ATE511753T1 - Postnatale stammzellen und deren verwendungen - Google Patents

Postnatale stammzellen und deren verwendungen

Info

Publication number
ATE511753T1
ATE511753T1 AT03724136T AT03724136T ATE511753T1 AT E511753 T1 ATE511753 T1 AT E511753T1 AT 03724136 T AT03724136 T AT 03724136T AT 03724136 T AT03724136 T AT 03724136T AT E511753 T1 ATE511753 T1 AT E511753T1
Authority
AT
Austria
Prior art keywords
cells
stem cells
postnatal
relates
postnatal stem
Prior art date
Application number
AT03724136T
Other languages
English (en)
Inventor
Songtao Shi
Pamela Robey
Masako Miura
Stan Gronthos
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE511753T1 publication Critical patent/ATE511753T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1361—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from dental pulp or dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03724136T 2003-04-19 2003-04-19 Postnatale stammzellen und deren verwendungen ATE511753T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/012276 WO2004094588A2 (en) 2003-04-19 2003-04-19 Postnatal stem cells and uses thereof

Publications (1)

Publication Number Publication Date
ATE511753T1 true ATE511753T1 (de) 2011-06-15

Family

ID=33308987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724136T ATE511753T1 (de) 2003-04-19 2003-04-19 Postnatale stammzellen und deren verwendungen

Country Status (7)

Country Link
US (3) US9175264B2 (de)
EP (1) EP1619949B1 (de)
AT (1) ATE511753T1 (de)
AU (1) AU2003231015B2 (de)
CA (1) CA2522669C (de)
ES (1) ES2366085T3 (de)
WO (1) WO2004094588A2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
AUPQ147799A0 (en) * 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US20050158289A1 (en) * 1999-07-07 2005-07-21 Simmons Paul J. Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals
CA2522669C (en) 2003-04-19 2013-06-18 Songtao Shi Postnatal stem cells and uses thereof
ITNA20040043A1 (it) * 2004-07-28 2004-10-28 Francesco Carinci Tecnica di ingegneria tissutale ottenibile mediante isolamento di una nuova sottopopolazione di cellule staminali mbp-shed ed mbp-dpsc, isolate da polpa di denti decidui e permanenti in grado di produrre in vitro tessuto osseo umano.
AU2005287855B2 (en) * 2004-09-24 2011-06-16 Mesoblast, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)
US20070258957A1 (en) * 2006-05-04 2007-11-08 Russell Bowermaster Method for obtaining and storing multipotent stem cells
EP1748066B1 (de) * 2005-07-29 2008-12-31 Stiftung CAESAR Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne
WO2008080200A1 (en) * 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
KR100970753B1 (ko) 2007-10-01 2010-07-16 재단법인서울대학교산학협력재단 광화능을 갖는 인간 치아 줄기세포 및 그의 배양방법
US20110002895A1 (en) * 2007-12-05 2011-01-06 Minoru Ueda Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition
JP5621105B2 (ja) 2008-03-12 2014-11-05 公益財団法人ヒューマンサイエンス振興財団 根管充填材
US20110236977A1 (en) * 2008-04-02 2011-09-29 The Trustees Of Columbia University In The City Of New York Dental stem cell differentiation
ITRM20080342A1 (it) 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
JP5793724B2 (ja) * 2008-08-22 2015-10-14 公益財団法人ヒューマンサイエンス振興財団 脳梗塞治療材
US20100172951A1 (en) 2009-01-03 2010-07-08 Ray Wasielewski Enhanced Medical Implant
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
CN103432007A (zh) * 2009-01-23 2013-12-11 首都医科大学 牙齿相关干细胞的新用途
US20150335400A1 (en) * 2009-06-17 2015-11-26 The Trustees Of Columbia University In The City Of New York Tooth scaffolds
EP2446020A4 (de) * 2009-06-25 2013-08-14 Univ Columbia Neuprogrammierung dentaler stammzellen
EP2476442B1 (de) 2009-09-11 2019-04-17 National Center for Geriatrics and Gerontology Wurzelkanalfüllstoff für nicht gezogene zähne und verfahren zur zahngewebewiederherstellung ohne ziehung
KR20130008594A (ko) * 2010-03-26 2013-01-22 고쿠리츠 다이가쿠 호우징 나고야 다이가쿠 손상부 치료용 조성물
EP2625264B1 (de) 2010-10-08 2022-12-07 Terumo BCT, Inc. Verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem mit steuerungsbedingungen
WO2013011131A2 (en) * 2011-07-20 2013-01-24 Angewandte Biotechnologie Gmbh Pluripotent tendon and ligament perivascular cells
CA2846318C (en) * 2013-03-15 2020-04-28 Ray C. Wasielewski Enhanced medical implant
EP3068866B1 (de) 2013-11-16 2018-04-25 Terumo BCT, Inc. Zellenexpansion in einem bioreaktor
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
EP3817753A1 (de) * 2018-07-03 2021-05-12 Universidad del País Vasco - Euskal Herriko Unibertsitatea Zellaggregate zur verwendung in der vaskularisierungstherapie
CN109321522A (zh) * 2018-11-20 2019-02-12 潍坊市康华生物技术有限公司 一种制备牙髓干细胞的方法
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
WO2024040050A2 (en) * 2022-08-16 2024-02-22 University Of Washington System and method to direct the differentiation of pluripotent stem cell-derived odontoblasts
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7707801A (en) * 2000-07-21 2002-02-05 Us Health Adult human dental pulp stem cells in vitro and in vivo
NZ534540A (en) 2002-02-06 2005-07-29 Stiftung Caesar Described is the development of a stem cell bank for teeth or teeth derived tissues, as well as the development of membrane-like meso/endodermal matrices which can be used in regenerative medicine
CA2522669C (en) 2003-04-19 2013-06-18 Songtao Shi Postnatal stem cells and uses thereof

