SG10202108183SA - Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections - Google Patents

Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections

Info

Publication number
SG10202108183SA
SG10202108183SA SG10202108183SA SG10202108183SA SG10202108183SA SG 10202108183S A SG10202108183S A SG 10202108183SA SG 10202108183S A SG10202108183S A SG 10202108183SA SG 10202108183S A SG10202108183S A SG 10202108183SA SG 10202108183S A SG10202108183S A SG 10202108183SA
Authority
SG
Singapore
Prior art keywords
diffuse reflection
fluorescent tracer
tracer agent
invasive monitoring
corrections
Prior art date
Application number
SG10202108183SA
Inventor
Kimberly Shultz
Jennifer Keating
Edward Solomon
Kate Bechtel
Original Assignee
Medibeacon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medibeacon Inc filed Critical Medibeacon Inc
Publication of SG10202108183SA publication Critical patent/SG10202108183SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0407—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44—Electric circuits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0224—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using polarising or depolarising elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0237—Adjustable, e.g. focussing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32—Investigating bands of a spectrum in sequence by a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/36—Investigating two or more bands of a spectrum by separate detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/46—Measurement of colour; Colour measuring devices, e.g. colorimeters
    • G01J3/50—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors
    • G01J3/51—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters
    • G01J3/513—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters having fixed filter-detector pairs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0271—Thermal or temperature sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1213—Filters in general, e.g. dichroic, band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G01J2003/2826—Multispectral imaging, e.g. filter imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/46—Measurement of colour; Colour measuring devices, e.g. colorimeters
    • G01J3/50—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors
    • G01J3/51—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters
    • G01J3/513—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters having fixed filter-detector pairs
    • G01J2003/516—Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters having fixed filter-detector pairs with several stacked filters or stacked filter-detector pairs

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
SG10202108183SA 2017-01-30 2018-01-30 Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections SG10202108183SA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762452025P 2017-01-30 2017-01-30

Publications (1)

Publication Number Publication Date
SG10202108183SA true SG10202108183SA (en) 2021-09-29

Family

ID=62977348

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202108183SA SG10202108183SA (en) 2017-01-30 2018-01-30 Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
SG11201906938WA SG11201906938WA (en) 2017-01-30 2018-01-30 Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201906938WA SG11201906938WA (en) 2017-01-30 2018-01-30 Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections

Country Status (15)

Country Link
US (5) US10548521B2 (en)
EP (1) EP3573518A4 (en)
JP (2) JP6861288B2 (en)
KR (2) KR102429632B1 (en)
CN (3) CN110520035B (en)
AU (1) AU2018213422B2 (en)
BR (1) BR112019015520A2 (en)
CA (2) CA3203465A1 (en)
IL (2) IL300236B2 (en)
MX (2) MX2019009040A (en)
PH (1) PH12019501749A1 (en)
RU (1) RU2721652C1 (en)
SG (2) SG10202108183SA (en)
WO (1) WO2018140978A1 (en)
ZA (1) ZA201904973B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102327738B1 (en) 2015-06-18 2021-11-17 삼성전기주식회사 Semiconductor package and method of manufacturing the same
KR20180052089A (en) * 2016-11-09 2018-05-17 가부시키가이샤 한도오따이 에네루기 켄큐쇼 Operation method of electronic device
WO2019084475A1 (en) 2017-10-27 2019-05-02 Medibeacon Inc. Compositions and systems for renal function determination
WO2020121852A1 (en) 2018-12-12 2020-06-18 浜松ホトニクス株式会社 Photodetector
JP7455520B2 (en) 2018-12-12 2024-03-26 浜松ホトニクス株式会社 light detection device
US11513002B2 (en) 2018-12-12 2022-11-29 Hamamatsu Photonics K.K. Light detection device having temperature compensated gain in avalanche photodiode
CA3125119A1 (en) * 2019-01-16 2020-07-23 Medibeacon Inc. Two piece sensor assembly and method of use
WO2020163342A1 (en) 2019-02-04 2020-08-13 Copious Imaging Llc Computational pixel imager with in-pixel histogram acquisition
WO2021178771A1 (en) * 2020-03-06 2021-09-10 Verily Life Sciences Llc Temperature sensor and fever alert generator with tunable parameters
EP4185194A1 (en) * 2020-07-24 2023-05-31 MediBeacon Inc. Systems and methods for home transdermal assessment of gastrointestinal function
KR20220046186A (en) * 2020-10-07 2022-04-14 삼성전자주식회사 Electronic device and method for measuring for skin autofluorescence in the electronic device
EP4019916A1 (en) * 2020-12-23 2022-06-29 OTT HydroMet B.V. Pyranometer
CN113476043A (en) * 2021-07-01 2021-10-08 深圳亿杉医疗科技有限公司 Non-invasive sensing device, detection method and detector
CN113720825B (en) * 2021-11-04 2022-02-08 四川丹诺迪科技有限公司 Optical instant detector and detection method and application
DE102022121505A1 (en) 2022-08-25 2024-03-07 Carl Zeiss Meditec Ag Method, computer program and data processing unit for preparing the observation of a fluorescence intensity, method for observing a fluorescence intensity and optical observation system
CN115728276B (en) * 2022-11-14 2024-01-23 中船重工安谱（湖北）仪器有限公司 Explosive detection method and detection system

