BR112019015309A2 - métodos e microrganismos para a produção de ácido glicólico e/ou ácido glioxílico - Google Patents
métodos e microrganismos para a produção de ácido glicólico e/ou ácido glioxílico Download PDFInfo
- Publication number
- BR112019015309A2 BR112019015309A2 BR112019015309-8A BR112019015309A BR112019015309A2 BR 112019015309 A2 BR112019015309 A2 BR 112019015309A2 BR 112019015309 A BR112019015309 A BR 112019015309A BR 112019015309 A2 BR112019015309 A2 BR 112019015309A2
- Authority
- BR
- Brazil
- Prior art keywords
- gene
- acid
- glycolic acid
- microorganism
- production
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03015—(S)-2-Hydroxy-acid oxidase (1.1.3.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02009—Phosphoketolase (4.1.2.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02022—Fructose-6-phosphate phosphoketolase (4.1.2.22)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305084.0 | 2017-01-26 | ||
| EP17305084.0A EP3354742A1 (en) | 2017-01-26 | 2017-01-26 | Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid |
| PCT/EP2018/051919 WO2018138240A1 (en) | 2017-01-26 | 2018-01-26 | Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019015309A2 true BR112019015309A2 (pt) | 2020-05-19 |
Family
ID=58016654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019015309-8A BR112019015309A2 (pt) | 2017-01-26 | 2018-01-26 | métodos e microrganismos para a produção de ácido glicólico e/ou ácido glioxílico |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10774320B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3354742A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7043504B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102324663B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110234768B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019015309A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3050042A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018138240A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11414664B2 (en) * | 2008-12-18 | 2022-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| BR112021015719A2 (pt) * | 2019-02-20 | 2021-12-14 | Braskem Sa | Micro-organismos e métodos para produção de compostos oxigenados a partir de hexoses |
| CN110760561A (zh) * | 2019-10-31 | 2020-02-07 | 申友基因组研究院(南京)有限公司 | 一种酶法检测甘氨酸含量的方法及其应用 |
| EP4631928A1 (en) | 2024-04-10 | 2025-10-15 | Metabolic Explorer | Method of purification of glycolic acid, composition and use thereof |
| CN118638831B (zh) * | 2024-08-13 | 2024-10-29 | 中国农业科学院北京畜牧兽医研究所 | 具有噬菌体抗性生产甲基苹果酸的大肠杆菌工程菌株、构建及发酵生产方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05501800A (ja) * | 1989-10-16 | 1993-04-08 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | グリコール酸の酵素酸化によるグリオキシル酸の製造法 |
| TW294723B (cg-RX-API-DMAC7.html) | 1991-09-06 | 1997-01-01 | Du Pont | |
| ATE139796T1 (de) | 1992-01-06 | 1996-07-15 | Du Pont | Oxydation von glykolsäure zur herstellung von glyoxylsäure unter verwendung von transformierten mikrobiellen zellen als katalysator. |
| HUT73214A (en) | 1993-03-03 | 1996-06-28 | Du Pont | Production of glycolate oxidase in methylotrophic yeast |
| JPH10501984A (ja) | 1993-03-03 | 1998-02-24 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 形質転換微生物を用いて製造されるグリオキシル酸／アミノメチルホスホン酸混合物 |
| CN1124981A (zh) | 1993-05-28 | 1996-06-19 | 纳幕尔杜邦公司 | 水合乙醛酸/氨甲基膦酸二烷基酯混合物的制备方法 |
| WO1995001444A1 (en) | 1993-07-01 | 1995-01-12 | E.I. Du Pont De Nemours And Company | Glycolate oxidase production |
| AU4386699A (en) | 1998-04-22 | 1999-11-08 | Forskarpatent I Syd Ab | Polymer conjugates of polyethylene glycols or oxides with polyethyleneimine or polypropyleneimine for extracting carboxylic acids from solutions |
| JPWO2004072281A1 (ja) | 2003-02-14 | 2006-06-01 | 株式会社カネカ | グリオキシル酸の生化学的製造方法 |
| US20060270013A1 (en) | 2003-02-18 | 2006-11-30 | Michel Chateau | Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways |
| KR100869623B1 (ko) | 2004-04-27 | 2008-11-21 | 미쓰이 가가쿠 가부시키가이샤 | 하이드록시 카복실산류의 생산 방법 |
| BRPI0514201B1 (pt) | 2004-08-10 | 2020-09-15 | Ajinomoto Co., Inc | Bactéria, e, método para produzir um metabólito útil |
| CN102796769B (zh) | 2004-12-22 | 2014-06-04 | 纳幕尔杜邦公司 | 乙醇酸的酶促生产 |
| RU2413001C2 (ru) | 2005-07-18 | 2011-02-27 | Эвоник Дегусса Гмбх | Применение диметилдисульфида для продукции метионина микроорганизмами |
