BR112022012191A2 - Construtos de anticorpos multiespecíficos agonistas de cd40 visados à mesotelina para o tratamento de tumores sólidos - Google Patents

Construtos de anticorpos multiespecíficos agonistas de cd40 visados à mesotelina para o tratamento de tumores sólidos

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Publication number
BR112022012191A2
BR112022012191A2 BR112022012191A BR112022012191A BR112022012191A2 BR 112022012191 A2 BR112022012191 A2 BR 112022012191A2 BR 112022012191 A BR112022012191 A BR 112022012191A BR 112022012191 A BR112022012191 A BR 112022012191A BR 112022012191 A2 BR112022012191 A2 BR 112022012191A2
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Prior art keywords
agonist
solid tumors
mesothelin
targeted
treatment
Prior art date
Application number
BR112022012191A
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English (en)
Inventor
Yu Xin
Egen Jackson
Garces Fernando
Takenaka Shunsuke
Kim Aeryon
Sawant Deepali
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Amgen Inc
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Publication date
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Publication of BR112022012191A2 publication Critical patent/BR112022012191A2/pt

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07KPEPTIDES
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

CONSTRUTOS DE ANTICORPOS MULTIESPECÍFICOS AGONISTAS DE CD40 VISADOS À MESOTELINA PARA O TRATAMENTO DE TUMORES SÓLIDOS. A presente invenção se relaciona com um construto de anticorpo multiespecífico agonista de CD40 humano para tratamento de tumores sólidos por manipulação de uma molécula que visa especificamente a via de CD40 em APCs associadas a tumores, sem ativação sistêmica de CD40.
BR112022012191A 2019-12-20 2020-12-18 Construtos de anticorpos multiespecíficos agonistas de cd40 visados à mesotelina para o tratamento de tumores sólidos BR112022012191A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962951408P 2019-12-20 2019-12-20
PCT/US2020/066157 WO2021127528A1 (en) 2019-12-20 2020-12-18 Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors

Publications (1)

Publication Number Publication Date
BR112022012191A2 true BR112022012191A2 (pt) 2022-12-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012191A BR112022012191A2 (pt) 2019-12-20 2020-12-18 Construtos de anticorpos multiespecíficos agonistas de cd40 visados à mesotelina para o tratamento de tumores sólidos

Country Status (16)

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US (2) US11926672B2 (pt)
EP (1) EP4077392A1 (pt)
JP (1) JP2023507323A (pt)
KR (1) KR20220117300A (pt)
CN (1) CN115175936A (pt)
AR (1) AR120832A1 (pt)
AU (1) AU2020405230A1 (pt)
BR (1) BR112022012191A2 (pt)
CA (1) CA3164129A1 (pt)
CL (1) CL2022001697A1 (pt)
IL (1) IL293640A (pt)
MX (1) MX2022007688A (pt)
TW (1) TW202136306A (pt)
UY (1) UY38995A (pt)
WO (1) WO2021127528A1 (pt)
ZA (1) ZA202206541B (pt)

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