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018006A1 (en) 1990-05-15 1991-11-28 Diatron Corporation Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1994012096A1 (en) 1992-12-01 1994-06-09 Somanetics Corporation Patient sensor for optical cerebral oximeters
US5847395A (en) * 1996-10-23 1998-12-08 Siemens Medical Systems Adaptive baseline correction for gamma camera
EP0934986A1 (en) 1997-12-17 1999-08-11 Roche Diagnostics GmbH Dye-polysaccharide or -cyclosaccharide conjugates and their use as diagnostic agent
US6720572B1 (en) 1999-06-25 2004-04-13 The Penn State Research Foundation Organic light emitters with improved carrier injection
DE10023051B4 (en) 2000-05-11 2004-02-19 Roche Diagnostics Gmbh Process for the preparation of fluorescein isothiocyanate sinistrin, its use and diagnostic preparation containing fluorescein isothiocyanate sinistrin
JP2001321363A (en) * 2000-05-16 2001-11-20 Nippon Koden Corp Organism parameter measuring device
GB2369428B (en) 2000-11-22 2004-11-10 Imperial College Detection system
US6697652B2 (en) * 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US20030215391A1 (en) 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
US6619838B2 (en) 2001-08-22 2003-09-16 Scimed Life Systems, Inc. Two-piece sensor assembly
US6909912B2 (en) 2002-06-20 2005-06-21 University Of Florida Non-invasive perfusion monitor and system, specially configured oximeter probes, methods of using same, and covers for probes
DE10249853A1 (en) 2002-10-25 2004-05-13 Liedtke, Rainer K., Dr. Flexible, plaster-type chip heating system, for thermodynamic control of topical (trans)dermal systems, including supporting matrix, electrical energy source, controlling microprocessor and electric heater
US7510699B2 (en) 2003-02-19 2009-03-31 Sicel Technologies, Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
AU2004233870B2 (en) 2003-04-24 2009-11-05 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
US7050175B1 (en) 2003-08-08 2006-05-23 Carl Zeiss Smt Ag Method for calibrating an interferometer apparatus, for qualifying an optical surface, and for manufacturing a substrate having an optical surface
US20060095102A1 (en) 2003-09-17 2006-05-04 Thomas Perez Method and apparatus for sublingual application of light to blood
US20050137459A1 (en) 2003-12-17 2005-06-23 Scimed Life Systems, Inc. Medical device with OLED illumination light source
AU2005232350A1 (en) 2004-04-14 2005-10-27 Led Medical Diagnostics, Inc. Systems and methods for detection of disease including oral scopes and ambient light management systems (ALMS)
US20060020216A1 (en) 2004-07-20 2006-01-26 Sharp Kabushiki Kaisha Medical information detection apparatus and health management system using the medical information detection apparatus
DE102004045748A1 (en) 2004-09-21 2006-04-06 Roche Diagnostics Gmbh Stoichiometrically defined dye-labeled substances for measuring the glomerular filtration rate, their preparation and use
DE102004048864A1 (en) 2004-10-07 2006-04-13 Roche Diagnostics Gmbh Analytical test element with wireless data transmission
WO2006062895A2 (en) * 2004-12-06 2006-06-15 Cambridge Research And Instrumentation, Inc. Systems and methods for in-vivo optical imaging and measurement
WO2006063246A1 (en) * 2004-12-08 2006-06-15 The General Hospital Corporation System and method for normalized fluorescence or bioluminescence imaging
US8664392B2 (en) 2004-12-23 2014-03-04 Medibeacon, LLC Pyrazine derivatives for bioconjugation
WO2006071759A2 (en) 2004-12-23 2006-07-06 Mallinckrodt Inc. Fluorescent pyrazine derivatives and methods of using the same in assessing renal function
US20060224055A1 (en) 2005-03-30 2006-10-05 Kermani Mahyar Z Fluorescence measurement analytical kit
CA2649391C (en) * 2005-04-19 2017-11-28 Indiana University Research And Technology Corporation Method and apparatus for kidney function analysis
US7993585B2 (en) 2005-07-14 2011-08-09 Battelle Memorial Institute Biological and chemical monitoring
US20070038046A1 (en) 2005-08-09 2007-02-15 Hayter Paul G Kinematic fluorescence measurement band
US20070036723A1 (en) 2005-08-09 2007-02-15 Hayter Paul G Kinematic adhesive fluorescence measurement patch
CA2847144A1 (en) * 2005-10-24 2007-05-03 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
JP2009527322A (en) 2006-02-24 2009-07-30 マリンクロッド・インコーポレイテッド How to use optical materials
US8115000B2 (en) 2006-06-22 2012-02-14 Mallinckrodt Llc Pyrazine derivatives and uses thereof in renal monitoring
US20080082004A1 (en) 2006-09-08 2008-04-03 Triage Wireless, Inc. Blood pressure monitor
