ATE164517T1 - Lipid-a-derivate sowie deren verwendungen - Google Patents

Lipid-a-derivate sowie deren verwendungen

Info

Publication number
ATE164517T1
ATE164517T1 AT90911354T AT90911354T ATE164517T1 AT E164517 T1 ATE164517 T1 AT E164517T1 AT 90911354 T AT90911354 T AT 90911354T AT 90911354 T AT90911354 T AT 90911354T AT E164517 T1 ATE164517 T1 AT E164517T1
Authority
AT
Austria
Prior art keywords
lipid
derivatives
rhodopsuedomonas
dpla
lipopolysaccharide
Prior art date
Application number
AT90911354T
Other languages
English (en)
Inventor
Kuni K Takayama
Nilofer Oureshi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/467,449 external-priority patent/US5041427A/en
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE164517T1 publication Critical patent/ATE164517T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT90911354T 1989-07-21 1990-07-23 Lipid-a-derivate sowie deren verwendungen ATE164517T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38383289A 1989-07-21 1989-07-21
US07/467,449 US5041427A (en) 1989-07-21 1990-01-19 Lipid A derivatives
US07/522,446 US5158939A (en) 1989-07-21 1990-05-11 Method of stimulating the immune systems of animals and compositions useful therefor

Publications (1)

Publication Number Publication Date
ATE164517T1 true ATE164517T1 (de) 1998-04-15

Family

ID=27409639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90911354T ATE164517T1 (de) 1989-07-21 1990-07-23 Lipid-a-derivate sowie deren verwendungen

Country Status (9)

Country Link
US (1) US5158939A (de)
EP (1) EP0466838B1 (de)
JP (1) JPH04503363A (de)
AT (1) ATE164517T1 (de)
AU (1) AU6051790A (de)
DE (1) DE69032206T2 (de)
DK (1) DK0466838T3 (de)
ES (1) ES2113861T3 (de)
WO (1) WO1991001134A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9105992D0 (en) * 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
US5530113A (en) * 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
US7189834B2 (en) * 1993-05-11 2007-03-13 Marshall William E Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
US5840318A (en) * 1993-05-11 1998-11-24 Immunom Technologies, Inc. Methods and compositions for modulating immune systems of animals
DK0729473T3 (da) * 1993-11-17 2000-10-30 Deutsche Om Arzneimittel Gmbh Glucosamin-disaccharider, fremgangsmåde til deres fremstilling farmaceutisk sammensætning deraf og deres anvendelse
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5750664A (en) 1995-06-05 1998-05-12 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6649170B1 (en) * 1999-05-12 2003-11-18 Statens Serum Institut Adjuvant combinations for immunization composition and vaccines
IL130087A0 (en) 1999-05-24 2000-02-29 Nova Measuring Instr Ltd Optical inspection method and system
WO2001025254A2 (en) 1999-10-04 2001-04-12 University Of Maryland Biotechnology Institute Novel adjuvant comprising a lipopolysaccharide antagonist
JP4207108B2 (ja) * 2000-02-17 2009-01-14 ティーエフケイ株式会社 健康食品
US7314732B2 (en) * 2000-02-17 2008-01-01 Tfk Inc. Drug and manufacturing method of same
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
CA2449736A1 (en) * 2001-06-11 2002-12-19 Kyowa Hakko Kogyo Co., Ltd. Crystals of oligosaccharides and processes for preparation thereof
WO2003090685A2 (en) * 2002-04-24 2003-11-06 The Regents Of The University Of California Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses
KR100456681B1 (ko) * 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
EP1638581A2 (de) 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Zwitterionische immunomodulatorem zur behandlung von asthma und allergien
EP1644408A1 (de) 2003-07-15 2006-04-12 Barros Research Institute Eimeria tenella-antigen zur immuntherapie von kokzidiose
FR2862062B1 (fr) * 2003-11-06 2005-12-23 Oreal Lipide a et composition topique, notamment cosmetique, le comprenant
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
EP2468300B1 (de) 2006-09-26 2017-12-20 Infectious Disease Research Institute Impfstoffzusammensetzung mit einem synthetischen Adjuvans
JP6273200B2 (ja) 2011-07-12 2018-01-31 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド 脂質含有ｐｓａ組成物、その単離の方法および使用の方法
WO2016115097A2 (en) 2015-01-12 2016-07-21 Children's Medical Center Corporation Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists
EP3337321A4 (de) 2015-08-19 2019-07-17 President and Fellows of Harvard College Lipidierte psa-zusammensetzungen und verfahren
WO2017090047A1 (en) 2015-11-27 2017-06-01 Technology Innovation Momentum Fund (Israel) Limited Partnership Glucosamine and derivatives thereof in imaging
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987237A (en) * 1983-08-26 1991-01-22 Ribi Immunochem Research, Inc. Derivatives of monophosphoryl lipid A
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
WO1986005687A1 (en) * 1985-04-03 1986-10-09 Wisconsin Alumni Research Foundation Method of preventing diseases caused by gram-negative endotoxin in mammals
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
US4746742A (en) * 1985-11-28 1988-05-24 Toho Yakuhin Kogyo Kabushiki Kaisha Analogs of nonreducing monosaccharide moiety of lipid A

