BR112021019113A2 - Conjugados de hialuronano e usos dos mesmos - Google Patents
Conjugados de hialuronano e usos dos mesmosInfo
- Publication number
- BR112021019113A2 BR112021019113A2 BR112021019113A BR112021019113A BR112021019113A2 BR 112021019113 A2 BR112021019113 A2 BR 112021019113A2 BR 112021019113 A BR112021019113 A BR 112021019113A BR 112021019113 A BR112021019113 A BR 112021019113A BR 112021019113 A2 BR112021019113 A2 BR 112021019113A2
- Authority
- BR
- Brazil
- Prior art keywords
- hyaluronan
- conjugates
- sex hormone
- hyaluronan conjugates
- document
- Prior art date
Links
- 229920002674 hyaluronan Polymers 0.000 title abstract 7
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 title abstract 4
- 229940099552 hyaluronan Drugs 0.000 title abstract 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 abstract 3
- 239000003163 gonadal steroid hormone Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000000600 disaccharide group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
conjugados de hialuronano e usos dos mesmos. o presente documento revela um conjugado de hialuronano, que inclui um ácido hialurônico (ha), um hormônio sexual e um ligante para acoplar uma das unidades de dissacarídeo de ha e o hormônio sexual. também são revelados neste documento os usos do conjugado de hialuronano no tratamento ou prevenção de doenças neurodegenerativas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962856714P | 2019-06-03 | 2019-06-03 | |
| PCT/US2020/035780 WO2020247407A1 (en) | 2019-06-03 | 2020-06-02 | Hyaluronan conjugates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021019113A2 true BR112021019113A2 (pt) | 2021-12-14 |
Family
ID=73550112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021019113A BR112021019113A2 (pt) | 2019-06-03 | 2020-06-02 | Conjugados de hialuronano e usos dos mesmos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11524079B2 (pt) |
| EP (2) | EP3976019A4 (pt) |
| JP (1) | JP7275320B2 (pt) |
| KR (1) | KR20210151062A (pt) |
| CN (1) | CN113660933B (pt) |
| AU (1) | AU2020288834B2 (pt) |
| BR (1) | BR112021019113A2 (pt) |
| CA (1) | CA3133671C (pt) |
| CO (1) | CO2021012240A2 (pt) |
| EA (1) | EA202192225A1 (pt) |
| IL (1) | IL287917A (pt) |
| MX (1) | MX2021013140A (pt) |
| SG (1) | SG11202109152UA (pt) |
| TW (2) | TWI737330B (pt) |
| WO (2) | WO2020247407A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024080183A1 (ja) * | 2022-10-14 | 2024-04-18 | 国立大学法人東海国立大学機構 | 糖鎖複合体、薬物担体、及びドラッグデリバリーシステム |
| CN115970046B (zh) * | 2022-12-02 | 2024-04-26 | 南京工业大学 | 一种多功能水凝胶在制备治疗糖尿病伤口药物中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002087552A2 (en) * | 2001-05-01 | 2002-11-07 | Mcgill University | Androgen-mediated neuroprotection and uses thereof |
| AU2002951868A0 (en) * | 2002-10-04 | 2002-10-24 | Prana Biotechnology Limited | Compound i |
| US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
| WO2007009087A2 (en) * | 2005-07-12 | 2007-01-18 | Dmi Biosciences, Inc. | Methods and products for treatment of diseases |
| CA2616607C (en) * | 2005-07-27 | 2015-06-02 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| KR100806088B1 (ko) | 2007-08-09 | 2008-02-21 | 고려대학교 산학협력단 | 히알루론산과 폴리에틸렌이민으로 이루어진 양이온성고분자 접합체를 이용한 핵산 전달용 조성물 |
| WO2011148116A2 (fr) | 2010-05-27 | 2011-12-01 | Laboratoire Idenov | Acide hyaluronique modifie, procede de fabrication et utilisations |
| US8895069B2 (en) | 2011-05-16 | 2014-11-25 | Postech Academy-Industry Foundation | Drug delivery system using hyaluronic acid-peptide conjugate micelle |
| US20130116411A1 (en) | 2011-09-06 | 2013-05-09 | Allergan, Inc. | Methods of making hyaluronic acid/collagen compositions |
