BR112022022530A2 - Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk - Google Patents

Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk

Info

Publication number
BR112022022530A2
BR112022022530A2 BR112022022530A BR112022022530A BR112022022530A2 BR 112022022530 A2 BR112022022530 A2 BR 112022022530A2 BR 112022022530 A BR112022022530 A BR 112022022530A BR 112022022530 A BR112022022530 A BR 112022022530A BR 112022022530 A2 BR112022022530 A2 BR 112022022530A2
Authority
BR
Brazil
Prior art keywords
ros1
compound
cancer
pharmaceutical composition
selective inhibition
Prior art date
Application number
BR112022022530A
Other languages
English (en)
Inventor
Courtney Horan Joshua
Richard Mente Scot
Efrem Pelish Henry
D Shair Matthew
Tang Xinxing
Tangpeerachaikul Anupong
Original Assignee
Nuvalent Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvalent Inc filed Critical Nuvalent Inc
Publication of BR112022022530A2 publication Critical patent/BR112022022530A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Abstract

COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, MÉTODO DE TRATAMENTO DE CÂNCER, MÉTODO DE INIBIÇÃO SELETIVA, MÉTODO DE REDUÇÃO DE UM. NÍVEL DE ROS1 OU ALSão divulgados compostos de éter macrocíclico heteroaromático heterocíclico, sais farmaceuticamente aceitáveis dos compostos e composições farmacêuticas dos mesmos. Também são divulgados métodos de tratamento ou prevenção de câncer usando os compostos de éter macrocíclico heteroaromático heterocíclico, sais farmaceuticamente aceitáveis dos compostos e composições farmacêuticas dos mesmos.
BR112022022530A 2020-05-05 2021-05-05 Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk BR112022022530A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/088589 2020-05-05
US202063060331P 2020-08-03 2020-08-03
US202063125747P 2020-12-15 2020-12-15
PCT/US2021/030940 WO2021226269A1 (en) 2020-05-05 2021-05-05 Heteroaromatic macrocyclic ether chemotherapeutic agents

Publications (1)

Publication Number Publication Date
BR112022022530A2 true BR112022022530A2 (pt) 2023-02-23

Family

ID=78468373

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022530A BR112022022530A2 (pt) 2020-05-05 2021-05-05 Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk

Country Status (12)

Country Link
US (2) US11667649B2 (pt)
EP (1) EP4146205A1 (pt)
JP (1) JP2023525040A (pt)
KR (1) KR20230005987A (pt)
AU (1) AU2021268345A1 (pt)
BR (1) BR112022022530A2 (pt)
CA (1) CA3179702A1 (pt)
CL (1) CL2022003046A1 (pt)
IL (1) IL297898A (pt)
MX (1) MX2022013051A (pt)
PE (1) PE20230309A1 (pt)
WO (1) WO2021226269A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
AU2021268345A1 (en) 2020-05-05 2022-11-10 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
WO2023179600A1 (zh) * 2022-03-21 2023-09-28 杭州德睿智药科技有限公司 新型取代大杂环类新化合物及其应用
TW202400608A (zh) * 2022-04-07 2024-01-01 美商努法倫特公司 雜芳族巨環醚化合物之固體形式、醫藥組合物及製備
WO2023196910A1 (en) 2022-04-07 2023-10-12 Nuvalent, Inc Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine
WO2024054832A1 (en) 2022-09-09 2024-03-14 Innovo Therapeutics, Inc. CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS
WO2024074414A1 (en) * 2022-10-06 2024-04-11 Syngenta Crop Protection Ag Herbicidal imidazole compounds

