DE60321440D1 - Aus zähnen gewonnene pluripotente embryonalähnliche stammzellen und verwendungen davon - Google Patents

Aus zähnen gewonnene pluripotente embryonalähnliche stammzellen und verwendungen davon

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Publication number
DE60321440D1
DE60321440D1 DE60321440T DE60321440T DE60321440D1 DE 60321440 D1 DE60321440 D1 DE 60321440D1 DE 60321440 T DE60321440 T DE 60321440T DE 60321440 T DE60321440 T DE 60321440T DE 60321440 D1 DE60321440 D1 DE 60321440D1
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Germany
Prior art keywords
pluripotente
embryonal
tears
tongue
derived
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Expired - Lifetime
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DE60321440T
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English (en)
Inventor
Joerg Schierholz
N Brenner
F Zeilhofer
K H Hoffmann
Christian Morsczeck
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Stiftung Caesar Center of Advanced European Studies and Research
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Stiftung Caesar Center of Advanced European Studies and Research
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2503/00—Use of cells in diagnostics
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    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • General Physics & Mathematics (AREA)
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  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
DE60321440T 2002-02-06 2003-02-05 Aus zähnen gewonnene pluripotente embryonalähnliche stammzellen und verwendungen davon Expired - Lifetime DE60321440D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35415202P 2002-02-06 2002-02-06
PCT/EP2003/001131 WO2003066840A2 (en) 2002-02-06 2003-02-05 Pluripotent embryonic-like stem cells derived from teeth and uses thereof

Publications (1)

Publication Number Publication Date
DE60321440D1 true DE60321440D1 (de) 2008-07-17

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DE60321440T Expired - Lifetime DE60321440D1 (de) 2002-02-06 2003-02-05 Aus zähnen gewonnene pluripotente embryonalähnliche stammzellen und verwendungen davon

Country Status (9)

Country Link
US (2) US20050106724A1 (de)
EP (1) EP1456357B1 (de)
JP (1) JP4125241B2 (de)
AT (1) ATE397654T1 (de)
AU (1) AU2003206844B2 (de)
CA (1) CA2474783A1 (de)
DE (1) DE60321440D1 (de)
NZ (1) NZ534540A (de)
WO (1) WO2003066840A2 (de)

