BR112019002584A2 - método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo - Google Patents

método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo

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Publication number
BR112019002584A2
BR112019002584A2 BR112019002584-7A BR112019002584A BR112019002584A2 BR 112019002584 A2 BR112019002584 A2 BR 112019002584A2 BR 112019002584 A BR112019002584 A BR 112019002584A BR 112019002584 A2 BR112019002584 A2 BR 112019002584A2
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BR
Brazil
Prior art keywords
cells
mesoderm
generation
blood vessel
aplnr
Prior art date
Application number
BR112019002584-7A
Other languages
English (en)
Portuguese (pt)
Inventor
C. Yoder Mervin
Prasain Nutan
Original Assignee
Indiana University Research And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research And Technology Corporation filed Critical Indiana University Research And Technology Corporation
Publication of BR112019002584A2 publication Critical patent/BR112019002584A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
BR112019002584-7A 2016-08-10 2017-08-04 método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo BR112019002584A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662372907P 2016-08-10 2016-08-10
US62/372,907 2016-08-10
PCT/US2017/045496 WO2018031404A1 (en) 2016-08-10 2017-08-04 Method for generating mesoderm and/or endothelial colony forming cell-like cells having in vivo blood vessel forming capacity

Publications (1)

Publication Number Publication Date
BR112019002584A2 true BR112019002584A2 (pt) 2019-05-21

Family

ID=61162479

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002584-7A BR112019002584A2 (pt) 2016-08-10 2017-08-04 método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo

Country Status (10)

Country Link
US (2) US11739293B2 (cg-RX-API-DMAC10.html)
EP (1) EP3497204B1 (cg-RX-API-DMAC10.html)
JP (2) JP7045363B2 (cg-RX-API-DMAC10.html)
KR (1) KR102456031B1 (cg-RX-API-DMAC10.html)
CN (1) CN109689858B (cg-RX-API-DMAC10.html)
AU (1) AU2017308738B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019002584A2 (cg-RX-API-DMAC10.html)
CA (1) CA3033381A1 (cg-RX-API-DMAC10.html)
IL (1) IL264273B2 (cg-RX-API-DMAC10.html)
WO (1) WO2018031404A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3755354A4 (en) * 2018-02-21 2022-01-19 Indiana University Research and Technology Corporation COMPOSITIONS AND METHODS FOR THE TREATMENT OR PROPHYLAXIS OF A PERFUSION DISORDER
JP7184202B2 (ja) * 2019-08-05 2022-12-06 日本製鉄株式会社 プレス成形品の製造方法、プレス成形品、およびプレス成形装置
US20220288131A1 (en) * 2019-08-28 2022-09-15 Astellas Institute For Regenerative Medicine Compositions and methods of treating vascular diseases
GB202003309D0 (en) * 2020-03-06 2020-04-22 Imp College Innovations Ltd Methods of generating endothelial cells
EP4204544A4 (en) * 2020-08-25 2024-10-30 University Health Network COMPOSITIONS AND METHODS FOR GENERATING HUMAN YOLK SAC-TYPE HEMATOPOIETIC CELLS
CN115137740B (zh) * 2022-03-29 2023-12-12 广州大学 miRNA-497b或miRNA-5106在制备治疗缺血心肌的药物中的应用
CN116769710A (zh) * 2023-01-28 2023-09-19 深圳市寰宇生物科技有限公司 一种从人诱导性多能干细胞分化的巨噬细胞及其制备方法和应用
CN117070442B (zh) * 2023-10-18 2024-01-30 北京大学 静脉内皮细胞及其制备方法、静脉血管畸形模型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101755046B (zh) 2007-07-20 2012-08-08 东国大学校产学协力团 采用间充质干细胞制备真皮乳头组织的方法
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
EP2318520B1 (en) * 2008-07-25 2017-10-11 The University Of Georgia Research Foundation, Inc. Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use
WO2013028684A1 (en) * 2011-08-23 2013-02-28 Wisconsin Alumni Research Foundation Angiohematopoietic progenitor cells
JP6494515B2 (ja) 2012-10-19 2019-04-03 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 幹細胞を１又は２以上の細胞系列に分化させる方法
WO2014145871A1 (en) * 2013-03-15 2014-09-18 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
US10563175B2 (en) * 2014-03-11 2020-02-18 Indiana University Research And Technology Corporation Method for generating endothelial colony forming cell-like cells

Also Published As

Publication number Publication date
EP3497204A1 (en) 2019-06-19
IL264273B1 (en) 2024-04-01
IL264273B2 (en) 2024-08-01
CA3033381A1 (en) 2018-02-15
JP7045363B2 (ja) 2022-03-31
JP2019528057A (ja) 2019-10-10
JP2022081657A (ja) 2022-05-31
US11739293B2 (en) 2023-08-29
CN109689858B (zh) 2024-07-26
AU2017308738A1 (en) 2019-01-31
US20190211304A1 (en) 2019-07-11
EP3497204B1 (en) 2025-04-30
WO2018031404A1 (en) 2018-02-15
CN109689858A (zh) 2019-04-26
AU2017308738B2 (en) 2023-09-21
KR20190037299A (ko) 2019-04-05
IL264273A (en) 2019-02-28
EP3497204A4 (en) 2020-05-06
US20230174929A1 (en) 2023-06-08
KR102456031B1 (ko) 2022-10-17

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B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements