BR112019026452A2 - compostos químicos como inibidores de h-pgds - Google Patents

compostos químicos como inibidores de h-pgds Download PDF

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Publication number
BR112019026452A2
BR112019026452A2 BR112019026452-3A BR112019026452A BR112019026452A2 BR 112019026452 A2 BR112019026452 A2 BR 112019026452A2 BR 112019026452 A BR112019026452 A BR 112019026452A BR 112019026452 A2 BR112019026452 A2 BR 112019026452A2
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BR
Brazil
Prior art keywords
carboxamide
naphthyridine
muscle
trans
hydroxypropan
Prior art date
Application number
BR112019026452-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Dave Norman Deaton
Barry George Shearer
Mark Andrew Youngman
Original Assignee
Glaxosmithkline Intellectual Property Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Glaxosmithkline Intellectual Property Development Limited filed Critical Glaxosmithkline Intellectual Property Development Limited
Publication of BR112019026452A2 publication Critical patent/BR112019026452A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112019026452-3A 2017-06-13 2018-06-11 compostos químicos como inibidores de h-pgds BR112019026452A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762518779P 2017-06-13 2017-06-13
US62/518,779 2017-06-13
US201762522869P 2017-06-21 2017-06-21
US62/522,869 2017-06-21
PCT/IB2018/054206 WO2018229629A1 (en) 2017-06-13 2018-06-11 Chemical compounds as h-pgds inhibitors

Publications (1)

Publication Number Publication Date
BR112019026452A2 true BR112019026452A2 (pt) 2020-07-14

Family

ID=62948277

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019026452-3A BR112019026452A2 (pt) 2017-06-13 2018-06-11 compostos químicos como inibidores de h-pgds

Country Status (9)

Country Link
US (1) US11149035B2 (enExample)
EP (1) EP3638672A1 (enExample)
JP (1) JP2020523367A (enExample)
CN (1) CN110753692A (enExample)
BR (1) BR112019026452A2 (enExample)
CA (1) CA3066979A1 (enExample)
TW (1) TW201908311A (enExample)
UY (1) UY37764A (enExample)
WO (1) WO2018229629A1 (enExample)

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JP2022506850A (ja) * 2018-11-08 2022-01-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 化学化合物
CN109651241B (zh) * 2018-12-27 2021-02-09 上海毕得医药科技股份有限公司 一种4-溴-6-氯烟醛的合成方法
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CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
US20250074906A1 (en) 2021-12-17 2025-03-06 Sato Pharmaceutical Co., Ltd. Azaindole derivative that inhibits h-pgds

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CN111479814A (zh) * 2017-12-13 2020-07-31 葛兰素史密斯克莱知识产权发展有限公司 作为h-pgds抑制剂的稠合的吡啶

Also Published As

Publication number Publication date
US11149035B2 (en) 2021-10-19
JP2020523367A (ja) 2020-08-06
CN110753692A (zh) 2020-02-04
TW201908311A (zh) 2019-03-01
US20200123152A1 (en) 2020-04-23
CA3066979A1 (en) 2018-12-20
EP3638672A1 (en) 2020-04-22
WO2018229629A1 (en) 2018-12-20
UY37764A (es) 2019-01-02

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements