BR112019002584A2 - método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo - Google Patents

método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo

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Publication number
BR112019002584A2
BR112019002584A2 BR112019002584-7A BR112019002584A BR112019002584A2 BR 112019002584 A2 BR112019002584 A2 BR 112019002584A2 BR 112019002584 A BR112019002584 A BR 112019002584A BR 112019002584 A2 BR112019002584 A2 BR 112019002584A2
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Brazil
Prior art keywords
cells
mesoderm
generation
blood vessel
aplnr
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BR112019002584-7A
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English (en)
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C. Yoder Mervin
Prasain Nutan
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Indiana University Research And Technology Corporation
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Publication of BR112019002584A2 publication Critical patent/BR112019002584A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

a presente descrição se refere, em geral, a métodos e composições úteis na biologia e terapêutica celular e de tecidos. em particular, um método in vitro para a diferenciação de células tronco pluripotentes em células do mesoderma kdr+ncam+aplnr+ e/ou células do mesoderma ssea5-kdr+ncam+aplnr+ é fornecido. as células do mesoderma descritas podem ser usadas para gerar vasos sanguíneos in vivo e/ou ainda serem diferenciadas in vitro em células do tipo células formadoras de colônia endotelial (células do tipo ecfc). populações de célula do tipo ecfc de células do mesoderma kdr+ncam+aplnr+ e células do tipo ecfc são fornecidas. seleção de agentes de teste e métodos terapêuticos para uso das populações de célula da presente descrição são fornecidos.
BR112019002584-7A 2016-08-10 2017-08-04 método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo BR112019002584A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662372907P 2016-08-10 2016-08-10
US62/372,907 2016-08-10
PCT/US2017/045496 WO2018031404A1 (en) 2016-08-10 2017-08-04 Method for generating mesoderm and/or endothelial colony forming cell-like cells having in vivo blood vessel forming capacity

Publications (1)

Publication Number Publication Date
BR112019002584A2 true BR112019002584A2 (pt) 2019-05-21

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BR112019002584-7A BR112019002584A2 (pt) 2016-08-10 2017-08-04 método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo

Country Status (10)

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US (2) US11739293B2 (pt)
EP (1) EP3497204A4 (pt)
JP (2) JP7045363B2 (pt)
KR (1) KR102456031B1 (pt)
CN (1) CN109689858A (pt)
AU (1) AU2017308738B2 (pt)
BR (1) BR112019002584A2 (pt)
CA (1) CA3033381A1 (pt)
IL (1) IL264273B1 (pt)
WO (1) WO2018031404A1 (pt)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
US20190388477A1 (en) * 2018-02-21 2019-12-26 Indiana University Research And Technology Corporation Compositions and methods for the treatment or prophylaxis of a perfusion disorder
CN114173952A (zh) * 2019-08-05 2022-03-11 日本制铁株式会社 冲压成型品的制造方法、冲压成型品以及冲压成型装置
GB202003309D0 (en) * 2020-03-06 2020-04-22 Imp College Innovations Ltd Methods of generating endothelial cells
CA3190402A1 (en) * 2020-08-25 2022-03-03 Gordon Keller Compositions and methods for generating human yolk sac-like hematopoietic cells
CN115137740B (zh) * 2022-03-29 2023-12-12 广州大学 miRNA-497b或miRNA-5106在制备治疗缺血心肌的药物中的应用
CN116769710A (zh) * 2023-01-28 2023-09-19 深圳市寰宇生物科技有限公司 一种从人诱导性多能干细胞分化的巨噬细胞及其制备方法和应用
CN117070442B (zh) * 2023-10-18 2024-01-30 北京大学 静脉内皮细胞及其制备方法、静脉血管畸形模型及其制备方法

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KR101022032B1 (ko) 2007-07-20 2011-03-16 동국대학교 산학협력단 중간엽 줄기세포를 이용하여 모유두 조직을 제조하는 방법
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
CA2731821A1 (en) 2008-07-25 2010-01-28 Stephen Dalton Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use
AU2012298997B2 (en) 2011-08-23 2018-10-04 Wisconsin Alumni Research Foundation Angiohematopoietic progenitor cells
US20150329821A1 (en) * 2012-10-19 2015-11-19 Agency For Science, Technology And Research Methods of differentiating stem cells into one or more cell lineages
AU2014232381A1 (en) * 2013-03-15 2015-10-29 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
EP3964564A1 (en) * 2014-03-11 2022-03-09 Indiana University Research and Technology Corporation Method for generating endothelial colony forming cell-like cells

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US20190211304A1 (en) 2019-07-11
KR102456031B1 (ko) 2022-10-17
EP3497204A4 (en) 2020-05-06
KR20190037299A (ko) 2019-04-05
CN109689858A (zh) 2019-04-26
WO2018031404A1 (en) 2018-02-15
AU2017308738B2 (en) 2023-09-21
EP3497204A1 (en) 2019-06-19
IL264273A (en) 2019-02-28
US20230174929A1 (en) 2023-06-08
JP2019528057A (ja) 2019-10-10
JP7045363B2 (ja) 2022-03-31
CA3033381A1 (en) 2018-02-15
US11739293B2 (en) 2023-08-29
JP2022081657A (ja) 2022-05-31
AU2017308738A1 (en) 2019-01-31
IL264273B1 (en) 2024-04-01

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