Also Published As

Publication number Publication date
EP1619949A4 (de) 2007-07-04
AU2003231015A1 (en) 2004-11-19
ES2366085T3 (es) 2011-10-17
US9682107B2 (en) 2017-06-20
CA2522669C (en) 2013-06-18
WO2004094588A3 (en) 2004-12-16
EP1619949B1 (de) 2011-06-08
US9175264B2 (en) 2015-11-03
US20170258847A1 (en) 2017-09-14
EP1619949A2 (de) 2006-02-01
US20070274958A1 (en) 2007-11-29
WO2004094588A2 (en) 2004-11-04
AU2003231015B2 (en) 2009-10-08
CA2522669A1 (en) 2004-11-04
US20160008404A1 (en) 2016-01-14

Similar Documents

Publication Publication Date Title
ATE511753T1 (de) Postnatale stammzellen und deren verwendungen
IL273422A (en) Methods and systems for extracorporeal organ treatment
TW200618817A (en) Diffractive colorants for cosmetics
ATE437663T1 (de) Legierungszusammensetzungen und diese enthaltende vorrichtungen
DE60321440D1 (de) Aus zähnen gewonnene pluripotente embryonalähnliche stammzellen und verwendungen davon
UA94221C2 (en) Lipocalin protein
SG155947A1 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1670450A4 (de) Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
EP1809280A4 (de) Mitotische kinesinhemmer und verfahren zu ihrer verwendung
ITRM20030210A1 (it) Protesi da impiegarsi nella terapia chirurgica del prolasso
TW200637522A (en) Skin treatment articles and methods
MX2009012690A (es) Composiciones, metodos, dispositivos y sistemas para el cuidado bucal.
NO20075009L (no) Ernaeringstilsetning for HIV-pasienter
DE602005027899D1 (de) Mundpflegezusammensetzung mit dem extrakt von unoxidierter kamelie
ATE350377T1 (de) Substituierte 3-pyrrolidin-indol-derivate
MY155032A (en) High fluoride ion oral care composition and method for maintaining anticaries activity
WO2005052140A3 (en) Multipotent postnatal stem cells from human periodontal ligament and uses thereof
ATE322901T1 (de) Maca und geweih zur steigerung des testosteronspiegels
CO5660287A2 (es) Derivados de tetrahidrocarbazol y su uso farmaceutico
TW200716091A (en) New therapeutic combinations for the treatment or prevention of psychotic disorders
TW200602076A (en) O, O'-amidomalonate and N, O-amidomalonate platinum complexes
ATE431846T1 (de) Neurale stammzellen
HRP20090513T1 (hr) S-mirtazapin, namijenjen liječenju napadaja vrućine
IL175303A0 (en) Oral formulations for 5-ht-receptor agonists, uses and methods of treatment employing the same
DE602004019541D1 (de) Cycloalkyläbü kondensierte indole

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties