CO6382126A2 - Compuestos heteroaromaticos fusionados y espirociclicos para el tratamiento de infecciones bacterianas - Google Patents

Compuestos heteroaromaticos fusionados y espirociclicos para el tratamiento de infecciones bacterianas

Info

Publication number
CO6382126A2
CO6382126A2 CO11043260A CO11043260A CO6382126A2 CO 6382126 A2 CO6382126 A2 CO 6382126A2 CO 11043260 A CO11043260 A CO 11043260A CO 11043260 A CO11043260 A CO 11043260A CO 6382126 A2 CO6382126 A2 CO 6382126A2
Authority
CO
Colombia
Prior art keywords
bacterial infections
espirociclic
fusioned
treatment
heteroaromatic compounds
Prior art date
Application number
CO11043260A
Other languages
English (en)
Inventor
Kevin K Barvian
Gregory Basarab
Madhusudhan Gowravaram
Sheila Irene Hauck
Fei Zhou
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6382126A2 publication Critical patent/CO6382126A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula (I):que corresponden a un heterotetraciclo de 18 a 20 miembros con 2 a 7 heteroátomos seleccionados de N, O, S, con un grupo pirimidin-2,4,6(1H,3H,5H)-triona unido mediante un enlace tipo espiro a dicho heterotetraciclo; a sales farmacéuticamente aceptables de éstos; a métodos para su preparación; y a su actividad para tratar infecciones bacterianas debido a su supuesta actividad inhibitoria de la DNA girasa bacteriana.
CO11043260A 2008-10-14 2011-04-07 Compuestos heteroaromaticos fusionados y espirociclicos para el tratamiento de infecciones bacterianas CO6382126A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10518908P 2008-10-14 2008-10-14

Publications (1)

Publication Number Publication Date
CO6382126A2 true CO6382126A2 (es) 2012-02-15

Family

ID=41668347

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11043260A CO6382126A2 (es) 2008-10-14 2011-04-07 Compuestos heteroaromaticos fusionados y espirociclicos para el tratamiento de infecciones bacterianas

Country Status (24)

Country Link
US (1) US8658641B2 (es)
EP (1) EP2350077B1 (es)
JP (2) JP5749169B2 (es)
KR (1) KR101676886B1 (es)
CN (2) CN102245605B (es)
AR (1) AR073862A1 (es)
AU (1) AU2009305203B2 (es)
BR (1) BRPI0920180B1 (es)
CA (1) CA2736335C (es)
CL (1) CL2011000838A1 (es)
CO (1) CO6382126A2 (es)
CR (1) CR20110195A (es)
CU (1) CU20110083A7 (es)
DO (1) DOP2011000102A (es)
EA (1) EA201100613A1 (es)
EC (1) ECSP11010980A (es)
ES (1) ES2565611T3 (es)
HK (2) HK1160127A1 (es)
IL (1) IL211728A0 (es)
MX (1) MX2011003598A (es)
TW (1) TW201020258A (es)
UY (1) UY32174A (es)
WO (1) WO2010043893A1 (es)
ZA (1) ZA201103533B (es)

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PT2888269T (pt) 2012-08-21 2019-01-17 Janssen Pharmaceutica Nv Haptenos de olanzapina
TR201816416T4 (tr) 2012-08-21 2018-11-21 Janssen Pharmaceutica Nv Risperidona yönelik antikorlar ve bunların kullanımı.
EP3556759B1 (en) 2012-08-21 2023-11-29 Janssen Pharmaceutica NV Haptens of paliperidone
US20140057303A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Antibodies to Olanzapine Haptens and Use Thereof
CN104736567B (zh) 2012-08-21 2019-09-03 詹森药业有限公司 阿立哌唑半抗原的抗体及其用途
JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
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CN104755479B (zh) 2012-08-21 2016-11-09 詹森药业有限公司 利培酮和帕潘立酮的半抗原
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SG11201609404SA (en) * 2014-05-29 2016-12-29 Entasis Therapeutics Ltd Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
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ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
AU2015342883B2 (en) 2014-11-06 2020-07-02 Bial - R&D Investments, S.A. Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
EP3215511B1 (en) 2014-11-06 2024-04-17 Bial-R&D Investments, S.A. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
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US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
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WO2017024455A1 (zh) * 2015-08-07 2017-02-16 苏州大学张家港工业技术研究院 一种螺环羟吲哚咪唑啉并氧氮杂卓化合物及其合成方法
CN105152962B (zh) * 2015-09-30 2017-06-16 淄博亿丰高分子材料科技股份有限公司 N‑异丙基羟胺的制备方法
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US11124516B2 (en) 2016-04-06 2021-09-21 BIAL-BioTech Investments, Inc. Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
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EP2350077B1 (en) * 2008-10-14 2016-01-27 Entasis Therapeutics Limited Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections

Also Published As

Publication number Publication date
AU2009305203A1 (en) 2010-04-22
BRPI0920180A2 (pt) 2020-12-29
CU20110083A7 (es) 2013-05-31
ECSP11010980A (es) 2011-05-31
ES2565611T3 (es) 2016-04-05
IL211728A0 (en) 2011-06-30
JP2012505261A (ja) 2012-03-01
CL2011000838A1 (es) 2011-10-21
BRPI0920180B1 (pt) 2021-10-26
EA201100613A1 (ru) 2011-12-30
AU2009305203B2 (en) 2013-03-07
CA2736335C (en) 2017-05-09
CN102245605B (zh) 2016-01-27
WO2010043893A1 (en) 2010-04-22
CR20110195A (es) 2011-06-08
KR20110090895A (ko) 2011-08-10
DOP2011000102A (es) 2011-05-15
HK1160127A1 (zh) 2012-08-10
CN104086565A (zh) 2014-10-08
EP2350077A1 (en) 2011-08-03
JP5749169B2 (ja) 2015-07-15
ZA201103533B (en) 2012-01-25
US20110245224A1 (en) 2011-10-06
HK1203483A1 (en) 2015-10-30
CA2736335A1 (en) 2010-04-22
EP2350077B1 (en) 2016-01-27
AR073862A1 (es) 2010-12-09
UY32174A (es) 2010-05-31
CN102245605A (zh) 2011-11-16
US8658641B2 (en) 2014-02-25
JP2015178510A (ja) 2015-10-08
MX2011003598A (es) 2011-04-27
TW201020258A (en) 2010-06-01
KR101676886B1 (ko) 2016-11-16

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