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569655A (en) 1993-09-14 1996-10-29 Sterling Winthrop Inc. Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof
TW401301B (en) 1994-10-07 2000-08-11 Takeda Chemical Industries Ltd Antihypertriglyceridemic composition
AR002459A1 (es) 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US5849735A (en) 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
EP1334998B1 (en) 2000-12-20 2006-08-02 Kyowa Hakko Chemical Co., Ltd. Metal complex type squarylium compounds and optical recording media made by using the same
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
EP2325224A1 (en) 2002-10-30 2011-05-25 Sumitomo Chemical Company, Limited Aryl copolymer compounds and polymer light emitting devices made by using the same
PA8631101A1 (es) 2004-04-27 2006-09-08 Wyeth Corp Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos
US7514466B2 (en) 2004-04-27 2009-04-07 Wyeth Purification of progesterone receptor modulators
WO2006034090A1 (en) 2004-09-20 2006-03-30 Janssen Pharmaceutica N.V. Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
US7445211B1 (en) 2005-03-11 2008-11-04 Walton Daniel J Wall decoration and game apparatus
US20070116984A1 (en) 2005-09-21 2007-05-24 Doosan Corporation Spiro-compound for electroluminescent display device and electroluminescent display device comprising the same
US20090022694A1 (en) 2005-10-18 2009-01-22 Distefano Peter Sirt1 inhibition
US20070213526A1 (en) 2006-03-07 2007-09-13 Wyeth Purification of progesterone receptor modulators
GB0609492D0 (en) * 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
US7915414B2 (en) 2006-11-24 2011-03-29 Yun Chi Blue-emitting organometallic complexes and their application
FR2913882B1 (fr) 2007-03-20 2009-05-01 Oreal Utilisation pour la coloration des fibres keratiniques d'une composition comprenant un compose halochromique et/ou le colorant correspondant a ce compose
BRPI0813273A2 (pt) 2007-06-26 2014-12-30 Sanofi Aventis Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados
RU2010103101A (ru) 2007-07-02 2011-08-10 Астразенека Аб (Se) Химические соединения
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
JP2009234928A (ja) 2008-03-25 2009-10-15 Kyoto Univ 縮合多環芳香族化合物、およびその製造方法
JP5304010B2 (ja) 2008-04-23 2013-10-02 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
JP5499519B2 (ja) 2009-05-27 2014-05-21 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
MX2012001414A (es) 2009-08-04 2012-03-26 Tokuyama Corp Compuesto de cromeno.
JP4599469B1 (ja) 2009-08-31 2010-12-15 富士フイルム株式会社 有機電界発光素子用材料及び有機電界発光素子
JP2013505252A (ja) 2009-09-16 2013-02-14 サイリーン ファーマシューティカルズ インコーポレーティッド 三環式タンパク質キナーゼ調節剤
WO2011138751A2 (en) 2010-05-04 2011-11-10 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
EP2598510A4 (en) 2010-07-30 2014-02-26 Reddys Lab Ltd Dr LIGANDS FOR SELECTIVE ASYMMETRIC HYDROFORMYLATION
WO2012071458A1 (en) 2010-11-22 2012-05-31 Array Biopharma Inc. Heterocyclic inhibitors of beta - secretase for the treatment of neurodegenerative diseases
DK2655344T3 (da) 2010-12-22 2016-02-01 Univ Catholique Louvain Hidtil ukendte phenazin-derivater og deres anvendelse
FR2969611B1 (fr) 2010-12-28 2013-02-08 Sanofi Aventis Nouveaux derives de thiazoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
ES2612492T3 (es) 2010-12-28 2017-05-17 Sanofi Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB)
WO2012102409A1 (ja) 2011-01-27 2012-08-02 株式会社トクヤマ クロメン化合物
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
CN102977150B (zh) 2011-09-06 2016-07-06 郑建鸿 含有碳烯配位基的过渡金属错合物结构及其在发光材料的应用
CA2863892C (en) 2012-03-06 2016-08-30 Pfizer Inc. Macrocyclic derivatives for the treatment of proliferative diseases
KR20140032823A (ko) 2012-09-07 2014-03-17 롬엔드하스전자재료코리아유한회사 유기 전계 발광 소자
