BR112017016638A2 - anticorpos direcionados contra o gene de ativação de linfócitos 3 (lag-3) - Google Patents
anticorpos direcionados contra o gene de ativação de linfócitos 3 (lag-3)Info
- Publication number
- BR112017016638A2 BR112017016638A2 BR112017016638A BR112017016638A BR112017016638A2 BR 112017016638 A2 BR112017016638 A2 BR 112017016638A2 BR 112017016638 A BR112017016638 A BR 112017016638A BR 112017016638 A BR112017016638 A BR 112017016638A BR 112017016638 A2 BR112017016638 A2 BR 112017016638A2
- Authority
- BR
- Brazil
- Prior art keywords
- lag
- directed against
- antibodies directed
- lymphocyte activation
- activation gene
- Prior art date
Links
- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 title 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 title 1
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111486P | 2015-02-03 | 2015-02-03 | |
| US62/111,486 | 2015-02-03 | ||
| PCT/US2016/016424 WO2016126858A2 (en) | 2015-02-03 | 2016-02-03 | Antibodies directed against lymphocyte activation gene 3 (lag-3) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017016638A2 true BR112017016638A2 (pt) | 2018-06-19 |
| BR112017016638B1 BR112017016638B1 (pt) | 2023-11-07 |
Family
ID=56564868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017016638-0A BR112017016638B1 (pt) | 2015-02-03 | 2016-02-03 | Agente de ligação do gene de ativação de linfócitos-3, uso do mesmo e composição farmacêutica |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10836824B2 (pt) |
| EP (2) | EP4011914A1 (pt) |
| JP (1) | JP6949713B2 (pt) |
| KR (1) | KR20170116067A (pt) |
| CN (2) | CN107428836A (pt) |
| BR (1) | BR112017016638B1 (pt) |
| CA (1) | CA2975753A1 (pt) |
| EA (1) | EA201791742A1 (pt) |
| HK (2) | HK1246814A1 (pt) |
| IL (1) | IL253718B (pt) |
| MA (1) | MA41463A (pt) |
| MX (2) | MX2017009904A (pt) |
| SG (2) | SG10201907161YA (pt) |
| WO (1) | WO2016126858A2 (pt) |
| ZA (1) | ZA201705303B (pt) |
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|---|---|---|---|---|
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| MA41463A (fr) | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
| MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
| WO2017055404A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
| KR20180086502A (ko) | 2015-12-16 | 2018-07-31 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항원-결합 단편 |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| CN117586403A (zh) | 2016-10-11 | 2024-02-23 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
| JP7212821B2 (ja) | 2016-10-13 | 2023-01-26 | チア・タイ・ティエンチン・ファーマシューティカル・グループ・カンパニー・リミテッド | 抗ｌａｇ－３抗体および組成物 |
| BR112019008861A2 (pt) | 2016-11-01 | 2019-07-09 | Anaptysbio Inc | anticorpos direcionados contra imunoglobulina de células t e proteína de mucina 3 (tim-3) |
| AU2017354070A1 (en) | 2016-11-01 | 2019-05-16 | Anaptysbio, Inc. | Antibodies directed against programmed death- 1 (PD-1) |
| BR112019014187A2 (pt) | 2017-01-09 | 2020-02-11 | Tesaro, Inc. | Métodos de tratamento de câncer com anticorpos anti-pd-1 |
| CA3049536A1 (en) | 2017-01-09 | 2018-07-12 | Tesaro, Inc. | Methods of treating cancer with anti-tim-3 antibodies |
| CN110650974B (zh) | 2017-02-10 | 2024-04-19 | 瑞泽恩制药公司 | 用于免疫-pet成像的放射性标记的抗-lag3抗体 |
| EP3389702A4 (en) | 2017-02-22 | 2019-08-14 | I-Mab | ANTI-LAG-3 ANTIBODIES AND USES THEREOF |
| KR102461885B1 (ko) | 2017-04-03 | 2022-11-03 | 에프. 호프만-라 로슈 아게 | 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체 |
