CO6160246A2 - Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado - Google Patents

Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado

Info

Publication number
CO6160246A2
CO6160246A2 CO09015685A CO09015685A CO6160246A2 CO 6160246 A2 CO6160246 A2 CO 6160246A2 CO 09015685 A CO09015685 A CO 09015685A CO 09015685 A CO09015685 A CO 09015685A CO 6160246 A2 CO6160246 A2 CO 6160246A2
Authority
CO
Colombia
Prior art keywords
stem cells
tissue
inactivated
mitotically
lethally
Prior art date
Application number
CO09015685A
Other languages
English (en)
Inventor
Richard Burt
Original Assignee
Richard Burt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard Burt filed Critical Richard Burt
Publication of CO6160246A2 publication Critical patent/CO6160246A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- Un método para reparar tejido, que comprende: inactivar mitóticamente y/o letalmente células troncales; y trasplantar las células troncales inactivadas mitóticamente y/o letalmente inactivadas en el tejido. 2.- El método de la reivindicación 1 en donde las células troncales son células troncales pluripotentes. 3.- El método de la reivindicación 2 en donde las células troncales pluripotentes se aíslan de embriones, placenta, o líquido amniótico: o se generan de cualquier estirpe de células o tejido. 4.- El método de la reivindicación 1 en donde las células troncales se inactivan usando un método efectivo para inhibir la proliferación ilimitada de células troncales embrionarias. 5.- El método de la reivindicación 2 en donde las células troncales se inactivan con irradiación o mitomicina C, fototerapia, o cualquier agente que inhiba la proliferación celular. 6.- El método de la reivindicación 1 en donde el tejido que se está reparando se selecciona del grupo conformado por tejido cardiaco, tejido nervioso, tejido muscular, tejido pancreático, tejido epitelial, tejido hematopoyético, tejido hepático, o cualquier tejido u árgano en el cuerpo.7.- El método de la reivindicación 1 en donde las células troncales inactivadas mitóticamente y/o letalmente inactivadas no forman teratomas.8.- Un método de inactivar mitóticamente y/o letalmente células troncales, que comprende: proveer células troncales pluripotentes; e inactivar las células troncales pluripotentes con un método efectivo para inhibir la proliferación limitada de las células troncales pluripotentes y efectivo para inactivar células troncales adultas, tales como sangre del cordón umbilical, para impedir su crecimiento o persistencia en el receptor.
CO09015685A 2006-07-20 2009-02-18 Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado CO6160246A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80786106P 2006-07-20 2006-07-20

Publications (1)

Publication Number Publication Date
CO6160246A2 true CO6160246A2 (es) 2010-05-20

Family

ID=38957623

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09015685A CO6160246A2 (es) 2006-07-20 2009-02-18 Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado

Country Status (11)

Country Link
US (3) US9017658B2 (es)
EP (1) EP2049655A4 (es)
JP (1) JP2009544362A (es)
CN (1) CN101490244A (es)
AU (1) AU2009200637A1 (es)
BR (1) BRPI0714455A8 (es)
CA (1) CA2659021A1 (es)
CO (1) CO6160246A2 (es)
MX (1) MX2009000741A (es)
RU (1) RU2009105890A (es)
WO (1) WO2008011524A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000741A (es) 2006-07-20 2009-07-17 Richard Burt Metodo de usar celulas madre mitoticamente inactivadas para reparacion de tejidos dañados.
PL2726603T3 (pl) 2011-06-29 2020-10-05 Biorestorative Therapies, Inc. Kompozycje i sposoby dotyczące brązowych komórek tłuszczowych
WO2013142192A1 (en) 2012-03-19 2013-09-26 Richard Burt Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells
EP2986714B1 (en) 2013-04-19 2021-01-06 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
US10813955B2 (en) 2015-09-29 2020-10-27 Genani Corporation Methods for treating age-related organ or tissue dysfunction through heterochronic transbiosis using nonviable pluripotent stem cells
WO2019040790A1 (en) * 2017-08-23 2019-02-28 Merakris Therapeutics, Llc COMPOSITIONS CONTAINING AMNIOTIC COMPONENTS AND METHODS FOR THEIR PREPARATION AND USE
DE102018202268A1 (de) * 2018-02-14 2019-08-14 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Verfahren zur Erhöhung der Sicherheit von Gewebepräparaten (tissue engineered products) für die klinische Anwendung
WO2023046709A1 (en) 2021-09-23 2023-03-30 Aarhus Universitet Ready-to-use stem cell therapeutic