| CA2884142C (en) * | 2012-09-05 | 2020-11-10 | Chugai Seiyaku Kabushiki Kaisha | Hyaluronic acid derivative having amino acid and steryl group introduced thereinto |
| KR20150128856A (ko) * | 2013-03-08 | 2015-11-18 | 알러간, 인코포레이티드 | 스테로이드 약물과 결합된 항생제 컨쥬게이트 |
| US10000582B2 (en) * | 2013-04-02 | 2018-06-19 | The Regents Of The University Of California | Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof |
| US9572832B2 (en) | 2013-08-29 | 2017-02-21 | Holy Stone Healthcare Co., Ltd. | Compound of glycosaminoglycan and its fabrication method as well as application |
| JP6355842B2 (ja) * | 2014-07-10 | 2018-07-11 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | マルチドラッグ送達システム及びその使用 |
| US20160279108A1 (en) | 2015-02-24 | 2016-09-29 | University Of Kansas | Targeted mtor inhibitors |
| KR101818705B1 (ko) | 2015-07-20 | 2018-01-16 | 포항공과대학교 산학협력단 | 약물이 충전된 히알루론산 가교물 하이드로겔 및 이의 이용 |
| WO2017120193A1 (en) | 2016-01-04 | 2017-07-13 | University Of Kansas | Drug delivery compositions and methods |
| CZ2016826A3 (cs) | 2016-12-22 | 2018-07-04 | Contipro A.S. | Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití |
| TWI626043B (zh) * | 2017-06-13 | 2018-06-11 | 心悅生醫股份有限公司 | 苯甲酸鋰用於治療中樞神經系統疾病的用途 |
| TW201912152A (zh) * | 2017-08-30 | 2019-04-01 | 保羅 L 曼弗雷蒂 | 用於治療或預防神經系統病症及其症狀及表現、以及用於對抗疾病及細胞老化及其症狀及表現之細胞保護之化合物 |
-
2020
- 2020-06-02 EP EP20818542.1A patent/EP3976019A4/en active Pending
- 2020-06-02 EA EA202192225A patent/EA202192225A1/ru unknown
- 2020-06-02 CA CA3133671A patent/CA3133671C/en active Active
- 2020-06-02 JP JP2021568410A patent/JP7275320B2/ja active Active
- 2020-06-02 AU AU2020288834A patent/AU2020288834B2/en active Active
- 2020-06-02 KR KR1020217029017A patent/KR20210151062A/ko not_active Application Discontinuation
- 2020-06-02 US US16/891,020 patent/US11524079B2/en active Active
- 2020-06-02 WO PCT/US2020/035780 patent/WO2020247407A1/en active Application Filing
- 2020-06-02 CN CN202080016386.9A patent/CN113660933B/zh active Active
- 2020-06-02 MX MX2021013140A patent/MX2021013140A/es unknown
- 2020-06-02 SG SG11202109152UA patent/SG11202109152UA/en unknown
- 2020-06-02 BR BR112021019113A patent/BR112021019113A2/pt unknown
- 2020-06-03 TW TW109118583A patent/TWI737330B/zh active
- 2020-12-10 WO PCT/US2020/064293 patent/WO2021247076A1/en unknown
- 2020-12-10 EP EP20938836.2A patent/EP4157256A1/en active Pending
- 2020-12-11 TW TW109143747A patent/TWI817065B/zh active
-
2021
- 2021-09-17 CO CONC2021/0012240A patent/CO2021012240A2/es unknown
- 2021-11-08 IL IL287917A patent/IL287917A/en unknown
-
2022
- 2022-11-02 US US17/979,450 patent/US20230080473A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI737330B (zh) | 2021-08-21 |
| SG11202109152UA (en) | 2021-12-30 |
| TWI817065B (zh) | 2023-10-01 |
| US20230080473A1 (en) | 2023-03-16 |
| CN113660933A (zh) | 2021-11-16 |
| AU2020288834A1 (en) | 2021-09-16 |
| WO2020247407A1 (en) | 2020-12-10 |
| EP4157256A1 (en) | 2023-04-05 |
| MX2021013140A (es) | 2021-12-10 |
| CO2021012240A2 (es) | 2021-09-30 |
| EA202192225A1 (ru) | 2022-03-15 |
| CA3133671A1 (en) | 2020-12-10 |
| CA3133671C (en) | 2023-12-19 |
| US11524079B2 (en) | 2022-12-13 |
| EP3976019A4 (en) | 2023-03-01 |
| JP7275320B2 (ja) | 2023-05-17 |
| CN113660933B (zh) | 2023-12-01 |
| JP2022539652A (ja) | 2022-09-13 |
| TW202110456A (zh) | 2021-03-16 |
| KR20210151062A (ko) | 2021-12-13 |
| IL287917A (en) | 2022-01-01 |
| EP3976019A1 (en) | 2022-04-06 |
| TW202146051A (zh) | 2021-12-16 |
| US20200376132A1 (en) | 2020-12-03 |
| WO2021247076A1 (en) | 2021-12-09 |
| AU2020288834B2 (en) | 2022-12-22 |
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