) * 2003-04-11 2011-02-24 Etex Corporation Osteoinductive bone material
JP4982084B2 (ja) * 2004-02-09 2012-07-25 株式会社サンギ 抗腫瘍剤
WO2005100398A1 (ja) * 2004-04-14 2005-10-27 Bio Matrix Research Inc. 抗体ライブラリー作製方法
WO2005117919A2 (en) * 2004-04-15 2005-12-15 Etex Corporation Delayed-setting calcium phosphate pastes
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
RU2357758C2 (ru) * 2004-10-07 2009-06-10 Кабусики Кайся Санги Препараты для чрескожной и чресслизистой доставки
WO2006109635A1 (ja) * 2005-04-06 2006-10-19 Kabushiki Kaisha Sangi 腸管吸収用抗腫瘍剤
FR2885525B1 (fr) * 2005-05-13 2009-09-18 Urodelia Sa Medicament notamment anti-cancereux, destine a des traitements par immunotherapie, en particulier autologue
US20090035326A1 (en) * 2005-11-01 2009-02-05 Novartis Ag Compositions with antigens adsorbed to calcium phosphate
US8697087B2 (en) 2005-11-04 2014-04-15 Novartis Ag Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
CA2710480A1 (en) * 2007-12-24 2009-07-02 Novartis Ag Assays for adsorbed influenza vaccines
GB201319548D0 (en) 2013-11-05 2013-12-18 Medical Res Council Amorphous magnesium-substituted calcium phosphate compositions and their uses
TWI654993B (zh) * 2016-11-04 2019-04-01 National Health Research Institutes 陽離子型生物可降解性陶瓷聚合物微粒子用以遞送疫苗之用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3599150A (en) * 1969-08-01 1971-08-10 Miles Lab Stabilized aluminum hydroxide suspensions
US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
JPS59101145A (ja) * 1982-11-30 1984-06-11 日本特殊陶業株式会社 薬液含浸多孔質セラミツクス
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
EP0231039B1 (en) * 1986-01-14 1992-01-08 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Process for preparing immunological complexes and pharmaceutical composition containing these complexes
JPS62248487A (ja) * 1986-04-22 1987-10-29 Dentaru Kagaku Kk グルカナーゼを固定化したアパタイトおよびその製造法
JPS63196281A (ja) * 1987-02-12 1988-08-15 Sumitomo Electric Ind Ltd 細胞培養用基材
US5008116A (en) * 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
CN1057785A (zh) * 1990-04-16 1992-01-15 哈佛大学校长及研究员协会 合成多聚免疫球蛋白受体，受体-抗体复合物，生产及应用
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response

Also Published As

Publication number Publication date
US6541000B1 (en) 2003-04-01
AU643011B2 (en) 1993-11-04
AU7684991A (en) 1991-11-11
JPH04507106A (ja) 1992-12-10
RO109817B1 (ro) 1995-06-30
HU216103B (hu) 1999-04-28
DE69122828T2 (de) 1997-05-28
EP0477339B1 (en) 1996-10-23
WO1991016072A1 (en) 1991-10-31
KR100188836B1 (ko) 1999-06-01
EP0477339A1 (en) 1992-04-01
HUT63337A (en) 1993-08-30
US5443832A (en) 1995-08-22
KR920702628A (ko) 1992-10-06
BG60371B1 (bg) 1994-11-15
DE69122828D1 (de) 1996-11-28
HU9200135D0 (en) 1992-04-28
ATE144428T1 (de) 1996-11-15
EP0477339A4 (en) 1993-04-21
CA2060318A1 (en) 1991-10-17
ZA912838B (en) 1992-03-25
OA09525A (en) 1992-11-15
RU2126270C1 (ru) 1999-02-20

Similar Documents

Publication Publication Date Title
BR9105718A (pt) Conjugados de hidroxiapatita-antigeno e metodos para a geracao de uma resposta poli-ig imune
EG19304A (en) Method of treating pre-menstrual syndrome
ATE164517T1 (de) Lipid-a-derivate sowie deren verwendungen
GB2149301B (en) Pyridine-soluble extract - refined detoxified endotoxin composition and use
ES2138102T3 (es) Procedimiento para la deteccion de antigeno urinario asociado a tumores.
DE3380053D1 (en) Conjugates of haptenes and muramyl peptides having an immunogenic activity, and compositions containing them
GB9319429D0 (en) Methods and products for controlling immune responses in mammals
FI875015A0 (fi) Vaccin mot juverinflammation.
ES2131308T3 (es) Composiciones y metodos que utilizan el receptor de mpl no ligado para estimular la produccion de plaquetas.
HU9301797D0 (en) Utilization of il-4 for producing pharmaceutical preparatives improving immunoreaction
DE3681036D1 (de) Verfahren und vorrichtung zum einstellen und befestigen eines kuenstlichen beines.
DE68917138T2 (de) Toleranzinduktion gegenüber einem fremdantigen.
EP0293333A3 (en) A synthetic nonapeptide of use as an adjuvant
NO914945L (no) Hydroksyapatit-antigenkonjugater og fremgangsmaater for aa frembringe en poly- ig immunreaksjon
EP0589348A3 (de) Verfahren zur immunchemischen Quantifizierung von inaktivierten, immunreaktiven Antigenen.
YU80389A (en) Process for obtaining pertusis toxoide
WO1990015132A3 (en) Cloned treponema hyodysenteriae endoflagellar antigen
MX9205607A (es) Procedimiento para la preparacion de: griseofulvina
ATE171219T1 (de) Antigenspezifische plasmacytome und davon gewonnene antikörper

Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
B15K Others concerning applications: alteration of classification

Ipc: A61K 39/39 (2006.01), A61K 47/52 (2017.0