| CA3185303A1 (en) * | 2017-04-05 | 2018-10-11 | Symphogen A/S | Combination therapies targeting pd-a, tim-3, and lag-3 |
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| KR102346336B1 (ko) | 2017-04-05 | 2022-01-04 | 에프. 호프만-라 로슈 아게 | Pd1 및 lag3에 특이적으로 결합하는 이중특이적 항체 |
| BR112019022515A2 (pt) | 2017-04-27 | 2020-06-16 | Tesaro, Inc. | Agentes de anticorpo direcionados contra o gene 3 de ativação linfocitária (lag-3) e usos dos mesmos |
| JP2020520921A (ja) | 2017-05-18 | 2020-07-16 | テサロ， インコーポレイテッド | 癌を処置する併用療法 |
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| BR112019021847A2 (pt) | 2017-05-30 | 2020-06-02 | Bristol-Myers Squibb Company | Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1 |
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-
2016
- 2016-02-02 MA MA041463A patent/MA41463A/fr unknown
- 2016-02-03 SG SG10201907161YA patent/SG10201907161YA/en unknown
- 2016-02-03 CN CN201680020117.3A patent/CN107428836A/zh active Pending
- 2016-02-03 BR BR112017016638-0A patent/BR112017016638B1/pt active IP Right Grant
- 2016-02-03 JP JP2017540834A patent/JP6949713B2/ja active Active
- 2016-02-03 EP EP21198994.2A patent/EP4011914A1/en active Pending
- 2016-02-03 CN CN202210381152.5A patent/CN114634573A/zh active Pending
- 2016-02-03 KR KR1020177024728A patent/KR20170116067A/ko not_active Application Discontinuation
- 2016-02-03 EA EA201791742A patent/EA201791742A1/ru unknown
- 2016-02-03 US US15/548,405 patent/US10836824B2/en active Active
- 2016-02-03 CA CA2975753A patent/CA2975753A1/en active Pending
- 2016-02-03 SG SG11201706199RA patent/SG11201706199RA/en unknown
- 2016-02-03 WO PCT/US2016/016424 patent/WO2016126858A2/en active Application Filing
- 2016-02-03 MX MX2017009904A patent/MX2017009904A/es unknown
- 2016-02-03 EP EP16747220.8A patent/EP3253798A4/en not_active Ceased
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2017
- 2017-07-30 IL IL253718A patent/IL253718B/en unknown
- 2017-07-31 MX MX2022000112A patent/MX2022000112A/es unknown
- 2017-08-04 ZA ZA2017/05303A patent/ZA201705303B/en unknown
-
2018
- 2018-05-17 HK HK18106454.6A patent/HK1246814A1/zh unknown
- 2018-05-25 HK HK18106890.8A patent/HK1247618A1/zh unknown
-
2019
- 2019-05-01 US US16/400,198 patent/US20190256596A1/en not_active Abandoned
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2020
- 2020-10-19 US US17/074,269 patent/US20210095026A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1247618A1 (zh) | 2018-09-28 |
| WO2016126858A3 (en) | 2016-09-29 |
| MA41463A (fr) | 2017-12-12 |
| EA201791742A1 (ru) | 2018-01-31 |
| MX2022000112A (es) | 2022-02-10 |
| EP4011914A1 (en) | 2022-06-15 |
| HK1246814A1 (zh) | 2018-09-14 |
| BR112017016638B1 (pt) | 2023-11-07 |
| ZA201705303B (en) | 2022-12-21 |
| US10836824B2 (en) | 2020-11-17 |
| SG11201706199RA (en) | 2017-08-30 |
| US20190256596A1 (en) | 2019-08-22 |
| US20180127496A1 (en) | 2018-05-10 |
| KR20170116067A (ko) | 2017-10-18 |
| CA2975753A1 (en) | 2016-08-11 |
| IL253718A0 (en) | 2017-09-28 |
| CN114634573A (zh) | 2022-06-17 |
| EP3253798A4 (en) | 2018-07-25 |
| JP6949713B2 (ja) | 2021-10-13 |
| EP3253798A2 (en) | 2017-12-13 |
| CN107428836A (zh) | 2017-12-01 |
| MX2017009904A (es) | 2018-06-27 |
| IL253718B (en) | 2021-08-31 |
| US20210095026A1 (en) | 2021-04-01 |
| SG10201907161YA (en) | 2019-09-27 |
| WO2016126858A2 (en) | 2016-08-11 |
| JP2018505674A (ja) | 2018-03-01 |
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