KR100853655B1 (en) 2006-12-15 2008-08-25 한국전기연구원 Apparatus, light source system and method for photo-diagnosis and phototherapy of skin disease
WO2009005748A1 (en) * 2007-06-29 2009-01-08 The Trustees Of Columbia University In The City Ofnew York Optical imaging or spectroscopy systems and methods
US8492734B2 (en) * 2007-10-19 2013-07-23 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
EP2279010A2 (en) * 2008-04-18 2011-02-02 Pharmacophotonics, Inc. Renal function analysis method and apparatus
MX2010012035A (en) * 2008-05-14 2011-02-23 Novadaq Technologies Inc Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging.
EP2291640B1 (en) * 2008-05-20 2018-12-26 University Health Network Device and method for fluorescence-based imaging and monitoring
DK2317911T3 (en) 2008-08-22 2019-01-28 Medibeacon Inc TRANSCUTAN ORGAN FUNCTION MEASUREMENT
EP2376459B1 (en) 2008-12-17 2015-02-18 MediBeacon, LLC Modified pyrazine derivatives and uses thereof
US9084554B2 (en) * 2009-03-19 2015-07-21 The Regents Of The University Of California Multi-phase pseudo-continuous arterial spin labeling
CA2784576C (en) * 2009-12-15 2020-01-07 Shuming Nie System and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
JP2013515528A (en) 2009-12-23 2013-05-09 デルタ、ダンスク・エレクトリニク、リス・オ・アクスティク Monitoring device
EP2529202B1 (en) * 2010-01-25 2022-09-14 University Health Network Device, system and method for quantifying fluorescence and optical properties
WO2011089258A2 (en) * 2010-01-25 2011-07-28 Imec A variability-aware reliability simulation method of electronic systems
FR2957599B1 (en) * 2010-03-18 2014-01-10 Commissariat Energie Atomique PROCESS FOR THE DEPOLYMERIZATION OF LIGNOCELLULOSIC BIOMASS
US8818733B2 (en) * 2010-04-20 2014-08-26 Mayo Foundation For Medical Education And Research Determination of photodynamic therapy (PDT) treatment parameters
EP2405256B1 (en) * 2010-07-09 2019-01-09 SoftScan HealthCare Group Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage
US9066657B2 (en) * 2010-11-23 2015-06-30 General Electric Company Methods and systems of optical imaging for target detection in a scattering medium
US20120172679A1 (en) 2010-12-30 2012-07-05 Logan Robert J Systems and methods for monitoring and processing biometric data
WO2012149227A2 (en) 2011-04-26 2012-11-01 Incube Labs, Llc Mouthpiece for measurement of biometric data of a diver and underwater communication
US20130109963A1 (en) * 2011-10-31 2013-05-02 The University Of Connecticut Method and apparatus for medical imaging using combined near-infrared optical tomography, fluorescent tomography and ultrasound
US20130289414A1 (en) * 2012-03-09 2013-10-31 Mahmoudreza Adibnazari Combined absorption-reflection based instrument and technique to measure antioxidants (including carotenoids) in human tissue
US9155473B2 (en) 2012-03-21 2015-10-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
KR101454298B1 (en) 2013-01-29 2014-10-27 한국전기연구원 A pyramidal skin autofluorescence measurement apparatus for detecting reflected light
US9955871B2 (en) * 2012-03-21 2018-05-01 Korea Electrotechnology Research Institute Transmitted light detection type measurement apparatus for skin autofluorescence
DE102012018076B4 (en) * 2012-09-13 2014-06-12 Lohmann Gmbh & Co. Kg Adhesive functional strip for transcutaneous fluorescence measurement and related manufacturing processes and uses
US10743768B2 (en) 2012-10-15 2020-08-18 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
US9386932B2 (en) 2012-10-29 2016-07-12 Microsoft Technology Licensing, Llc Wearable personal information system
US9704209B2 (en) 2013-03-04 2017-07-11 Hello Inc. Monitoring system and device with sensors and user profiles based on biometric user information
EP2967454B1 (en) * 2013-03-14 2020-04-22 Profusa, Inc. Method and device for correcting optical signals
JP6502630B2 (en) * 2013-09-30 2019-04-17 株式会社リコー Optical sensor, optical inspection apparatus, and optical characteristic detection method
US10264977B2 (en) * 2013-10-22 2019-04-23 Medibeacon Inc. Transcutaneous organ function measurement
US9648254B2 (en) * 2014-03-21 2017-05-09 Hypermed Imaging, Inc. Compact light sensor
WO2016055260A1 (en) * 2014-10-09 2016-04-14 Koninklijke Philips N.V. Optical vital signs sensor.
JP2016112375A (en) 2014-12-16 2016-06-23 イオム株式会社 Dermofluorometer
US9892513B2 (en) * 2015-02-02 2018-02-13 Novadaq Technologies ULC Methods and systems for characterizing tissue of a subject
BR112019021040A2 (en) 2017-10-27 2020-05-12 Medibeacon Inc. METHODS FOR DETERMINING KIDNEY FUNCTION