| JP2007228927A (ja) | 2006-03-02 | 2007-09-13 | Kaneka Corp | グリコール酸の製造方法 |
| JP4886775B2 (ja) | 2006-05-09 | 2012-02-29 | 三井化学株式会社 | 補酵素再生によるグリコール酸の生産方法 |
| KR101183001B1 (ko) | 2006-05-09 | 2012-09-18 | 미쓰이 가가쿠 가부시키가이샤 | 보효소 합성 강화에 의한 히드록시카르복실산류의 생산방법 |
| WO2007140816A1 (en) | 2006-06-09 | 2007-12-13 | Metabolic Explorer | Glycolic acid production by fermentation from renewable resources |
| US7439391B2 (en) | 2006-10-12 | 2008-10-21 | E.I. Du Pont De Nemours And Company | Multi-stage glycolic acid crystallization |
| EP2139985A1 (en) * | 2007-03-23 | 2010-01-06 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of 1,2-propanediol |
| CN101802208B (zh) | 2007-09-27 | 2016-05-18 | Reg生命科学有限责任公司 | 通过提取式发酵减少原料中杂质的毒性作用 |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| US7741088B2 (en) | 2007-10-31 | 2010-06-22 | E.I. Dupont De Nemours And Company | Immobilized microbial nitrilase for production of glycolic acid |
| US7871802B2 (en) | 2007-10-31 | 2011-01-18 | E.I. Du Pont De Nemours And Company | Process for enzymatically converting glycolonitrile to glycolic acid |
| EP2233562A1 (en) | 2009-03-24 | 2010-09-29 | Metabolic Explorer | Method for producing high amount of glycolic acid by fermentation |
| JP2010246483A (ja) * | 2009-04-17 | 2010-11-04 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| US20120178136A1 (en) | 2009-09-25 | 2012-07-12 | Roquette Freres | Fermentation process for producing glycolic acid |
| WO2011157728A1 (en) | 2010-06-15 | 2011-12-22 | Metabolic Explorer | Use of inducible promoters in the production of glycolic acid |
| JP2013537429A (ja) * | 2010-08-27 | 2013-10-03 | メタボリック エクスプローラー | 改変微生物による改良されたグリコール酸発酵生産 |
| FR2974802B1 (fr) | 2011-05-06 | 2013-09-13 | Roquette Freres | Procede de purification de l'acide glycolique par distillation |
| FR2974803B1 (fr) | 2011-05-06 | 2013-05-03 | Roquette Freres | Procede de preparation d'un acide glycolique partiellement purifie |
| FR2974804B1 (fr) | 2011-05-06 | 2013-05-03 | Roquette Freres | Procede de preparation d'un acide glycolique de haute purete |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| FI125136B (en) | 2011-10-04 | 2015-06-15 | Teknologian Tutkimuskeskus Vtt Oy | Eukaryotic cells and a method for preparing glycolic acid |
| KR102157502B1 (ko) * | 2013-03-29 | 2020-09-18 | 아지노모토 가부시키가이샤 | 변형된 글리신 옥시다제 |
| FI20135333L (fi) | 2013-04-05 | 2014-10-06 | Teknologian Tutkimuskeskus Vtt Oy | Hapon / happojen ja alkoholin tuotto sokereista käyttämällä hiivaa |
| WO2016044713A1 (en) | 2014-09-18 | 2016-03-24 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| FR3028529B1 (fr) | 2014-11-19 | 2016-12-30 | Inst Nat De La Rech Agronomique Inra | Procede de production d'au moins un metabolite d'interet par transformation d'un pentose dans un microorganisme |
| FI20155412A7 (fi) | 2015-05-29 | 2016-11-30 | Teknologian Tutkimuskeskus Vtt Oy | Sokerien suora konversio glykolihapoksi |
| CN105647844B (zh) | 2016-03-02 | 2020-02-21 | 中国科学院青岛生物能源与过程研究所 | 一种利用木糖生产乙醇酸的重组菌及其构建方法与应用 |
| CN106011185B (zh) | 2016-06-27 | 2019-12-17 | 江南大学 | 一种无基因敲除提高大肠杆菌中乙醇酸产率的方法 |
-
2017
- 2017-01-26 EP EP17305084.0A patent/EP3354742A1/en not_active Withdrawn
-
2018
- 2018-01-26 US US16/476,208 patent/US10774320B2/en active Active
- 2018-01-26 BR BR112019015309-8A patent/BR112019015309A2/pt active Search and Examination
- 2018-01-26 KR KR1020197024400A patent/KR102324663B1/ko active Active
- 2018-01-26 EP EP18702225.6A patent/EP3574106A1/en active Pending
- 2018-01-26 WO PCT/EP2018/051919 patent/WO2018138240A1/en not_active Ceased
- 2018-01-26 CN CN201880008604.7A patent/CN110234768B/zh active Active
- 2018-01-26 JP JP2019540435A patent/JP7043504B2/ja active Active
- 2018-01-26 CA CA3050042A patent/CA3050042A1/en active Pending
-
2022
- 2022-01-04 JP JP2022000299A patent/JP2022046736A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7043504B2 (ja) | 2022-03-29 |
| KR20190103441A (ko) | 2019-09-04 |
| US20190367898A1 (en) | 2019-12-05 |
| KR102324663B1 (ko) | 2021-11-10 |
| JP2022046736A (ja) | 2022-03-23 |
| US10774320B2 (en) | 2020-09-15 |
| CN110234768A (zh) | 2019-09-13 |
| EP3574106A1 (en) | 2019-12-04 |
| CA3050042A1 (en) | 2018-08-02 |
| EP3354742A1 (en) | 2018-08-01 |
| WO2018138240A1 (en) | 2018-08-02 |
| CN110234768B (zh) | 2023-09-01 |
| JP2020505922A (ja) | 2020-02-27 |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |