BR112023005674A2 - Construtos anti-cd93 e usos dos mesmos - Google Patents

Construtos anti-cd93 e usos dos mesmos

Info

Publication number
BR112023005674A2
BR112023005674A2 BR112023005674A BR112023005674A BR112023005674A2 BR 112023005674 A2 BR112023005674 A2 BR 112023005674A2 BR 112023005674 A BR112023005674 A BR 112023005674A BR 112023005674 A BR112023005674 A BR 112023005674A BR 112023005674 A2 BR112023005674 A2 BR 112023005674A2
Authority
BR
Brazil
Prior art keywords
constructs
construct
vectors
methods
nucleic acid
Prior art date
Application number
BR112023005674A
Other languages
English (en)
Inventor
Angela Norton
Gregory Jones
Jian Li
Lihua Wu
Roxann Guerrette
Shigeru Komaba
Zhinan Xia
Zirong Chen
Original Assignee
Dynamicure Biotechnology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2021/035542 external-priority patent/WO2021247769A1/en
Priority claimed from PCT/US2021/043784 external-priority patent/WO2022026763A1/en
Application filed by Dynamicure Biotechnology Llc filed Critical Dynamicure Biotechnology Llc
Publication of BR112023005674A2 publication Critical patent/BR112023005674A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

construtos anti-cd93 e usos dos mesmos. a presente invenção refere-se a construtos anti-cd93 que se ligam à cd93 (por exemplo, anticorpos anti-cd93), moléculas de ácido nucleico codificando uma sequência de aminoácido do anti-cd93, vetores compreendendo as moléculas de ácido nucleico, células hospedeiras contendo os vetores, métodos de preparação do construto anti-cd93, composições farmacêuticas contendo o construto anti-cd93 e métodos de uso do construto anti-cd93 ou composições.
BR112023005674A 2020-09-28 2021-09-28 Construtos anti-cd93 e usos dos mesmos BR112023005674A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063084474P 2020-09-28 2020-09-28
PCT/US2021/035542 WO2021247769A1 (en) 2020-06-02 2021-06-02 Anti-cd93 constructs and uses thereof
PCT/US2021/043784 WO2022026763A1 (en) 2020-07-29 2021-07-29 Anti-cd93 constructs and uses thereof
PCT/US2021/052446 WO2022067262A1 (en) 2020-09-28 2021-09-28 Anti-cd93 constructs and uses thereof

Publications (1)

Publication Number Publication Date
BR112023005674A2 true BR112023005674A2 (pt) 2024-02-15

Family

ID=80846938

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023005674A BR112023005674A2 (pt) 2020-09-28 2021-09-28 Construtos anti-cd93 e usos dos mesmos

Country Status (11)

Country Link
US (1) US20230365705A1 (pt)
EP (1) EP4217069A1 (pt)
JP (1) JP2023543031A (pt)
KR (1) KR20230143604A (pt)
CN (2) CN116529260A (pt)
AR (1) AR123628A1 (pt)
AU (1) AU2021349280A1 (pt)
BR (1) BR112023005674A2 (pt)
CA (1) CA3197179A1 (pt)
TW (1) TW202229347A (pt)
WO (1) WO2022067262A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240059744A1 (en) * 2022-07-25 2024-02-22 Interius Biotherapeutics, Inc. Mutated polypeptides, compositions comprising the same, and uses thereof
CN115819571B (zh) * 2022-09-14 2024-09-10 北京纳百生物科技有限公司 一种抗黄曲霉毒素b1单克隆抗体及其应用

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Also Published As

Publication number Publication date
CN116997569A (zh) 2023-11-03
KR20230143604A (ko) 2023-10-12
CN116529260A (zh) 2023-08-01
EP4217069A1 (en) 2023-08-02
TW202229347A (zh) 2022-08-01
CA3197179A1 (en) 2022-03-31
AU2021349280A9 (en) 2023-04-27
US20230365705A1 (en) 2023-11-16
AR123628A1 (es) 2022-12-28
WO2022067262A1 (en) 2022-03-31
JP2023543031A (ja) 2023-10-12
AU2021349280A1 (en) 2023-04-20

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