CO6160246A2 - Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado - Google Patents

Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado

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Publication number
CO6160246A2
CO6160246A2 CO09015685A CO09015685A CO6160246A2 CO 6160246 A2 CO6160246 A2 CO 6160246A2 CO 09015685 A CO09015685 A CO 09015685A CO 09015685 A CO09015685 A CO 09015685A CO 6160246 A2 CO6160246 A2 CO 6160246A2
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CO
Colombia
Prior art keywords
stem cells
tissue
inactivated
mitotically
lethally
Prior art date
Application number
CO09015685A
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English (en)
Inventor
Richard Burt
Original Assignee
Richard Burt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard Burt filed Critical Richard Burt
Publication of CO6160246A2 publication Critical patent/CO6160246A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- Un método para reparar tejido, que comprende: inactivar mitóticamente y/o letalmente células troncales; y trasplantar las células troncales inactivadas mitóticamente y/o letalmente inactivadas en el tejido. 2.- El método de la reivindicación 1 en donde las células troncales son células troncales pluripotentes. 3.- El método de la reivindicación 2 en donde las células troncales pluripotentes se aíslan de embriones, placenta, o líquido amniótico: o se generan de cualquier estirpe de células o tejido. 4.- El método de la reivindicación 1 en donde las células troncales se inactivan usando un método efectivo para inhibir la proliferación ilimitada de células troncales embrionarias. 5.- El método de la reivindicación 2 en donde las células troncales se inactivan con irradiación o mitomicina C, fototerapia, o cualquier agente que inhiba la proliferación celular. 6.- El método de la reivindicación 1 en donde el tejido que se está reparando se selecciona del grupo conformado por tejido cardiaco, tejido nervioso, tejido muscular, tejido pancreático, tejido epitelial, tejido hematopoyético, tejido hepático, o cualquier tejido u árgano en el cuerpo.7.- El método de la reivindicación 1 en donde las células troncales inactivadas mitóticamente y/o letalmente inactivadas no forman teratomas.8.- Un método de inactivar mitóticamente y/o letalmente células troncales, que comprende: proveer células troncales pluripotentes; e inactivar las células troncales pluripotentes con un método efectivo para inhibir la proliferación limitada de las células troncales pluripotentes y efectivo para inactivar células troncales adultas, tales como sangre del cordón umbilical, para impedir su crecimiento o persistencia en el receptor.
CO09015685A 2006-07-20 2009-02-18 Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado CO6160246A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80786106P 2006-07-20 2006-07-20

Publications (1)

Publication Number Publication Date
CO6160246A2 true CO6160246A2 (es) 2010-05-20

Family

ID=38957623

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09015685A CO6160246A2 (es) 2006-07-20 2009-02-18 Metodo de usar celulas troncales inactivadas mitoticamente para preparacion de tejido dañado

Country Status (11)

Country Link
US (3) US9017658B2 (es)
EP (1) EP2049655A4 (es)
JP (1) JP2009544362A (es)
CN (1) CN101490244A (es)
AU (1) AU2009200637A1 (es)
BR (1) BRPI0714455A8 (es)
CA (1) CA2659021A1 (es)
CO (1) CO6160246A2 (es)
MX (1) MX2009000741A (es)
RU (1) RU2009105890A (es)
WO (1) WO2008011524A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2659021A1 (en) * 2006-07-20 2008-01-24 Richard Burt Method of using mitotically inactivated stem cells for damaged tissue repair
JP6243839B2 (ja) 2011-06-29 2017-12-06 バイオリストーラティブ セラピーズ， インコーポレイテッド 褐色脂肪細胞の組成物および方法
US9364425B2 (en) * 2012-03-19 2016-06-14 Richard Burt Methods and compositions for regenerating and repairing damaged or aged tissue or organs using nonviable irradiated or lyophilized pluripotent stem cells
AU2014253920B2 (en) 2013-04-19 2019-07-04 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
US10813955B2 (en) 2015-09-29 2020-10-27 Genani Corporation Methods for treating age-related organ or tissue dysfunction through heterochronic transbiosis using nonviable pluripotent stem cells
US11590175B2 (en) 2017-08-23 2023-02-28 Merakris Therapeutics Llc Compositions containing amniotic components and methods for preparation and use thereof
DE102018202268A1 (de) * 2018-02-14 2019-08-14 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Verfahren zur Erhöhung der Sicherheit von Gewebepräparaten (tissue engineered products) für die klinische Anwendung
WO2023046709A1 (en) 2021-09-23 2023-03-30 Aarhus Universitet Ready-to-use stem cell therapeutic

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WO1999027076A1 (en) * 1997-11-25 1999-06-03 Arc Genomic Research Pluripotent embryonic stem cells and methods of obtaining them
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JP2007508018A (ja) 2003-10-08 2007-04-05 べト−ステム インコーポレイテッド 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット
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Also Published As

Publication number Publication date
US9867855B2 (en) 2018-01-16
US20150328265A1 (en) 2015-11-19
US20160022744A1 (en) 2016-01-28
EP2049655A4 (en) 2010-04-21
WO2008011524A2 (en) 2008-01-24
CA2659021A1 (en) 2008-01-24
US9017658B2 (en) 2015-04-28
BRPI0714455A8 (pt) 2018-10-16
JP2009544362A (ja) 2009-12-17
US20090214491A1 (en) 2009-08-27
AU2009200637A1 (en) 2009-03-12
EP2049655A2 (en) 2009-04-22
MX2009000741A (es) 2009-07-17
RU2009105890A (ru) 2010-08-27
WO2008011524A3 (en) 2008-12-24
BRPI0714455A2 (pt) 2013-04-02
CN101490244A (zh) 2009-07-22

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