JP2020523367A - Ｈ−ｐｇｄｓ阻害剤としての化学化合物 - Google Patents

Ｈ−ｐｇｄｓ阻害剤としての化学化合物 Download PDF

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Publication number
JP2020523367A
JP2020523367A JP2019568760A JP2019568760A JP2020523367A JP 2020523367 A JP2020523367 A JP 2020523367A JP 2019568760 A JP2019568760 A JP 2019568760A JP 2019568760 A JP2019568760 A JP 2019568760A JP 2020523367 A JP2020523367 A JP 2020523367A
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JP
Japan
Prior art keywords
alkyl
naphthyridine
carboxamide
substituted
fluoro
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Ceased
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JP2019568760A
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English (en)
Japanese (ja)
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JP2020523367A5 (enExample
Inventor
デイブ、ノーマン、ディートン
バリー、ジョージ、シアラー
マーク、アンドリュー、ヤングマン
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Publication of JP2020523367A publication Critical patent/JP2020523367A/ja
Publication of JP2020523367A5 publication Critical patent/JP2020523367A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019568760A 2017-06-13 2018-06-11 Ｈ−ｐｇｄｓ阻害剤としての化学化合物 Ceased JP2020523367A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762518779P 2017-06-13 2017-06-13
US62/518,779 2017-06-13
US201762522869P 2017-06-21 2017-06-21
US62/522,869 2017-06-21
PCT/IB2018/054206 WO2018229629A1 (en) 2017-06-13 2018-06-11 Chemical compounds as h-pgds inhibitors

Publications (2)

Publication Number Publication Date
JP2020523367A true JP2020523367A (ja) 2020-08-06
JP2020523367A5 JP2020523367A5 (enExample) 2021-06-10

Family

ID=62948277

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019568760A Ceased JP2020523367A (ja) 2017-06-13 2018-06-11 Ｈ−ｐｇｄｓ阻害剤としての化学化合物

Country Status (9)

Country Link
US (1) US11149035B2 (enExample)
EP (1) EP3638672A1 (enExample)
JP (1) JP2020523367A (enExample)
CN (1) CN110753692A (enExample)
BR (1) BR112019026452A2 (enExample)
CA (1) CA3066979A1 (enExample)
TW (1) TW201908311A (enExample)
UY (1) UY37764A (enExample)
WO (1) WO2018229629A1 (enExample)

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* Cited by examiner, † Cited by third party
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US20210139507A1 (en) * 2017-12-13 2021-05-13 Glaxosmithkline Intellectual Property Development Limited Fused pyridines which act as inhibitors of h pgds
BR112021008976A2 (pt) * 2018-11-08 2021-08-03 Glaxosmithkline Intellectual Property Development Limited compostos químicos
CN109651241B (zh) * 2018-12-27 2021-02-09 上海毕得医药科技股份有限公司 一种4-溴-6-氯烟醛的合成方法
JP7734129B2 (ja) 2020-06-19 2025-09-04 佐藤製薬株式会社 Ｈ－ｐｇｄｓを阻害する縮環化合物
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
PE20231311A1 (es) 2020-11-18 2023-08-24 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos
CA3240926A1 (en) 2021-12-17 2023-06-22 Sato Pharmaceutical Co., Ltd. Azaindole derivative inhibiting h-pgds

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WO2005094805A1 (ja) * 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体

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Also Published As

Publication number Publication date
CA3066979A1 (en) 2018-12-20
TW201908311A (zh) 2019-03-01
BR112019026452A2 (pt) 2020-07-14
EP3638672A1 (en) 2020-04-22
US11149035B2 (en) 2021-10-19
WO2018229629A1 (en) 2018-12-20
US20200123152A1 (en) 2020-04-23
CN110753692A (zh) 2020-02-04
UY37764A (es) 2019-01-02

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