DE69122828D1 - Hydroxyapatit-antigen-konjugate und verfahren zur auslösung einer poly-ig-immunantwort - Google Patents

Hydroxyapatit-antigen-konjugate und verfahren zur auslösung einer poly-ig-immunantwort

Info

Publication number
DE69122828D1
DE69122828D1 DE69122828T DE69122828T DE69122828D1 DE 69122828 D1 DE69122828 D1 DE 69122828D1 DE 69122828 T DE69122828 T DE 69122828T DE 69122828 T DE69122828 T DE 69122828T DE 69122828 D1 DE69122828 D1 DE 69122828D1
Authority
DE
Germany
Prior art keywords
hydroxyapatite
releasing
poly
immune response
antigen conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122828T
Other languages
English (en)
Other versions
DE69122828T2 (de
Inventor
Jean-Pierre Kraehenbuhl
Helen Amerongen
Marian Neutra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUISSE RECH EXPERIMENT
Harvard College
Original Assignee
SUISSE RECH EXPERIMENT
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUISSE RECH EXPERIMENT, Harvard College filed Critical SUISSE RECH EXPERIMENT
Application granted granted Critical
Publication of DE69122828D1 publication Critical patent/DE69122828D1/de
Publication of DE69122828T2 publication Critical patent/DE69122828T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69122828T 1990-04-16 1991-04-16 Hydroxyapatit-antigen-konjugate und verfahren zur auslösung einer poly-ig-immunantwort Expired - Fee Related DE69122828T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/510,154 US5443832A (en) 1990-04-16 1990-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
PCT/US1991/002599 WO1991016072A1 (en) 1990-04-16 1991-04-16 Hydroxyapatite-antigen conjugates and methods for generating a poly-ig immune response

Publications (2)

Publication Number Publication Date
DE69122828D1 true DE69122828D1 (de) 1996-11-28
DE69122828T2 DE69122828T2 (de) 1997-05-28

Family

ID=24029591

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69122828T Expired - Fee Related DE69122828T2 (de) 1990-04-16 1991-04-16 Hydroxyapatit-antigen-konjugate und verfahren zur auslösung einer poly-ig-immunantwort

Country Status (16)

Country Link
US (2) US5443832A (de)
EP (1) EP0477339B1 (de)
JP (1) JPH04507106A (de)
KR (1) KR100188836B1 (de)
AT (1) ATE144428T1 (de)
AU (1) AU643011B2 (de)
BG (1) BG60371B1 (de)
BR (1) BR9105718A (de)
CA (1) CA2060318A1 (de)
DE (1) DE69122828T2 (de)
HU (1) HU216103B (de)
OA (1) OA09525A (de)
RO (1) RO109817B1 (de)
RU (1) RU2126270C1 (de)
WO (1) WO1991016072A1 (de)
ZA (1) ZA912838B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6440425B1 (en) 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US6290970B1 (en) 1995-10-11 2001-09-18 Aventis Pasteur Limited Transferrin receptor protein of Moraxella
JPH107575A (ja) * 1996-06-21 1998-01-13 Synsorb Biotec Inc 細菌性赤痢の処置
EP0914162A2 (de) * 1996-06-21 1999-05-12 SYNSORB Biotech Inc. Verwendung von oligosacchariden zur neutralisierung von e. coli toxinen
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
WO2000045847A1 (en) * 1999-02-05 2000-08-10 Alk-Abelló A/S Novel mucosal delivery system
US20020051794A1 (en) * 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
AUPR011700A0 (en) * 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
AU2006204620B2 (en) * 2000-09-14 2008-05-29 Px Biosolutions Pty Ltd Composition comprising immunogenic nanoparticles
AU2002248289A1 (en) * 2000-10-20 2002-09-04 Etex Corporation Chemotherapeutic composition using calcium phosphate paste
JP5189763B2 (ja) * 2003-04-11 2013-04-24 エテックス コーポレーション 骨誘導性骨材料
WO2005074991A1 (ja) * 2004-02-09 2005-08-18 Kabushiki Kaisha Sangi 抗腫瘍剤
WO2005100398A1 (ja) * 2004-04-14 2005-10-27 Bio Matrix Research Inc. 抗体ライブラリー作製方法
WO2005117919A2 (en) * 2004-04-15 2005-12-15 Etex Corporation Delayed-setting calcium phosphate pastes
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
RU2357758C2 (ru) * 2004-10-07 2009-06-10 Кабусики Кайся Санги Препараты для чрескожной и чресслизистой доставки
JP5097540B2 (ja) * 2005-04-06 2012-12-12 株式会社サンギ 腸管吸収用抗腫瘍剤
FR2885525B1 (fr) * 2005-05-13 2009-09-18 Urodelia Sa Medicament notamment anti-cancereux, destine a des traitements par immunotherapie, en particulier autologue
WO2007053781A2 (en) * 2005-11-01 2007-05-10 Novartis Ag Compositions with antigens adsorbed to calcium phosphate
EP1951299B1 (de) 2005-11-04 2012-01-04 Novartis Vaccines and Diagnostics S.r.l. Grippeimpfstoffe mit kombinationen aus teilchenförmigen adjuvantien und immunverstärkern
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
AU2008339631B2 (en) * 2007-12-24 2014-07-24 Novartis Ag Assays for adsorbed influenza vaccines
GB201319548D0 (en) 2013-11-05 2013-12-18 Medical Res Council Amorphous magnesium-substituted calcium phosphate compositions and their uses
TWI654993B (zh) * 2016-11-04 2019-04-01 National Health Research Institutes 陽離子型生物可降解性陶瓷聚合物微粒子用以遞送疫苗之用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3599150A (en) * 1969-08-01 1971-08-10 Miles Lab Stabilized aluminum hydroxide suspensions
US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
JPS59101145A (ja) * 1982-11-30 1984-06-11 日本特殊陶業株式会社 薬液含浸多孔質セラミツクス
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
ES2039229T3 (es) * 1986-01-14 1993-09-16 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.
JPS62248487A (ja) * 1986-04-22 1987-10-29 Dentaru Kagaku Kk グルカナーゼを固定化したアパタイトおよびその製造法
JPS63196281A (ja) * 1987-02-12 1988-08-15 Sumitomo Electric Ind Ltd 細胞培養用基材
US5008116A (en) * 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
CN1057785A (zh) * 1990-04-16 1992-01-15 哈佛大学校长及研究员协会 合成多聚免疫球蛋白受体，受体-抗体复合物，生产及应用
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response

Also Published As

Publication number Publication date
DE69122828T2 (de) 1997-05-28
EP0477339A4 (en) 1993-04-21
OA09525A (en) 1992-11-15
US5443832A (en) 1995-08-22
EP0477339B1 (de) 1996-10-23
KR100188836B1 (ko) 1999-06-01
HUT63337A (en) 1993-08-30
EP0477339A1 (de) 1992-04-01
ATE144428T1 (de) 1996-11-15
JPH04507106A (ja) 1992-12-10
AU7684991A (en) 1991-11-11
BR9105718A (pt) 1992-07-21
CA2060318A1 (en) 1991-10-17
KR920702628A (ko) 1992-10-06
US6541000B1 (en) 2003-04-01
HU9200135D0 (en) 1992-04-28
BG95635A (bg) 1993-12-24
RU2126270C1 (ru) 1999-02-20
HU216103B (hu) 1999-04-28
AU643011B2 (en) 1993-11-04
ZA912838B (en) 1992-03-25
WO1991016072A1 (en) 1991-10-31
BG60371B1 (bg) 1994-11-15
RO109817B1 (ro) 1995-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee