BR112021024147A2 - Métodos para limpar um material de cromatografia de troca iônica para reutilização e para purificar um polipeptídeo - Google Patents
Métodos para limpar um material de cromatografia de troca iônica para reutilização e para purificar um polipeptídeoInfo
- Publication number
- BR112021024147A2 BR112021024147A2 BR112021024147A BR112021024147A BR112021024147A2 BR 112021024147 A2 BR112021024147 A2 BR 112021024147A2 BR 112021024147 A BR112021024147 A BR 112021024147A BR 112021024147 A BR112021024147 A BR 112021024147A BR 112021024147 A2 BR112021024147 A2 BR 112021024147A2
- Authority
- BR
- Brazil
- Prior art keywords
- reuse
- ion exchange
- methods
- exchange chromatography
- cleaning
- Prior art date
Links
- 238000004255 ion exchange chromatography Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000004140 cleaning Methods 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/50—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents
- B01J49/53—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents for cationic exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/05—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds
- B01J49/06—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds containing cationic exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/05—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds
- B01J49/07—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds containing anionic exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/50—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents
- B01J49/57—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents for anionic exchangers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Abstract
métodos para limpar um material de cromatografia de troca iônica para reutilização e para purificar um polipeptídeo. a presente invenção fornece métodos para limpar ou regenerar um material de cromatografia para reutilização. os métodos da invenção podem ser usados para limpar ou regenerar colunas de cromatografia de troca iônica para reutilização na fabricação em grande escala de produtos polipeptídicos múltiplos, em que a coluna de cromatografia de troca iônica é usada em modo de sobrecarga.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962857734P | 2019-06-05 | 2019-06-05 | |
PCT/US2020/036126 WO2020247634A1 (en) | 2019-06-05 | 2020-06-04 | A method for regeneration of an overload chromatography column |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021024147A2 true BR112021024147A2 (pt) | 2022-01-11 |
Family
ID=71608042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021024147A BR112021024147A2 (pt) | 2019-06-05 | 2020-06-04 | Métodos para limpar um material de cromatografia de troca iônica para reutilização e para purificar um polipeptídeo |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220203347A1 (pt) |
EP (1) | EP3980153A1 (pt) |
JP (1) | JP2022535526A (pt) |
KR (1) | KR20220017436A (pt) |
CN (1) | CN114096553A (pt) |
AR (1) | AR119264A1 (pt) |
AU (1) | AU2020286442A1 (pt) |
BR (1) | BR112021024147A2 (pt) |
CA (1) | CA3140903A1 (pt) |
IL (1) | IL288518A (pt) |
MX (1) | MX2021014920A (pt) |
SG (1) | SG11202112816WA (pt) |
TW (1) | TW202112799A (pt) |
WO (1) | WO2020247634A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113842673B (zh) * | 2021-09-07 | 2023-01-06 | 济宁海关综合技术服务中心 | 液相色谱柱再生方法 |
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FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
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US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
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US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
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-
2020
- 2020-06-03 AR ARP200101568A patent/AR119264A1/es unknown
- 2020-06-03 TW TW109118701A patent/TW202112799A/zh unknown
- 2020-06-04 MX MX2021014920A patent/MX2021014920A/es unknown
- 2020-06-04 CA CA3140903A patent/CA3140903A1/en active Pending
- 2020-06-04 WO PCT/US2020/036126 patent/WO2020247634A1/en unknown
- 2020-06-04 AU AU2020286442A patent/AU2020286442A1/en active Pending
- 2020-06-04 SG SG11202112816WA patent/SG11202112816WA/en unknown
- 2020-06-04 BR BR112021024147A patent/BR112021024147A2/pt unknown
- 2020-06-04 JP JP2021571606A patent/JP2022535526A/ja active Pending
- 2020-06-04 KR KR1020217043257A patent/KR20220017436A/ko unknown
- 2020-06-04 CN CN202080050604.0A patent/CN114096553A/zh active Pending
- 2020-06-04 EP EP20740101.9A patent/EP3980153A1/en active Pending
-
2021
- 2021-11-29 IL IL288518A patent/IL288518A/en unknown
- 2021-12-03 US US17/542,138 patent/US20220203347A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220203347A1 (en) | 2022-06-30 |
AU2020286442A1 (en) | 2021-12-16 |
SG11202112816WA (en) | 2021-12-30 |
WO2020247634A1 (en) | 2020-12-10 |
MX2021014920A (es) | 2022-01-24 |
JP2022535526A (ja) | 2022-08-09 |
IL288518A (en) | 2022-01-01 |
CN114096553A (zh) | 2022-02-25 |
AR119264A1 (es) | 2021-12-09 |
KR20220017436A (ko) | 2022-02-11 |
TW202112799A (zh) | 2021-04-01 |
EP3980153A1 (en) | 2022-04-13 |
CA3140903A1 (en) | 2020-12-10 |
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B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |