BR112019015520A2 - Método para monitoramento não invasivo de agente traçador fluorescente com correções de reflexão difusa - Google Patents
Método para monitoramento não invasivo de agente traçador fluorescente com correções de reflexão difusa Download PDFInfo
- Publication number
- BR112019015520A2 BR112019015520A2 BR112019015520-1A BR112019015520A BR112019015520A2 BR 112019015520 A2 BR112019015520 A2 BR 112019015520A2 BR 112019015520 A BR112019015520 A BR 112019015520A BR 112019015520 A2 BR112019015520 A2 BR 112019015520A2
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- Prior art keywords
- signal
- detector during
- during illumination
- fluorescent agent
- light detector
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Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000000700 radioactive tracer Substances 0.000 title 1
- 238000005259 measurement Methods 0.000 abstract 4
- 238000005286 illumination Methods 0.000 abstract 3
- 230000005284 excitation Effects 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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Abstract
a presente invenção refere-se a um método para monitorar um sinal de fluorescência variável no tempo emitido de um agente fluorescente de dentro de um meio com propriedades ópticas variáveis no tempo que inclui fornecer um conjunto de dados de medida que inclui uma pluralidade de entradas de medida que inclui pelo menos duas medidas obtidas de um paciente antes e após a administração do agente fluorescente. as medidas podem incluir um ou mais dentre: um sinal drex detectado por um detector de luz não filtrada durante a iluminação pela luz de comprimento de onda excitória da primeira região adjacente ao meio refletor difuso; um sinal flr detectado por um detector de luz filtrada durante a iluminação pela luz de comprimento de onda excitória; e um sinal drem detectado pelo detector de luz não filtrada durante a iluminação pela luz de comprimento de onda por emissão. o método ainda inclui identificar uma porção de administração pós-agente do conjunto de dados de medida; e transformar cada sinal flr a um sinal if representando uma intensidade de fluorescência detectada emitida apenas pelo agente fluorescente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762452025P | 2017-01-30 | 2017-01-30 | |
US62/452,025 | 2017-01-30 | ||
PCT/US2018/016041 WO2018140978A1 (en) | 2017-01-30 | 2018-01-30 | Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections |
Publications (1)
Publication Number | Publication Date |
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BR112019015520A2 true BR112019015520A2 (pt) | 2020-03-17 |
Family
ID=62977348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112019015520-1A BR112019015520A2 (pt) | 2017-01-30 | 2018-01-30 | Método para monitoramento não invasivo de agente traçador fluorescente com correções de reflexão difusa |
Country Status (15)
Country | Link |
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US (5) | US10548521B2 (pt) |
EP (1) | EP3573518A4 (pt) |
JP (2) | JP6861288B2 (pt) |
KR (2) | KR102429632B1 (pt) |
CN (3) | CN110520035B (pt) |
AU (1) | AU2018213422B2 (pt) |
BR (1) | BR112019015520A2 (pt) |
CA (2) | CA3203465A1 (pt) |
IL (2) | IL300236B2 (pt) |
MX (2) | MX2019009040A (pt) |
PH (1) | PH12019501749A1 (pt) |
RU (1) | RU2721652C1 (pt) |
SG (2) | SG10202108183SA (pt) |
WO (1) | WO2018140978A1 (pt) |
ZA (1) | ZA201904973B (pt) |
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