BR112023018321A2 - Inibidores de glicogênio sintase 1 (gys1) e métodos de uso dos mesmos - Google Patents

Inibidores de glicogênio sintase 1 (gys1) e métodos de uso dos mesmos

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Publication number
BR112023018321A2
BR112023018321A2 BR112023018321A BR112023018321A BR112023018321A2 BR 112023018321 A2 BR112023018321 A2 BR 112023018321A2 BR 112023018321 A BR112023018321 A BR 112023018321A BR 112023018321 A BR112023018321 A BR 112023018321A BR 112023018321 A2 BR112023018321 A2 BR 112023018321A2
Authority
BR
Brazil
Prior art keywords
methods
gys1
inhibitors
glycogen synthase
formula
Prior art date
Application number
BR112023018321A
Other languages
English (en)
Inventor
Joseph Sinz Christopher
John Morgans David Jr
L Powers Hannah
Kevin Mellem
Sang Tae Lee Patrick
Walter Won
Original Assignee
Maze Therapeutics Inc
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Publication date
Application filed by Maze Therapeutics Inc filed Critical Maze Therapeutics Inc
Publication of BR112023018321A2 publication Critical patent/BR112023018321A2/pt

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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    • C07D213/09—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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Abstract

inibidores de glicogênio sintase 1 (gys1) e métodos de uso dos mesmos. a presente invenção refere-se a compostos de fórmula (i): (i), ou um estereoisômero ou tautômero do mesmo, ou um sal farmaceuticamente aceitável de qualquer um dos anteriores, em que y2, y3, l1, l2, x1, x2, x3, x4, x5, q1, r1, r2, rk, rm, e rn são como definidos em outro lugar neste documento. também são fornecidos neste documento métodos de preparação de compostos de fórmula (i). também são fornecidos neste documento métodos de inibição de gys1 e métodos de tratamento de uma doença, distúrbio ou condição mediada por gys1 em um indivíduo em necessidade dos mesmos.
BR112023018321A 2021-03-15 2022-03-14 Inibidores de glicogênio sintase 1 (gys1) e métodos de uso dos mesmos BR112023018321A2 (pt)

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US202163161347P 2021-03-15 2021-03-15
US202263266572P 2022-01-09 2022-01-09
PCT/US2022/071139 WO2022198196A1 (en) 2021-03-15 2022-03-14 Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

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US (1) US11814367B2 (pt)
EP (1) EP4308095A1 (pt)
JP (1) JP2024511979A (pt)
KR (1) KR20230159839A (pt)
AU (1) AU2022239717A1 (pt)
BR (1) BR112023018321A2 (pt)
CA (1) CA3179181A1 (pt)
CO (1) CO2023013399A2 (pt)
IL (1) IL305835A (pt)
TW (1) TW202302570A (pt)
WO (1) WO2022198196A1 (pt)

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IL305835A (en) 2021-03-15 2023-11-01 Maze Therapeutics Inc Glycogen synthase 1 (GYS1) inhibitors and methods of using them
WO2024059661A1 (en) * 2022-09-14 2024-03-21 Maze Therapeutics, Inc. N-(benzhydryl)cycloalkylcarboxamide derivatives as inhibitors of glycogen synthase 1 (gys1) and methods of use thereof
WO2024059665A1 (en) * 2022-09-14 2024-03-21 Maze Therapeutics, Inc. Dimeric compounds as inhibitors of glycogen synthase 1 (gys1) and methods of use thereof
WO2024059659A1 (en) * 2022-09-14 2024-03-21 Maze Therapeutics, Inc. Cycloalkyl carboxylic acid derivatives as inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

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