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AU7707801A (en) * 2000-07-21 2002-02-05 Us Health Adult human dental pulp stem cells in vitro and in vivo
ATE511753T1 (de) 2003-04-19 2011-06-15 Us Gov Health & Human Serv Postnatale stammzellen und deren verwendungen
WO2005037996A2 (en) * 2003-10-10 2005-04-28 Transform Pharmaceuticals, Inc. In vitro development of tissues and organs
BRPI0402659A (pt) * 2004-06-23 2006-01-31 Univ Fed Sao Paulo Unifesp Uso de células tronco, método de engenharia tecidual, usos de tecidos dentais e substituto biológico do dente
WO2006009291A1 (ja) * 2004-07-23 2006-01-26 Hitachi Medical Corporation 間葉系幹細胞から象牙芽細胞への分化誘導方法
EP1796693A2 (de) * 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantierbare gewebezusammensetzungen und verfahren
JP4734669B2 (ja) * 2005-02-04 2011-07-27 独立行政法人産業技術総合研究所 ヒト歯乳頭からの幹細胞及びその利用方法
DE602005014537D1 (de) * 2005-03-23 2009-07-02 Stiftung Caesar Neurale Stammzellen
US20070258957A1 (en) * 2006-05-04 2007-11-08 Russell Bowermaster Method for obtaining and storing multipotent stem cells
DE602005012081D1 (de) 2005-07-29 2009-02-12 Univ Bonn Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne
JP4781037B2 (ja) * 2005-08-01 2011-09-28 株式会社カネカ ヒト歯髄細胞の判別及び選択方法
EP1780265A1 (de) * 2005-10-25 2007-05-02 Stiftung CAESAR Differenzierung von Stammzellen in Chondrozyten
US7448871B2 (en) * 2005-12-09 2008-11-11 Krasner Paul R Apparatus and method for storing and transporting teeth
ITNA20060017A1 (it) * 2006-02-20 2007-08-21 Aquino Riccardo D Tecnica di prelievo e selezione di un una popolazione di cellule staminali di tipo embrionale da tessuti follicolari peridentari di uomo adulto.
CA2659021A1 (en) 2006-07-20 2008-01-24 Richard Burt Method of using mitotically inactivated stem cells for damaged tissue repair
WO2008031451A1 (en) * 2006-09-11 2008-03-20 Institut Für Molekulare Diagnostik Und Innovative Therapie - Molthera - Gmbh A post-natal periodontal-derived neural stem cell
DE102007005946A1 (de) 2007-02-01 2008-08-14 Stiftung Caesar Therapeutische Zusammensetzung und Verwendung einer zellfreien Substanz
KR101212548B1 (ko) 2007-10-01 2012-12-14 재단법인서울대학교산학협력재단 새로운 치소낭 유래의 치아 줄기세포 및 그의 배양 방법
WO2009044943A1 (en) * 2007-10-01 2009-04-09 Seoul National University Industry Foundation Various human dental stem cells having a mineralization ability and the method for culturing them
ITRM20080342A1 (it) * 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
CN102341696B (zh) * 2009-03-03 2013-12-11 万迈医疗仪器有限公司 用于高灵敏度荧光分析的检测系统和方法
EP2502985B1 (de) * 2009-11-17 2015-04-29 National University Corporation Okayama University Verfahren zur induktion der differenzierung von zahnablagerungszellen in odontoblasten
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
EP2633870B1 (de) * 2012-02-29 2018-08-01 Technische Universität Berlin Verfahren zur Herstellung eines künstlichen Zahn-Primordiums und davon abgeleitetes künstliches Zahn-Primordium
SG11201405875PA (en) 2012-03-19 2014-11-27 Richard Burt Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells
US10041039B2 (en) 2012-03-29 2018-08-07 Jcr Pharmaceuticals Co., Ltd. Method for producing pluripotent stem cells derived from dental pulp
US9790468B2 (en) 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10813955B2 (en) 2015-09-29 2020-10-27 Genani Corporation Methods for treating age-related organ or tissue dysfunction through heterochronic transbiosis using nonviable pluripotent stem cells
IT201700025741A1 (it) * 2017-03-08 2018-09-08 Univ Degli Studi G Dannunzio Chieti Pescara Saggi farmacologici per la fibrosi cistica
CN108165465A (zh) * 2018-03-27 2018-06-15 成都曌昊科技有限公司 一种用于牙齿中获取干细胞的采集处理试剂盒
MX2021001029A (es) 2018-07-31 2021-04-19 Japan Chem Res Metodo para producir celulas derivadas de pulpa dental.
EP4098267A4 (de) 2020-01-30 2024-03-06 Japan Chem Res Medizinische zusammensetzung mit zellen aus zahnmark

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Publication number Priority date Publication date Assignee Title
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
AU3214797A (en) * 1996-05-28 1998-01-05 Regents Of The University Of Michigan, The Engineering oral tissues
EP1218489B1 (de) * 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonale stammzellen-ähnliche zellen, zusammensetzungen und ihre vervendungen
AU7707801A (en) 2000-07-21 2002-02-05 Us Health Adult human dental pulp stem cells in vitro and in vivo

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WO2003066840A3 (en) 2003-12-24
AU2003206844B2 (en) 2010-04-08
EP1456357B1 (de) 2008-06-04
CA2474783A1 (en) 2003-08-14
AU2003206844A1 (en) 2003-09-02
US8192987B2 (en) 2012-06-05
US20050106724A1 (en) 2005-05-19
JP2005516616A (ja) 2005-06-09
NZ534540A (en) 2005-07-29
US20090035282A1 (en) 2009-02-05
ATE397654T1 (de) 2008-06-15
WO2003066840A2 (en) 2003-08-14
JP4125241B2 (ja) 2008-07-30
EP1456357A2 (de) 2004-09-15

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