Also Published As

Publication number Publication date
DE69032206D1 (de) 1998-05-07
JPH04503363A (ja) 1992-06-18
EP0466838A4 (de) 1995-02-22
US5158939A (en) 1992-10-27
DK0466838T3 (da) 1998-04-27
WO1991001134A1 (en) 1991-02-07
ES2113861T3 (es) 1998-05-16
AU6051790A (en) 1991-02-22
EP0466838A1 (de) 1992-01-22
DE69032206T2 (de) 1998-07-23
EP0466838B1 (de) 1998-04-01

Similar Documents

Publication Publication Date Title
ATE164517T1 (de) Lipid-a-derivate sowie deren verwendungen
BR9101650A (pt) Metodo e sistema para geracao de uma representacao visual
BR9201475A (pt) Sistema para a producao de tiras helicoidais de legumes e turbina para ele
IT8903622A0 (it) Metodo e dispositivo per la realizzazione di incarti tubolari
BR8702755A (pt) Metodo para posicionar axialmente uma fibra otica num conector de feixe dilatado e respectivo conector
IT1195845B (it) Metodo e dispositivo per la sterilizzazione di fluidi
FR2642039B1 (fr) Procede et dispositif d'alimentation en continu de flans
DE3855053D1 (de) Bestrahlungsfelderkennungsverfahren
SE8404707D0 (sv) Komposition innehallande pyridinlosligt extrakt och raffinerat detoxifierat endotoxin samt anvendning derav
BR8707345A (pt) Dispositivo e metodo de otimizacao da combustao de camaras para cozimento de blocos carbonados
FR2632230B1 (fr) Procede et appareillage de rivetage
MX14446A (es) Derivados de la adenosina 2- substituida y proceso para su preparacion.
EP0383943A4 (en) Light emitting device and method of producing the same
FI901732A0 (fi) Menetelmä Cefodizim-dinatriumin valmistamiseksi
PT98121A (pt) Processo para a preparacao de novos 3,3'-ditio-bis (acidos propionicos) e seus esteres e de composicoes farmaceuticas que os contem
FR2579593B1 (fr) Procede de preparation de derives dichlorotrifluoroethoxy et ethylthiobenzeniques
DE68905858D1 (de) Verfahren und vorrichtung fuer die herstellung eines roentgenstrahlenspiegels.
FR2549746B1 (fr) Procede, dispositif et installation de nettoyage par ultra-sons d'objets creux
BR1100170A (pt) Composto tendo atividade imunoestimulante, e, vacina para a profilaxia e tratamento de condições que requeiram uma resposta imunológica intensificada
ES2129047T3 (es) Metodo para mejorar la memoria y la calidad de vida.
IT1195844B (it) Metodo e dispositivo per la sterilizzazione di fluidi
KR900009173A (ko) 연결부들을 형성하는 방법 및 상기 방법을 수행하기 위한 조립체
FR2614306B1 (fr) Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
IT1213891B (it) Metodo e dispositivo per la perforazione di sigarette o simili mediante raggi laser
IT1223118B (it) Procedimento perfezionato di roccatura e dispositivi per la realizzazione di detto procedimento

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee
UEP Publication of translation of european patent specification