JP6199752B2 (ja) 2013-01-24 2017-09-20 出光興産株式会社 有機エレクトロルミネッセンス素子用材料及びそれを用いた有機エレクトロルミネッセンス素子、並びに含窒素複素環化合物
WO2014138912A1 (en) 2013-03-13 2014-09-18 Queen's University At Kingston Luminescent compounds and methods of using same
WO2014207606A1 (en) 2013-06-28 2014-12-31 Pfizer Inc. Solid forms of a macrocyclic kinase inhibitor
KR102100929B1 (ko) 2013-09-04 2020-04-14 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
CN104513253A (zh) * 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
KR102167048B1 (ko) 2013-12-03 2020-10-19 삼성디스플레이 주식회사 화합물 및 이를 포함한 유기 발광 소자
EP3091999B1 (en) 2014-01-09 2021-10-20 Hadasit Medical Research Services and Development Ltd. Improved cell compositions and methods for cancer therapy
KR102191992B1 (ko) 2014-01-22 2020-12-17 삼성디스플레이 주식회사 유기 발광 소자
KR102253441B1 (ko) 2014-03-10 2021-05-20 삼성디스플레이 주식회사 화합물 및 이를 포함한 유기 발광 소자
KR101793335B1 (ko) 2014-09-30 2017-11-02 주식회사 엘지화학 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자
US20160140491A1 (en) 2014-11-17 2016-05-19 Gregory Forgatch System and method for integrating intermediary and end-user online retail experiences
US9887372B2 (en) 2015-06-11 2018-02-06 Samsung Display Co., Ltd. Amine-based compound and organic light-emitting device including the same
US10335392B2 (en) 2015-08-03 2019-07-02 Bristol-Myers Squibb Company Cyclic compounds useful as modulators of TNF α
AU2016354661B2 (en) 2015-11-13 2020-12-10 Domain Therapeutics Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group II metabotropic glutamate receptors
CN108699081B (zh) 2016-03-03 2019-10-18 深圳市塔吉瑞生物医药有限公司 一种大环化合物及包含该化合物的组合物
CN106243096B (zh) 2016-07-29 2019-11-29 上海璃道医药科技有限公司 三环类药物的新用途
JP6798851B2 (ja) 2016-10-14 2020-12-09 株式会社トクヤマ クロメン化合物、及び該クロメン化合物を含む硬化性組成物
CN109528717B (zh) 2017-09-21 2021-08-17 中国科学院分子细胞科学卓越创新中心 治疗或预防肥胖或其相关疾病的化合物及其应用
US20210283261A1 (en) 2017-12-05 2021-09-16 Icahn School Of Medicine At Mount Sinai Compositions and Methods for Treating ALK-Mediated Cancer
WO2019120263A1 (zh) 2017-12-21 2019-06-27 广州华睿光电材料有限公司 有机混合物及其在有机电子器件中的应用
WO2019164301A1 (ko) 2018-02-21 2019-08-29 주식회사 엘지화학 화합물 및 이를 포함하는 유기 발광 소자
KR102192368B1 (ko) 2018-02-28 2020-12-17 주식회사 엘지화학 유기 발광 소자
CN110357905B (zh) 2018-03-26 2021-10-01 武汉誉祥医药科技有限公司 作为蛋白激酶抑制剂的大环类衍生物及其制备方法和用途
CN108912175A (zh) 2018-06-05 2018-11-30 长春海谱润斯科技有限公司 一种金属铱配合物及其有机发光器件
CN112771035A (zh) 2018-07-26 2021-05-07 恩特姆生物科学公司 用于制备甘露糖衍生物的方法
US10593889B1 (en) 2018-09-26 2020-03-17 Idemitsu Kosan Co., Ltd. Compound and organic electroluminescence device
EP3856192A4 (en) 2018-09-27 2023-01-04 Dana Farber Cancer Institute, Inc. ALK-TARGETING DEGRADING AGENTS AND THEIR THERAPEUTIC USES
CN109912433B (zh) 2019-03-07 2022-04-08 石家庄诚志永华显示材料有限公司 化合物、有机电致发光材料、有机电致发光器件、电子装置
KR20200111577A (ko) 2019-03-19 2020-09-29 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
WO2020228747A1 (en) 2019-05-14 2020-11-19 Teligene Ltd Substituted macrocycles useful as kinase inhibitors
US20220298130A1 (en) 2019-08-02 2022-09-22 Duk San Neolux Co., Ltd. Organic electronic device
CN112321604A (zh) 2019-08-05 2021-02-05 华东理工大学 大环类jak2抑制剂及其应用
GB201913756D0 (en) 2019-09-24 2019-11-06 Chromatwist Ltd Contrast agent
CN112812128B (zh) 2019-11-18 2024-04-02 正大天晴药业集团股份有限公司 作为alk和ros调节剂的大环化合物
CN114867732A (zh) 2019-12-16 2022-08-05 爱-森新株式会社 具有c-n配体的新型过渡金属电子传输络合物及使用其的电化学生物传感器
TW202136246A (zh) 2019-12-19 2021-10-01 德商麥克專利有限公司 電子裝置用化合物
CN113121607B (zh) 2019-12-31 2023-07-04 马鞍山南大高新技术研究院有限公司 一种主配体含喹啉/喹唑啉的红光铱配合物与应用
CN111362967B (zh) 2020-04-28 2021-09-07 南京雷正医药科技有限公司 苯并氧杂二氮杂十四碳烯衍生物及其用途
AU2021268345A1 (en) 2020-05-05 2022-11-10 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
CN115362155A (zh) 2020-07-22 2022-11-18 中国医药研究开发中心有限公司 芳胺类衍生物及其制备方法和医药用途
CN111808147B (zh) 2020-07-28 2023-04-18 奥来德(上海)光电材料科技有限公司 一种有机磷光材料及其制备方法和电致发光器件
CN113105440B (zh) 2021-04-15 2022-10-04 吉林奥来德光电材料股份有限公司 一种有机电致发光化合物及其制备方法和应用

