BR112023023186A2 - 3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8 - Google Patents
3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8Info
- Publication number
- BR112023023186A2 BR112023023186A2 BR112023023186A BR112023023186A BR112023023186A2 BR 112023023186 A2 BR112023023186 A2 BR 112023023186A2 BR 112023023186 A BR112023023186 A BR 112023023186A BR 112023023186 A BR112023023186 A BR 112023023186A BR 112023023186 A2 BR112023023186 A2 BR 112023023186A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxopiperazine
- carboxamides
- inhibitors
- aryl
- disorders
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000003857 carboxamides Chemical class 0.000 title 2
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 title 2
- 101000654356 Homo sapiens Sodium channel protein type 10 subunit alpha Proteins 0.000 title 1
- 102100031374 Sodium channel protein type 10 subunit alpha Human genes 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 3
- -1 Aryl 3-oxopiperazine carboxamides Chemical class 0.000 abstract 2
- 108091006146 Channels Proteins 0.000 abstract 2
- 208000003251 Pruritus Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 206010011224 Cough Diseases 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8. novos compostos de fórmula estrutural (i) e sais farmaceuticamente aceitáveis destes, são inibidores de atividade de canal nav1,8 e podem ser úteis no tratamento, prevenção, manejo, melhoria, controle e supressão de doenças mediadas por atividade de canal nav1.8. os compostos da presente invenção podem ser úteis no tratamento, prevenção ou manejo de distúrbios de dor, distúrbios de tosse, distúrbios de coceira aguda e distúrbios de coceira crônica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163185608P | 2021-05-07 | 2021-05-07 | |
| PCT/US2022/027262 WO2022235558A1 (en) | 2021-05-07 | 2022-05-02 | Aryl 3-oxopiperazine carboxamides and heteroaryl 3-oxopiperazine carboxamides as nav1.8 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023023186A2 true BR112023023186A2 (pt) | 2024-01-30 |
Family
ID=83932809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023023186A BR112023023186A2 (pt) | 2021-05-07 | 2022-05-02 | 3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240246932A1 (pt) |
| EP (1) | EP4334306A1 (pt) |
| JP (1) | JP2024519487A (pt) |
| KR (1) | KR20240006606A (pt) |
| CN (1) | CN117597339A (pt) |
| AU (1) | AU2022270061A1 (pt) |
| BR (1) | BR112023023186A2 (pt) |
| CA (1) | CA3217605A1 (pt) |
| MX (1) | MX2023013147A (pt) |
| WO (1) | WO2022235558A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202404969A (zh) | 2022-04-22 | 2024-02-01 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
| WO2023205468A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205465A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| US20230382910A1 (en) | 2022-04-22 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070063526A (ko) * | 2004-08-30 | 2007-06-19 | 뉴로메드 파머큐티칼즈 리미티드 | 칼슘 채널 차단제인 우레아 유도체 |
| WO2006050476A2 (en) * | 2004-11-03 | 2006-05-11 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as ion channel modulators and methods of use |
| DE602008000809D1 (de) * | 2007-03-23 | 2010-04-29 | Icagen Inc | Ionenkanal-Hemmer |
| BR112021008524A8 (pt) * | 2018-11-02 | 2023-02-07 | Merck Sharp & Dohme | 2-amino-n-heteroaril-nicotinamidas como inibidores de nav 1.8 |
-
2022
- 2022-05-02 EP EP22799359.9A patent/EP4334306A1/en active Pending
- 2022-05-02 CA CA3217605A patent/CA3217605A1/en active Pending
- 2022-05-02 WO PCT/US2022/027262 patent/WO2022235558A1/en active Application Filing
- 2022-05-02 CN CN202280047884.9A patent/CN117597339A/zh active Pending
- 2022-05-02 JP JP2023567930A patent/JP2024519487A/ja active Pending
- 2022-05-02 BR BR112023023186A patent/BR112023023186A2/pt unknown
- 2022-05-02 AU AU2022270061A patent/AU2022270061A1/en active Pending
- 2022-05-02 US US18/557,667 patent/US20240246932A1/en active Pending
- 2022-05-02 MX MX2023013147A patent/MX2023013147A/es unknown
- 2022-05-02 KR KR1020237042102A patent/KR20240006606A/ko active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| US20240246932A1 (en) | 2024-07-25 |
| KR20240006606A (ko) | 2024-01-15 |
| WO2022235558A1 (en) | 2022-11-10 |
| EP4334306A1 (en) | 2024-03-13 |
| CN117597339A (zh) | 2024-02-23 |
| MX2023013147A (es) | 2023-11-28 |
| AU2022270061A1 (en) | 2023-11-16 |
| CA3217605A1 (en) | 2022-11-10 |
| JP2024519487A (ja) | 2024-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112021008524A8 (pt) | 2-amino-n-heteroaril-nicotinamidas como inibidores de nav 1.8 | |
| BR112022024476A2 (pt) | 5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8 | |
| BR112022024450A2 (pt) | 2-oxo-oxazolidina-5-carboxamidas como inibidores de nav1.8 | |
| BR112023023186A2 (pt) | 3-oxopiperazina carboxamidas de arila e 3-oxopiperazina carboxamidas de heteroarla como inibidores de nav1.8 | |
| BR112022025805A2 (pt) | Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir um distúrbio, condição ou doença | |
| BR112023023239A2 (pt) | Carboxamidas de cicloalquil 3-oxopiperazina e carboxamidas de cicloheteroalquil 3-oxopiperazina como inibidores de nav1.8 | |
| MX2023007192A (es) | Inhibidores de prmt5. | |
| BR112022010924A2 (pt) | Tetra-hidrofuranos substituídos como moduladores de canais de sódio | |
| MX2022015857A (es) | Compuestos de dihidroquinolin sulfonamida de heteroalquilo. | |
| BR112022022535A2 (pt) | Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk | |
| BR112023002659A2 (pt) | Inibidores de cetona não hidratados de nav1.7 para o tratamento da dor | |
| BR112022009185A2 (pt) | Heteroarilaminossulfonamidas de 5 membros para tratar afecções mediadas por atividade de cftr deficiente | |
| CO2021002976A2 (es) | Amidas heterocíclicas de 5 a 7 miembros como inhibidores de jak | |
| BR112019018615A2 (pt) | compostos antimicrobianos, composições e usos dos mesmos | |
| BR112021025764A2 (pt) | Derivado de pirimidina que inibe o crescimento de células cancerígenas e uso medicinal do mesmo | |
| BR112022014861A2 (pt) | Métodos de tratamento para deficiência de alfa-1 antittripsina | |
| WO2022192594A3 (en) | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease | |
| BR112021024999A2 (pt) | Inibidores de prmt5 | |
| MX2023007150A (es) | Compuestos de pirazol que contienen boro, composiciones que los comprenden, métodos y usos de los mismos. | |
| EA202193211A1 (ru) | Лечение синуклеопатий | |
| BR112021025618A2 (pt) | Composto, método para prevenir, tratar ou diminuir a gravidade de uma doença, composição farmacêutica e uso de um composto | |
| WO2019066548A3 (ko) | 심부전의 예방 또는 치료용 약학적 조성물 | |
| EA201992005A1 (ru) | Арильные, гетероарильные и гетероциклические фармацевтические соединения для лечения медицинских нарушений | |
| BR112018067718A2 (pt) | composições e métodos para tratamento de doenças da mucosa nasal e paranasal com agonistas do receptor de acetilcolina nicotínica |