Also Published As

Publication number Publication date
RU2721652C1 (en) 2020-05-21
US10952656B2 (en) 2021-03-23
KR102429632B1 (en) 2022-08-05
US20200138352A1 (en) 2020-05-07
CN110520035A (en) 2019-11-29
SG11201906938WA (en) 2019-08-27
PH12019501749A1 (en) 2020-06-01
EP3573518A4 (en) 2020-11-04
KR20210118253A (en) 2021-09-29
IL268335B2 (en) 2023-07-01
JP2021106888A (en) 2021-07-29
US10980459B2 (en) 2021-04-20
IL300236B2 (en) 2024-04-01
AU2018213422B2 (en) 2020-02-06
CN112932413A (en) 2021-06-11
KR102306048B1 (en) 2021-09-29
JP7263425B2 (en) 2023-04-24
IL268335B1 (en) 2023-03-01
MX2023002896A (en) 2023-04-05
MX2019009040A (en) 2019-11-11
JP6861288B2 (en) 2021-04-21
WO2018140978A1 (en) 2018-08-02
IL300236A (en) 2023-03-01
CA3203465A1 (en) 2018-08-02
CN110520035B (en) 2023-03-10
US20200383617A1 (en) 2020-12-10
IL300236B1 (en) 2023-12-01
ZA201904973B (en) 2020-05-27
IL268335A (en) 2019-09-26
NZ755765A (en) 2021-03-26
US10548521B2 (en) 2020-02-04
US20230021174A1 (en) 2023-01-19
KR20190107720A (en) 2019-09-20
US11478172B2 (en) 2022-10-25
JP2020506764A (en) 2020-03-05
EP3573518A1 (en) 2019-12-04
CN115120241A (en) 2022-09-30
AU2018213422A1 (en) 2019-09-19
CA3051963A1 (en) 2018-08-02
BR112019015520A2 (en) 2020-03-17
US20180214057A1 (en) 2018-08-02
US11950907B2 (en) 2024-04-09
US20210219883A1 (en) 2021-07-22

Similar Documents

Publication Publication Date Title
ZA201904973B (en) Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
HK1251614A1 (en) Method for the treatment of malignancies
IL250757A0 (en) Apparatus and methods for the simultaneous production of cannabinoid compound
HK1254674A1 (en) Method and apparatus for extracorporeal support of premature fetus
IL251875A0 (en) Use of circulating cell-free rna for diagnosis and/or monitoring cancer
ZA201904972B (en) Method for non-invasive monitoring of fluorescent tracer agent with background separation corrections
IL258150B (en) Methods of treating intraocular pressure with activators of tie-2
GB201511152D0 (en) Method of diagnosing bladder cancer
PT3137679T (en) Method for producing a suspension of microfibrillated cellulose, microfibrillated cellulose and its use
HUE063284T2 (en) Method of detecting vascular inflammation
PL3461379T3 (en) Pressure cooker with bayonet and method for manufacturing same
PL3167285T3 (en) Non-invasive device and method for determining fertility and/or sex of an egg
FI20145205L (en) Method and system for intraocular pressure measurements
KR102440002B9 (en) Method and apparatus for diagnosis of brake light
HK1253082A1 (en) Method of diagnosis of breast cancer
EP3370725A4 (en) Pediatric dosing for treatment of cancer with an ezh2 inhibitor
IL269561A (en) Method of measuring
EP3277285A4 (en) Methods of monitoring estriol therapy
EP3335692A4 (en) Method for preparing high-water-content emulsion gel using oil gel-forming agent
IL247270B (en) Method of detecting cancer
IL275127A (en) Glycosidic derivatives of treprostinil
ZA202002925B (en) Method of tomographic radiography
EP3156502A4 (en) Evaluation method for evaluating the likelihood of breast cancer
EP3147099C0 (en) Profiled body for lamps and its method of manufacturing
GB201513188D0 (en) Method of tomography