BR112019023260A2 - Fatores de crescimento de fibroblastos recombinantes modificados e seus usos terapêuticos - Google Patents

Fatores de crescimento de fibroblastos recombinantes modificados e seus usos terapêuticos

Info

Publication number
BR112019023260A2
BR112019023260A2 BR112019023260-5A BR112019023260A BR112019023260A2 BR 112019023260 A2 BR112019023260 A2 BR 112019023260A2 BR 112019023260 A BR112019023260 A BR 112019023260A BR 112019023260 A2 BR112019023260 A2 BR 112019023260A2
Authority
BR
Brazil
Prior art keywords
fibroblast growth
growth factors
modified
therapeutic uses
modified recombinant
Prior art date
Application number
BR112019023260-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Eveleth David
Jenkins-Eveleth Jennifer
Subramaniam Amuthakannan
Bradshaw Ralph
Original Assignee
Trefoil Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trefoil Therapeutics, Inc. filed Critical Trefoil Therapeutics, Inc.
Publication of BR112019023260A2 publication Critical patent/BR112019023260A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112019023260-5A 2017-05-05 2018-05-04 Fatores de crescimento de fibroblastos recombinantes modificados e seus usos terapêuticos BR112019023260A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762502540P 2017-05-05 2017-05-05
US201762502529P 2017-05-05 2017-05-05
US62/502,540 2017-05-05
US62/502,529 2017-05-05
US201762584624P 2017-11-10 2017-11-10
US62/584,624 2017-11-10
PCT/US2018/031189 WO2018204847A2 (en) 2017-05-05 2018-05-04 Recombinant modified fibroblast growth factors and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
BR112019023260A2 true BR112019023260A2 (pt) 2022-02-22

Family

ID=64016756

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019023260-5A BR112019023260A2 (pt) 2017-05-05 2018-05-04 Fatores de crescimento de fibroblastos recombinantes modificados e seus usos terapêuticos

Country Status (12)

Country Link
US (2) US11479591B2 (https=)
EP (2) EP4621067A3 (https=)
JP (2) JP2020518287A (https=)
KR (1) KR20200078425A (https=)
CN (1) CN111148755A (https=)
AU (1) AU2018261021B2 (https=)
BR (1) BR112019023260A2 (https=)
CA (1) CA3062473A1 (https=)
DK (1) DK3619324T3 (https=)
ES (1) ES3041527T3 (https=)
MX (1) MX2019013210A (https=)
WO (1) WO2018204847A2 (https=)

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MX2019013210A (es) 2017-05-05 2020-07-20 Trefoil Therapeutics Inc Factores de crecimiento recombinantes modificados de fibroblastos y usos terapéuticos de los mismos.
WO2021261946A1 (ko) 2020-06-26 2021-12-30 엘티소재주식회사 헤테로고리 화합물 및 이를 이용한 유기 발광 소자
CN116710568A (zh) * 2020-06-26 2023-09-05 特里福伊尔治疗公司 重组修饰成纤维细胞生长因子及其治疗用途
EP4574211A3 (en) * 2021-05-14 2025-09-10 Claris Biotherapeutics, Inc. Compositions of growth factor for the treatment of eye disease
CN113289005B (zh) * 2021-07-06 2022-05-31 温州医科大学 rhFGF-21在制备治疗干眼症药物中的应用
WO2023019218A1 (en) * 2021-08-12 2023-02-16 Trefoil Therapeutics, Inc. Modified fibroblast growth factors for treating fibrotic diseases
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CN115177717B (zh) * 2022-08-31 2026-02-06 贵州医科大学附属医院 一种治疗眼表及角膜上皮疾病的药物

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Also Published As

Publication number Publication date
US20200190158A1 (en) 2020-06-18
US11479591B2 (en) 2022-10-25
RU2019139358A (ru) 2021-06-07
EP3619324B1 (en) 2025-07-09
MX2019013210A (es) 2020-07-20
US12600756B2 (en) 2026-04-14
KR20200078425A (ko) 2020-07-01
AU2018261021A1 (en) 2019-12-12
EP4621067A3 (en) 2025-11-19
EP3619324A4 (en) 2020-12-30
RU2019139358A3 (https=) 2021-08-26
AU2018261021B2 (en) 2024-09-12
EP4621067A2 (en) 2025-09-24
JP2020518287A (ja) 2020-06-25
US20230130851A1 (en) 2023-04-27
ES3041527T3 (en) 2025-11-12
JP2024112824A (ja) 2024-08-21
DK3619324T3 (da) 2025-09-22
EP3619324A2 (en) 2020-03-11
CA3062473A1 (en) 2018-11-08
WO2018204847A2 (en) 2018-11-08
CN111148755A (zh) 2020-05-12

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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