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
WO1994000484A1 (en) 1992-06-22 1994-01-06 Young Henry E Scar inhibitory factor and use thereof
WO1999027076A1 (en) * 1997-11-25 1999-06-03 Arc Genomic Research Pluripotent embryonic stem cells and methods of obtaining them
US20030161817A1 (en) 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
CA2474783A1 (en) 2002-02-06 2003-08-14 Joerg Schierholz Pluripotent embryonic-like stem cells derived from teeth and uses thereof
JP2006506987A (ja) * 2002-06-28 2006-03-02 エクサイト セラピーズ インコーポレーティッド 自己免疫および臓器または造血幹細胞移植に関連する免疫学的欠損を有する患者における免疫レパートリー回復のための組成物および方法
US20050249731A1 (en) 2002-07-16 2005-11-10 Hadi Aslan Methods of implating mesenchymal stem cells for tissue repair and formation
EP2450433A3 (en) 2003-10-08 2012-08-08 Vet-Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
US20070092494A1 (en) 2005-10-26 2007-04-26 Biomet Manufacturing Corp. Composition for wound healing using lyophilized skin or skin-derived collagen
US8871198B2 (en) 2006-03-29 2014-10-28 Stemnion, Inc. Methods related to wound healing
US20070292401A1 (en) 2006-06-20 2007-12-20 Harmon Alexander M Soft tissue repair and regeneration using stem cell products
MX2009000741A (es) 2006-07-20 2009-07-17 Richard Burt Metodo de usar celulas madre mitoticamente inactivadas para reparacion de tejidos dañados.
AR065584A1 (es) 2007-03-01 2009-06-17 Cryo Cell Internat Inc Obtencion aislamiento y crioconservacion de celulas endometriales / menstruales
WO2009065093A2 (en) 2007-11-17 2009-05-22 University Of Medicine And Dentistry Of New Jersey Use of stem cells for wound healing
CN101449822A (zh) 2007-12-05 2009-06-10 詹承镇 胚胎端粒酶食品
EP2282746B8 (en) 2008-03-27 2015-12-09 Caladrius Biosciences, Inc. Compositions and methods using stem cells in cutaneous wound healing

Also Published As

Publication number Publication date
BRPI0714455A2 (pt) 2013-04-02
WO2008011524A3 (en) 2008-12-24
MX2009000741A (es) 2009-07-17
US20090214491A1 (en) 2009-08-27
EP2049655A4 (en) 2010-04-21
US9017658B2 (en) 2015-04-28
US20150328265A1 (en) 2015-11-19
US20160022744A1 (en) 2016-01-28
BRPI0714455A8 (pt) 2018-10-16
EP2049655A2 (en) 2009-04-22
JP2009544362A (ja) 2009-12-17
AU2009200637A1 (en) 2009-03-12
WO2008011524A2 (en) 2008-01-24
RU2009105890A (ru) 2010-08-27
CN101490244A (zh) 2009-07-22
US9867855B2 (en) 2018-01-16
CA2659021A1 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
CO6160246A2 (es) Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado
BR112021023571A2 (pt) Enxerto de emplastro de células-tronco / progenitores em órgãos sólidos
Batsivari et al. Understanding hematopoietic stem cell development through functional correlation of their proliferative status with the intra-aortic cluster architecture
Xiao et al. Neurotrophic factor GDNF promotes survival of salivary stem cells
EP3673732A3 (en) Engineering of humanized car t-cells and platelets by genetic complementation
AR110962A1 (es) Composiciones y métodos de tratamiento de hemoglobinopatías
GB2476624A (en) Compositions and methods for tissue repair with extracellular matrices
BR112017021536A2 (pt) composições e métodos para o condicionamento não mieloablativo
BRPI0514387A (pt) isolamento, cultivo e usos de células-tronco/progenitoras
ATE485065T1 (de) Gewebekonstruktionsvorrichtungen zur reparatur und regeneration von gewebe
BRPI0506474A (pt) sistema de tecido com células tronco não diferenciadas derivadas no limbus da córnea
EP4269566A3 (en) Genetic markers for engraftment of human cardiac ventricular progenitor cells
NZ609731A (en) Compositions of adult organ stem cells and uses thereof
MX2020002474A (es) Metodo de injerto de celulas a partir de tejidos solidos.
BR112015021453A2 (pt) método de tratamento condições de pâncreas e fígado por transplante de células-tronco em paredes de ducto biliar
BR112019002584A2 (pt) método para a geração de células do tipo células formadoras de colônia do mesoderma e/ou endoteliais apresentando capacidade de formação de vasos sanguíneos in vivo
UY38321A (es) Proceso de obtención de un sustituto dérmico a partir de membrana amniótica descelularizada y su uso como agente de regeneración
GB2441268A (en) Engineered extracellular matrices control stem cell behavior
MX2020006321A (es) Celulas estromales mesenquimales y metodos para obtener celulas estromales mesenquimales del cordon umbilical.
RU2012104553A (ru) Клетки, производные от кардиальной ткани
George et al. Comparison of the response of human embryonic stem cells and their differentiated progenies to oxidative stress
WO2007116408A3 (en) Pluripotent stem cells characterized by expression of germline specific genes
AR058796A1 (es) Oligonucleotidos estimulantes de l a proliferacion de celulas madre mesenquimatosas y sus usos
Bieniasz et al. Stem Cells–general characteristic and sources
MX2023005549A (es) Celulas, tejidos, organos y animales que tienen uno o mas genes modificados para potenciar la supervivencia y tolerancia al xenoinjerto.