BR112021006280A2 - terapias imunoablativas - Google Patents
terapias imunoablativasInfo
- Publication number
- BR112021006280A2 BR112021006280A2 BR112021006280A BR112021006280A BR112021006280A2 BR 112021006280 A2 BR112021006280 A2 BR 112021006280A2 BR 112021006280 A BR112021006280 A BR 112021006280A BR 112021006280 A BR112021006280 A BR 112021006280A BR 112021006280 A2 BR112021006280 A2 BR 112021006280A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunoablative
- therapies
- diseases
- compositions
- immunoablation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
Abstract
terapias imunoablativas. esta invenção pertence a composições farmacêuticas compreendendo um glicocorticoide para uso no tratamento de doenças por imunoablação. as composições da invenção podem ser para uso no tratamento de doenças que são mediadas por células imunes como os linfócitos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18198491.5A EP3488851A1 (en) | 2018-10-03 | 2018-10-03 | Immunoablative therapies |
PCT/US2019/054395 WO2020072713A1 (en) | 2018-10-03 | 2019-10-03 | Immunoablative therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021006280A2 true BR112021006280A2 (pt) | 2021-07-06 |
Family
ID=63762311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021006280A BR112021006280A2 (pt) | 2018-10-03 | 2019-10-03 | terapias imunoablativas |
Country Status (14)
Country | Link |
---|---|
US (2) | US11446314B2 (pt) |
EP (2) | EP3488851A1 (pt) |
JP (1) | JP2020059703A (pt) |
KR (1) | KR20210072039A (pt) |
CN (1) | CN113164497A (pt) |
AU (1) | AU2019355004A1 (pt) |
BR (1) | BR112021006280A2 (pt) |
CA (1) | CA3113969A1 (pt) |
EA (1) | EA202190927A1 (pt) |
ES (1) | ES2863369T3 (pt) |
MX (1) | MX2021003797A (pt) |
SG (1) | SG11202103031SA (pt) |
WO (1) | WO2020072713A1 (pt) |
ZA (1) | ZA202102727B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3118505A1 (en) * | 2018-11-14 | 2020-05-22 | Avm Biotechnology, Llc | Stable glucocorticoid formulation |
US20230096897A1 (en) * | 2020-02-28 | 2023-03-30 | Avm Biotechnology, Llc | Lymphocyte Population and Methods for Producing Same |
CN115666583A (zh) | 2020-04-29 | 2023-01-31 | Avm生物技术有限责任公司 | 用于治疗sars-cov-2病毒的糖皮质激素受体(gr)调节剂 |
KR20230018422A (ko) * | 2020-06-01 | 2023-02-07 | 에이브이엠 바이오테크놀로지, 엘엘씨 | Icam-조절제를 이용한 치료 방법 |
KR20220163638A (ko) | 2021-06-03 | 2022-12-12 | 현대모비스 주식회사 | 차량용 제동장치 및 그 제어방법 |
CA3229529A1 (en) | 2021-09-01 | 2023-03-09 | Avm Biotechnology, Llc | Lymphocyte population and methods for producing same |
Family Cites Families (40)
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US3368937A (en) * | 1965-01-26 | 1968-02-13 | Merck & Co Inc | Injectable solid steroid-anesthetic |
US4554271A (en) * | 1984-02-24 | 1985-11-19 | The Upjohn Company | Use of high doses of derivatives of 6α-methylprednisolone for the acute treatment of stroke syndrome |
US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
GB9323199D0 (en) | 1993-11-10 | 1994-01-05 | Falkenberg J H F | Leukaemia treatment |
JPH10507758A (ja) * | 1994-10-19 | 1998-07-28 | ジェネティック セラピー,インコーポレイテッド | アデノウイルスおよび免疫抑制剤同時反復投与を伴う遺伝子治療 |
EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
AU2003225791A1 (en) | 2002-03-15 | 2003-09-29 | Department Of Veterans Affairs, Rehabilitation R And D Service | Methods and compositions for directing cells to target organs |
BR0309754A (pt) * | 2002-05-02 | 2007-03-13 | Univ Washington | métodos e composições para tratamento de distúrbios e doenças auto-imunes/inflamatórias mediados por célula t em indivìduos tendo uma deficiência de regulação de glicocorticóide |
WO2003095090A1 (en) * | 2002-05-08 | 2003-11-20 | Dana Corporation | Plasma-assisted carburizing |
CN103393695A (zh) | 2002-05-17 | 2013-11-20 | 细胞基因公司 | 用于治疗和控制多发性骨髓瘤的方法及组合物 |
JP3968334B2 (ja) | 2002-09-11 | 2007-08-29 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置及び荷電粒子線照射方法 |
GB0310593D0 (en) | 2003-05-08 | 2003-06-11 | Leuven K U Res & Dev | Peptidic prodrugs |
US20040247574A1 (en) | 2003-05-27 | 2004-12-09 | Christopherson Kent W. | Methods for enhancing stem cell engraftment during transplantation |
AU2005322068B2 (en) | 2004-12-23 | 2011-09-01 | Ethicon Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
