BR112022018596A2 - Formas cristalinas de um agonista de receptor farnesoide x - Google Patents
Formas cristalinas de um agonista de receptor farnesoide xInfo
- Publication number
- BR112022018596A2 BR112022018596A2 BR112022018596A BR112022018596A BR112022018596A2 BR 112022018596 A2 BR112022018596 A2 BR 112022018596A2 BR 112022018596 A BR112022018596 A BR 112022018596A BR 112022018596 A BR112022018596 A BR 112022018596A BR 112022018596 A2 BR112022018596 A2 BR 112022018596A2
- Authority
- BR
- Brazil
- Prior art keywords
- farnesoid
- receptor agonist
- crystalline forms
- hydroxyazetidine
- octan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062991213P | 2020-03-18 | 2020-03-18 | |
| PCT/US2021/022790 WO2021188692A1 (en) | 2020-03-18 | 2021-03-17 | Crystalline forms of a farnesoid x receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022018596A2 true BR112022018596A2 (pt) | 2023-03-07 |
Family
ID=77771306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022018596A BR112022018596A2 (pt) | 2020-03-18 | 2021-03-17 | Formas cristalinas de um agonista de receptor farnesoide x |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12545660B2 (https=) |
| EP (1) | EP4121010A4 (https=) |
| JP (2) | JP7664278B2 (https=) |
| KR (1) | KR20220155356A (https=) |
| CN (1) | CN115666521A (https=) |
| AR (1) | AR121596A1 (https=) |
| AU (1) | AU2021236648A1 (https=) |
| BR (1) | BR112022018596A2 (https=) |
| CA (1) | CA3171987A1 (https=) |
| IL (1) | IL296532A (https=) |
| MX (2) | MX2022011582A (https=) |
| TW (1) | TW202144332A (https=) |
| WO (1) | WO2021188692A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019344903B2 (en) | 2018-09-18 | 2025-02-27 | Eli Lilly And Company | Farnesoid X receptor agonists and uses thereof |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| KR20220155356A (ko) | 2020-03-18 | 2022-11-22 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제의 결정형 |
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| AU2003249983A1 (en) | 2002-07-18 | 2004-02-09 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
| BR0314126A (pt) | 2002-09-20 | 2005-06-28 | Pfizer Prod Inc | Ligandos de amida acìclica e sulfonamida para o receptor de estrogênio |
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| WO2020060007A1 (ko) | 2018-09-17 | 2020-03-26 | 엘지전자 주식회사 | 5g 이동통신에서 pdu 세션을 핸들링하는 방법 및 무선 기기 |
| JP2022500393A (ja) * | 2018-09-18 | 2022-01-04 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストおよびその使用 |
| WO2020061118A1 (en) | 2018-09-18 | 2020-03-26 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| EP3852749A4 (en) | 2018-09-18 | 2022-08-24 | Metacrine, Inc. | CRYSTALLINE FORMS OF A FARNESOID X RECEPTOR AGONIST |
| WO2020061116A1 (en) * | 2018-09-18 | 2020-03-26 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
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| CN113056264A (zh) | 2018-09-18 | 2021-06-29 | 梅塔科林公司 | 法尼醇x受体激动剂及其用途 |
| AU2019344903B2 (en) | 2018-09-18 | 2025-02-27 | Eli Lilly And Company | Farnesoid X receptor agonists and uses thereof |
| CN120732855A (zh) | 2020-03-18 | 2025-10-03 | 伊莱利利公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| KR20220155356A (ko) | 2020-03-18 | 2022-11-22 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제의 결정형 |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
-
2021
- 2021-03-17 KR KR1020227036019A patent/KR20220155356A/ko active Pending
- 2021-03-17 IL IL296532A patent/IL296532A/en unknown
- 2021-03-17 JP JP2022555915A patent/JP7664278B2/ja active Active
- 2021-03-17 AU AU2021236648A patent/AU2021236648A1/en active Pending
- 2021-03-17 AR ARP210100667A patent/AR121596A1/es not_active Application Discontinuation
- 2021-03-17 MX MX2022011582A patent/MX2022011582A/es unknown
- 2021-03-17 TW TW110109624A patent/TW202144332A/zh unknown
- 2021-03-17 US US17/906,582 patent/US12545660B2/en active Active
- 2021-03-17 WO PCT/US2021/022790 patent/WO2021188692A1/en not_active Ceased
- 2021-03-17 EP EP21770893.2A patent/EP4121010A4/en active Pending
- 2021-03-17 CA CA3171987A patent/CA3171987A1/en active Pending
- 2021-03-17 BR BR112022018596A patent/BR112022018596A2/pt not_active Application Discontinuation
- 2021-03-17 CN CN202180036362.4A patent/CN115666521A/zh active Pending
-
2022
- 2022-09-15 MX MX2025009319A patent/MX2025009319A/es unknown
-
2025
- 2025-04-04 JP JP2025062686A patent/JP2025121901A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202144332A (zh) | 2021-12-01 |
| CA3171987A1 (en) | 2021-09-23 |
| US12545660B2 (en) | 2026-02-10 |
| AU2021236648A1 (en) | 2022-10-13 |
| CN115666521A (zh) | 2023-01-31 |
| MX2022011582A (es) | 2022-12-13 |
| WO2021188692A1 (en) | 2021-09-23 |
| KR20220155356A (ko) | 2022-11-22 |
| MX2025009319A (es) | 2025-09-02 |
| EP4121010A1 (en) | 2023-01-25 |
| IL296532A (en) | 2022-11-01 |
| US20230147756A1 (en) | 2023-05-11 |
| JP7664278B2 (ja) | 2025-04-17 |
| EP4121010A4 (en) | 2024-04-10 |
| JP2025121901A (ja) | 2025-08-20 |
| AR121596A1 (es) | 2022-06-22 |
| JP2023518399A (ja) | 2023-05-01 |
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