Also Published As

Publication number Publication date
US20230076627A1 (en) 2023-03-09
US20220098212A1 (en) 2022-03-31
CA3179702A1 (en) 2021-11-11
CL2022003046A1 (es) 2023-10-06
WO2021226269A1 (en) 2021-11-11
US11667649B2 (en) 2023-06-06
JP2023525040A (ja) 2023-06-14
KR20230005987A (ko) 2023-01-10
IL297898A (en) 2023-01-01
AU2021268345A1 (en) 2022-11-10
EP4146205A1 (en) 2023-03-15
MX2022013051A (es) 2023-01-24
US20220340586A9 (en) 2022-10-27
PE20230309A1 (es) 2023-02-14

Similar Documents

Publication Publication Date Title
BR112022022530A2 (pt) Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk
BR112022022535A2 (pt) Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk
BR112023021111A2 (pt) Composto, composição farmacêutica, método de tratamento de câncer, método para inibir seletivamente her2, método de regulação de um nível de her2, método para aumentar um nível de her2, método de diminuição da fosforilação de her2
CY1123186T1 (el) Μακροκυκλικοι mcl1 αναστολεις για τη θεραπευτικη αντιμετωπιση του καρκινου
BR112021008524A8 (pt) 2-amino-n-heteroaril-nicotinamidas como inibidores de nav 1.8
BR112018007526A2 (pt) compostos de benzolactama como inibidores de proteína quinase
BR112022017393A2 (pt) Composto, composição farmacêutica, método para tratar um transtorno mediado por brd9, e, uso de um composto
DE60309701D1 (de) 2-ureido-6-heteroaryl-3h-benzoimidazol-4-carbonsäurederivate und verwandte verbindungen als gyrase und/oder topoisomerase iv inhibitoren zur behandlung von bakteriellen infektionen
BR112022024476A2 (pt) 5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8
EA200801041A1 (ru) Ингибиторы мек и способы их применения
BR112022000019A2 (pt) Composto da fórmula, composição farmacêutica e método de tratamento de câncer
BR112022025805A2 (pt) Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir um distúrbio, condição ou doença
BR112015006990A2 (pt) composto, composição farmacêutica, e, uso de pelo menos um composto
BR112022024450A2 (pt) 2-oxo-oxazolidina-5-carboxamidas como inibidores de nav1.8
EA200971026A1 (ru) Новые макроциклические ингибиторы репликации вируса гепатита с
TN2010000204A1 (en) Kinesin inhibitors as cancer therapeutics
BRPI0716069A2 (pt) composto, composiÇço farmacÊutica, e, mÉtodo para tratar um distérbio
BR112022014480A2 (pt) Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
CL2023001461A1 (es) Inhibidores de prmt5 novedosos
MX2022009059A (es) Compuestos heterociclicos novedosos utiles como inhibidores selectivos de aurora a.
MX2022009197A (es) Metodos de tratamiento para deficiencia de alfa-1 antitripsina.
BR112023023186A2 (pt) 3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8
BR112021019817A2 (pt) Compostos de pirrol
BR112012015129A2 (pt) "composto, composição farmacêutica e método para tratar, controlar ou prevenir uma doença ou distúrbio"