PT1888033E (pt) * | 2005-06-09 | 2014-05-15 | Meda Ab | Método e composição para tratamento de distúrbios inflamatórios |
DE102005030733A1 (de) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
RU2486204C2 (ru) | 2005-07-22 | 2013-06-27 | Уай'З Терапьютикс Ко., Лтд. | Антитела против сd26 и способы их применения |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
GB0700058D0 (en) | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
US20100247491A1 (en) | 2007-02-01 | 2010-09-30 | Christof Westenfelder | Potentiation of Stem Cell Homing and Treatment of Organ Dysfunction or Organ Failure |
US20090299269A1 (en) | 2008-05-29 | 2009-12-03 | John Foley | Vascular stimulation to aid intravascular cell replacement therapy |
EP2300599B1 (en) | 2008-06-09 | 2017-03-01 | Targazyme, Inc. | Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase |
WO2009152186A1 (en) | 2008-06-09 | 2009-12-17 | American Stem Cell, Inc. | Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors |
JP5537104B2 (ja) * | 2009-09-16 | 2014-07-02 | テルモ株式会社 | 制吐剤 |
KR20190017065A (ko) | 2010-08-18 | 2019-02-19 | 테레사 데이셔 | 림프양 조직에 줄기 세포와 조상 세포 결합을 저해하고, 그리고 림프 조직에서 배 중심을 재생하기 위한 조성물과 방법 |
US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
KR20230133410A (ko) | 2010-12-09 | 2023-09-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도 |
EA201391059A1 (ru) | 2011-01-18 | 2014-05-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Композиции для лечения рака и способы их применения |
EP2532740A1 (en) | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
EP2756521A4 (en) | 2011-09-16 | 2015-04-22 | Univ Pennsylvania | RNA-MANIPULATED T-CELLS FOR THE TREATMENT OF CANCER |
WO2013166026A1 (en) | 2012-04-30 | 2013-11-07 | Allocure, Inc. | Methods of treating acute kidney injury using mesenchymal stem cells |
WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
US11091543B2 (en) * | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
IL295224A (en) | 2015-05-28 | 2022-10-01 | Kite Pharma Inc | Methods for training patients for t-cell therapy |
IL301948B1 (en) * | 2016-08-29 | 2024-05-01 | Tiziana Life Sciences Plc | Anti-CD3 antibody formulations |
MX2019004766A (es) * | 2016-10-24 | 2019-09-27 | Novimmune Sa | Metodos, composiciones y regimenes de dosificacion para tratar o prevenir indicaciones relacionadas con interferon-gamma. |
WO2018153984A1 (en) * | 2017-02-23 | 2018-08-30 | Universität Bern | Mtor inhibitor-corticoid combination therapy for multiple sclerosis |
JP6748221B2 (ja) | 2017-04-01 | 2020-08-26 | エーブイエム・バイオテクノロジー・エルエルシー | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
-
2018
- 2018-10-03 EP EP18198491.5A patent/EP3488851A1/en not_active Withdrawn
- 2018-12-20 US US16/227,068 patent/US11446314B2/en active Active
-
2019
- 2019-10-03 JP JP2019182659A patent/JP2020059703A/ja active Pending
- 2019-10-03 BR BR112021006280A patent/BR112021006280A2/pt unknown
- 2019-10-03 ES ES19201254T patent/ES2863369T3/es active Active
- 2019-10-03 US US17/281,016 patent/US20210338689A1/en active Pending
- 2019-10-03 SG SG11202103031SA patent/SG11202103031SA/en unknown
- 2019-10-03 AU AU2019355004A patent/AU2019355004A1/en active Pending
- 2019-10-03 EP EP19786713.8A patent/EP3860612A1/en active Pending
- 2019-10-03 EA EA202190927A patent/EA202190927A1/ru unknown
- 2019-10-03 CN CN201980076619.1A patent/CN113164497A/zh active Pending
- 2019-10-03 MX MX2021003797A patent/MX2021003797A/es unknown
- 2019-10-03 CA CA3113969A patent/CA3113969A1/en active Pending
- 2019-10-03 KR KR1020217013417A patent/KR20210072039A/ko unknown
- 2019-10-03 WO PCT/US2019/054395 patent/WO2020072713A1/en unknown
-
2021
- 2021-04-23 ZA ZA2021/02727A patent/ZA202102727B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020072713A1 (en) | 2020-04-09 |
EP3860612A1 (en) | 2021-08-11 |
MX2021003797A (es) | 2021-08-11 |
ES2863369T3 (es) | 2021-10-11 |
KR20210072039A (ko) | 2021-06-16 |
CA3113969A1 (en) | 2020-04-09 |
US20200108078A1 (en) | 2020-04-09 |
ZA202102727B (en) | 2022-05-25 |
US20210338689A1 (en) | 2021-11-04 |
EP3488851A1 (en) | 2019-05-29 |
JP2020059703A (ja) | 2020-04-16 |
AU2019355004A1 (en) | 2021-05-06 |
US11446314B2 (en) | 2022-09-20 |
EA202190927A1 (ru) | 2021-08-02 |
SG11202103031SA (en) | 2021-04-29 |
CN113164497A (zh) | 2021-07-23 |
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