AR123628A1 - Constructos anti-cd93 y usos de estos - Google Patents

Constructos anti-cd93 y usos de estos

Info

Publication number
AR123628A1
AR123628A1 ARP210102689A ARP210102689A AR123628A1 AR 123628 A1 AR123628 A1 AR 123628A1 AR P210102689 A ARP210102689 A AR P210102689A AR P210102689 A ARP210102689 A AR P210102689A AR 123628 A1 AR123628 A1 AR 123628A1
Authority
AR
Argentina
Prior art keywords
construct
nucleic acid
chain variable
variable region
host cell
Prior art date
Application number
ARP210102689A
Other languages
English (en)
Inventor
Zirong Chen
Roxann Guerrette
Gregory Jones
Shigeru Komaba
Jian Li
Angela Norton
Lihua Wu
Zhinan Xia
Original Assignee
Dynamicure Biotechnology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynamicure Biotechnology Llc filed Critical Dynamicure Biotechnology Llc
Publication of AR123628A1 publication Critical patent/AR123628A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente solicitud proporciona constructos anti-CD93 que se unen a CD93 (por ejemplo, anticuerpos anti-CD93), moléculas de ácido nucleico que codifican una secuencia de aminoácidos de anti-CD93, vectores que comprenden las moléculas de ácido nucleico, células hospedadoras que contienen los vectores, métodos de preparación del constructo anti-CD93, composiciones farmacéuticas que contienen el constructo anti-CD93 y métodos de uso del constructo o las composiciones anti-CD93. Un constructo anti-CD93 que comprende una porción de anticuerpo que comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), caracterizado porque la porción de anticuerpo compite por un epítopo de unión de CD93 con un anticuerpo o un fragmento de anticuerpo que comprende una segunda región variable de cadena pesada (VH₋₂) y una segunda región variable de cadena ligera (VL₋₂). Reivindicación 34: Una composición farmacéutica caracterizada porque comprende el constructo anti-CD93 de una cualquiera de las reivindicaciones 1 a 33 y un vehículo farmacéuticamente aceptable. Reivindicación 35: Un ácido nucleico aislado caracterizado porque codifica el constructo anti-CD93 de una cualquiera de las reivindicaciones 1 a 33 o una porción de este. Reivindicación 36: Un vector caracterizado porque comprende el ácido nucleico aislado de la reivindicación 35. Reivindicación 37: Una célula hospedadora aislada caracterizada porque comprende el ácido nucleico aislado de la reivindicación 35, o el vector de la reivindicación 36. Reivindicación 38: Un inmunoconjugado caracterizado porque comprende el constructo anti-CD93 de una cualquiera de las reivindicaciones 1 a 33, ligado a un agente terapéutico o a un marcador. Reivindicación 39: Un método de producir un constructo anti-CD93 caracterizado porque comprende: a) cultivar la célula hospedadora aislada de la reivindicación 37 en condiciones eficaces para expresar el constructo anti-CD93; y b) obtener el constructo anti-CD93 expresado de la célula hospedadora.
ARP210102689A 2020-09-28 2021-09-28 Constructos anti-cd93 y usos de estos AR123628A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063084474P 2020-09-28 2020-09-28

Publications (1)

Publication Number Publication Date
AR123628A1 true AR123628A1 (es) 2022-12-28

Family

ID=80846938

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210102689A AR123628A1 (es) 2020-09-28 2021-09-28 Constructos anti-cd93 y usos de estos

Country Status (11)

Country Link
US (1) US20230365705A1 (es)
EP (1) EP4217069A1 (es)
JP (1) JP2023543031A (es)
KR (1) KR20230143604A (es)
CN (2) CN116529260A (es)
AR (1) AR123628A1 (es)
AU (1) AU2021349280A1 (es)
BR (1) BR112023005674A2 (es)
CA (1) CA3197179A1 (es)
TW (1) TW202229347A (es)
WO (1) WO2022067262A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240059744A1 (en) * 2022-07-25 2024-02-22 Interius Biotherapeutics, Inc. Mutated polypeptides, compositions comprising the same, and uses thereof
CN115819571B (zh) * 2022-09-14 2024-09-10 北京纳百生物科技有限公司 一种抗黄曲霉毒素b1单克隆抗体及其应用

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Publication number Publication date
CA3197179A1 (en) 2022-03-31
AU2021349280A9 (en) 2023-04-27
TW202229347A (zh) 2022-08-01
AU2021349280A1 (en) 2023-04-20
CN116997569A (zh) 2023-11-03
BR112023005674A2 (pt) 2024-02-15
CN116529260A (zh) 2023-08-01
WO2022067262A1 (en) 2022-03-31
US20230365705A1 (en) 2023-11-16
JP2023543031A (ja) 2023-10-12
EP4217069A1 (en) 2023-08-02
KR20230143604A (ko) 2023-10-12

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